AU2002231353A1 - Knockout mice thyroid stimulating hormone receptor (tsh-r) gene - Google Patents

Knockout mice thyroid stimulating hormone receptor (tsh-r) gene

Info

Publication number
AU2002231353A1
AU2002231353A1 AU2002231353A AU3135302A AU2002231353A1 AU 2002231353 A1 AU2002231353 A1 AU 2002231353A1 AU 2002231353 A AU2002231353 A AU 2002231353A AU 3135302 A AU3135302 A AU 3135302A AU 2002231353 A1 AU2002231353 A1 AU 2002231353A1
Authority
AU
Australia
Prior art keywords
tsh
gene
stimulating hormone
hormone receptor
knockout mice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002231353A
Other languages
English (en)
Inventor
Keith D. Allen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deltagen Inc
Original Assignee
Deltagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc filed Critical Deltagen Inc
Publication of AU2002231353A1 publication Critical patent/AU2002231353A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2002231353A 2000-10-26 2001-10-26 Knockout mice thyroid stimulating hormone receptor (tsh-r) gene Abandoned AU2002231353A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24389500P 2000-10-26 2000-10-26
US60/243,895 2000-10-26
USNOTGIVEN 2000-11-08
PCT/US2001/051013 WO2002034042A2 (fr) 2000-10-26 2001-10-26 Souris transgeniques contenant des disruptions geniques du recepteur de l'hormone de stimulation thyroidienne (tch-r)

Publications (1)

Publication Number Publication Date
AU2002231353A1 true AU2002231353A1 (en) 2002-05-06

Family

ID=22920575

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002231353A Abandoned AU2002231353A1 (en) 2000-10-26 2001-10-26 Knockout mice thyroid stimulating hormone receptor (tsh-r) gene

Country Status (3)

Country Link
US (1) US20030009778A1 (fr)
AU (1) AU2002231353A1 (fr)
WO (1) WO2002034042A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230150525A (ko) 2022-04-22 2023-10-31 연세대학교 산학협력단 신규한 자가면역질환 동물모델

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68927461T2 (de) * 1989-12-14 1997-03-20 B.R.A.H.M.S Diagnostica Gmbh, 12099 Berlin Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide
ATE510552T1 (de) * 1996-06-05 2011-06-15 Basil Rapoport Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors
DE19728991A1 (de) * 1996-11-06 1999-02-11 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
WO2000000590A1 (fr) * 1998-06-30 2000-01-06 Basil Rapoport Compositions a base de recepteur de la thyrotropine humaine et leur utilisation

Also Published As

Publication number Publication date
WO2002034042A2 (fr) 2002-05-02
US20030009778A1 (en) 2003-01-09
WO2002034042A3 (fr) 2003-09-04

Similar Documents

Publication Publication Date Title
EP1412073A4 (fr) Systeme d'alimentation en charge de processeur de carburant
AU4080100A (en) User interface for an electronic trading system
IL153799A0 (en) Improved thyroid hormone formulations
AU2002239538A1 (en) Transgenic mice containing glucagon receptor gene disruptions
AU2002305944A1 (en) Mouse cytokine receptor
AU2441801A (en) Urotensin-ii receptor antagonists
EP1144628A3 (fr) Gene de recepteur de vanilloide humain
AU2002231353A1 (en) Knockout mice thyroid stimulating hormone receptor (tsh-r) gene
IL149277A0 (en) Transgenic mice containing trp gene disruptions
AU2002250181A1 (en) Franking system user interface
GB9927215D0 (en) Hormone receptor expression
AU2001275362A1 (en) Nuclear hormone receptors
AU2002220228A1 (en) Knockout mice for trp6 gene
AU4711800A (en) Cytokine receptor mouse zcytor10
AU2001241422A1 (en) A novel steroid hormone receptor interacting protein kinase
AU2002359352A1 (en) Antisense modulation of thyroid hormone receptor interactor 6 expression
AU2002220273A1 (en) Transgenic mice containing adrenocorticotropin hormone receptor gene disruptions
AU2003242852A1 (en) Nuclear hormone receptor
AU143244S (en) Fuel dispenser interface
EP1599494A4 (fr) Restauration des fonctions des recepteurs mutants de l'hormone de liberation de la gonadotrophine
AU2001233051A1 (en) Nuclear hormone receptors
AU2003242849A1 (en) Nuclear hormone receptor
AU2003244831A1 (en) Human nuclear hormone receptor
GB2356946B (en) Computer system user interface design
AU143245S (en) Fuel dispenser interface