WO1996010998B1 - Anti-acne method and composition - Google Patents
Anti-acne method and compositionInfo
- Publication number
- WO1996010998B1 WO1996010998B1 PCT/US1994/011502 US9411502W WO9610998B1 WO 1996010998 B1 WO1996010998 B1 WO 1996010998B1 US 9411502 W US9411502 W US 9411502W WO 9610998 B1 WO9610998 B1 WO 9610998B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition according
- acne
- peroxide
- composition
- antibiotic
- Prior art date
Links
- 230000003255 anti-acne Effects 0.000 title 1
- 206010000496 Acne Diseases 0.000 claims abstract 7
- 230000003115 biocidal Effects 0.000 claims abstract 6
- 150000002978 peroxides Chemical class 0.000 claims abstract 5
- OJMMVQQUTAEWLP-KIDUDLJLSA-N Lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 claims abstract 3
- 239000003242 anti bacterial agent Substances 0.000 claims abstract 3
- 229960005287 lincomycin Drugs 0.000 claims abstract 3
- 230000000699 topical Effects 0.000 claims 4
- 239000004342 Benzoyl peroxide Substances 0.000 claims 3
- KDLRVYVGXIQJDK-AWPVFWJPSA-N Clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 3
- OMPJBNCRMGITSC-UHFFFAOYSA-N Incidol Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims 3
- 235000019400 benzoyl peroxide Nutrition 0.000 claims 3
- 229960002227 clindamycin Drugs 0.000 claims 3
- -1 dioctyl sodium Chemical compound 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 229940064005 Antibiotic throat preparations Drugs 0.000 abstract 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 abstract 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 abstract 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 abstract 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 abstract 1
- OFVLGDICTFRJMM-WESIUVDSSA-N Tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 abstract 1
- 229960002180 Tetracycline Drugs 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 abstract 1
- 229940079866 intestinal antibiotics Drugs 0.000 abstract 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
Abstract
Composition and method for the treatment of acne including a peroxide and an antibiotic selected from the lincomycin or tetracycline family of antibiotics.
Claims
1. A composition for the topical treatment of acne comprising a peroxide and antibiotic of the lincomycin family, said composition being substantially stable at a temperature of 50°C for a period of thirty (30) days.
2. The composition according to claim 1 , wherein the peroxide comprises benzoyl peroxide, and the antibiotic comprises clindamycin or a pharmaceutically acceptable salt or ester thereof.
3. The composition according to claim 2 comprising about 1 to about 30 weight percent benzoyl peroxide and about 0.01 to about 5 weight percent clindamycin or a pharmaceutically acceptable salt or ester thereof.
4. An aqueous gel composition for the topical treatment of acne comprising a peroxide, an antibiotic of the lincomycin family and a surfactant.
5. The aqueous gel composition according to claim 4, wherein the peroxide comprises benzoyl peroxide, the antibiotic comprises clindamycin and the surfactant comprises dioctyl sodium sulfocuccinate.
6. The aqueous gel composition according to claim 5, comprising about 0.5 to about 3 weight percent of dioctyl sodium sulfocuccinate.
7. A method for treating acne comprising topical administration to a patient afflicted with acne of an effective amount of the composition according to claim 1.
8. A method for treating acne comprising topical administration to a patient afflicted with acne of an effective amount of the composition according to claim 4.
9. A composition according to claim 1 , having a pH of about 4.6 to about 5.7.
10. A composition according to claim 4, having a pH of about 4.6 to about 5.7.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/225,409 US5446028A (en) | 1985-12-12 | 1994-04-08 | Anti-acne method and composition |
| US08/776,005 US5767098A (en) | 1985-12-12 | 1994-10-11 | Anti-acne method and composition |
| AU79740/94A AU7974094A (en) | 1994-10-11 | 1994-10-11 | Anti-acne method and composition |
| PCT/US1994/011502 WO1996010998A1 (en) | 1994-04-08 | 1994-10-11 | Anti-acne method and composition |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/225,409 US5446028A (en) | 1985-12-12 | 1994-04-08 | Anti-acne method and composition |
| PCT/US1994/011502 WO1996010998A1 (en) | 1994-04-08 | 1994-10-11 | Anti-acne method and composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996010998A1 WO1996010998A1 (en) | 1996-04-18 |
| WO1996010998B1 true WO1996010998B1 (en) | 1996-07-11 |
Family
ID=26788447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1994/011502 WO1996010998A1 (en) | 1985-12-12 | 1994-10-11 | Anti-acne method and composition |
Country Status (2)
| Country | Link |
|---|---|
| US (2) | US5446028A (en) |
| WO (1) | WO1996010998A1 (en) |
Families Citing this family (55)
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| US6028105A (en) * | 1989-04-06 | 2000-02-22 | Nigra; Thomas P. | Topical drug delivery composition and method |
| US6117843A (en) * | 1992-02-18 | 2000-09-12 | Lloyd J. Baroody | Compositions for the treatment of acne containing clindamycin and benzoyl peroxide |
| TW203552B (en) * | 1992-02-18 | 1993-04-11 | J Baroody Lloyd | Compositions of clindamycin and benzoyl peroxide for acne treatment |
| US6221847B1 (en) | 1996-09-13 | 2001-04-24 | Clemson University | Composition and method for treating bacterial infection |
| EP0927023B1 (en) * | 1996-09-13 | 2004-11-03 | Clemson University | Composition for treating acne |
| US5912255A (en) * | 1998-02-27 | 1999-06-15 | Bussell; Letantia | Topical fluoroquinolone antibiotics combined with benzoyl peroxide |
| US7758888B2 (en) | 2000-04-21 | 2010-07-20 | Sol-Gel Technologies Ltd. | Composition exhibiting enhanced formulation stability and delivery of topical active ingredients |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| US6774100B2 (en) | 2000-12-06 | 2004-08-10 | Imaginative Research Associates, Inc. | Anhydrous creams, lotions and gels |
| US20060189552A1 (en) * | 2000-12-12 | 2006-08-24 | Mohan Vishnupad | Dispenser for dispensing three or more actives |
| US6462025B2 (en) | 2000-12-12 | 2002-10-08 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
| US7060732B2 (en) * | 2000-12-12 | 2006-06-13 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
| US7326420B2 (en) * | 2001-03-06 | 2008-02-05 | Burkhart Craig G | Benzoyl peroxide compositions having increased potency |
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| US20040043946A1 (en) * | 2002-09-03 | 2004-03-04 | Popp Karl F. | Topical formulations for treatment of skin disorders |
| US20040167223A1 (en) * | 2002-09-03 | 2004-08-26 | Popp Karl F. | Topical antibacterial formulations |
| US20040171561A1 (en) * | 2002-09-03 | 2004-09-02 | Popp Karl F. | Topical formulations for treatment of rosacea |
| GB0301577D0 (en) * | 2003-01-23 | 2003-02-26 | Edko Pazarlama Tanitim Ltd Sti | Topical pharmaceutical and/or cosmetic dispense systems |
| CA2513773C (en) * | 2003-01-24 | 2013-03-26 | Connetics Australia Pty Ltd | Clindamycin phosphate foam |
| US7186416B2 (en) * | 2003-05-28 | 2007-03-06 | Stiefel Laboratories, Inc. | Foamable pharmaceutical compositions and methods for treating a disorder |
| US20050025817A1 (en) * | 2003-07-03 | 2005-02-03 | Bhatia Kuljit S. | Delivery system for topical medications |
| US7776355B2 (en) * | 2003-07-03 | 2010-08-17 | Medics Pharmaceutical Corporation | Delivery system for topical medications |
| US20070086977A1 (en) * | 2003-12-22 | 2007-04-19 | Stockel Richard F | Method of treating dermatological conditions |
| US20050136024A1 (en) * | 2003-12-22 | 2005-06-23 | Stockel Richard F. | Dermatological compositions |
| US20070244195A1 (en) * | 2004-05-18 | 2007-10-18 | Burkhart Craig N | Treatment methods with peroxides and tertiary amines |
| US7479289B2 (en) * | 2004-07-02 | 2009-01-20 | Medicis Pharmaceutical Corporation | Stable cleanser compositions containing sulfur |
| US7655682B2 (en) | 2004-07-02 | 2010-02-02 | Medicis Pharmaceutical Corporation | Triple anti-irritant composition |
| US20060093675A1 (en) * | 2004-10-29 | 2006-05-04 | Mathew Ebmeier | Intravaginal treatment of vaginal infections with metronidazole compositions |
| EP1814560A2 (en) * | 2004-11-19 | 2007-08-08 | Aventis Pharmaceuticals, Inc. | Antibiotic compounds, compositions and medical uses |
| EP1898898A2 (en) * | 2005-03-10 | 2008-03-19 | Jr Chem, LLC | Benzoyl peroxide compositions and methods of use |
| WO2006099192A2 (en) | 2005-03-10 | 2006-09-21 | Jr Chem, Llc | Stable organic peroxide compositions |
| US20090306023A1 (en) * | 2005-06-29 | 2009-12-10 | Ramirez Jose E | Stable organic peroxide compositions |
| WO2007005471A2 (en) * | 2005-06-29 | 2007-01-11 | Jr Chem, Llc | Stable organic peroxide compositions |
| AR054805A1 (en) * | 2005-06-29 | 2007-07-18 | Stiefel Laboratories | TOPICAL COMPOSITIONS FOR SKIN TREATMENT |
| US7556820B2 (en) | 2005-06-29 | 2009-07-07 | Jr Chem, Llc | Stable organic peroxide compositions |
| CA2617681C (en) * | 2005-08-02 | 2015-02-03 | Sol-Gel Technologies Ltd. | Metal oxide coating of water insoluble ingredients |
| US9107844B2 (en) * | 2006-02-03 | 2015-08-18 | Stiefel Laboratories Inc. | Topical skin treating compositions |
| PL2206494T3 (en) | 2006-03-31 | 2016-06-30 | Stiefel Res Australia Pty Ltd | Foamable suspension gel |
| US20100047357A1 (en) * | 2007-02-01 | 2010-02-25 | Sol-Gel Technologies Ltd. | Compositions for topical application comprising a peroxide and retinoid |
| EA018275B1 (en) * | 2007-02-01 | 2013-06-28 | Сол-Джел Текнолоджиз Лтд. | Method for preparing particles comprising metal oxide coating and particles with metal oxide coating |
| WO2008097850A1 (en) * | 2007-02-02 | 2008-08-14 | Warner Chilcott Company, Inc. | Tretracycline compositions for topical administration |
| US20080188446A1 (en) * | 2007-02-02 | 2008-08-07 | Warner Chilcott Company Inc. | Tetracycline compositions for topical administration |
| US20080287373A1 (en) * | 2007-05-17 | 2008-11-20 | Popp Karl F | Topical skin treating kits |
| US20090217924A1 (en) * | 2008-02-28 | 2009-09-03 | Gregory William Pearson | Treatment systems and methods |
| EP2280718B1 (en) * | 2008-04-01 | 2016-07-27 | Lucas Meyer Cosmetics Canada Inc. | Extracts from plants of the tsuga genus and uses thereof in the treatment of inflammation, irritation and/or infection |
| WO2009148584A1 (en) | 2008-06-05 | 2009-12-10 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| GB0911213D0 (en) | 2009-06-30 | 2009-08-12 | Syntopix Group Plc | Formulation |
| JP5753089B2 (en) * | 2008-10-20 | 2015-07-22 | ドウ ファーマシューティカル サイエンシーズ、インク． | Method for obtaining a stable dispersion of benzoyl peroxide |
| CA2753290A1 (en) | 2009-07-02 | 2011-01-06 | Sanofi | Topical skin treatment kits |
| US9744150B2 (en) * | 2009-10-21 | 2017-08-29 | Dow Pharmaceutical Sciences Inc. | Suspension containing micronized benzoyl peroxide |
| US20110236503A1 (en) * | 2010-03-23 | 2011-09-29 | Cosmalabs International, Llc | Topical Skincare Composition |
| EP2817069A1 (en) | 2012-02-21 | 2014-12-31 | Ranbaxy Laboratories Limited | Composition comprising a retinoid and benzoyl peroxide |
| US9687465B2 (en) | 2012-11-27 | 2017-06-27 | Sol-Gel Technologies Ltd. | Compositions for the treatment of rosacea |
| US20180235924A1 (en) | 2015-08-20 | 2018-08-23 | Sol-Gel Technologies Ltd. | Compositions for topical application comprising benzoyl peroxide and adapalene |
| KR101986177B1 (en) | 2016-10-31 | 2019-06-05 | (주)동구바이오제약 | Pharmaceutical composition with improved bioavailability for acne treatment |
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| FR2378523A1 (en) * | 1977-01-26 | 1978-08-25 | Grupper Charles | ACNE TREATMENT MEDICINE |
| US4505896A (en) * | 1979-04-19 | 1985-03-19 | Elorac, Ltd. | Method of treating acne vulgaris and composition |
| US4387107A (en) * | 1979-07-25 | 1983-06-07 | Dermik Laboratories, Inc. | Stable benzoyl peroxide composition |
| US4299826A (en) * | 1979-10-12 | 1981-11-10 | The Procter & Gamble Company | Anti-acne composition |
| US4444762A (en) * | 1980-04-04 | 1984-04-24 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacyclopentan-2-ones |
| LU85111A1 (en) * | 1983-12-01 | 1985-09-12 | Oreal | ANTI-ACNETIC COMPOSITION BASED ON BENZOYL PEROXIDE AND AT LEAST ONE SOLAR FILTER |
-
1994
- 1994-04-08 US US08/225,409 patent/US5446028A/en not_active Expired - Lifetime
- 1994-10-11 US US08/776,005 patent/US5767098A/en not_active Expired - Lifetime
- 1994-10-11 WO PCT/US1994/011502 patent/WO1996010998A1/en active Application Filing
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