AU2001281798A1 - Bioisosteric benzamide derivatives and their use as apob-100 secretion inhibitors - Google Patents
Bioisosteric benzamide derivatives and their use as apob-100 secretion inhibitorsInfo
- Publication number
- AU2001281798A1 AU2001281798A1 AU2001281798A AU8179801A AU2001281798A1 AU 2001281798 A1 AU2001281798 A1 AU 2001281798A1 AU 2001281798 A AU2001281798 A AU 2001281798A AU 8179801 A AU8179801 A AU 8179801A AU 2001281798 A1 AU2001281798 A1 AU 2001281798A1
- Authority
- AU
- Australia
- Prior art keywords
- bioisosteric
- apob
- benzamide derivatives
- secretion inhibitors
- secretion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0013383 | 2000-06-01 | ||
GBGB0013383.5A GB0013383D0 (en) | 2000-06-01 | 2000-06-01 | Therapeutic benzamide derivatives |
PCT/EP2001/006243 WO2001096327A1 (en) | 2000-06-01 | 2001-06-01 | BIOISOSTERIC BENZAMIDE DERIVATIVES AND THEIR USE AS APoB-100 SECRETION INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001281798A1 true AU2001281798A1 (en) | 2001-12-24 |
Family
ID=9892825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001281798A Abandoned AU2001281798A1 (en) | 2000-06-01 | 2001-06-01 | Bioisosteric benzamide derivatives and their use as apob-100 secretion inhibitors |
Country Status (6)
Country | Link |
---|---|
US (1) | US20040009988A1 (ja) |
EP (1) | EP1289982A1 (ja) |
JP (1) | JP2004503549A (ja) |
AU (1) | AU2001281798A1 (ja) |
GB (1) | GB0013383D0 (ja) |
WO (1) | WO2001096327A1 (ja) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002338537A (ja) * | 2001-05-16 | 2002-11-27 | Mitsubishi Pharma Corp | アミド化合物およびその医薬用途 |
AU2002307839B2 (en) | 2001-06-28 | 2006-03-16 | Zoetis P Llc | Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion |
AR036375A1 (es) | 2001-08-30 | 2004-09-01 | Novartis Ag | Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos |
US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
UA79300C2 (en) * | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
ATE556056T1 (de) | 2003-07-29 | 2012-05-15 | Xenon Pharmaceuticals Inc | Pyridylderivate und deren verwendung als therapeutische mittel |
NZ545265A (en) | 2003-07-30 | 2009-11-27 | Xenon Pharmaceuticals Inc | Pyridazine derivatives and their use for treating diseases mediated by stearoyl-CoA desaturase (SCD) enzymes |
KR20060036106A (ko) * | 2003-07-30 | 2006-04-27 | 제논 파마슈티칼스 인크. | 피리딜 유도체 및 그의 치료제로서의 용도 |
SG145701A1 (en) | 2003-07-30 | 2008-09-29 | Xenon Pharmaceuticals Inc | Piperazine derivatives and their use as therapeutic agents |
UA83510C2 (en) * | 2003-12-09 | 2008-07-25 | Янссен Фармацевтика Н.В. | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b |
EP1751131B1 (en) * | 2004-03-10 | 2008-11-19 | Janssen Pharmaceutica N.V. | Mtp inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles |
DE602005011127D1 (de) * | 2004-03-10 | 2009-01-02 | Janssen Pharmaceutica Nv | Durch 5gliedrige heterocyclen substituierte mtp-inhibierende arylpiperidine oder -piperazine |
US20080167321A1 (en) | 2004-09-20 | 2008-07-10 | Xenon Pharmaceuticals Inc. | Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase |
MX2007003321A (es) * | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
WO2006034440A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
CN101084212A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
US7592343B2 (en) | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
CN101084207A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
AU2005311534B2 (en) | 2004-12-03 | 2011-02-17 | F. Hoffmann-La Roche Ag | 3-substituted pyridine derivatives as H3 antagonists |
CN101208089A (zh) | 2005-06-03 | 2008-06-25 | 泽农医药公司 | 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂 |
US7754717B2 (en) | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
US7683058B2 (en) * | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
BRPI0817211A2 (pt) | 2007-09-20 | 2017-05-16 | Irm Llc | composto composições como moduladores da atividade de gpr119 |
EP3006031A1 (en) | 2009-02-05 | 2016-04-13 | Takeda Pharmaceutical Company Limited | Pyridazinone compounds |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
WO1996040640A1 (en) * | 1995-06-07 | 1996-12-19 | Pfizer Inc. | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION |
YU23499A (sh) * | 1996-11-27 | 2001-07-10 | Pfizer Inc. | Inhibitorski amidi apo-b-sekrecije/mtp-a |
WO1998027979A1 (en) * | 1996-12-20 | 1998-07-02 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of microsomal triglyceride transfer protein and method |
GB9826412D0 (en) * | 1998-12-03 | 1999-01-27 | Glaxo Group Ltd | Chemical compounds |
WO2001053260A1 (en) * | 2000-01-18 | 2001-07-26 | Novartis Ag | Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion |
-
2000
- 2000-06-01 GB GBGB0013383.5A patent/GB0013383D0/en not_active Ceased
-
2001
- 2001-06-01 US US10/296,795 patent/US20040009988A1/en not_active Abandoned
- 2001-06-01 AU AU2001281798A patent/AU2001281798A1/en not_active Abandoned
- 2001-06-01 WO PCT/EP2001/006243 patent/WO2001096327A1/en not_active Application Discontinuation
- 2001-06-01 JP JP2002510469A patent/JP2004503549A/ja active Pending
- 2001-06-01 EP EP01960259A patent/EP1289982A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2001096327A1 (en) | 2001-12-20 |
US20040009988A1 (en) | 2004-01-15 |
GB0013383D0 (en) | 2000-07-26 |
JP2004503549A (ja) | 2004-02-05 |
EP1289982A1 (en) | 2003-03-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2001281798A1 (en) | Bioisosteric benzamide derivatives and their use as apob-100 secretion inhibitors | |
PL348042A1 (en) | Benzamide derivatives and their use as apob-100 secretion inhibitors | |
HK1057214A1 (en) | New mandelic acid derivatives and their use as throbin inhibitors | |
AU2001249969A1 (en) | Inha inhibitors and their use as antibacterials | |
AU2001244355A1 (en) | Heterobiarylsulphonamides and their use as pde 7 inhibitors | |
AU2001240542A1 (en) | Heterocyclic compounds and their use as parp inhibitors | |
IL157659A0 (en) | New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | |
AU2001244399A1 (en) | Gamma-secretase inhibitors | |
AU2001249670A1 (en) | Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1 | |
AU2003302919A1 (en) | Pyridine derivatives as jnk inhibitors and their use | |
GB0025782D0 (en) | Use of inhibitors | |
AU2001270260A1 (en) | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | |
AU2002361861A1 (en) | SELECTIVE 11Beta-HSD INHIBITORS AND METHODS FOR USE THEREOF | |
AU2002230836A1 (en) | Benzylamine derivatives and their use as thrombin inhibitors | |
AU2003232848A1 (en) | Phenylaminopyrimidines and their use as rho-kinase inhibitors | |
AU2002248269A1 (en) | Use of p38 inhibitors for the treatment of inflammation-enhanced cough | |
AU2001281799A1 (en) | Benzamide derivatives and their use as apob-100 and mtp inhibitors | |
IL143987A0 (en) | New amidinobenzylamine derivatives and their use as thrombin inhibitors | |
IL152396A0 (en) | New thiochromane derivatives derivatives and their use as thrombin inhibitors | |
AU2003258942A1 (en) | Imidazolidinedione-derivatives and their use as metalloproteinase inhibitors | |
AU2001277561A1 (en) | Biphenyl derivatives and the use thereof as integrin inhibitors | |
AU2001266124A1 (en) | 2-aminothiazoline derivatives and their use as no-synthase inhibitors | |
AU1039801A (en) | Compounds and their use as cysteine protease inhibitors | |
AU2003218715A1 (en) | Azepane derivatives and their use as atk1 inhibitors | |
AU2001259626A1 (en) | Indole derivatives and their use as 15-lipoxygenase inhibitors |