AU2002212970B2 - Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies - Google Patents

Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies Download PDF

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Publication number
AU2002212970B2
AU2002212970B2 AU2002212970A AU2002212970A AU2002212970B2 AU 2002212970 B2 AU2002212970 B2 AU 2002212970B2 AU 2002212970 A AU2002212970 A AU 2002212970A AU 2002212970 A AU2002212970 A AU 2002212970A AU 2002212970 B2 AU2002212970 B2 AU 2002212970B2
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Australia
Prior art keywords
antibody
hydrogen peroxide
superoxide
antigen
oxygen
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AU2002212970A
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AU2002212970A1 (en
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Kim D. Janda
Lyn H. Jones
Richard A. Lerner
Anita D. Wentworth
Paul Wentworth
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Scripps Research Institute
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Scripps Research Institute
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    • AHUMAN NECESSITIES
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
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    • A61K31/365Lactones
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • AHUMAN NECESSITIES
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    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • A61K38/446Superoxide dismutase (1.15)
    • AHUMAN NECESSITIES
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
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  • Biomedical Technology (AREA)
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  • Addiction (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Hematology (AREA)
  • Cardiology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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AU2002212970A 2000-09-15 2001-09-17 Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies Ceased AU2002212970B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23270200P 2000-09-15 2000-09-15
US60/232,702 2000-09-15
US23547500P 2000-09-26 2000-09-26
US60/235,475 2000-09-26
US31590601P 2001-08-29 2001-08-29
US60/315,906 2001-08-29
PCT/US2001/029165 WO2002022573A2 (fr) 2000-09-15 2001-09-17 Procedes et compositions concernant le peroxyde d'hydrogene et la production de superoxyde par des anticorps

Publications (2)

Publication Number Publication Date
AU2002212970A1 AU2002212970A1 (en) 2002-06-13
AU2002212970B2 true AU2002212970B2 (en) 2007-05-31

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AU2002212970A Ceased AU2002212970B2 (en) 2000-09-15 2001-09-17 Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies
AU1297002A Pending AU1297002A (en) 2000-09-15 2001-09-17 Methods and compositions relating to hydrogen peroxide and superoxide productionby antibodies

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AU1297002A Pending AU1297002A (en) 2000-09-15 2001-09-17 Methods and compositions relating to hydrogen peroxide and superoxide productionby antibodies

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EP (1) EP1367998A4 (fr)
JP (1) JP2005524601A (fr)
AU (2) AU2002212970B2 (fr)
CA (1) CA2422586A1 (fr)
WO (1) WO2002022573A2 (fr)

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GB2380481B (en) 2001-08-22 2003-12-03 Cambridge Theranostics Ltd Means for treatment of atherosclerosis
JP2006506419A (ja) * 2002-11-14 2006-02-23 ノバルティス アクチエンゲゼルシャフト 活性酸素種を産生する抗体の抗微生物活性
DE10258239A1 (de) * 2002-12-13 2004-06-24 Degussa Ag Formulierung enthaltend alpha-Liponsäure(-Derivate) als alleinigen Wirkstoff bei nichtchronischen alkoholinduzierten Intoxikationen
US20050020666A1 (en) * 2003-07-25 2005-01-27 Dabur Research Foundation Cardioprotective agents
JP4615470B2 (ja) 2006-03-29 2011-01-19 卓郎 簑和田 大脳の認知力を用いた疾患治療・予防の方法および医薬
EP2123259A1 (fr) * 2007-01-16 2009-11-25 Hokkaido University Préparation liposomale pour une iontophorèse incluant un composant anti-oxydant encapsulé
US20140314778A1 (en) 2013-03-13 2014-10-23 Genentech, Inc. Formulations with reduced oxidation
AR095399A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida, método
ES2688895T3 (es) * 2013-03-13 2018-11-07 F. Hoffmann-La Roche Ag Formulaciones con oxidación reducida
JP6269946B2 (ja) * 2014-03-25 2018-01-31 国立大学法人名古屋大学 細菌の増殖抑制
KR101774636B1 (ko) * 2015-04-06 2017-09-04 한국생명공학연구원 나노 프로브 기반 항체의 무표지 검출 방법
AU2018375151A1 (en) * 2017-11-29 2020-06-11 Figene, Llc Interaction of fibroblasts and immune cells for activation and uses thereof

Citations (7)

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Publication number Priority date Publication date Assignee Title
US5162217A (en) * 1984-08-27 1992-11-10 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US5268371A (en) * 1990-01-10 1993-12-07 Cis Bio International Derivatives of porphyrin and metalloporphyrins optionally coupled to a biologically active molecule and pharmaceutical composition containing them
US5362492A (en) * 1990-12-04 1994-11-08 Gruenenthal Gmbh Method of inhibiting multiple organ failure in trauma patients by administration of superoxide dismutase
US5472961A (en) * 1994-03-03 1995-12-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Acetamides
US5637315A (en) * 1993-01-04 1997-06-10 Thomas Jefferson University Treatment of disease states induced by oxidative stress
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers

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US5248603A (en) * 1985-09-03 1993-09-28 Symbicom Aktiebolag Superoxide dismutase
SE9604581D0 (sv) * 1996-12-12 1996-12-12 Karolinska Innovations Ab An agent against cancer and virus infections

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162217A (en) * 1984-08-27 1992-11-10 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US5268371A (en) * 1990-01-10 1993-12-07 Cis Bio International Derivatives of porphyrin and metalloporphyrins optionally coupled to a biologically active molecule and pharmaceutical composition containing them
US5362492A (en) * 1990-12-04 1994-11-08 Gruenenthal Gmbh Method of inhibiting multiple organ failure in trauma patients by administration of superoxide dismutase
US5637315A (en) * 1993-01-04 1997-06-10 Thomas Jefferson University Treatment of disease states induced by oxidative stress
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
US5472961A (en) * 1994-03-03 1995-12-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Acetamides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Pogrebniak et al. Surg Oncol. 1993; vol. 2 no.1 pages 31-42. *

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Publication number Publication date
EP1367998A4 (fr) 2004-03-17
WO2002022573A2 (fr) 2002-03-21
EP1367998A2 (fr) 2003-12-10
AU1297002A (en) 2002-03-26
JP2005524601A (ja) 2005-08-18
CA2422586A1 (fr) 2002-03-21
WO2002022573A3 (fr) 2003-10-02

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