AU2001281821A1 - Method for the extraction and the use of antibiotically effective peptides for treating infectious diseases - Google Patents
Method for the extraction and the use of antibiotically effective peptides for treating infectious diseasesInfo
- Publication number
- AU2001281821A1 AU2001281821A1 AU2001281821A AU8182101A AU2001281821A1 AU 2001281821 A1 AU2001281821 A1 AU 2001281821A1 AU 2001281821 A AU2001281821 A AU 2001281821A AU 8182101 A AU8182101 A AU 8182101A AU 2001281821 A1 AU2001281821 A1 AU 2001281821A1
- Authority
- AU
- Australia
- Prior art keywords
- peptide
- amino acids
- gkvkvgvngfgrigrlvtraafnsgkvdiva
- extraction
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 208000035473 Communicable disease Diseases 0.000 title 1
- 238000000605 extraction Methods 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 5
- 230000003115 biocidal effect Effects 0.000 abstract 3
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 241000588722 Escherichia Species 0.000 abstract 1
- 241000196833 Kocuria rhizophila DC2201 Species 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 239000000417 fungicide Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002423 protozoacide Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000012873 virucide Substances 0.000 abstract 1
Classifications
-
- A23L3/3526—
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Antibiotic peptides (A), their derivatives (amidated, acetylated, sulfated, phosphorylated, glycosylated or oxidized) and their active fragments, preferably with conserved exchanges or deletions of amino acids, are new. New antibiotic peptides (A), have formulae (1) - (12). (1) R 1-WGKMVTAVASALSSRYH-R 2; (2) R 1-GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA-R 2; (3) R 1-VCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH-R 2; (4) R 1-KAGAHLKGGAKRVIISAPS-R 2; (5) R 1-YIVYKIRSADKRSKALK-R 2; (6) R 1-KAASKKAPSKASPNPRSGTRRSP-R 2; (7) R 1-KAASKKAPSKASPNPRSGTRRSPRIATTAASAATAAASAAATTPRAKGKAKH-R 2; (8) R 1-CAIHAKRVTIMPKDIQLARRIRGERA-R 2; (9) R 1-LSKGLIKLVSKHRAQVIYTRNTKGGDAPAAG-R 2; (10) R 1-QQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPG-R 2; (11) R 1-LKSLVSKGTLVQTKGTGASGSFKLNLLAATGEAKPKGKKAGAAKPKKAAGAAKKPKK-R 2; or (12) R-1-SSGEEVVIPQKKGKKAATTPAKKMVVSPTKKVAVATPAKKAVVTPGKKAAAMPAKKTVTPAKAVVTPGKKGATPGKAVVATSGKKGAATPGKGAKNGKNAKKED-R 2. R 1amino, amino acid or peptide of up to 50 amino acids; R 2carboxy, aminocarbonyl, amino acid or peptide of up to 50 amino acids An independent claim is also included for methods for preparing (A). ACTIVITY : Antibiotic; fungicide; protozoacide; virucide; cytostatic; antiinflammatory; antidiarrheic. The peptide (2) had typical minimum inhibitory concentrations (Microg/ml) of 7.8 for Bacillus subtilisAmerican Type Culture Collection (ATCC) 6051 and Escherichia coliBL21(DE3) and 31.25 against Pseudomonas aeruginosa(clinical isolate) or Micrococcus luteusATCC 9341. GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA (2) MECHANISM OF ACTION : Peptide therapy.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10027992.9 | 2000-06-08 | ||
| DE10027992 | 2000-06-08 | ||
| PCT/EP2001/006518 WO2001094386A2 (en) | 2000-06-08 | 2001-06-08 | Method for the extraction and the use of antibiotically effective peptides for treating infectious diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001281821A1 true AU2001281821A1 (en) | 2001-12-17 |
Family
ID=7644875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001281821A Abandoned AU2001281821A1 (en) | 2000-06-08 | 2001-06-08 | Method for the extraction and the use of antibiotically effective peptides for treating infectious diseases |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP1481988A3 (en) |
| AT (1) | ATE319740T1 (en) |
| AU (1) | AU2001281821A1 (en) |
| DE (1) | DE50109168D1 (en) |
| ES (1) | ES2199098T3 (en) |
| WO (1) | WO2001094386A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005532784A (en) | 2001-12-07 | 2005-11-04 | イーペーエフ ファルマシューティカルス ゲゼルシャフト ミット ベシュレンクテル ハフツング | New antibacterial voricin peptide |
| DE10327518A1 (en) * | 2003-06-17 | 2005-01-13 | Klett-Loch, Lore Maria | Synthetic peptide combinations and methods for their preparation |
| JP5101280B2 (en) * | 2004-08-18 | 2012-12-19 | イーペーエフ ファルマシューティカルス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Peptides for the treatment of herpes virus infection |
| EP2789343A1 (en) * | 2013-04-11 | 2014-10-15 | Clinique La Prairie | Novel hemoglobin-derived peptide based pharmaceutical compositions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998031706A1 (en) * | 1997-01-15 | 1998-07-23 | Johns Hopkins University | METHODS OF TREATING LUNG INFECTIONS WITH HUMAN TRACHEAL ANTIMICROBIAL PEPTIDE (hTAP) |
| KR20010012554A (en) * | 1997-05-14 | 2001-02-15 | 벤슨 로버트 에이치. | Antimicrobial peptide |
| ATE285786T1 (en) * | 1997-10-08 | 2005-01-15 | Theragem Inc | MAMMAL-DERIVED PEPTIDES FOR THE TREATMENT OF MICROBIAL INFECTIONS |
-
2001
- 2001-06-08 EP EP04019254A patent/EP1481988A3/en not_active Withdrawn
- 2001-06-08 AU AU2001281821A patent/AU2001281821A1/en not_active Abandoned
- 2001-06-08 ES ES01960288T patent/ES2199098T3/en not_active Expired - Lifetime
- 2001-06-08 AT AT01960288T patent/ATE319740T1/en not_active IP Right Cessation
- 2001-06-08 DE DE50109168T patent/DE50109168D1/en not_active Expired - Fee Related
- 2001-06-08 WO PCT/EP2001/006518 patent/WO2001094386A2/en active IP Right Grant
- 2001-06-08 EP EP01960288A patent/EP1313763B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001094386A3 (en) | 2003-03-20 |
| ES2199098T1 (en) | 2004-02-16 |
| ES2199098T3 (en) | 2006-10-01 |
| ATE319740T1 (en) | 2006-03-15 |
| DE50109168D1 (en) | 2006-05-04 |
| EP1313763B1 (en) | 2006-03-08 |
| EP1313763A2 (en) | 2003-05-28 |
| EP1481988A3 (en) | 2005-02-23 |
| WO2001094386A2 (en) | 2001-12-13 |
| EP1481988A2 (en) | 2004-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wiedow et al. | Elafin is a potent inhibitor of proteinase 3 | |
| JP3147904B2 (en) | Broad spectrum antimicrobial compounds and methods of use | |
| JP5053096B2 (en) | Debriding composition from bromelain and method for producing the same | |
| US5324716A (en) | Broad spectrum antimicrobial compounds and methods of use | |
| CA2057053A1 (en) | Recombinant alzheimer's amyloid protein | |
| WO1996010998B1 (en) | Anti-acne method and composition | |
| US4329430A (en) | Enzyme mixture | |
| AU2001281821A1 (en) | Method for the extraction and the use of antibiotically effective peptides for treating infectious diseases | |
| EP0998489A1 (en) | A NOVEL ANTIMICROBIAL PEPTIDE ISOLATED FROM $i(PARASILURUS ASOTUS) AND ITS USES | |
| US5145681A (en) | Compositions containing protease produced by vibrio and method of use in debridement and wound healing | |
| WO1996034890A3 (en) | Inhibitors of fibrin cross-linking and/or transglutaminases | |
| Pellegrini et al. | Identification and isolation of the bactericidal domains in the proteinase inhibitor aprotinin | |
| AU2001289641A1 (en) | Method for producing and using novel human defensins as biologically active proteins for treating infections and other illnesses | |
| CA1339189C (en) | Amblyommin, a new active substance for anticoagulant therapy | |
| AU4648985A (en) | Depolymerase enzymes and treatment of fireblight | |
| CN101473034A (en) | Larval polypeptides having a nuclease activity | |
| JP2002508390A (en) | Antifungal and antibacterial peptides | |
| US20030087823A1 (en) | Compositions comprising endotoxin neutralizing protein and derivatives and uses thereof | |
| EP0241136A3 (en) | Human class 1 heparin-binding growth factor | |
| EP0856519A3 (en) | Antibacterial insect protein | |
| AU5848690A (en) | Preparation for topical treatment of infections caused by virus, bacteria and fungi | |
| ATE258229T1 (en) | SUBSTANCE FA-70D, PRODUCTION METHODS AND USES | |
| US20020077282A1 (en) | Method for treating cystic fibrosis | |
| JP2000507941A (en) | Antibiotic peptides obtained from milk | |
| JP2671912B2 (en) | Novel antibacterial protein, production method and use thereof |