AU2001271786A1 - Interferon-like protein zcyto21 - Google Patents
Interferon-like protein zcyto21Info
- Publication number
- AU2001271786A1 AU2001271786A1 AU2001271786A AU7178601A AU2001271786A1 AU 2001271786 A1 AU2001271786 A1 AU 2001271786A1 AU 2001271786 A AU2001271786 A AU 2001271786A AU 7178601 A AU7178601 A AU 7178601A AU 2001271786 A1 AU2001271786 A1 AU 2001271786A1
- Authority
- AU
- Australia
- Prior art keywords
- amino acid
- zcyto21
- interferon
- acid sequence
- genetically engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 238000011813 knockout mouse model Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000011830 transgenic mouse model Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
There is provided a transgenic mouse that has been genetically engineered to express a Zcyto21 gene, and a knock-out mouse, which has been genetically engineered to exhibit a complete absence of Zcyto21 gene function; wherein said Zcyto21 gene encodes a polypeptide comprising an amino acid sequence that has at least 90% amino acid sequence identity to amino acid residues 20-200 of SEQ ID NO: 2.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21544600P | 2000-06-30 | 2000-06-30 | |
US60/215,446 | 2000-06-30 | ||
US28542401P | 2001-04-20 | 2001-04-20 | |
US60/285,424 | 2001-04-20 | ||
PCT/US2001/021087 WO2002002627A2 (en) | 2000-06-30 | 2001-06-29 | Interferon-like protein zcyto21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001271786A1 true AU2001271786A1 (en) | 2002-01-14 |
Family
ID=26910034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001271786A Abandoned AU2001271786A1 (en) | 2000-06-30 | 2001-06-29 | Interferon-like protein zcyto21 |
Country Status (13)
Country | Link |
---|---|
US (18) | US6927040B2 (en) |
EP (4) | EP1939293A3 (en) |
JP (1) | JP4377126B2 (en) |
CN (1) | CN100448993C (en) |
AT (2) | ATE360696T1 (en) |
AU (1) | AU2001271786A1 (en) |
BR (1) | BR0112119A (en) |
CA (1) | CA2413258C (en) |
DE (2) | DE60135393D1 (en) |
DK (2) | DK1294888T3 (en) |
ES (2) | ES2286128T3 (en) |
RU (1) | RU2292394C2 (en) |
WO (1) | WO2002002627A2 (en) |
Families Citing this family (31)
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---|---|---|---|---|
EP1939293A3 (en) * | 2000-06-30 | 2008-07-09 | ZymoGenetics, Inc. | Interferon-Like Protein ZCYTO21 |
US7038032B2 (en) * | 2001-04-20 | 2006-05-02 | Zymogenetics, Inc. | Cytokine protein family |
US7910313B2 (en) * | 2001-04-20 | 2011-03-22 | Zymogenetics, Inc. | Cytokine protein family |
EP1412499A4 (en) * | 2001-05-10 | 2005-04-06 | Immunex Corp | Cytokine polypeptides |
AU2002357643A1 (en) * | 2001-08-29 | 2003-04-14 | Vanderbilt University | The human mob-5 (il-24) receptors and uses thereof |
WO2003066002A2 (en) * | 2002-02-08 | 2003-08-14 | University Of Medicine And Dentistry Of New Jersey | IFN-a/b-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION |
WO2003089603A2 (en) | 2002-04-19 | 2003-10-30 | Zymogenetics, Inc. | Cytokine receptor |
CA2496002A1 (en) * | 2002-08-07 | 2004-02-19 | Delta Biotechnology Ltd. | Albumin-fused ciliary neurotrophic factor |
US7135170B2 (en) * | 2002-10-23 | 2006-11-14 | Zymogenetics, Inc. | Methods for treating viral infection using IL-28 and IL-29 |
ES2303132T3 (en) | 2003-08-07 | 2008-08-01 | Zymogenetics, Inc. | HOMOGENEAS PREPARATIONS OF IL-29. |
CA2558829C (en) * | 2004-04-02 | 2014-03-11 | Zymogenetics, Inc. | Methods for treating viral infection using il-28 and il-29 cysteine mutants |
WO2006012644A2 (en) * | 2004-07-29 | 2006-02-02 | Zymogenetics, Inc. | Use of il-28 and il-29 to treat cancer |
US20060178301A1 (en) * | 2005-02-04 | 2006-08-10 | Mathias Jurs | Albumin-fused ciliary neurotrophic factor |
WO2007013944A2 (en) * | 2005-07-20 | 2007-02-01 | Zymogenetics, Inc. | Use of truncated cysteine il28 and il29 mutants to treat cancers and autoimmune disorders |
EP1912668A2 (en) * | 2005-07-20 | 2008-04-23 | ZymoGenetics, Inc. | Il28 and il29 truncated cysteine mutants and antiviral methods of using same |
PL1931704T3 (en) | 2005-10-04 | 2011-06-30 | Zymogenetics L L C | Production and purification of il-29 |
TW200744634A (en) * | 2006-02-21 | 2007-12-16 | Wyeth Corp | Methods of using antibodies against human IL-22 |
US7883700B2 (en) | 2007-12-07 | 2011-02-08 | Zymogenetics, Inc. | Anti-human IL-21 monoclonal antibodies |
AU2009231598B2 (en) | 2008-04-04 | 2015-03-12 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same |
CN103536906A (en) * | 2008-06-05 | 2014-01-29 | 津莫吉尼蒂克斯公司 | Use of pegylated Type III Interferons for the treatment of hepatitis C |
WO2010045261A1 (en) * | 2008-10-13 | 2010-04-22 | Zymogenetics, Llc | Single chain fc type iii interferons and methods of using same |
CN102858691B (en) | 2010-04-28 | 2015-09-23 | 株式会社村田制作所 | There is the perovskite material of the dielectric properties that negatively charged ion controls, film capacitor device and manufacture method thereof |
FR2975185A1 (en) * | 2011-05-12 | 2012-11-16 | Univ Claude Bernard Lyon | METHOD FOR IN VITRO DETERMINATION OF THE PRESENCE OF A MULTIPLE SCLEROSIS |
RU2549710C2 (en) * | 2012-06-29 | 2015-04-27 | Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) | Method for purifying recombinant protein of type iii interferon-like factor |
CN102998450B (en) * | 2012-11-22 | 2014-10-15 | 北京正旦国际科技有限责任公司 | Immuno-mass spectrometric detection kit for esophagus cancer |
JP6730926B2 (en) | 2014-01-08 | 2020-07-29 | プロージット ソウル バイオテクノロジー (ベイジン) カンパニー リミテッド | Fusion polypeptides and methods of use |
US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
KR102514971B1 (en) | 2015-04-21 | 2023-03-27 | 아이거 바이오파마슈티컬스 인코포레이티드 | Pharmaceutical composition comprising lonafarnib and ritonavir |
WO2017143253A1 (en) | 2016-02-19 | 2017-08-24 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection with interferon lambda |
EP3518958A4 (en) * | 2016-09-30 | 2021-03-31 | The Board of Trustees of the Leland Stanford Junior University | Variant type iii interferons and synthekines |
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ES2303132T3 (en) | 2003-08-07 | 2008-08-01 | Zymogenetics, Inc. | HOMOGENEAS PREPARATIONS OF IL-29. |
CA2558829C (en) | 2004-04-02 | 2014-03-11 | Zymogenetics, Inc. | Methods for treating viral infection using il-28 and il-29 cysteine mutants |
WO2007013944A2 (en) * | 2005-07-20 | 2007-02-01 | Zymogenetics, Inc. | Use of truncated cysteine il28 and il29 mutants to treat cancers and autoimmune disorders |
CN103536906A (en) | 2008-06-05 | 2014-01-29 | 津莫吉尼蒂克斯公司 | Use of pegylated Type III Interferons for the treatment of hepatitis C |
WO2010045261A1 (en) | 2008-10-13 | 2010-04-22 | Zymogenetics, Llc | Single chain fc type iii interferons and methods of using same |
-
2001
- 2001-06-29 EP EP08100616A patent/EP1939293A3/en not_active Withdrawn
- 2001-06-29 ES ES01950827T patent/ES2286128T3/en not_active Expired - Lifetime
- 2001-06-29 CA CA2413258A patent/CA2413258C/en not_active Expired - Lifetime
- 2001-06-29 RU RU2003103099/13A patent/RU2292394C2/en active
- 2001-06-29 EP EP01950827A patent/EP1294888B1/en not_active Expired - Lifetime
- 2001-06-29 EP EP06012489A patent/EP1717316B1/en not_active Expired - Lifetime
- 2001-06-29 DE DE60135393T patent/DE60135393D1/en not_active Expired - Lifetime
- 2001-06-29 ES ES06012489T patent/ES2311253T3/en not_active Expired - Lifetime
- 2001-06-29 DK DK01950827T patent/DK1294888T3/en active
- 2001-06-29 JP JP2002507878A patent/JP4377126B2/en not_active Expired - Lifetime
- 2001-06-29 EP EP09172071A patent/EP2132984A3/en not_active Withdrawn
- 2001-06-29 CN CNB018131530A patent/CN100448993C/en not_active Ceased
- 2001-06-29 DK DK06012489T patent/DK1717316T3/en active
- 2001-06-29 AT AT01950827T patent/ATE360696T1/en active
- 2001-06-29 WO PCT/US2001/021087 patent/WO2002002627A2/en active IP Right Grant
- 2001-06-29 AT AT06012489T patent/ATE404670T1/en active
- 2001-06-29 US US09/895,834 patent/US6927040B2/en not_active Expired - Lifetime
- 2001-06-29 AU AU2001271786A patent/AU2001271786A1/en not_active Abandoned
- 2001-06-29 BR BR0112119-7A patent/BR0112119A/en active Search and Examination
- 2001-06-29 DE DE60128093T patent/DE60128093T2/en not_active Expired - Lifetime
-
2004
- 2004-03-02 US US10/790,996 patent/US20040146988A1/en not_active Abandoned
- 2004-08-27 US US10/927,891 patent/US7252969B2/en not_active Expired - Lifetime
- 2004-08-27 US US10/927,815 patent/US7253261B2/en not_active Expired - Lifetime
- 2004-08-27 US US10/928,539 patent/US7241870B2/en not_active Expired - Lifetime
-
2006
- 2006-10-10 US US11/548,023 patent/US7445913B2/en not_active Expired - Lifetime
- 2006-10-10 US US11/548,056 patent/US7485700B2/en not_active Expired - Lifetime
- 2006-10-10 US US11/548,138 patent/US20070049736A1/en not_active Abandoned
- 2006-10-10 US US11/548,108 patent/US20070043209A1/en not_active Abandoned
-
2007
- 2007-10-16 US US11/873,272 patent/US7655223B2/en not_active Expired - Lifetime
- 2007-10-26 US US11/925,097 patent/US7498154B2/en not_active Expired - Lifetime
-
2008
- 2008-01-09 US US11/971,624 patent/US20080214788A1/en not_active Abandoned
- 2008-12-22 US US12/341,273 patent/US20090326204A1/en not_active Abandoned
-
2009
- 2009-11-30 US US12/628,078 patent/US7833520B2/en not_active Expired - Fee Related
-
2010
- 2010-09-30 US US12/895,139 patent/US7919595B2/en not_active Expired - Fee Related
-
2011
- 2011-03-02 US US13/039,223 patent/US20110172170A1/en not_active Abandoned
- 2011-09-08 US US13/227,548 patent/US20120036590A1/en not_active Abandoned
-
2012
- 2012-05-03 US US13/463,046 patent/US20120258458A1/en not_active Abandoned
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