AU2002229576A1 - Method for producing lipoic acid and dihydrolipoic acid - Google Patents

Method for producing lipoic acid and dihydrolipoic acid

Info

Publication number
AU2002229576A1
AU2002229576A1 AU2002229576A AU2957602A AU2002229576A1 AU 2002229576 A1 AU2002229576 A1 AU 2002229576A1 AU 2002229576 A AU2002229576 A AU 2002229576A AU 2957602 A AU2957602 A AU 2957602A AU 2002229576 A1 AU2002229576 A1 AU 2002229576A1
Authority
AU
Australia
Prior art keywords
sub
acid
sulfur
dihydrolipoic
sodium sulfide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002229576A
Inventor
Martin Jochen Klatt
Markus Niebel
Joachim Paust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of AU2002229576A1 publication Critical patent/AU2002229576A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Abstract

The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising (a) reaction of where MS is SO<SUB>2</SUB>-R' and R and R' independently of one another are C<SUB>1</SUB>-C<SUB>6</SUB>-alkyl, C<SUB>3</SUB>-C<SUB>8</SUB>-cycloalkyl, C<SUB>3</SUB>-C<SUB>8</SUB>-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.
AU2002229576A 2000-11-30 2001-11-29 Method for producing lipoic acid and dihydrolipoic acid Abandoned AU2002229576A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10059718.1 2000-11-30
DE10059718 2000-11-30
PCT/EP2001/013955 WO2002044163A2 (en) 2000-11-30 2001-11-29 Method for producing lipoic acid and dihydrolipoic acid

Publications (1)

Publication Number Publication Date
AU2002229576A1 true AU2002229576A1 (en) 2002-06-11

Family

ID=7665405

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002229576A Abandoned AU2002229576A1 (en) 2000-11-30 2001-11-29 Method for producing lipoic acid and dihydrolipoic acid

Country Status (10)

Country Link
US (1) US7109362B2 (en)
EP (1) EP1339705B1 (en)
JP (1) JP2004514716A (en)
AT (1) ATE328877T1 (en)
AU (1) AU2002229576A1 (en)
CA (1) CA2430073A1 (en)
DE (1) DE50110077D1 (en)
DK (1) DK1339705T3 (en)
ES (1) ES2266299T3 (en)
WO (1) WO2002044163A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10201464B4 (en) * 2002-01-16 2005-06-16 Viatris Gmbh & Co. Kg Process for the preparation of pure thioctic acid
DE10255242A1 (en) 2002-11-26 2004-06-03 Basf Ag Process for the purification of lipoic acid
US20070299093A1 (en) * 2005-01-27 2007-12-27 Alma Mater Studiorum-Universitá Di Bologna Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation
WO2006080043A2 (en) * 2005-01-27 2006-08-03 Alma Mater Studiorum- Universita' Di Bologna Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
WO2009003284A1 (en) * 2007-06-29 2009-01-08 Innovactiv Inc. Novel peptides, use thereof in cosmetic and cosmeceutic applications, and compositions comprising same
US20090078581A1 (en) * 2007-09-24 2009-03-26 Applied Intellectual Capital Configurations and Methods of Reduction of Lipoic Acid
US8476427B2 (en) 2010-03-09 2013-07-02 Novus International, Inc. Preparation of methionine or selenomethionine from homoserine via a carbamate intermediate
US9944960B2 (en) 2015-11-17 2018-04-17 Premier Research Labs, Lp Process for microbial production of dihydrolipoic acid and extraction of dihydrolipoic acid with edible oils
DE102017000811A1 (en) 2017-01-28 2018-08-02 Alzchem Trostberg Gmbh Process for the preparation of dihydrolipoic acid
CN111377840A (en) * 2018-12-29 2020-07-07 江苏同禾药业有限公司 Preparation method of R- (+) -dihydrolipoic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2029596C (en) 1989-11-09 2000-05-23 Heinz Ulrich Medicaments containing r-a-lipoic acid
DE4037440A1 (en) 1990-11-24 1992-05-27 Basf Ag METHOD FOR PRODUCING (6S) -6,8-DIHYDROXYOCTANIC ACID ESTERS
DE4137773A1 (en) 1991-11-16 1993-05-19 Degussa PRODUCTION AND USE OF SALTS OF THE PURE ENANTIOMERS OF (ALPHA) LIPONIC ACID
DE4343593C2 (en) 1993-12-21 1998-05-20 Asta Medica Ag Use of R - (+) - alpha-lipoic acid, R - (-) - dihydrolipoic acid or the metabolites as well as their salts, esters, amides for the treatment of compensated and decompensated insulin resistance
DE4343592C2 (en) 1993-12-21 1998-04-16 Asta Medica Ag Use of R - (+) - alpha-lipoic acid and its metabolites in the form of the free acid or as salts or esters or amides for the treatment of glucose metabolic disorders in the central nervous system
DE19834608A1 (en) 1998-07-31 2000-02-03 Basf Ag Crystal modification of lipoic acid
EP1124820B1 (en) 1998-10-26 2004-09-22 The Research Foundation Of State University Of New York Lipoic acid derivatives and their use in treatment of disease
US6204288B1 (en) 1999-03-08 2001-03-20 The University Of Mississippi 1,2-dithiolane derivatives
AR042572A1 (en) 1999-04-02 2005-06-29 Sod Conseils Rech Applic DERIVATIVES OF LIPOIC ACID, PROCEDURE FOR THE PREPARATION, MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF SUCH DERIVATIVES FOR THE PREPARATION OF THE REFERRED MEDICATIONS
CN1680364A (en) * 2000-08-02 2005-10-12 巴斯福股份公司 Method for producing lipoic acid and dihydrolipoic acid

Also Published As

Publication number Publication date
ATE328877T1 (en) 2006-06-15
WO2002044163A2 (en) 2002-06-06
ES2266299T3 (en) 2007-03-01
EP1339705B1 (en) 2006-06-07
CA2430073A1 (en) 2002-06-06
EP1339705A2 (en) 2003-09-03
US20050101669A1 (en) 2005-05-12
US7109362B2 (en) 2006-09-19
JP2004514716A (en) 2004-05-20
WO2002044163A3 (en) 2003-01-30
DE50110077D1 (en) 2006-07-20
DK1339705T3 (en) 2006-10-09

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