AU2001267515A1 - Mammalion haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof - Google Patents

Mammalion haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof

Info

Publication number
AU2001267515A1
AU2001267515A1 AU2001267515A AU6751501A AU2001267515A1 AU 2001267515 A1 AU2001267515 A1 AU 2001267515A1 AU 2001267515 A AU2001267515 A AU 2001267515A AU 6751501 A AU6751501 A AU 6751501A AU 2001267515 A1 AU2001267515 A1 AU 2001267515A1
Authority
AU
Australia
Prior art keywords
mammalion
haemoglobin
conjugated
compatible
linked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001267515A
Inventor
Wolfgang Barnikol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanguibiotech AG
Original Assignee
Sanguibiotech AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanguibiotech AG filed Critical Sanguibiotech AG
Publication of AU2001267515A1 publication Critical patent/AU2001267515A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
AU2001267515A 2000-06-29 2001-06-02 Mammalion haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof Abandoned AU2001267515A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10031744 2000-06-29
DE10031744A DE10031744A1 (en) 2000-06-29 2000-06-29 Mammalian hemoglobins compatible with blood plasma, crosslinked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, their production and their use
PCT/EP2001/006322 WO2002000768A1 (en) 2000-06-29 2001-06-02 Mammalion haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof

Publications (1)

Publication Number Publication Date
AU2001267515A1 true AU2001267515A1 (en) 2002-01-08

Family

ID=7647247

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001267515A Abandoned AU2001267515A1 (en) 2000-06-29 2001-06-02 Mammalion haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof

Country Status (6)

Country Link
US (1) US6956025B2 (en)
EP (1) EP1299457B1 (en)
AU (1) AU2001267515A1 (en)
DE (1) DE10031744A1 (en)
ES (1) ES2395894T3 (en)
WO (1) WO2002000768A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10220992A1 (en) * 2002-05-11 2003-12-04 Sanguibiotech Ag Use of one or more oxygen carriers selected from hemoglobin, myoglobin and derivatives thereof for the treatment of an organ dysfunction due to an acute lack of supply and for the treatment / prevention of tissue damage due to such a disorder
US20040072729A1 (en) * 2002-10-10 2004-04-15 Sunbio Inc. High oxygen affinity PEG-hemoglobin as treatment for brain stroke
DE10352692A1 (en) 2003-11-12 2005-06-23 Sanguibiotech Gmbh Use of hypo-oncotic solutions in the blood of addable, hyperpolymeric hemoglobins for the treatment of pulmonary edema
FI2341905T4 (en) 2008-09-04 2023-12-04 Amylin Pharmaceuticals Llc Sustained release formulations using non-aqueous carriers
US8048856B1 (en) * 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
EP2550973B1 (en) 2011-07-23 2013-08-28 SastoMed GmbH Wound spray
EP2614833A1 (en) 2012-01-13 2013-07-17 SastoMed GmbH Scarring reducing wound treatment
BR112015023233A8 (en) 2013-03-15 2019-12-03 Sangart Inc hemoglobin conjugates, pharmaceutical composition and use of a hemoglobin conjugate
DE102013014651A1 (en) 2013-09-03 2015-03-05 Sanguibiotech Gmbh Preparations for improved tissue oxygenation by peritoneal ventilation
EP3421044A1 (en) 2017-06-26 2019-01-02 SastoMed GmbH Oxygen carriers for the treatment of skin indispositions
AU2018304174A1 (en) 2017-07-18 2020-02-06 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1001401A (en) * 1910-03-26 1911-08-22 James A Hicks Reducing-valve and means for operating same.
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2449885C3 (en) 1974-10-21 1980-04-30 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Process for the production of chemically modified, long-life hemoglobin preparations as well as the modified hemoglobin preparation produced by this process
US4001401A (en) 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4001200A (en) 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
DE2616086C2 (en) 1976-04-13 1986-04-03 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg Substance for use in a colloidal blood volume substitute made from hydroxyethyl starch and hemoglobin
JPS6023084B2 (en) 1979-07-11 1985-06-05 味の素株式会社 blood substitute
DE3265790D1 (en) 1981-05-15 1985-10-03 Cegedur Method for the extrusion characteristics of aluminium alloys of the al-mg-si-type
JPS57206622A (en) 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
DE3130770C2 (en) 1981-08-04 1986-06-19 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Process for obtaining hepatitis-safe, sterile, pyrogen-free and stroma-free hemoglobin solutions
DE3320752A1 (en) 1983-06-09 1984-12-13 Wolfgang Prof. Dr.Dr. 6500 Mainz Barnikol LUMINESCENT LAYERS FOR USE IN DEVICES FOR DETERMINING THE OXYGEN CONCENTRATION IN GASES AND THE LIKE BY MEASURING THE LUMINESCENT REDUCTION
DE3675588D1 (en) 1985-06-19 1990-12-20 Ajinomoto Kk HAEMOGLOBIN TIED TO A POLY (ALKENYLENE OXIDE).
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US5312808A (en) 1989-11-22 1994-05-17 Enzon, Inc. Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
US5386014A (en) * 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
SE9001378D0 (en) 1990-04-18 1990-04-18 Kabivitrum Ab A METHOD FOR THE PREPARATION OF PYRIDOXYLATED HEMOGLOBIN
DE4418973A1 (en) 1994-05-31 1995-12-14 Barnikol Wolfgang Process for the production of molecularly uniform hyperpolymeric hemoglobins
DE4423257C2 (en) 1994-07-02 2001-07-12 Ulrich Heinrich Implant to be inserted between the vertebral body of the spine as a placeholder
EP0854151A1 (en) 1997-01-20 1998-07-22 SanguiBioTech AG Process for the preparation of uniform fractions of hyperpolymers of haemoglobin
DE10031740A1 (en) * 2000-06-29 2002-02-14 Sanguibio Tech Ag Artificial oxygen carriers from cross-linked modified human or pig hemoglobin with improved properties, processes for their technically simple production from purified material in high yields, and their use
DE10031742A1 (en) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Production of cross-linked hemoglobin useful as artificial oxygen carrier comprises cross-linkage of hemoglobin in presence of a chemically inert effector of the hemoglobin oxygen affinity

Also Published As

Publication number Publication date
WO2002000768A1 (en) 2002-01-03
US6956025B2 (en) 2005-10-18
EP1299457A1 (en) 2003-04-09
US20040014641A1 (en) 2004-01-22
EP1299457B1 (en) 2012-10-17
DE10031744A1 (en) 2002-01-17
ES2395894T3 (en) 2013-02-15

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