AU2002245996A1 - Modified cyclosporine which can be used as a pro-drug and use thereof - Google Patents
Modified cyclosporine which can be used as a pro-drug and use thereofInfo
- Publication number
- AU2002245996A1 AU2002245996A1 AU2002245996A AU2002245996A AU2002245996A1 AU 2002245996 A1 AU2002245996 A1 AU 2002245996A1 AU 2002245996 A AU2002245996 A AU 2002245996A AU 2002245996 A AU2002245996 A AU 2002245996A AU 2002245996 A1 AU2002245996 A1 AU 2002245996A1
- Authority
- AU
- Australia
- Prior art keywords
- pro
- drug
- cyclosporine
- modified
- modified cyclosporine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 229940064638 modified cyclosporine Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 229940002612 prodrugs Drugs 0.000 title 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH7202001 | 2001-04-20 | ||
| CH720/01 | 2001-04-20 | ||
| PCT/CH2002/000222 WO2002085928A2 (en) | 2001-04-20 | 2002-04-22 | Modified cyclosporine which can be used as a pro-drug and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2002245996A1 true AU2002245996A1 (en) | 2003-04-17 |
| AU2002245996B2 AU2002245996B2 (en) | 2005-06-30 |
| AU2002245996B8 AU2002245996B8 (en) | 2005-07-14 |
Family
ID=4531478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002245996A Ceased AU2002245996B8 (en) | 2001-04-20 | 2002-04-22 | Modified cyclosporine which can be used as a pro-drug and use thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6995139B2 (en) |
| EP (1) | EP1379547B1 (en) |
| JP (1) | JP4588979B2 (en) |
| KR (1) | KR100932859B1 (en) |
| CN (1) | CN1507451A (en) |
| AT (1) | ATE313557T1 (en) |
| AU (1) | AU2002245996B8 (en) |
| BR (1) | BR0208923A (en) |
| CA (1) | CA2444278C (en) |
| DE (1) | DE60208180T2 (en) |
| ES (1) | ES2256450T3 (en) |
| IL (1) | IL158385A0 (en) |
| MX (1) | MXPA03009586A (en) |
| RU (1) | RU2290196C2 (en) |
| UA (1) | UA75136C2 (en) |
| WO (1) | WO2002085928A2 (en) |
| ZA (1) | ZA200307794B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| EP1904056B1 (en) | 2005-07-18 | 2009-04-29 | Minu, L.L.C. | Use of a macrolide to restore corneal sensation |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| TW200820963A (en) * | 2006-07-28 | 2008-05-16 | Xenoport Inc | Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use |
| AU2008304313B2 (en) | 2007-09-26 | 2013-01-10 | Oregon Health & Science University | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
| WO2009098533A1 (en) * | 2008-02-08 | 2009-08-13 | Debiopharm Sa | Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy |
| GB0912584D0 (en) * | 2009-07-20 | 2009-08-26 | Ucl Business Plc | Cyclosporin conjugates |
| SG191069A1 (en) | 2010-12-15 | 2013-07-31 | Isotechnika Pharma Inc | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| AR090964A1 (en) * | 2012-05-09 | 2014-12-17 | Novartis Ag | PROCESS FOR THE PREPARATION OF CYCLE UNDECAPEPTIDES |
| CN113388002A (en) * | 2021-06-10 | 2021-09-14 | 梯尔希（南京）药物研发有限公司 | Preparation method of cyclosporine related compound |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4396542A (en) * | 1980-02-14 | 1983-08-02 | Sandoz Ltd. | Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| EP0034567B1 (en) * | 1980-02-14 | 1984-11-07 | Sandoz Ag | A method for the total synthesis of cyclosporins and novel cyclosporins |
| US5169773A (en) * | 1984-10-04 | 1992-12-08 | Sandoz Ltd. | Monoclonal antibodies to cyclosporins |
| DE3478398D1 (en) * | 1984-10-10 | 1989-07-06 | Ile De France | Synergistic contraceptive mixture |
| US4764503A (en) * | 1986-11-19 | 1988-08-16 | Sandoz Ltd. | Novel cyclosporins |
| SK278808B6 (en) * | 1990-11-02 | 1998-03-04 | Novartis Ag | Cyclosporines, their use at the preparation of drug for treating and preventing aids, preparation method thereof and fungal strains useable at this method |
| US6187547B1 (en) * | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
| GB9624038D0 (en) * | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| US6017879A (en) * | 1998-04-03 | 2000-01-25 | B.M.R.A. Corporation B.V. | Template associated NPY Y2-receptor agonists |
| JP4350898B2 (en) | 1998-07-01 | 2009-10-21 | デビオファーム・ソシエテ・アノニム | Novel cyclosporine with improved activity characteristics |
| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| EP1150999B1 (en) * | 1999-02-05 | 2006-06-21 | Debiopharm S.A. | Cyclosporin derivatives and method for the production of said derivatives |
| US6765019B1 (en) * | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| WO2001005819A1 (en) * | 1999-07-15 | 2001-01-25 | Kuhnil Pharm. Co., Ltd. | Novel water soluble-cyclosporine conjugated compounds |
| US6593292B1 (en) | 1999-08-24 | 2003-07-15 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
-
2002
- 2002-04-22 CA CA2444278A patent/CA2444278C/en not_active Expired - Fee Related
- 2002-04-22 EP EP02713992A patent/EP1379547B1/en not_active Expired - Lifetime
- 2002-04-22 ES ES02713992T patent/ES2256450T3/en not_active Expired - Lifetime
- 2002-04-22 WO PCT/CH2002/000222 patent/WO2002085928A2/en active IP Right Grant
- 2002-04-22 JP JP2002583454A patent/JP4588979B2/en not_active Expired - Fee Related
- 2002-04-22 CN CNA028094050A patent/CN1507451A/en active Pending
- 2002-04-22 MX MXPA03009586A patent/MXPA03009586A/en active IP Right Grant
- 2002-04-22 RU RU2003133742/15A patent/RU2290196C2/en not_active IP Right Cessation
- 2002-04-22 AU AU2002245996A patent/AU2002245996B8/en not_active Ceased
- 2002-04-22 IL IL15838502A patent/IL158385A0/en not_active IP Right Cessation
- 2002-04-22 BR BR0208923-8A patent/BR0208923A/en active Search and Examination
- 2002-04-22 US US10/474,396 patent/US6995139B2/en not_active Expired - Fee Related
- 2002-04-22 UA UA20031110436A patent/UA75136C2/en unknown
- 2002-04-22 DE DE60208180T patent/DE60208180T2/en not_active Expired - Lifetime
- 2002-04-22 AT AT02713992T patent/ATE313557T1/en not_active IP Right Cessation
-
2003
- 2003-10-06 ZA ZA200307794A patent/ZA200307794B/en unknown
- 2003-10-17 KR KR1020037013666A patent/KR100932859B1/en not_active IP Right Cessation
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