AU2001261958A1 - Atmospheric pressure ion lens for generating a larger and more stable ion flux - Google Patents
Atmospheric pressure ion lens for generating a larger and more stable ion fluxInfo
- Publication number
- AU2001261958A1 AU2001261958A1 AU2001261958A AU6195801A AU2001261958A1 AU 2001261958 A1 AU2001261958 A1 AU 2001261958A1 AU 2001261958 A AU2001261958 A AU 2001261958A AU 6195801 A AU6195801 A AU 6195801A AU 2001261958 A1 AU2001261958 A1 AU 2001261958A1
- Authority
- AU
- Australia
- Prior art keywords
- ion
- lens
- source
- ion source
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000004907 flux Effects 0.000 title claims abstract description 11
- 150000002500 ions Chemical class 0.000 claims abstract description 998
- 238000013467 fragmentation Methods 0.000 claims abstract description 9
- 238000006062 fragmentation reaction Methods 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims description 56
- 239000012491 analyte Substances 0.000 claims description 25
- 230000008859 change Effects 0.000 claims description 9
- 230000003247 decreasing effect Effects 0.000 claims description 9
- 238000004458 analytical method Methods 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 5
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 4
- 230000008021 deposition Effects 0.000 claims description 3
- 230000001788 irregular Effects 0.000 claims description 2
- 238000000132 electrospray ionisation Methods 0.000 description 73
- 238000001819 mass spectrum Methods 0.000 description 67
- 108090000765 processed proteins & peptides Proteins 0.000 description 41
- 238000004088 simulation Methods 0.000 description 38
- 239000007789 gas Substances 0.000 description 30
- 229920000858 Cyclodextrin Polymers 0.000 description 27
- 239000001116 FEMA 4028 Substances 0.000 description 22
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 22
- 229960004853 betadex Drugs 0.000 description 22
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 21
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- 229960003147 reserpine Drugs 0.000 description 7
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- 238000005070 sampling Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- 102100030497 Cytochrome c Human genes 0.000 description 6
- 108010075031 Cytochromes c Proteins 0.000 description 6
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 6
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- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 6
- 230000007704 transition Effects 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 238000004949 mass spectrometry Methods 0.000 description 5
- 238000005457 optimization Methods 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 4
- 239000005695 Ammonium acetate Substances 0.000 description 4
- 229940043376 ammonium acetate Drugs 0.000 description 4
- 235000019257 ammonium acetate Nutrition 0.000 description 4
- 238000010884 ion-beam technique Methods 0.000 description 4
- 238000007614 solvation Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 102400000967 Bradykinin Human genes 0.000 description 3
- 101800004538 Bradykinin Proteins 0.000 description 3
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 description 3
- 238000000151 deposition Methods 0.000 description 3
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- 239000005350 fused silica glass Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- -1 β-cyclodextrin ions Chemical class 0.000 description 3
- 229910001369 Brass Inorganic materials 0.000 description 2
- 102000007079 Peptide Fragments Human genes 0.000 description 2
- 108010033276 Peptide Fragments Proteins 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000010951 brass Substances 0.000 description 2
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- 238000005040 ion trap Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000001301 oxygen Chemical group 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical group FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 description 2
- 229960000909 sulfur hexafluoride Drugs 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 229920005372 Plexiglas® Polymers 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 238000000738 capillary electrophoresis-mass spectrometry Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000001360 collision-induced dissociation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
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- 229910003460 diamond Inorganic materials 0.000 description 1
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- 238000009826 distribution Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
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- 239000012530 fluid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
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- 230000000155 isotopic effect Effects 0.000 description 1
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- 238000001690 micro-dialysis Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005319 nano flow HPLC Methods 0.000 description 1
- 238000002663 nebulization Methods 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000012811 non-conductive material Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
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- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/067—Ion lenses, apertures, skimmers
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Shaping Of Tube Ends By Bending Or Straightening (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20554900P | 2000-05-22 | 2000-05-22 | |
| US60205549 | 2000-05-22 | ||
| US22932100P | 2000-09-01 | 2000-09-01 | |
| US60229321 | 2000-09-01 | ||
| PCT/CA2001/000728 WO2001091158A2 (en) | 2000-05-22 | 2001-05-22 | Atmospheric pressure ion lens for generating a larger and more stable ion flux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001261958A1 true AU2001261958A1 (en) | 2001-12-03 |
Family
ID=26900525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001261958A Abandoned AU2001261958A1 (en) | 2000-05-22 | 2001-05-22 | Atmospheric pressure ion lens for generating a larger and more stable ion flux |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7067804B2 (de) |
| EP (1) | EP1290712B1 (de) |
| JP (1) | JP2003536207A (de) |
| AT (1) | ATE392006T1 (de) |
| AU (1) | AU2001261958A1 (de) |
| CA (1) | CA2409860A1 (de) |
| DE (1) | DE60133548T2 (de) |
| WO (1) | WO2001091158A2 (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110232489A (zh) * | 2011-06-03 | 2019-09-13 | 苹果公司 | 生成和处理代表待执行任务的任务项目 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399961B2 (en) * | 2001-04-20 | 2008-07-15 | The University Of British Columbia | High throughput ion source with multiple ion sprayers and ion lenses |
| US7479630B2 (en) * | 2004-03-25 | 2009-01-20 | Bandura Dmitry R | Method and apparatus for flow cytometry linked with elemental analysis |
| WO2004038752A2 (en) | 2002-10-21 | 2004-05-06 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Contiguous capillary electrospray sources and analytical device |
| DE102004002729B4 (de) * | 2004-01-20 | 2008-11-27 | Bruker Daltonik Gmbh | Ionisierung desorbierter Analytmoleküle bei Atmosphärendruck |
| GB2422951B (en) * | 2005-02-07 | 2010-07-28 | Microsaic Systems Ltd | Integrated analytical device |
| US20060208186A1 (en) * | 2005-03-15 | 2006-09-21 | Goodley Paul C | Nanospray ion source with multiple spray emitters |
| US20080160170A1 (en) * | 2006-12-28 | 2008-07-03 | Varian Semiconductor Equipment Assoicates, Inc. | Technique for using an improved shield ring in plasma-based ion implantation |
| EP2287600B1 (de) * | 2008-05-20 | 2018-09-19 | Shimadzu Corporation | Verfahren zur atmosphärendruck-ionisation-massenspektrometrie |
| WO2013061155A1 (en) | 2011-10-26 | 2013-05-02 | Dvs Sciences Inc. | Sample transferring apparatus for mass cytometry |
| DE102015120860B4 (de) * | 2014-12-02 | 2022-10-20 | Micromass Uk Limited | Ringförmige Gegenelektrode zum Verbessern der Strahlstabilität und der Verbindungsempfindlichkeit auf einer Mikrofluidikvorrichtung vom Keramikkacheltyp |
| US10297433B2 (en) * | 2016-07-05 | 2019-05-21 | Bruker Daltonik Gmbh | Suppressing harmonic signals in ion cyclotron resonance mass spectrometry |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885076A (en) * | 1987-04-06 | 1989-12-05 | Battelle Memorial Institute | Combined electrophoresis-electrospray interface and method |
| US4842701A (en) * | 1987-04-06 | 1989-06-27 | Battelle Memorial Institute | Combined electrophoretic-separation and electrospray method and system |
| USRE34757E (en) * | 1988-04-05 | 1994-10-18 | Battelle Memorial Institute | Combined electrophoresis-electrospray interface and method |
| US6462337B1 (en) * | 2000-04-20 | 2002-10-08 | Agilent Technologies, Inc. | Mass spectrometer electrospray ionization |
| US5432343A (en) * | 1993-06-03 | 1995-07-11 | Gulcicek; Erol E. | Ion focusing lensing system for a mass spectrometer interfaced to an atmospheric pressure ion source |
| US5412208A (en) * | 1994-01-13 | 1995-05-02 | Mds Health Group Limited | Ion spray with intersecting flow |
| US5750988A (en) * | 1994-07-11 | 1998-05-12 | Hewlett-Packard Company | Orthogonal ion sampling for APCI mass spectrometry |
| US5495108A (en) * | 1994-07-11 | 1996-02-27 | Hewlett-Packard Company | Orthogonal ion sampling for electrospray LC/MS |
| DE19520276C2 (de) * | 1995-06-02 | 1999-08-26 | Bruker Daltonik Gmbh | Vorrichtung für die Einführung von Ionen in ein Massenspektrometer |
| US5838002A (en) * | 1996-08-21 | 1998-11-17 | Chem-Space Associates, Inc | Method and apparatus for improved electrospray analysis |
| US5838003A (en) * | 1996-09-27 | 1998-11-17 | Hewlett-Packard Company | Ionization chamber and mass spectrometry system containing an asymmetric electrode |
| EP1021819B1 (de) * | 1997-09-12 | 2005-03-16 | Analytica Of Branford, Inc. | Mehrprobeneinführungs-massenspektrometrie |
| EP1023742A4 (de) | 1997-10-15 | 2006-03-22 | Analytica Of Branford Inc | Gebogene einlassvorrichtung für massenspektrometer |
| US6060705A (en) * | 1997-12-10 | 2000-05-09 | Analytica Of Branford, Inc. | Electrospray and atmospheric pressure chemical ionization sources |
| CA2343055C (en) | 1998-09-17 | 2011-07-12 | Advanced Bioanalytical Services, Inc. | Integrated monolithic microfabricated electrospray and liquid chromatography system and method |
| US6245227B1 (en) * | 1998-09-17 | 2001-06-12 | Kionix, Inc. | Integrated monolithic microfabricated electrospray and liquid chromatography system and method |
| US6633031B1 (en) | 1999-03-02 | 2003-10-14 | Advion Biosciences, Inc. | Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method |
| US6586731B1 (en) * | 1999-04-12 | 2003-07-01 | Mds Inc. | High intensity ion source apparatus for mass spectrometry |
| US6359275B1 (en) * | 1999-07-14 | 2002-03-19 | Agilent Technologies, Inc. | Dielectric conduit with end electrodes |
| US6690004B2 (en) * | 1999-07-21 | 2004-02-10 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry |
| CA2395694C (en) | 1999-12-30 | 2006-11-21 | Advion Biosciences, Inc. | Multiple electrospray device, systems and methods |
| US6596988B2 (en) * | 2000-01-18 | 2003-07-22 | Advion Biosciences, Inc. | Separation media, multiple electrospray nozzle system and method |
| GB2367685B (en) | 2000-07-26 | 2004-06-16 | Masslab Ltd | Ion source for a mass spectrometer |
| AU2002240143A1 (en) | 2001-01-26 | 2002-08-06 | Advion Biosciences, Inc. | Robotic autosampler for automated electrospray from a microfluidic chip |
-
2001
- 2001-05-22 AU AU2001261958A patent/AU2001261958A1/en not_active Abandoned
- 2001-05-22 DE DE60133548T patent/DE60133548T2/de not_active Expired - Lifetime
- 2001-05-22 WO PCT/CA2001/000728 patent/WO2001091158A2/en active IP Right Grant
- 2001-05-22 JP JP2001587461A patent/JP2003536207A/ja not_active Withdrawn
- 2001-05-22 EP EP01935868A patent/EP1290712B1/de not_active Expired - Lifetime
- 2001-05-22 US US10/275,990 patent/US7067804B2/en not_active Expired - Lifetime
- 2001-05-22 CA CA002409860A patent/CA2409860A1/en not_active Abandoned
- 2001-05-22 AT AT01935868T patent/ATE392006T1/de not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110232489A (zh) * | 2011-06-03 | 2019-09-13 | 苹果公司 | 生成和处理代表待执行任务的任务项目 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1290712B1 (de) | 2008-04-09 |
| US7067804B2 (en) | 2006-06-27 |
| JP2003536207A (ja) | 2003-12-02 |
| ATE392006T1 (de) | 2008-04-15 |
| EP1290712A2 (de) | 2003-03-12 |
| DE60133548D1 (de) | 2008-05-21 |
| CA2409860A1 (en) | 2001-11-29 |
| WO2001091158A2 (en) | 2001-11-29 |
| US20040011953A1 (en) | 2004-01-22 |
| DE60133548T2 (de) | 2009-05-07 |
| WO2001091158A3 (en) | 2002-12-19 |
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