AU2001275340A1 - Integrated active flux microfluidic devices and methods - Google Patents

Integrated active flux microfluidic devices and methods

Info

Publication number
AU2001275340A1
AU2001275340A1 AU2001275340A AU7534001A AU2001275340A1 AU 2001275340 A1 AU2001275340 A1 AU 2001275340A1 AU 2001275340 A AU2001275340 A AU 2001275340A AU 7534001 A AU7534001 A AU 7534001A AU 2001275340 A1 AU2001275340 A1 AU 2001275340A1
Authority
AU
Australia
Prior art keywords
methods
microfluidic devices
integrated active
active flux
flux microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001275340A
Inventor
Hou-Pu Chou
Stephen R. Quake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of AU2001275340A1 publication Critical patent/AU2001275340A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3022—Micromixers the materials to be mixed flowing in the form of droplets the components being formed by independent droplets which are alternated, the mixing of the components being achieved by diffusion between droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3039—Micromixers with mixing achieved by diffusion between layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71755—Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding components in a pulsating or intermittent manner
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7176—Feed mechanisms characterised by the means for feeding the components to the mixer using pumps
    • B01F35/717611—Peristaltic pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y10T137/0324—With control of flow by a condition or characteristic of a fluid
    • Y10T137/0329—Mixing of plural fluids of diverse characteristics or conditions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2202—By movable element
    • Y10T137/2218—Means [e.g., valve] in control input
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/2224—Structure of body of device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173845—Amine and quaternary ammonium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AU2001275340A 2000-06-05 2001-06-05 Integrated active flux microfluidic devices and methods Abandoned AU2001275340A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US20924300P 2000-06-05 2000-06-05
US60/209,243 2000-06-05
US21130900P 2000-06-13 2000-06-13
US60/211,309 2000-06-13
US24936000P 2000-11-16 2000-11-16
US60/249,360 2000-11-16
US09/724,548 2000-11-28
US09/724,548 US7351376B1 (en) 2000-06-05 2000-11-28 Integrated active flux microfluidic devices and methods
PCT/US2001/018400 WO2001094635A2 (en) 2000-06-05 2001-06-05 Integrated active flux microfluidic devices and methods

Publications (1)

Publication Number Publication Date
AU2001275340A1 true AU2001275340A1 (en) 2001-12-17

Family

ID=27498756

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001275340A Abandoned AU2001275340A1 (en) 2000-06-05 2001-06-05 Integrated active flux microfluidic devices and methods

Country Status (5)

Country Link
US (8) US7351376B1 (en)
EP (1) EP1290226A2 (en)
JP (1) JP2003536058A (en)
AU (1) AU2001275340A1 (en)
WO (1) WO2001094635A2 (en)

Families Citing this family (565)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8142708B2 (en) * 1995-04-03 2012-03-27 Wisconsin Alumni Research Foundation Micro fluidic system for single molecule imaging
US7775368B2 (en) * 1995-04-03 2010-08-17 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
JP4323571B2 (en) 1997-01-31 2009-09-02 エックスワイ， インコーポレイテッド Optical device
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US7306672B2 (en) * 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
ATE215673T1 (en) * 1999-06-28 2002-04-15 California Inst Of Techn ELASTOMERIC MICROPUMP AND MICROVALVE SYSTEMS
US8550119B2 (en) * 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US7217321B2 (en) * 2001-04-06 2007-05-15 California Institute Of Technology Microfluidic protein crystallography techniques
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US8052792B2 (en) * 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
US20080277007A1 (en) * 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
DE60132185T2 (en) * 2000-02-23 2009-01-02 Caliper Life Sciences, Inc., Mountain View MULTI-RESERVOIR PRESSURE CONTROL SYSTEM
US20020012926A1 (en) * 2000-03-03 2002-01-31 Mycometrix, Inc. Combinatorial array for nucleic acid analysis
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US20050118073A1 (en) * 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US7062418B2 (en) * 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
DE10036174B4 (en) * 2000-07-25 2006-12-07 Axaron Bioscience Ag Method and apparatus for analyzing chemical or biological samples
US7998746B2 (en) * 2000-08-24 2011-08-16 Robert Otillar Systems and methods for localizing and analyzing samples on a bio-sensor chip
US6610499B1 (en) * 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
EP1334347A1 (en) 2000-09-15 2003-08-13 California Institute Of Technology Microfabricated crossflow devices and methods
US7678547B2 (en) * 2000-10-03 2010-03-16 California Institute Of Technology Velocity independent analyte characterization
WO2002029106A2 (en) * 2000-10-03 2002-04-11 California Institute Of Technology Microfluidic devices and methods of use
US7097809B2 (en) * 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
EP1336097A4 (en) * 2000-10-13 2006-02-01 Fluidigm Corp Microfluidic device based sample injection system for analytical devices
US7232109B2 (en) * 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
US6951632B2 (en) * 2000-11-16 2005-10-04 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
EP1343973B2 (en) 2000-11-16 2020-09-16 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
CA2822983C (en) 2000-11-29 2017-05-09 Xy, Llc System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6575188B2 (en) * 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7010391B2 (en) * 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US20020164816A1 (en) * 2001-04-06 2002-11-07 California Institute Of Technology Microfluidic sample separation device
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6752922B2 (en) * 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
JP5162074B2 (en) 2001-04-06 2013-03-13 フルイディグム コーポレイション Polymer surface modification
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
US6981522B2 (en) * 2001-06-07 2006-01-03 Nanostream, Inc. Microfluidic devices with distributing inputs
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US20050149304A1 (en) * 2001-06-27 2005-07-07 Fluidigm Corporation Object oriented microfluidic design method and system
US7128876B2 (en) * 2001-07-17 2006-10-31 Agilent Technologies, Inc. Microdevice and method for component separation in a fluid
KR100421359B1 (en) * 2001-07-24 2004-03-06 엘지전자 주식회사 Method for delivering fluid in elastic substrate and device for it
US7075162B2 (en) * 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
US7192629B2 (en) 2001-10-11 2007-03-20 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
DE10150549A1 (en) * 2001-10-12 2003-04-17 Roche Diagnostics Gmbh Separation module, useful for the separation of corpuscles from blood, comprises two channels from a junction with a faster flow in one channel taking most of the particles, and a slower flow with few particles through the other channel
US8053249B2 (en) * 2001-10-19 2011-11-08 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
US7189580B2 (en) * 2001-10-19 2007-03-13 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
US20030156991A1 (en) * 2001-10-23 2003-08-21 William Marsh Rice University Optomechanically-responsive materials for use as light-activated actuators and valves
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
CA2467587A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
AU2002364177A1 (en) 2001-12-18 2003-06-30 Massachusetts Institute Of Technology Microfluidic pumps and mixers driven by induced-charge electro-osmosis
US7691244B2 (en) 2001-12-18 2010-04-06 Massachusetts Institute Of Technology Microfluidic pumps and mixers driven by induced-charge electro-osmosis
AU2002363895A1 (en) * 2001-12-31 2003-07-15 Institut Fur Physikalische Hochtechnologie E.V. Cell sorting system for the size-based sorting or separation of cells suspended in a flowing fluid
JP3740528B2 (en) * 2002-02-05 2006-02-01 独立行政法人産業技術総合研究所 Fine particle manufacturing method
US6827811B2 (en) * 2002-02-07 2004-12-07 Lynntech, Inc. Method for vacuum pressing electrochemical cell components
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
CA2480728A1 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US20030198962A1 (en) * 2002-04-18 2003-10-23 Yung-Chiang Chung Method and apparatus for nucleic acid hybridization
US7189581B2 (en) * 2002-04-30 2007-03-13 Wisconsin Alumni Research Foundation Method of obtaining a sample concentration of a solution in a microfluidic device
US8663909B2 (en) * 2002-05-09 2014-03-04 Nanologix, Inc. Device for rapid detection and identification of single microorganisms without preliminary growth
US7781159B2 (en) * 2002-05-09 2010-08-24 Nanologix, Inc. Micromethod and device for rapid detection, enumeration and identification of entities
US8361783B2 (en) * 2002-05-09 2013-01-29 Nanologix, Inc. Micromethod and device for the rapid detection, enumeration and identification of microorganisms
WO2003103082A2 (en) * 2002-05-31 2003-12-11 Lynntech, Inc. Electrochemical cell and bipolar assembly for an electrochemical cell
DE10224567B4 (en) * 2002-06-03 2014-10-23 Boehringer Ingelheim Vetmedica Gmbh Sensor arrangement and method for operating a sensor arrangement
CA2492064C (en) 2002-06-20 2016-03-15 Vision Biosystems Limited Biological reaction apparatus with draining mechanism
AU2003901871A0 (en) 2003-03-31 2003-05-08 Vision Biosystems Limited A method and apparatus for fluid dispensation, preparation and dilation
US8168139B2 (en) * 2002-06-24 2012-05-01 Fluidigm Corporation Recirculating fluidic network and methods for using the same
JP2006507921A (en) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Method and apparatus for fluid dispersion
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
EP1534429A4 (en) * 2002-07-26 2005-09-07 Applera Corp Micro-channel design features that facilitate centripetal fluid transfer
US7041258B2 (en) * 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US20040018115A1 (en) * 2002-07-29 2004-01-29 Nanostream, Inc. Fault tolerant detection regions in microfluidic systems
US7699767B2 (en) * 2002-07-31 2010-04-20 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
BR0313130A (en) * 2002-07-31 2007-07-17 Arryx Inc method and apparatus for classifying objects; object manipulation method; method of destruction of objects; and apparatus for destroying objects
BRPI0313163B1 (en) 2002-08-01 2015-11-17 Univ Colorado State low pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
AU2003265471B2 (en) 2002-08-15 2009-08-06 Xy, Llc. High resolution flow cytometer
WO2004084263A2 (en) * 2002-09-07 2004-09-30 Arizona Board Of Regents Integrated apparatus and methods for treating liquids
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
US7469076B2 (en) * 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US20060057625A1 (en) * 2002-09-16 2006-03-16 Carlson Robert E Scaffold-based artificial receptors and methods
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US8349276B2 (en) * 2002-09-24 2013-01-08 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
EP2298448A3 (en) * 2002-09-25 2012-05-30 California Institute of Technology Microfluidic large scale integration
US8220494B2 (en) * 2002-09-25 2012-07-17 California Institute Of Technology Microfluidic large scale integration
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
WO2004035212A1 (en) * 2002-10-18 2004-04-29 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
US7217542B2 (en) * 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
KR20050088476A (en) 2002-12-30 2005-09-06 더 리전트 오브 더 유니버시티 오브 캘리포니아 Methods and apparatus for pathogen detection and analysis
US7419638B2 (en) * 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
US20080199685A1 (en) * 2003-02-10 2008-08-21 Michael Jeremiah Bortner Spray self assembly
GB2398751A (en) * 2003-02-28 2004-09-01 Univ Surrey A dielectrophoretic separation device
CN100439515C (en) * 2003-03-03 2008-12-03 清华大学 Laboratory nucleic acid analyzing chip system and its application
US7041481B2 (en) * 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
DK2305173T3 (en) 2003-03-28 2016-08-22 Inguran Llc Apparatus and method for providing sorted particles
EP1613737A4 (en) * 2003-03-28 2008-12-03 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US7604965B2 (en) * 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US20050145496A1 (en) * 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
JP2006523142A (en) 2003-04-10 2006-10-12 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Formation and control of fluid species
EP1685282A2 (en) * 2003-04-17 2006-08-02 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
DE10320871B3 (en) * 2003-05-09 2004-09-16 Evotec Technologies Gmbh Sample distribution, for a cell sorter, comprises a fixed feed tube in a guide to deposit separate PCR samples at a moving micro-titration plate or sample strip without interfering with cell sorting
US20060263829A1 (en) 2003-05-15 2006-11-23 Evans Kenneth M Efficient haploid cell sorting flow cytometer systems
CN1280428C (en) * 2003-05-19 2006-10-18 清华大学 Biochip system based on minute particle and its application
EP1636017A2 (en) 2003-05-20 2006-03-22 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
JPWO2004113927A1 (en) * 2003-06-19 2006-08-24 アークレイ株式会社 Analytical tool with liquid reservoir
US20050026135A1 (en) * 2003-07-28 2005-02-03 Sergey Gazenko Method for rapid detection of microorganisms by changing the shape of micro colonies
US7583853B2 (en) * 2003-07-28 2009-09-01 Fluidigm Corporation Image processing method and system for microfluidic devices
US7524623B2 (en) 2003-07-28 2009-04-28 Nanologix, Inc. Method and device for rapid detection of microorganisms by changing the shape of micro-colonies
EP1654066B1 (en) 2003-07-31 2014-11-12 Handylab, Inc. Processing particle-containing samples
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7298478B2 (en) 2003-08-14 2007-11-20 Cytonome, Inc. Optical detector for a particle sorting system
KR20070029618A (en) * 2003-08-27 2007-03-14 더 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Electronic control of fluidic species
EP1670356A1 (en) * 2003-09-03 2006-06-21 Life Patch International, Inc. Personal diagnostic devices and related methods
US7800750B2 (en) * 2003-09-19 2010-09-21 The Regents Of The University Of California Optical trap utilizing a reflecting mirror for alignment
JP2007512148A (en) * 2003-09-19 2007-05-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Optical beam translation device and method using pivoting optical fiber
CN1997691B (en) * 2003-09-23 2011-07-20 北卡罗来纳大学查珀尔希尔分校 Photocurable perfluoropolyethers for use as novel materials in microfluidic devices
DE20317944U1 (en) * 2003-11-18 2004-03-11 Heiser, Volker, Dr. Sample carrier for molecules
EP1541991A1 (en) * 2003-12-12 2005-06-15 STMicroelectronics S.r.l. Integrated semiconductor chemical microreactor for real-time monitoring of biological reactions
JP4711326B2 (en) * 2003-12-22 2011-06-29 キヤノン株式会社 Preparation method of calibration sample and calibration curve
KR100703889B1 (en) * 2003-12-29 2007-04-05 전자부품연구원 Device for analyzing solution component and method of manufacturing the same
US20050147980A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
SG10202107927VA (en) * 2004-01-25 2021-08-30 Fluidigm Corp Crystal forming devices and systems and methods for making and using the same
CN101189271A (en) * 2004-02-13 2008-05-28 北卡罗来纳大学查珀尔希尔分校 Functional materials and novel methods for the fabrication of microfluidic devices
WO2005080606A1 (en) * 2004-02-18 2005-09-01 Xiaochuan Zhou Fluidic devices and methods for multiplex chemical and biochemical reactions
WO2005082535A1 (en) * 2004-02-27 2005-09-09 University Of Limerick Buoyancy-driven microfluidics
EP1720998A4 (en) * 2004-03-05 2009-05-06 Univ New York State Res Found Method and apparatus for measuring changes in cell volume
US8372600B2 (en) * 2004-03-05 2013-02-12 The Research Foundation Of State University Of New York Method and apparatus for measuring changes in cell volume
AU2005222931A1 (en) * 2004-03-12 2005-09-29 The Regents Of The University Of California Methods and apparatus for integrated cell handling and measurements
JP4643921B2 (en) * 2004-03-26 2011-03-02 独立行政法人科学技術振興機構 Method for detecting passage of fluid in a flow path and method for controlling fluid flow
AU2005229073B2 (en) 2004-03-29 2010-08-19 Inguran, Llc Sperm suspensions for use in insemination
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US20050249641A1 (en) * 2004-04-08 2005-11-10 Boehringer Ingelheim Microparts Gmbh Microstructured platform and method for manipulating a liquid
US7927550B2 (en) * 2004-04-27 2011-04-19 Agilent Technologies, Inc. Microfluidic connection
EP1796824A4 (en) * 2004-05-02 2016-10-19 Fluidigm Corp Thermal reaction device and method for using the same
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP5344817B2 (en) 2004-05-03 2013-11-20 ハンディーラブ インコーポレイテッド Processing of samples containing polynucleotides
JP5057968B2 (en) * 2004-05-10 2012-10-24 ザ エアロスペース コーポレーション Microfluidic device having separable operating module and fluid holding module
US8642353B2 (en) * 2004-05-10 2014-02-04 The Aerospace Corporation Microfluidic device for inducing separations by freezing and associated method
US7694694B2 (en) * 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
GB0410579D0 (en) * 2004-05-12 2004-06-16 Univ St Andrews Optoelectronic tweezers
US20060024751A1 (en) * 2004-06-03 2006-02-02 Fluidigm Corporation Scale-up methods and systems for performing the same
US7758814B2 (en) * 2004-06-05 2010-07-20 Freeslate, Inc. Microfluidic fluid distribution manifold for use with multi-channel reactor systems
CN100583434C (en) 2004-06-07 2010-01-20 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
US20050272144A1 (en) * 2004-06-08 2005-12-08 Konica Minolta Medical & Graphic, Inc. Micro-reactor for improving efficiency of liquid mixing and reaction
US7686040B2 (en) * 2004-06-24 2010-03-30 The Aerospace Corporation Electro-hydraulic devices
US7721762B2 (en) * 2004-06-24 2010-05-25 The Aerospace Corporation Fast acting valve apparatuses
JP2006006166A (en) * 2004-06-24 2006-01-12 Univ Of Tokyo Cell separator and method for separating cell
US7650910B2 (en) * 2004-06-24 2010-01-26 The Aerospace Corporation Electro-hydraulic valve apparatuses
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US8262909B2 (en) * 2004-07-06 2012-09-11 Schlumberger Technology Corporation Methods and devices for minimizing membrane fouling for microfluidic separators
US7575681B2 (en) * 2004-07-06 2009-08-18 Schlumberger Technology Corporation Microfluidic separator
US7833147B2 (en) 2004-07-22 2010-11-16 Inguran, LLC. Process for enriching a population of sperm cells
US7884052B2 (en) 2004-09-03 2011-02-08 Receptors Llc Combinatorial artificial receptors including tether building blocks on scaffolds
WO2006029383A2 (en) * 2004-09-11 2006-03-16 Receptors Llc Combinatorial artificial receptors including peptide building blocks
US20070248958A1 (en) 2004-09-15 2007-10-25 Microchip Biotechnologies, Inc. Microfluidic devices
AU2005289352B2 (en) * 2004-09-28 2007-02-22 Cleveland Biosensors Pty Ltd Microfluidic device
WO2006034525A1 (en) * 2004-09-28 2006-04-06 Cleveland Biosensors Pty Ltd Microfluidic device
WO2006039566A2 (en) * 2004-09-30 2006-04-13 Intelliseek, Inc. Topical sentiments in electronically stored communications
US20070243627A1 (en) * 2004-09-30 2007-10-18 Shuichi Takayama Computerized control method and system for microfluidics and computer program product for use therein
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
DE102004049730B4 (en) * 2004-10-11 2007-05-03 Technische Universität Darmstadt Microcapillary reactor and method for controlled mixing of non-homogeneously miscible fluids using this microcapillary reactor
US7832429B2 (en) * 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
US7674994B1 (en) * 2004-10-21 2010-03-09 Valerio Thomas A Method and apparatus for sorting metal
US8232095B2 (en) * 2004-11-18 2012-07-31 The Regents Of The University Of California Apparatus and methods for manipulation and optimization of biological systems
WO2006060748A2 (en) 2004-12-03 2006-06-08 California Institute Of Technology Microfluidic sieve valves
WO2006060783A2 (en) 2004-12-03 2006-06-08 Cytonome, Inc. Unitary cartridge for particle processing
WO2006071470A2 (en) * 2004-12-03 2006-07-06 California Institute Of Technology Microfluidic devices with chemical reaction circuits
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US20060166223A1 (en) * 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
US20060170905A1 (en) * 2005-02-02 2006-08-03 Tsai George P Common carrier for loading capillary vessels
US20060170444A1 (en) * 2005-02-02 2006-08-03 Wu Zong M Novel fluorescent and photoemission apparatus and method for submicron IC failure analysis
US20060171855A1 (en) * 2005-02-03 2006-08-03 Hongfeng Yin Devices,systems and methods for multi-dimensional separation
EP2248578B1 (en) 2005-03-04 2012-06-06 President and Fellows of Harvard College Method for forming multiple emulsions
US8017218B2 (en) * 2005-03-08 2011-09-13 Forskarpatent I Linkoping Ab Micro and nano structures in an elastomeric material
US7883669B2 (en) 2005-04-20 2011-02-08 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
US20070042427A1 (en) * 2005-05-03 2007-02-22 Micronics, Inc. Microfluidic laminar flow detection strip
US8206974B2 (en) * 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
US20060275852A1 (en) 2005-06-06 2006-12-07 Montagu Jean I Assays based on liquid flow over arrays
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
TWI253435B (en) * 2005-06-13 2006-04-21 Univ Chung Yuan Christian Loop micro fluid system
US9158855B2 (en) 2005-06-16 2015-10-13 Buzzmetrics, Ltd Extracting structured data from weblogs
US8343755B2 (en) * 2005-08-01 2013-01-01 University Of Virginia Patent Foundation Microdevices for chemical sensing and chemical actuation
EP2537657A3 (en) 2005-08-09 2016-05-04 The University of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
WO2007021755A2 (en) * 2005-08-11 2007-02-22 Eksigent Technologies, Llc Microfluidic systems, devices and methods for reducing noise generated by mechanical instabilities
US20090053814A1 (en) * 2005-08-11 2009-02-26 Eksigent Technologies, Llc Microfluidic apparatus and method for sample preparation and analysis
CA2618105A1 (en) * 2005-08-11 2007-03-01 Daniel M. Hartmann Microfluidic reduction of diffusion and complience effect in a fluid mixing region
US20070054293A1 (en) * 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US20070074972A1 (en) * 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US7745788B2 (en) 2005-09-23 2010-06-29 Massachusetts Institute Of Technology Optical trapping with a semiconductor
US8263022B2 (en) * 2005-10-04 2012-09-11 Headway Technologies, Inc. Microfluidic detection of analytes
JP4878601B2 (en) * 2005-10-13 2012-02-15 日水製薬株式会社 Test device
US7659486B2 (en) * 2005-10-20 2010-02-09 Valerio Thomas A Method and apparatus for sorting contaminated glass
EP1960111A4 (en) * 2005-10-24 2013-11-20 Thomas Valerio Dissimilar materials sorting process, system and apparatus
US8152477B2 (en) * 2005-11-23 2012-04-10 Eksigent Technologies, Llc Electrokinetic pump designs and drug delivery systems
US20080103746A1 (en) 2005-11-30 2008-05-01 Searete Llc, A Limited Liability Corporation Systems and methods for pathogen detection and response
WO2007078833A2 (en) * 2005-12-16 2007-07-12 The Curators Of The University Of Missouri Reusable pcr amplification system and method
CN101341405A (en) * 2005-12-21 2009-01-07 皇家飞利浦电子股份有限公司 A sensor for biomolecules and a method for preparing and using the same
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
CA2641271A1 (en) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US7569789B2 (en) * 2006-03-16 2009-08-04 Visiongate, Inc. Cantilevered coaxial flow injector apparatus and method for sorting particles
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
JP4664846B2 (en) * 2006-03-29 2011-04-06 株式会社東芝 Nucleic acid detection device
US20100028614A1 (en) * 2006-03-29 2010-02-04 Anne Shim Method of forming nanoscale features using soft lithography
DE102006016324A1 (en) * 2006-04-06 2007-10-25 Wacker Chemie Ag Apparatus and method for flexibly classifying polycrystalline silicon fragments
JP4167697B2 (en) * 2006-04-13 2008-10-15 株式会社東芝 Nucleic acid detection device
KR100773552B1 (en) * 2006-04-28 2007-11-07 삼성전자주식회사 Micro-fluid reaction vessel, method for manufacturing the vessel, and method of micro-fluid reaction using the vessel
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2007133710A2 (en) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Microfluidic devices and methods of use thereof
US8431080B2 (en) * 2006-06-02 2013-04-30 The Board Of Trustees Of The University Of Illinois Soft MEMS
JP4292279B2 (en) * 2006-07-18 2009-07-08 ファルマ・アクセス株式会社 Crystal production tool
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
US8656949B2 (en) 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
WO2008073168A2 (en) * 2006-08-25 2008-06-19 The Trustees Of Columbia University In The City Of New York Systems and methods for high-throughput radiation biodosimetry
US9255348B2 (en) 2006-08-25 2016-02-09 The Trustees Of Columbia University In The City Of New York Systems and methods for biodosimetry with biochip using gene expression signatures
US20090061508A1 (en) * 2007-08-27 2009-03-05 Biomimetics Technologies Inc Laminar flow reactor
US9057044B2 (en) 2006-08-30 2015-06-16 Meir Israelowitz Laminar flow reactor
US8050516B2 (en) * 2006-09-13 2011-11-01 Fluidigm Corporation Methods and systems for determining a baseline during image processing
US8055034B2 (en) * 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
US10753927B2 (en) 2006-09-22 2020-08-25 ALERE TECHNOLOGIES GmbH Methods for detecting an analyte
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
WO2008043041A1 (en) 2006-10-04 2008-04-10 University Of Washington Method and device for rapid parallel microfluidic molecular affinity assays
WO2008147428A1 (en) * 2006-10-05 2008-12-04 Nanopoint, Inc. Systems and methods for active microfluidic cell handling
WO2008052138A2 (en) 2006-10-25 2008-05-02 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated dna analysis system using same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
US9097671B2 (en) * 2006-11-22 2015-08-04 Clondiag Gmbh Assays
US9114398B2 (en) 2006-11-29 2015-08-25 Canon U.S. Life Sciences, Inc. Device and method for digital multiplex PCR assays
US8473216B2 (en) * 2006-11-30 2013-06-25 Fluidigm Corporation Method and program for performing baseline correction of amplification curves in a PCR experiment
US8681743B2 (en) * 2006-12-08 2014-03-25 Samsung Electronics Co., Ltd. Apparatus and method for selecting frame structure in multihop relay broadband wireless access communication system
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US20080160638A1 (en) * 2006-12-27 2008-07-03 David Lederman Functionalized Microcantilever Sensor and Associated Method For Detection of Targeted Analytes
WO2008083323A1 (en) * 2006-12-29 2008-07-10 Invitrogen Corporation Detection apparatus
US8338166B2 (en) * 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
EP2125253A4 (en) * 2007-01-05 2012-05-30 Thomas A Valerio System and method for sorting dissimilar materials
US7668526B2 (en) * 2007-01-16 2010-02-23 Harris Corporation Frequency mixer using current feedback amplifiers
US8157434B2 (en) 2007-01-19 2012-04-17 Fluidigm Corporation High efficiency and high precision microfluidic devices and methods
US20080181816A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Systems for allergen detection
US8617903B2 (en) * 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US20080180259A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for allergen detection
US20090050569A1 (en) * 2007-01-29 2009-02-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US10001496B2 (en) * 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
KR20100028526A (en) 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. Microfluidic and nanofluidic devices, systems, and applications
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US20080254530A1 (en) 2007-02-27 2008-10-16 Gettysburg College Isolation and characterization of a single mitochondrion
WO2008110019A1 (en) * 2007-03-13 2008-09-18 The Governors Of The University Of Alberta Clinical sample preparation on a microfluidic platform
US20100227338A1 (en) * 2007-03-22 2010-09-09 Nanologix, Inc. Method and Apparatus for Rapid Detection and Identification of Live Microorganisms Immobilized On Permeable Membrane by Antibodies
US9068216B2 (en) 2007-03-22 2015-06-30 Bret T. Barnhizer Methods and devices for rapid detection and identification of live microorganisms by aptamers and/or antibodies immobilized on permeable membranes
CN102014871A (en) 2007-03-28 2011-04-13 哈佛大学 Emulsions and techniques for formation
CA2682826C (en) 2007-04-02 2013-08-13 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
AU2008237428A1 (en) * 2007-04-05 2008-10-16 Massachusetts Institute Of Technology System for electrophoretic stretching of biomolecules using micro scale T-junctions
CN103630470B (en) 2007-04-16 2016-03-16 通用医疗公司以马萨诸塞州通用医疗公司名义经营 Make the system and method that particle is assembled in microchannel
KR20100016069A (en) * 2007-04-18 2010-02-12 토마스 에이. 바레리오 Method and system for sorting and processing recycled materials
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
EP2556890B1 (en) * 2007-05-03 2019-06-19 Alere Technologies GmbH Assays in closed fluid circuit
CA2692259C (en) 2007-06-22 2012-07-31 Fio Corporation Systems and methods for manufacturing quantum dot-doped polymer microbeads
WO2009006456A1 (en) * 2007-06-29 2009-01-08 The Trustees Of Columbia University Microfluidic device for counting biological particles
US8921121B2 (en) * 2007-06-29 2014-12-30 The Trustees Of Columbia University In The City Of New York Methods, devices, and systems for chemiluminescence-based microfluidic cell counting
CA2693055C (en) * 2007-07-09 2012-02-21 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
ES2877602T3 (en) 2007-07-13 2021-11-17 Handylab Inc Polynucleotide Capture Materials and Procedures for Using Them
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) * 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
BRPI0814205A2 (en) * 2007-07-23 2015-01-27 Fio Corp METHOD AND SYSTEM FOR COLLECTION, STORAGE, ANALYSIS AND PERMISSION OF ACCESS TO COLLECTED AND ANALYZED DATA ASSOCIATED WITH BIOLOGICAL AND ENVIRONMENTAL TEST INDIVIDUALS
WO2009015296A1 (en) * 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
JP2009031126A (en) * 2007-07-27 2009-02-12 Kazusa Dna Kenkyusho Chip for microbead array using micro-channel organizer, microbead array and method for detecting material to be tested using the same
US8268246B2 (en) * 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
US8308926B2 (en) 2007-08-20 2012-11-13 Purdue Research Foundation Microfluidic pumping based on dielectrophoresis
US8211709B2 (en) * 2007-08-22 2012-07-03 Wisconsin Alumni Research Foundation Method for controlling communication between multiple access ports in a microfluidic device
EA018555B1 (en) * 2007-09-07 2013-08-30 Флуидигм Корпорейшн Copy number variation determination, methods and systems
US8551763B2 (en) * 2007-10-12 2013-10-08 Fio Corporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
US20100297747A1 (en) * 2007-10-25 2010-11-25 Manalis Scott R System and method for monitoring cell growth
US8251672B2 (en) 2007-12-11 2012-08-28 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
CA2623793C (en) * 2008-03-03 2010-11-23 Schlumberger Canada Limited Microfluidic apparatus and method for measuring thermo-physical properties of a reservoir fluid
US8340913B2 (en) * 2008-03-03 2012-12-25 Schlumberger Technology Corporation Phase behavior analysis using a microfluidic platform
EP3636341B1 (en) * 2008-03-14 2021-12-08 Abbott Rapid Diagnostics Jena GmbH Assays and devices
US8623294B2 (en) * 2008-03-24 2014-01-07 Nec Corporation Flow passage control mechanism for microchip
EP2280905B1 (en) 2008-04-11 2016-07-06 Fluidigm Corporation Multilevel microfluidic systems and methods
US8298392B2 (en) * 2008-04-21 2012-10-30 University Of Louisville Research Foundation, Inc. Microfluidic devices and methods of using same
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
CN101587029B (en) * 2008-05-21 2013-10-23 同方威视技术股份有限公司 Sample processing system and method for trace quantity detector
US9068181B2 (en) 2008-05-23 2015-06-30 The General Hospital Corporation Microfluidic droplet encapsulation
US8389294B2 (en) * 2008-06-09 2013-03-05 Wisconsin Alumni Research Foundation Microfluidic device and method for coupling discrete microchannels and for co-culture
CA2727460C (en) 2008-06-11 2014-12-30 Thomas A. Valerio Method and system for recovering metal from processed recycled materials
US8075855B2 (en) * 2008-06-20 2011-12-13 Silverbrook Research Pty Ltd MEMS integrated circuit comprising peristaltic microfluidic pump
US8080220B2 (en) * 2008-06-20 2011-12-20 Silverbrook Research Pty Ltd Thermal bend actuated microfluidic peristaltic pump
US20090314368A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Microfluidic System Comprising Pinch Valve and On-Chip MEMS Pump
US20090315126A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Bonded Microfluidic System Comprising Thermal Bend Actuated Valve
US20090314367A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Bonded Microfluidics System Comprising CMOS-Controllable Microfluidic Devices
US20090317301A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Bonded Microfluidics System Comprising MEMS-Actuated Microfluidic Devices
US8092761B2 (en) 2008-06-20 2012-01-10 Silverbrook Research Pty Ltd Mechanically-actuated microfluidic diaphragm valve
US20090317302A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Microfluidic System Comprising MEMS Integrated Circuit
US7981386B2 (en) * 2008-06-20 2011-07-19 Silverbrook Research Pty Ltd Mechanically-actuated microfluidic valve
US8062612B2 (en) 2008-06-20 2011-11-22 Silverbrook Research Pty Ltd MEMS integrated circuit comprising microfluidic diaphragm valve
WO2009155704A1 (en) 2008-06-25 2009-12-30 Fio Corporation Bio-threat alert system
US8122901B2 (en) 2008-06-30 2012-02-28 Canon U.S. Life Sciences, Inc. System and method for microfluidic flow control
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
EP2315629B1 (en) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Droplet libraries
MX2011000836A (en) * 2008-07-21 2011-04-11 Mtd America Ltd Llc Method and system for removing polychlorinated biphenyls from plastics.
WO2010011852A1 (en) 2008-07-25 2010-01-28 Fluidigm Corporation Method and system for manufacturing integrated fluidic chips
US8617488B2 (en) 2008-08-07 2013-12-31 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
EP2329045A4 (en) * 2008-08-15 2012-09-19 Univ Cornell Device for rapid identification of nucleic acids for binding to specific chemical targets
RU2515209C2 (en) 2008-08-29 2014-05-10 Эф-Ай-Оу Корпорейшн Disposable portable diagnostic instrument and appropriate system and method to investigate biological and natural samples
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
US10512910B2 (en) * 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US20100075863A1 (en) * 2008-09-25 2010-03-25 Northrop Grumman Systems Corporation Rotary array module for multiplexing spot-based optical readouts
US20100081577A1 (en) * 2008-09-30 2010-04-01 Symyx Technologies, Inc. Reactor systems and methods
EP2349566B1 (en) 2008-10-03 2016-01-06 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
US20100099076A1 (en) * 2008-10-16 2010-04-22 Kent State University Sensitive and rapid detection of viral particles in early viral infection by laser tweezers
WO2010062441A1 (en) * 2008-10-31 2010-06-03 Massachusetts Institute Of Technology Fast curable liquid resin procedure for the manufacture of micro/nano featured parts
EP2202522A1 (en) * 2008-12-23 2010-06-30 Universiteit Leiden Methods for immobilizing microvesicles, means and methods for detecting them, and uses thereof
EP2384429A1 (en) 2008-12-31 2011-11-09 Integenx Inc. Instrument with microfluidic chip
WO2010081219A1 (en) 2009-01-13 2010-07-22 Fio Corporation A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test
US8058630B2 (en) * 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
US8828715B2 (en) * 2009-03-06 2014-09-09 Cfd Research Corporation Particle adhesion assay for microfluidic bifurcations
EP2411148B1 (en) 2009-03-23 2018-02-21 Raindance Technologies, Inc. Manipulation of microfluidic droplets
AU2010232439C1 (en) 2009-04-02 2017-07-13 Fluidigm Corporation Multi-primer amplification method for barcoding of target nucleic acids
WO2010115123A2 (en) * 2009-04-02 2010-10-07 Purdue Research Foundation Variable volume mixing and automatic fluid management for programmable microfluidics
KR101893613B1 (en) 2009-04-13 2018-08-30 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 Ensemble-decision aliquot ranking
EP2421651A4 (en) * 2009-04-21 2013-06-12 Advandx Inc Multiplex analysis of cells, particles, and other analytes
EP2424684A4 (en) * 2009-04-28 2014-03-19 Mtd America Ltd Llc Apparatus and method for separating materials using air
JP5187442B2 (en) * 2009-05-15 2013-04-24 コニカミノルタアドバンストレイヤー株式会社 Microchip
CN102459565A (en) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 Fluidic devices with diaphragm valves
GB2483402B (en) 2009-06-04 2014-04-09 Lockheed Corp Multiple-sample microfluidic chip for DNA analysis
RU2559541C2 (en) 2009-06-05 2015-08-10 Интедженкс Инк. Universal system for sample preparing and application in integrated system of analysis
EP4019977A1 (en) 2009-06-26 2022-06-29 President and Fellows of Harvard College Fluid injection
US20110001963A1 (en) * 2009-07-02 2011-01-06 Durack Gary P System and method for the measurement of multiple emissions from multiple parallel flow channels in a flow cytometry system
WO2011005781A1 (en) * 2009-07-06 2011-01-13 Sony Corporation Microfluidic device
US20110003324A1 (en) * 2009-07-06 2011-01-06 Durack Gary P Microfluidic device having onboard tissue or cell sample handling capability
WO2011005757A1 (en) * 2009-07-07 2011-01-13 Sony Corporation Microfluidic device adapted for post-centrifugation use with selective sample extraction and methods for its use
CN103331185A (en) * 2009-07-07 2013-10-02 索尼公司 Microfluidic device
US20110008817A1 (en) * 2009-07-08 2011-01-13 Durack Gary P Microfluidic device having a flow channel within a gain medium
CA2768783A1 (en) * 2009-07-21 2011-01-27 Thomas A. Valerio Method and system for separating and recovering like-type materials from an electronic waste stream
US8551787B2 (en) * 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
AU2010278693A1 (en) * 2009-07-31 2012-03-01 Thomas A. Valerio Method and system for separating and recovering wire and other metal from processed recycled materials
US8757523B2 (en) 2009-07-31 2014-06-24 Thomas Valerio Method and system for separating and recovering wire and other metal from processed recycled materials
US9364831B2 (en) 2009-08-08 2016-06-14 The Regents Of The University Of California Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting
CA3021714C (en) 2009-09-02 2021-03-09 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
JP5869482B2 (en) 2009-09-02 2016-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ Multiple emulsions produced using jetting and other techniques
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
EP2486409A1 (en) 2009-10-09 2012-08-15 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US8707734B2 (en) * 2009-10-19 2014-04-29 The Regents Of The University Of Michigan Method of embedding material in a glass substrate
KR101532314B1 (en) * 2009-10-27 2015-06-29 삼성전자주식회사 Quality control method and apparatus of microfluidic device
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
JP5701894B2 (en) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド Method and apparatus for performing an assay
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
WO2013134741A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
WO2011066588A1 (en) 2009-11-30 2011-06-03 Fluidigm Corporation Microfluidic device regeneration
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
RU2583068C2 (en) * 2010-01-24 2016-05-10 Институт Хеми Физичней Польской Академии Наук System and method for automated formation and handling of liquid mixtures
CN102740976B (en) 2010-01-29 2016-04-20 精密公司 Sampling-response microfluidic cartridge
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US8535889B2 (en) 2010-02-12 2013-09-17 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
ITTO20100068U1 (en) * 2010-04-20 2011-10-21 Eltek Spa MICROFLUID AND / OR EQUIPMENT DEVICES FOR MICROFLUID DEVICES
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US20130236985A1 (en) * 2010-05-31 2013-09-12 Gert Blankenstein Method and device for optical examination
US20110312732A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Test module using lanthanide metal-ligand complex, electrochemiluminescent luminophores
CN105342553B (en) * 2010-06-30 2019-05-07 安派科生物医学科技有限公司 Disease detection instrument
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
KR101251223B1 (en) * 2010-08-25 2013-04-08 서울대학교산학협력단 A Method for Manufacturing liquid Droplet Microarrays, Microarrays Prepared by Using the Same, a Device for Delivering Materials and a Method for Delivering Materials by Using a Device for Delivering Materials Comprising the Same
US20150041396A1 (en) * 2010-09-23 2015-02-12 Battelle Memorial Institute System and method of preconcentrating analytes in a microfluidic device
US20160084805A1 (en) * 2010-09-23 2016-03-24 Battelle Memorial Institute System and method of preconcentrating analytes in a microfluidic device
EP3447155A1 (en) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwich assays in droplets
WO2012047015A2 (en) * 2010-10-05 2012-04-12 피씨엘 (주) Multiplex microfluidic device for selecting nucleic acid aptamers, and high throughput selection method for nucleic acid aptamers using same
US8961764B2 (en) 2010-10-15 2015-02-24 Lockheed Martin Corporation Micro fluidic optic design
US9353406B2 (en) 2010-10-22 2016-05-31 Fluidigm Corporation Universal probe assay methods
WO2012061444A2 (en) 2010-11-01 2012-05-10 Hiddessen Amy L System for forming emulsions
US8815179B2 (en) * 2010-12-03 2014-08-26 Alfa Wassermann, Inc. Automated aseptic liquid collection workstations and collection devices therefore
US20120167410A1 (en) * 2010-12-21 2012-07-05 Basf Se Spray drying techniques
US9176504B2 (en) 2011-02-11 2015-11-03 The Regents Of The University Of California High-speed on demand droplet generation and single cell encapsulation driven by induced cavitation
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US9488613B2 (en) 2011-03-02 2016-11-08 Massachusetts Institute Of Technology Systems, devices and methods for multiplexed diagnostics
WO2012119128A1 (en) * 2011-03-02 2012-09-07 Massachusetts Institute Of Technology Multiplexed diagnostic systems
JP2014509865A (en) 2011-03-18 2014-04-24 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド Multiplexed digital assay using a combination of signals
JP5978287B2 (en) 2011-03-22 2016-08-24 サイヴェク・インコーポレイテッド Microfluidic device and method of manufacture and use
US9168531B2 (en) 2011-03-24 2015-10-27 Fluidigm Corporation Method for thermal cycling of microfluidic samples
CN103562728B (en) * 2011-03-24 2016-08-17 安派科生物医学科技有限公司 Micro element for disease detection
WO2012142516A1 (en) 2011-04-15 2012-10-18 Becton, Dickinson And Company Scanning real-time microfluidic thermo-cycler and methods for synchronized thermocycling and scanning optical detection
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
US20120275929A1 (en) * 2011-04-27 2012-11-01 Aptina Imaging Corporation Ferrofluid control and sample collection for microfluidic application
JP2014512839A (en) * 2011-05-05 2014-05-29 アンパック バイオ−メディカル サイエンス カンパニー リミテッド Device for detecting tumor cells
CN103813814A (en) 2011-05-05 2014-05-21 艾克西根特技术有限公司 Gel coupling for electrokinetic delivery system
CN108342453A (en) 2011-05-09 2018-07-31 富鲁达公司 Detection of nucleic acids based on probe
US9644231B2 (en) 2011-05-09 2017-05-09 Fluidigm Corporation Nucleic acid detection using probes
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
EP3216872B1 (en) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
KR101240210B1 (en) * 2011-06-03 2013-03-06 인제대학교 산학협력단 Microfluidic platform for parallel systematic evolution of ligands by exponential enrichment
CN103764265A (en) 2011-07-06 2014-04-30 哈佛学院院长等 Multiple emulsions and techniques for the formation of multiple emulsions
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2737089B1 (en) 2011-07-29 2017-09-06 Bio-rad Laboratories, Inc. Library characterization by digital assay
US20130083311A1 (en) * 2011-09-29 2013-04-04 Melissa Li Microfluidic system for optical measurement of platelet aggregation
ES2825905T3 (en) 2011-09-30 2021-05-17 Becton Dickinson Co Unified test strip
KR101294225B1 (en) * 2011-09-30 2013-08-07 한국과학기술원 Method for controlling water droplet movement using microfluidic device
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
EP2773892B1 (en) 2011-11-04 2020-10-07 Handylab, Inc. Polynucleotide sample preparation device
WO2013072790A1 (en) 2011-11-16 2013-05-23 International Business Machines Corporation Microfluidic device with deformable valve
CA2856779C (en) 2011-11-22 2021-07-20 Stephen G. Haralampu Stopped-flow, m icro-flu i imc device and method for the charge-based separation of complex analyte mixtures
BR112014018995B1 (en) 2012-02-03 2021-01-19 Becton, Dickson And Company systems to perform automated testing
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
CN104350374B (en) 2012-02-29 2018-04-27 富鲁达公司 Method, system and equipment for multiple unicellular captures and processing using microfluid
BR112014029760A2 (en) * 2012-05-30 2017-06-27 Univ California bioactive agent delivery devices and methods for making and using them
CN104540594B (en) 2012-06-25 2019-07-02 通用医疗公司 Classified using high-gradient magnetic field to particle
US8723104B2 (en) * 2012-09-13 2014-05-13 City University Of Hong Kong Methods and means for manipulating particles
DE102012217487A1 (en) * 2012-09-26 2014-04-17 Agilent Technologies, Inc. - A Delaware Corporation - Fluid interface between fluid lines of different cross sections
US9259353B2 (en) * 2012-10-11 2016-02-16 Alcon Research, Ltd. Capillary action in flow-regulating systems
WO2014062719A2 (en) 2012-10-15 2014-04-24 Nanocellect Biomedical, Inc. Systems, apparatus, and methods for sorting particles
KR20150097764A (en) 2012-12-21 2015-08-26 마이크로닉스 인코포레이티드. Portable fluorescence detection system and microassay cartridge
WO2014100732A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Fluidic circuits and related manufacturing methods
EP3549674B1 (en) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Low elasticity films for microfluidic use
US20160025723A1 (en) 2013-03-12 2016-01-28 The Regents Of The University Of Michigan Microfluidic device for immunoblotting
EP2972405B1 (en) 2013-03-15 2020-12-23 The Regents of The University of California High-speed on demand microfluidic droplet generation and manipulation
JP2016521350A (en) 2013-03-15 2016-07-21 フリューダイム・コーポレイション Method and apparatus for analysis of defined multicellular combinations
US20140323819A1 (en) * 2013-04-29 2014-10-30 Elwha LLC, a limited liability company of the State of Delaware Multi-parameter test units for initial indication of medical symptoms
WO2014182831A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
WO2014182847A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Device for preparation and analysis of nucleic acids
WO2015002975A1 (en) 2013-07-05 2015-01-08 University Of Washington Through Its Center For Commercialization Methods, compositions and systems for microfluidic assays
US9785731B1 (en) * 2013-08-26 2017-10-10 DataInfoCom USA, Inc. Prescriptive reservoir asset management
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
WO2015050998A2 (en) 2013-10-01 2015-04-09 The Broad Institute, Inc. Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte
US10132739B2 (en) * 2013-10-01 2018-11-20 Owl biomedical, Inc. Particle manipulation system with out-of-plane channel and recovery algorithm
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
WO2015058206A1 (en) 2013-10-18 2015-04-23 The General Hosptial Corporation Microfluidic sorting using high gradient magnetic fields
WO2015073999A1 (en) 2013-11-18 2015-05-21 Integenx Inc. Cartridges and instruments for sample analysis
FR3013839B1 (en) * 2013-11-26 2016-07-29 Inst Nat Polytechnique Toulouse DEVICE FOR TREATING A SAMPLE OF AN ACTIVE BIOLOGICAL FLUID
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
CA2937484C (en) * 2014-01-20 2023-09-19 Halcyon Biomedical, Incorporated Separation and concentration of particles
US9387451B2 (en) 2014-02-03 2016-07-12 International Business Machines Corporation Flow cell array and uses thereof
KR102376573B1 (en) 2014-03-07 2022-03-18 내셔날 리서치 카운실 오브 캐나다 Centrifugal microfluidic chip control
WO2015167990A1 (en) * 2014-04-29 2015-11-05 Battelle Memorial Institute Microfluidic sample injector absent electrokinetic injection
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
WO2016016825A1 (en) * 2014-07-30 2016-02-04 Dh Technologies Development Pte. Ltd. Devices and methods for processing fluid samples
WO2016044545A1 (en) 2014-09-17 2016-03-24 Alexandra Ros Methods, systems and apparatus for microfluidic crystallization based on gradient mixing
WO2016050584A1 (en) 2014-10-02 2016-04-07 Asml Netherlands B.V. Rule-based deployment of assist features
CN113092563B (en) 2014-10-22 2024-06-07 尹特根埃克斯有限公司 Systems and methods for sample preparation, processing, and analysis
CN107110765B (en) 2014-11-03 2020-10-02 通用医疗公司 Concentrating particles in microfluidic devices
EP3223945B1 (en) * 2014-11-26 2019-04-03 IMEC vzw Compact glass-based fluid analysis device and method to fabricate
WO2016145050A1 (en) 2015-03-10 2016-09-15 Carbon3D, Inc. Microfluidic devices having flexible features and methods of making the same
JP6678998B2 (en) 2015-03-24 2020-04-15 国立大学法人 東京大学 Fluidic devices, systems and methods
EP3276359A4 (en) * 2015-03-24 2018-08-29 The University of Tokyo Fluid device, system and method
GB201509640D0 (en) * 2015-06-03 2015-07-15 Sphere Fluidics Ltd Systems and methods
US11123740B2 (en) 2015-06-29 2021-09-21 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis
JP6882782B2 (en) 2015-08-04 2021-06-02 デューク ユニバーシティ Genetically encoded, essentially chaotic delivery stealth polymers and how to use them
WO2017027838A1 (en) 2015-08-13 2017-02-16 President And Fellows Of Harvard College Microfluidic devices and systems for cell culture and/or assay
US11071982B2 (en) * 2015-08-27 2021-07-27 Ativa Medical Corporation Fluid holding and dispensing micro-feature
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN208140648U (en) * 2015-10-14 2018-11-23 阿尔卑斯电气株式会社 The measurement device of flow channel structure and measure object liquid
US11141725B2 (en) 2015-10-26 2021-10-12 Idexx Laboratories, Inc. Hematology test slide
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
KR101840530B1 (en) * 2016-01-08 2018-05-04 고려대학교 산학협력단 Surface measurement sensing-based realtime nucleic acid amplification measuring apparatus
WO2017127120A1 (en) 2016-01-22 2017-07-27 Hewlett-Packard Development Company, L.P. Fluid sensing with control of particle aggregation in sensing zone
US20170241961A1 (en) * 2016-02-22 2017-08-24 University Of Utah Research Foundation Micro Circulatory Gas Chromatography System and Method
EP3442711B1 (en) 2016-04-15 2020-12-09 Fluid-Screen, Inc. Analyte detection methods and apparatus using dielectrophoresis and electroosmosis
US11467156B2 (en) 2016-06-01 2022-10-11 Duke University Nonfouling biosensors
KR102438219B1 (en) * 2016-07-06 2022-08-30 프레시젼 나노시스템스 유엘씨 Intelligent Microfluidic Mixing Instruments and Cartridges
US10500587B2 (en) 2016-07-20 2019-12-10 Boise State University Ferro-magnetic shape memory alloy microcavity fluid sensor
CN109642857B (en) 2016-07-22 2022-03-04 阿尔法韦士曼公司 Fluid handling system and method for ultracentrifuge
CN109477806A (en) * 2016-08-18 2019-03-15 深圳源光科技有限公司 Electrophoresis chip with integrated optics sensor
WO2018051242A1 (en) 2016-09-14 2018-03-22 Ecole Polytechnique Federale De Lausanne (Epfl) Device for high throughput single-cell studies
WO2018067878A1 (en) * 2016-10-05 2018-04-12 Abbott Laboratories Devices and methods for sample analysis
CN106568696B (en) * 2016-11-14 2019-02-05 江苏大学 Crop fungal disease prevention detection device and method based on micro-fluidic chip
CN106754241B (en) * 2016-11-27 2018-10-23 重庆科技学院 A kind of application method of the drug screening biochip with gas chamber
CN106350440B (en) * 2016-11-27 2018-06-26 重庆科技学院 A kind of drug screening biochip with gas chamber
JP2020500517A (en) 2016-11-28 2020-01-16 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ Systems and methods relating to continuous flow droplet reactions
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
US20200376499A1 (en) * 2017-01-26 2020-12-03 Delee Corp. Dielectrophoresis Separation Object Sorting
US11982611B2 (en) 2017-03-20 2024-05-14 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
US10596567B2 (en) * 2017-03-27 2020-03-24 International Business Machines Corporation Microfluidic ratchets for displacing particles
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2018217831A1 (en) 2017-05-22 2018-11-29 Arizona Board Of Regents On Behalf Of Arizona State University Metal electrode based 3d printed device for tuning microfluidic droplet generation frequency and synchronizing phase for serial femtosecond crystallography
US10557807B2 (en) 2017-05-22 2020-02-11 Arizona Board Of Regents On Behalf Of Arizona State University 3D printed microfluidic mixers and nozzles for crystallography
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University Order and disorder as a design principle for stimuli-responsive biopolymer networks
AU2018330610A1 (en) 2017-09-11 2020-04-02 Evorion Biotechnologies Gmbh Systems, methods and hydrogels for cell culture and analysis
US11173487B2 (en) 2017-12-19 2021-11-16 Arizona Board Of Regents On Behalf Of Arizona State University Deterministic ratchet for sub-micrometer bioparticle separation
US10935149B2 (en) 2018-03-15 2021-03-02 University Of Washington Temperature-actuated valve, fluidic device, and related methods of use
CN114713056A (en) 2018-04-02 2022-07-08 滴管公司 System and method for continuous flow emulsion processing
JP7151766B2 (en) * 2018-06-29 2022-10-12 株式会社ニコン Fluidic device, system and mixing method
EP3829622A4 (en) 2018-08-02 2022-05-11 Duke University Dual agonist fusion proteins
US11314375B2 (en) 2018-10-01 2022-04-26 Precigenome, LLC Multichannel pressure control system with user friendly interface
US20220145355A1 (en) 2019-03-13 2022-05-12 Evorion Biotechnologies Gmbh Methods and kits for determining cell secreted biomolecules
US11624718B2 (en) 2019-05-14 2023-04-11 Arizona Board Of Regents On Behalf Of Arizona State University Single piece droplet generation and injection device for serial crystallography
US11318487B2 (en) 2019-05-14 2022-05-03 Arizona Board Of Regents On Behalf Of Arizona State University Co-flow injection for serial crystallography
AU2020297612A1 (en) * 2019-06-20 2022-02-03 President And Fellows Of Harvard College Isolating live cells after high-throughput, long-term, time-lapse microscopy
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
GR1010186B (en) * 2019-09-25 2022-03-02 Nanoplasmas Private Company, Diagnostic chip for analyzing presence of bacteria in a sample
US11738340B2 (en) 2019-10-04 2023-08-29 Javelin Biotech, Inc. Neurodegenerative target discovery platform
CA3161454A1 (en) 2019-11-13 2021-05-20 Fluid-Screen, Inc. Methods and apparatus for detection of bacteria in a sample using dielectrophoresis
WO2021097205A1 (en) * 2019-11-13 2021-05-20 Fluid-Screen, Inc. Methods and apparatus for detection of bacteria in a sample using dielectrophoresis
EP3957397A1 (en) * 2020-08-20 2022-02-23 Evorion Biotechnologies GmbH Microfabricated device, system and method comprising such system
US20230338950A1 (en) * 2020-08-21 2023-10-26 Duke University Microfluidic assay device
US20230357822A1 (en) 2020-09-17 2023-11-09 Evorion Biotechnologies Gmbh Method for analyzing cell released biomolecules
US11485632B2 (en) 2020-10-09 2022-11-01 Arizona Board Of Regents On Behalf Of Arizona State University Modular 3-D printed devices for sample delivery and method
CN114768894B (en) * 2021-01-22 2023-08-11 中国科学院上海微系统与信息技术研究所 Detection chip and detection method

Family Cites Families (217)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656508A (en) 1949-08-27 1953-10-20 Wallace H Coulter Means for counting particles suspended in a fluid
US3560754A (en) 1965-11-17 1971-02-02 Ibm Photoelectric particle separator using time delay
US3570515A (en) 1969-06-19 1971-03-16 Foxboro Co Aminar stream cross-flow fluid diffusion logic gate
NL7102074A (en) 1971-02-17 1972-08-21
FR2287606A1 (en) 1974-10-08 1976-05-07 Pegourie Jean Pierre PNEUMATIC LOGIC CIRCUITS AND THEIR INTEGRATED CIRCUITS
US4018565A (en) 1975-10-17 1977-04-19 The Foxboro Company Automatic process titration system
JPS5941169B2 (en) 1975-12-25 1984-10-05 シチズン時計株式会社 Elastomer
US4108565A (en) * 1977-07-21 1978-08-22 Jacobus Wilhelmus Janssen Potato processing
US4153855A (en) 1977-12-16 1979-05-08 The United States Of America As Represented By The Secretary Of The Army Method of making a plate having a pattern of microchannels
US4245673A (en) 1978-03-01 1981-01-20 La Telemechanique Electrique Pneumatic logic circuit
US4434704A (en) 1980-04-14 1984-03-06 Halliburton Company Hydraulic digital stepper actuator
US4585209A (en) 1983-10-27 1986-04-29 Harry E. Aine Miniature valve and method of making same
US4581624A (en) 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5140161A (en) 1985-08-05 1992-08-18 Biotrack Capillary flow device
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4675300A (en) 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US5088515A (en) 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US4786165A (en) 1986-07-10 1988-11-22 Toa Medical Electronics Co., Ltd. Flow cytometry and apparatus therefor
DE3882011T2 (en) 1987-10-27 1993-09-30 Fujitsu Ltd Method and device for producing biopolymer single crystal.
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US4898582A (en) 1988-08-09 1990-02-06 Pharmetrix Corporation Portable infusion device assembly
US5032381A (en) 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US4992312A (en) 1989-03-13 1991-02-12 Dow Corning Wright Corporation Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby
CH679555A5 (en) 1989-04-11 1992-03-13 Westonbridge Int Ltd
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
JPH04501449A (en) 1989-06-14 1992-03-12 ウエストンブリッジ　インターナショナル　リミティド micro pump
KR910012538A (en) 1989-12-27 1991-08-08 야마무라 가쯔미 Micro pump and its manufacturing method
EP0517760A1 (en) 1990-02-24 1992-12-16 University Of Hertfordshire Biorheological measurement
DE4006152A1 (en) 1990-02-27 1991-08-29 Fraunhofer Ges Forschung MICROMINIATURIZED PUMP
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5096388A (en) 1990-03-22 1992-03-17 The Charles Stark Draper Laboratory, Inc. Microfabricated pump
GB9008044D0 (en) 1990-04-09 1990-06-06 Hatfield Polytechnic Higher Ed Microfabricated device for biological cell sorting
SE470347B (en) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Microstructure for fluid flow systems and process for manufacturing such a system
DE69106240T2 (en) 1990-07-02 1995-05-11 Seiko Epson Corp Micropump and method of making a micropump.
US6074818A (en) 1990-08-24 2000-06-13 The University Of Tennessee Research Corporation Fingerprinting of nucleic acids, products and methods
ES2075459T3 (en) 1990-08-31 1995-10-01 Westonbridge Int Ltd VALVE EQUIPPED WITH POSITION DETECTOR AND MICROPUMP THAT INCORPORATES SUCH VALVE.
DE4119955C2 (en) 1991-06-18 2000-05-31 Danfoss As Miniature actuator
US5164558A (en) 1991-07-05 1992-11-17 Massachusetts Institute Of Technology Micromachined threshold pressure switch and method of manufacture
JP3328300B2 (en) 1991-07-18 2002-09-24 アイシン精機株式会社 Fluid control device
DE4143573C2 (en) 1991-08-19 1996-07-04 Fraunhofer Ges Forschung Device for separating mixtures of microscopic dielectric particles suspended in a liquid or a gel
DE4143343C2 (en) 1991-09-11 1994-09-22 Fraunhofer Ges Forschung Microminiaturized, electrostatically operated micromembrane pump
US5265327A (en) 1991-09-13 1993-11-30 Faris Sadeg M Microchannel plate technology
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
GB2264296B (en) 1992-02-07 1995-06-28 Zortech Int Microporous thermal insulation material
US5558998A (en) 1992-02-25 1996-09-24 The Regents Of The Univ. Of California DNA fragment sizing and sorting by laser-induced fluorescence
GB2264496B (en) 1992-02-25 1995-10-25 Us Energy Sizing of fragments from a nucleic acid sequence
JPH05236997A (en) 1992-02-28 1993-09-17 Hitachi Ltd Chip for catching polynucleotide
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
DE4220077A1 (en) 1992-06-19 1993-12-23 Bosch Gmbh Robert Micro-pump for delivery of gases - uses working chamber warmed by heating element and controlled by silicon wafer valves.
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5364742A (en) 1992-09-21 1994-11-15 International Business Machines Corporation Micro-miniature structures and method of fabrication thereof
JP2812629B2 (en) 1992-11-25 1998-10-22 宇宙開発事業団 Crystal growth cell
US5290240A (en) 1993-02-03 1994-03-01 Pharmetrix Corporation Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid
US5400741A (en) 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
EP0700485B1 (en) 1993-05-27 1997-08-13 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Microvalve
SE501713C2 (en) 1993-09-06 1995-05-02 Pharmacia Biosensor Ab Diaphragm-type valve, especially for liquid handling blocks with micro-flow channels
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5642015A (en) 1993-07-14 1997-06-24 The University Of British Columbia Elastomeric micro electro mechanical systems
US5417235A (en) 1993-07-28 1995-05-23 Regents Of The University Of Michigan Integrated microvalve structures with monolithic microflow controller
US5659171A (en) 1993-09-22 1997-08-19 Northrop Grumman Corporation Micro-miniature diaphragm pump for the low pressure pumping of gases
DE69431994T2 (en) 1993-10-04 2003-10-30 Res Int Inc MICRO-MACHINED FLUID TREATMENT DEVICE WITH FILTER AND CONTROL VALVE
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
CH689836A5 (en) 1994-01-14 1999-12-15 Westonbridge Int Ltd Micropump.
EP0670489A3 (en) * 1994-03-03 1996-03-06 Ciba Geigy Ag Apparatus and process for separating fluid substances.
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
DE69527585T2 (en) 1994-06-08 2003-04-03 Affymetrix Inc Method and device for packaging chips
DE4433894A1 (en) 1994-09-22 1996-03-28 Fraunhofer Ges Forschung Method and device for controlling a micropump
EP0706004B1 (en) 1994-10-07 2003-08-06 Bayer Corporation Relief valve
US5500071A (en) 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5641400A (en) 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
DE4438785C2 (en) 1994-10-24 1996-11-07 Wita Gmbh Wittmann Inst Of Tec Microchemical reaction and analysis unit
US5788468A (en) 1994-11-03 1998-08-04 Memstek Products, Llc Microfabricated fluidic devices
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
JP3094880B2 (en) 1995-03-01 2000-10-03 住友金属工業株式会社 Method for controlling crystallization of organic compound and solid state element for controlling crystallization used therein
US5775371A (en) 1995-03-08 1998-07-07 Abbott Laboratories Valve control
US5876187A (en) 1995-03-09 1999-03-02 University Of Washington Micropumps with fixed valves
US5661222A (en) 1995-04-13 1997-08-26 Dentsply Research & Development Corp. Polyvinylsiloxane impression material
US5757482A (en) 1995-04-20 1998-05-26 Perseptive Biosystems, Inc. Module for optical detection in microscale fluidic analyses
DE19520298A1 (en) 1995-06-02 1996-12-05 Bayer Ag Sorting device for biological cells or viruses
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JPH0943251A (en) * 1995-08-03 1997-02-14 Olympus Optical Co Ltd Dispenser
CA2183478C (en) 1995-08-17 2004-02-24 Stephen A. Carter Digital gas metering system using tri-stable and bi-stable solenoids
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6048734A (en) * 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5726751A (en) 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
JPH09149799A (en) 1995-11-30 1997-06-10 Hitachi Ltd Analysis or detection of nucleic acid and analyser or inspection device of nucleic acid
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
KR100207410B1 (en) 1995-12-19 1999-07-15 전주범 Fabrication method for lightpath modulation device
US5660370A (en) 1996-03-07 1997-08-26 Integrated Fludics, Inc. Valve with flexible sheet member and two port non-flexing backer member
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5726404A (en) 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
FR2749663B1 (en) 1996-06-07 1998-07-31 Bio Merieux SINGLE USE ANALYSIS CARD COMPRISING A LIQUID FLOW CONDUIT
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
CN1329729C (en) 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 Electropipettor and compensation means for electrophoretic bias
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
WO1998002601A1 (en) 1996-07-15 1998-01-22 Sumitomo Metal Industries, Ltd. Equipment for crystal growth and crystal-growing method using the same
US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US6136212A (en) 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
EP0929658A4 (en) 1996-08-26 2005-11-02 Univ Princeton Reversibly sealable microstructure sorting devices
US5738799A (en) 1996-09-12 1998-04-14 Xerox Corporation Method and materials for fabricating an ink-jet printhead
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5971355A (en) 1996-11-27 1999-10-26 Xerox Corporation Microdevice valve structures to fluid control
US6117634A (en) 1997-03-05 2000-09-12 The Reagents Of The University Of Michigan Nucleic acid sequencing and mapping
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
US6235471B1 (en) * 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
CA2284612A1 (en) * 1997-04-04 1998-10-15 Michael Knapp Closed-loop biochemical analyzers
JP2002503336A (en) * 1997-05-16 2002-01-29 アルバータ リサーチ カウンシル Micro-distribution system and method of using the same
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
AU8275998A (en) 1997-06-27 1999-01-19 Immunetics, Inc. Rapid flow-through binding assay apparatus and method
US5880690A (en) * 1997-07-15 1999-03-09 Exar Corporation Pipeline ADC common-mode tracking circuit
AU8492998A (en) 1997-07-16 1999-02-10 Diversified Scientific, Inc. Method for acquiring, storing and analyzing crystal images
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6540895B1 (en) * 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US7214298B2 (en) 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5836750A (en) 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
US6345502B1 (en) * 1997-11-12 2002-02-12 California Institute Of Technology Micromachined parylene membrane valve and pump
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
WO1999036714A2 (en) 1998-01-20 1999-07-22 Triconex, Incorporated Two out of three voting solenoid arrangement
US6318970B1 (en) * 1998-03-12 2001-11-20 Micralyne Inc. Fluidic devices
AU3491299A (en) 1998-04-14 1999-11-01 Lumenal Technologies, L.P. Test cartridge with a single inlet port
AU763433B2 (en) 1998-05-22 2003-07-24 California Institute Of Technology Microfabricated cell sorter
AU4719399A (en) 1998-06-26 2000-01-17 University Of Washington Crystallization media
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
GB9822242D0 (en) * 1998-10-13 1998-12-09 Zeneca Ltd Device
RU2143343C1 (en) 1998-11-03 1999-12-27 Самсунг Электроникс Ко., Лтд. Microinjector and microinjector manufacture method
US6958865B1 (en) 1998-11-12 2005-10-25 California Institute Of Technology Microlicensing particles and applications
MXPA01009999A (en) 1999-04-06 2003-07-14 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth.
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US7459022B2 (en) 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
ATE215673T1 (en) 1999-06-28 2002-04-15 California Inst Of Techn ELASTOMERIC MICROPUMP AND MICROVALVE SYSTEMS
EP1206697A2 (en) 1999-08-02 2002-05-22 Emerald Biostructures Inc. Method and system for creating a crystallization results database
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
EP1202803A2 (en) 1999-12-22 2002-05-08 Gene Logic, Inc. Flow-through chip cartridge, chip holder, system & method thereof
US20020012926A1 (en) 2000-03-03 2002-01-31 Mycometrix, Inc. Combinatorial array for nucleic acid analysis
JP4927287B2 (en) * 2000-03-31 2012-05-09 マイクロニックス、インコーポレーテッド Microfluidic device for protein crystallization
US20050118073A1 (en) 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US6431212B1 (en) * 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6885982B2 (en) 2000-06-27 2005-04-26 Fluidigm Corporation Object oriented microfluidic design method and system
US7062418B2 (en) 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
US6301055B1 (en) 2000-08-16 2001-10-09 California Institute Of Technology Solid immersion lens structures and methods for producing solid immersion lens structures
EP1334347A1 (en) 2000-09-15 2003-08-13 California Institute Of Technology Microfabricated crossflow devices and methods
WO2002029106A2 (en) 2000-10-03 2002-04-11 California Institute Of Technology Microfluidic devices and methods of use
US7097809B2 (en) 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
US7678547B2 (en) 2000-10-03 2010-03-16 California Institute Of Technology Velocity independent analyte characterization
EP1336097A4 (en) 2000-10-13 2006-02-01 Fluidigm Corp Microfluidic device based sample injection system for analytical devices
US7232109B2 (en) 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
US6951632B2 (en) 2000-11-16 2005-10-04 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
EP1343973B2 (en) 2000-11-16 2020-09-16 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
JP5162074B2 (en) 2001-04-06 2013-03-13 フルイディグム コーポレイション Polymer surface modification
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
US6802342B2 (en) 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US7075162B2 (en) 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
JP2005505441A (en) 2001-10-08 2005-02-24 カリフォルニア インスティテュート オブ テクノロジー Microfabricated lens, its manufacturing method and application
US7192629B2 (en) 2001-10-11 2007-03-20 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
CA2467587A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
CA2480728A1 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US7059348B2 (en) 2002-05-13 2006-06-13 Fluidigm Corporation Drug delivery system
US8168139B2 (en) 2002-06-24 2012-05-01 Fluidigm Corporation Recirculating fluidic network and methods for using the same
EP2298448A3 (en) 2002-09-25 2012-05-30 California Institute of Technology Microfluidic large scale integration
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
GB0302302D0 (en) 2003-01-31 2003-03-05 Glaxo Group Ltd Microfluidic apparatus and method
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
EP1685282A2 (en) 2003-04-17 2006-08-02 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
EP1636017A2 (en) 2003-05-20 2006-03-22 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
US7583853B2 (en) 2003-07-28 2009-09-01 Fluidigm Corporation Image processing method and system for microfluidic devices
US7042649B2 (en) 2003-08-11 2006-05-09 California Institute Of Technology Microfabricated rubber microscope using soft solid immersion lenses
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
WO2005054441A2 (en) 2003-12-01 2005-06-16 California Institute Of Technology Device for immobilizing chemical and biomedical species and methods of using same
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
CN100583434C (en) 2004-06-07 2010-01-20 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
WO2006071470A2 (en) 2004-12-03 2006-07-06 California Institute Of Technology Microfluidic devices with chemical reaction circuits
WO2006060748A2 (en) 2004-12-03 2006-06-08 California Institute Of Technology Microfluidic sieve valves
US7883669B2 (en) 2005-04-20 2011-02-08 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
WO2007044091A2 (en) 2005-06-02 2007-04-19 Fluidigm Corporation Analysis using microfluidic partitioning devices
US20070054293A1 (en) 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US20070074972A1 (en) 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US8206975B2 (en) 2005-10-28 2012-06-26 California Institute Of Technology Method and device for regulating fluid flow in microfluidic devices
EP1984107A4 (en) 2006-01-26 2013-12-04 California Inst Of Techn Programming microfluidic devices with molecular information
US20070248971A1 (en) 2006-01-26 2007-10-25 California Institute Of Technology Programming microfluidic devices with molecular information
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US8828661B2 (en) 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
WO2008043046A2 (en) 2006-10-04 2008-04-10 Fluidigm Corporation Microfluidic check valves
US8473216B2 (en) 2006-11-30 2013-06-25 Fluidigm Corporation Method and program for performing baseline correction of amplification curves in a PCR experiment
US8157434B2 (en) 2007-01-19 2012-04-17 Fluidigm Corporation High efficiency and high precision microfluidic devices and methods
WO2008141183A2 (en) 2007-05-09 2008-11-20 Fluidigm Corporation Method and system for crystallization and x-ray diffraction screening
EA018555B1 (en) 2007-09-07 2013-08-30 Флуидигм Корпорейшн Copy number variation determination, methods and systems
US9157116B2 (en) 2008-02-08 2015-10-13 Fluidigm Corporation Combinatorial amplification and detection of nucleic acids
US9487822B2 (en) 2008-03-19 2016-11-08 Fluidigm Corporation Method and apparatus for determining copy number variation using digital PCR
WO2010011852A1 (en) 2008-07-25 2010-01-28 Fluidigm Corporation Method and system for manufacturing integrated fluidic chips
US8617488B2 (en) 2008-08-07 2013-12-31 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
SG10201404682WA (en) 2008-12-08 2014-10-30 Fluidigm Corp Programmable microfluidic digital array
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
WO2011053790A2 (en) 2009-10-30 2011-05-05 Fluidigm Corporation Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis

Also Published As

Publication number Publication date
US8129176B2 (en) 2012-03-06
US20100120018A1 (en) 2010-05-13
US20020037499A1 (en) 2002-03-28
US6767706B2 (en) 2004-07-27
US20160339423A1 (en) 2016-11-24
US20150031116A1 (en) 2015-01-29
WO2001094635A9 (en) 2002-08-08
WO2001094635A2 (en) 2001-12-13
US20130295653A1 (en) 2013-11-07
US20120178084A1 (en) 2012-07-12
US7351376B1 (en) 2008-04-01
US7622081B2 (en) 2009-11-24
JP2003536058A (en) 2003-12-02
WO2001094635A3 (en) 2002-10-31
US20040248167A1 (en) 2004-12-09
EP1290226A2 (en) 2003-03-12
US8257666B2 (en) 2012-09-04

Similar Documents

Publication Publication Date Title
AU2001275340A1 (en) Integrated active flux microfluidic devices and methods
AU2001247478A1 (en) Microlaboratory devices and methods
AU2002211389A1 (en) Microfluidic devices and methods of use
AU2001286419A1 (en) Endourethral device and method
AU2002227414A1 (en) Infusion devices and method
AU5499201A (en) Microfluidic devices
AU2001267079A1 (en) Integrated electronic-optoelectronic devices and method of making the same
AU2002218752A1 (en) Methods and devices for nebulizing fluids
AU2001247770A1 (en) Biased rotatable combdrive devices and methods
AU2002219163A1 (en) Cryostorage method and device
AU2002245675A1 (en) Electromanipulation device and method
AU2002211717A1 (en) Stresscopins and their uses
MXPA03003796A (en) Pour-on application method and devices.
AU2001292936A1 (en) Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines
AU3230801A (en) Semiconductor device fabrication method and semiconductor device fabrication device
AU2001274521A1 (en) Receiving device and receiving method
AU2001276269A1 (en) Tool and associated fixing device
AU3205501A (en) Tattooing device
AU2001242793A1 (en) Semiconductor device and fabrication method therefor
AU2001295185A1 (en) Multiplexing-interleaving and demultiplexing-deinterleaving
AU2001292329A1 (en) Path selection device and path selection method
AU2001269495A1 (en) Business-use laundering method and business-use laundering device using the method
AU2002222749A1 (en) Orthodontics device and method
AU2001292366A1 (en) Receiving device and receiving method
AUPR496501A0 (en) Method and device