AU2001280546B2 - Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging - Google Patents
Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging Download PDFInfo
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- AU2001280546B2 AU2001280546B2 AU2001280546A AU2001280546A AU2001280546B2 AU 2001280546 B2 AU2001280546 B2 AU 2001280546B2 AU 2001280546 A AU2001280546 A AU 2001280546A AU 2001280546 A AU2001280546 A AU 2001280546A AU 2001280546 B2 AU2001280546 B2 AU 2001280546B2
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
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| US21827300P | 2000-07-13 | 2000-07-13 | |
| US60/218,273 | 2000-07-13 | ||
| US25943100P | 2000-12-29 | 2000-12-29 | |
| US60/259,431 | 2000-12-29 | ||
| US25924201P | 2001-01-02 | 2001-01-02 | |
| US60/259,242 | 2001-01-02 | ||
| US29643501P | 2001-06-06 | 2001-06-06 | |
| US60/296,435 | 2001-06-06 | ||
| PCT/US2001/022200 WO2002008210A1 (en) | 2000-07-13 | 2001-07-13 | Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging |
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| AU2001280546A1 AU2001280546A1 (en) | 2002-05-02 |
| AU2001280546B2 true AU2001280546B2 (en) | 2005-10-20 |
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| AU2001280551A Ceased AU2001280551B9 (en) | 2000-07-13 | 2001-07-13 | Method for treating fibrotic diseases or other indications ic |
| AU8054601A Pending AU8054601A (en) | 2000-07-13 | 2001-07-13 | Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disordersassociated with protein aging |
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| AU8055101A Pending AU8055101A (en) | 2000-07-13 | 2001-07-13 | Method for treating fibrotic diseases or other indications ic |
| AU2001280551A Ceased AU2001280551B9 (en) | 2000-07-13 | 2001-07-13 | Method for treating fibrotic diseases or other indications ic |
| AU8054601A Pending AU8054601A (en) | 2000-07-13 | 2001-07-13 | Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disordersassociated with protein aging |
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| Country | Link |
|---|---|
| US (8) | US6610716B2 (enExample) |
| EP (3) | EP2085086A3 (enExample) |
| JP (2) | JP2004504348A (enExample) |
| AT (1) | ATE304849T1 (enExample) |
| AU (4) | AU2001280546B2 (enExample) |
| CA (2) | CA2415362A1 (enExample) |
| DE (1) | DE60113548T2 (enExample) |
| ES (1) | ES2251500T3 (enExample) |
| MX (2) | MXPA03000388A (enExample) |
| WO (2) | WO2002008210A1 (enExample) |
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| US6331539B1 (en) | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| EP1257272A4 (en) * | 2000-02-23 | 2004-12-15 | Alteon Inc | THIAZOLIUM COMPOUNDS AND TREATMENTS OF DISEASES RELATED TO PROTEIN AGING |
| GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| EP2085086A3 (en) * | 2000-07-13 | 2009-11-25 | Synvista Therapeutics, Inc. | Method for treating congestive heart failure or diabetic nephropathy |
| US7199102B2 (en) * | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US7148197B2 (en) * | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
| WO2002053161A1 (en) | 2000-12-29 | 2002-07-11 | Alteon, Inc. | Method for treating fibrotic diseases or other indications |
| US7226928B2 (en) | 2001-06-15 | 2007-06-05 | 3M Innovative Properties Company | Methods for the treatment of periodontal disease |
| CA2449754A1 (en) * | 2001-06-15 | 2002-12-27 | 3M Innovative Properties Company | Immune response modifiers for the treatment of periodontal disease |
| US7144570B2 (en) * | 2002-05-23 | 2006-12-05 | Alteon, Inc. | Sunscreen compositions and methods of use thereof |
| AU2003239868A1 (en) | 2002-05-23 | 2003-12-12 | Tony Maniscalco | Sunscreen compositions and methods of use thereof |
| US20050014747A1 (en) * | 2003-04-18 | 2005-01-20 | Emily Reinhard | Dihydrothiazine prodrugs of thiazolium agents |
| US8871782B2 (en) | 2003-10-03 | 2014-10-28 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| AR046781A1 (es) | 2003-11-25 | 2005-12-21 | 3M Innovative Properties Co | Derivados de imidazoquinolinas. composiciones farmaceuticas. |
| US7840263B2 (en) | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
| US20050191245A1 (en) * | 2004-02-27 | 2005-09-01 | Adams Christopher P. | Nasal administration of calcium channel, blockers for treatment of hypertension and other cardiovascular disorders |
| WO2005118166A2 (en) | 2004-06-04 | 2005-12-15 | Teva Pharmaceutical Industries, Ltd. | Pharmaceutical composition containing irbesartan |
| US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| US7764995B2 (en) * | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
| US7729761B2 (en) * | 2004-07-14 | 2010-06-01 | Cardiac Pacemakers, Inc. | Method and apparatus for controlled gene or protein delivery |
| US7828711B2 (en) * | 2004-08-16 | 2010-11-09 | Cardiac Pacemakers, Inc. | Method and apparatus for modulating cellular growth and regeneration using ventricular assist device |
| US20060205669A1 (en) * | 2004-09-16 | 2006-09-14 | The Regents Of The University Of California | G-type peptides and other agents to ameliorate atherosclerosis and other pathologies |
| KR20070089996A (ko) * | 2004-12-06 | 2007-09-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 세동맥의 구조 및 기능의 개선 방법 |
| US8060219B2 (en) | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
| US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
| AU2006210392A1 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune response modifiers |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US7774057B2 (en) | 2005-09-06 | 2010-08-10 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression for cardiac protection |
| ITMI20052216A1 (it) * | 2005-11-18 | 2007-05-19 | Dipharma Spa | Procedimento per la preparazione di ziprasidone |
| CN101007789B (zh) | 2006-01-27 | 2014-08-20 | 北京摩力克科技有限公司 | 取代五元氮杂环盐类化合物及其治疗蛋白老化相关疾病的用途 |
| WO2009023207A1 (en) * | 2007-08-13 | 2009-02-19 | Synvista Therapeutics, Inc. | Thiazolium compounds for treating gastrointestinal complications |
| WO2009051804A1 (en) * | 2007-10-18 | 2009-04-23 | Synvista Therapeutics, Inc. | Thiazolium compounds for treating or preventing diseases associated with insulin resistance |
| EP2249832A4 (en) * | 2008-01-30 | 2011-12-21 | Agency Science Tech & Res | METHOD FOR THE TREATMENT OF FIBROSIS AND CANCER WITH IMIDAZOLIUM AND IMIDAZOLINI COMPOUNDS |
| TNSN08110A1 (en) * | 2008-03-11 | 2009-07-14 | Rekik Raouf Dr | Drug delivery to the anterior and posterior segment of the eye from drops |
| US20110028513A1 (en) * | 2008-03-31 | 2011-02-03 | Lang Zhuo | Method for treating neurological disorders with imidazolium and imidazolinium compounds |
| CN104277011A (zh) * | 2013-07-09 | 2015-01-14 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻唑内盐类化合物及其治疗蛋白老化相关疾病的用途 |
| US9622469B2 (en) | 2013-10-03 | 2017-04-18 | David Spiegel | Crosslink breakers for preservation of biological substances |
| CA3022921A1 (en) * | 2016-05-06 | 2017-11-09 | Unicyte Ev Ag | Pharmaceutical carriers containing mirnas for use in the treatment of fibrotic diseases caused by hyperglycemia |
| CN106505185B (zh) * | 2016-11-16 | 2019-11-15 | 南京师范大学 | 一种锑/氮掺杂碳复合物及其制备方法和应用 |
| WO2021125905A1 (ko) * | 2019-12-20 | 2021-06-24 | 가천대학교 산학협력단 | 신규한 티아졸 유도체 및 이의 용도 |
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| GB9210096D0 (en) * | 1992-05-11 | 1992-06-24 | Fujisawa Pharmaceutical Co | 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives and their preparation |
| EP0808163B1 (en) * | 1995-01-18 | 2003-07-23 | Alteon, Inc. | Use of thiazolium compounds for preventing and reversing the formation of advanced glycosylation endproducts |
| NO315930B1 (no) * | 1995-01-18 | 2003-11-17 | Picower Inst For Medical Res T | Anvendelse av tiazoliumforbindelser ved fremstilling av farmasöytiske preparater, preparater som inneholder forbindelsene, samt nyetiazoliumforbindelser |
| US5656261A (en) | 1995-01-18 | 1997-08-12 | The Picower Institute For Medical Research | Preventing and reversing advanced glycosylation endproducts |
| US5850840A (en) * | 1995-11-15 | 1998-12-22 | Alteon Inc. | Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts |
| JPH107709A (ja) * | 1996-06-24 | 1998-01-13 | Toyo Ink Mfg Co Ltd | 感エネルギー線活性剤組成物、それを用いた感応性組成物ならびに画像形成用組成物 |
| US6391899B1 (en) * | 1998-07-17 | 2002-05-21 | North Shore—Long Island Jewish Research Institute | Compounds and compositions for treating tissue ischemia |
| WO2000012102A1 (en) * | 1998-08-31 | 2000-03-09 | Proteotech, Inc. | Blended compositions for treatment of alzheimer's disease and other amyloidoses |
| US6121300A (en) * | 1998-11-10 | 2000-09-19 | Wagle; Dilip R. | Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts |
| EP1267855A2 (en) * | 2000-04-03 | 2003-01-02 | Bristol-Myers Squibb Company | Vasopeptidase inhibitors to treat isolated systolic hypertension |
| EP2085086A3 (en) * | 2000-07-13 | 2009-11-25 | Synvista Therapeutics, Inc. | Method for treating congestive heart failure or diabetic nephropathy |
| US20030176426A1 (en) * | 2000-07-13 | 2003-09-18 | Alteon, Inc. | Method for treating fibrotic diseases or other indications with imidazolium agents |
| JP2004520329A (ja) * | 2000-12-29 | 2004-07-08 | アルテオン インコーポレイテッド | 緑内障ｉｂの治療方法 |
| US6853703B2 (en) * | 2001-07-20 | 2005-02-08 | Siemens Medical Solutions Usa, Inc. | Automated delivery of treatment fields |
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- 2001-07-13 CA CA002415362A patent/CA2415362A1/en not_active Abandoned
- 2001-07-13 US US09/905,035 patent/US6610716B2/en not_active Expired - Fee Related
- 2001-07-13 AU AU2001280546A patent/AU2001280546B2/en not_active Ceased
- 2001-07-13 AT AT01958941T patent/ATE304849T1/de not_active IP Right Cessation
- 2001-07-13 US US09/905,188 patent/US20020068729A1/en not_active Abandoned
- 2001-07-13 JP JP2002513460A patent/JP2004504348A/ja active Pending
- 2001-07-13 CA CA002415054A patent/CA2415054A1/en not_active Abandoned
- 2001-07-13 MX MXPA03000388A patent/MXPA03000388A/es not_active Application Discontinuation
- 2001-07-13 WO PCT/US2001/022200 patent/WO2002008210A1/en not_active Ceased
- 2001-07-13 WO PCT/US2001/022214 patent/WO2002007725A1/en not_active Ceased
- 2001-07-13 MX MXPA03000386A patent/MXPA03000386A/es active IP Right Grant
- 2001-07-13 EP EP01958946A patent/EP1305024A4/en not_active Withdrawn
- 2001-07-13 JP JP2002514116A patent/JP2004504389A/ja not_active Withdrawn
- 2001-07-13 ES ES01958941T patent/ES2251500T3/es not_active Expired - Lifetime
- 2001-07-13 EP EP01958941A patent/EP1303501B1/en not_active Expired - Lifetime
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2004
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2006
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2009
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- 2009-01-09 US US12/319,570 patent/US20090124674A1/en not_active Abandoned
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