AU2001258341A1 - 8beta-hydrocarbyl-substituted estratrienes for use as selective estrogens - Google Patents

8beta-hydrocarbyl-substituted estratrienes for use as selective estrogens

Info

Publication number
AU2001258341A1
AU2001258341A1 AU2001258341A AU2001258341A AU2001258341A1 AU 2001258341 A1 AU2001258341 A1 AU 2001258341A1 AU 2001258341 A AU2001258341 A AU 2001258341A AU 2001258341 A AU2001258341 A AU 2001258341A AU 2001258341 A1 AU2001258341 A1 AU 2001258341A1
Authority
AU
Australia
Prior art keywords
8beta
hydrocarbyl
selective estrogens
substituted estratrienes
estratrienes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2001258341A
Other versions
AU2001258341B2 (en
Inventor
Walter Elger
Karl-Heinrich Fritzemeier
Christa Hegele-Hartung
Alexander Hillisch
Uwe Kollenkirchen
Vladimir Patchev
Olaf Peters
Ina Thieme
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10019167A external-priority patent/DE10019167A1/en
Application filed by Schering AG filed Critical Schering AG
Priority claimed from PCT/EP2001/004290 external-priority patent/WO2001077139A1/en
Publication of AU2001258341A1 publication Critical patent/AU2001258341A1/en
Application granted granted Critical
Publication of AU2001258341B2 publication Critical patent/AU2001258341B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

AU2001258341A 2000-04-12 2001-04-12 8beta-hydrocarbyl-substituted estratrienes for use as selective estrogens Ceased AU2001258341B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10019167A DE10019167A1 (en) 2000-04-12 2000-04-12 New 8 beta-substituted 11 beta-(pentyl or hexyl)-estra-1,3,5(10)-triene derivatives, are ovary-selective estrogen receptor ligands useful e.g. as female or male contraceptives or for treating ovarian carcinoma
DE10019167.3 2000-04-12
US20737000P 2000-05-26 2000-05-26
US60/207,370 2000-05-26
PCT/EP2001/004290 WO2001077139A1 (en) 2000-04-12 2001-04-12 8ss-HYDROCARBYL-SUBSTITUTED ESTRATRIENES FOR USE AS SELECTIVE ESTROGENS

Publications (2)

Publication Number Publication Date
AU2001258341A1 true AU2001258341A1 (en) 2002-01-10
AU2001258341B2 AU2001258341B2 (en) 2007-03-15

Family

ID=26005365

Family Applications (3)

Application Number Title Priority Date Filing Date
AU5834101A Pending AU5834101A (en) 2000-04-12 2001-04-12 8ss-hydrocarbyl-substituted estratrienes for use as selective estrogens
AU2001273945A Abandoned AU2001273945A1 (en) 2000-04-12 2001-04-12 8beta-substituted-11beta-pentyl- and 11beta-hexyl-estra-1,3,5(10)-triene derivatives
AU2001258341A Ceased AU2001258341B2 (en) 2000-04-12 2001-04-12 8beta-hydrocarbyl-substituted estratrienes for use as selective estrogens

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AU5834101A Pending AU5834101A (en) 2000-04-12 2001-04-12 8ss-hydrocarbyl-substituted estratrienes for use as selective estrogens
AU2001273945A Abandoned AU2001273945A1 (en) 2000-04-12 2001-04-12 8beta-substituted-11beta-pentyl- and 11beta-hexyl-estra-1,3,5(10)-triene derivatives

Country Status (26)

Country Link
US (3) US20040029847A1 (en)
EP (2) EP1272504B1 (en)
JP (2) JP3828423B2 (en)
CN (1) CN100453549C (en)
AT (2) ATE302790T1 (en)
AU (3) AU5834101A (en)
BG (1) BG107173A (en)
BR (1) BR0109983A (en)
CA (1) CA2406177C (en)
CZ (1) CZ20023382A3 (en)
DE (1) DE50112561D1 (en)
DK (2) DK1272504T3 (en)
EA (1) EA006299B1 (en)
EE (1) EE200200589A (en)
ES (2) ES2287127T3 (en)
HK (1) HK1057219A1 (en)
HR (1) HRP20020892B1 (en)
HU (1) HUP0300335A2 (en)
IL (2) IL152248A0 (en)
MX (1) MXPA02010066A (en)
NO (2) NO325337B1 (en)
NZ (1) NZ543724A (en)
PL (1) PL207488B1 (en)
PT (1) PT1272504E (en)
SK (1) SK14632002A3 (en)
WO (2) WO2001077138A1 (en)

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DE10027887A1 (en) 2000-05-31 2001-12-13 Jenapharm Gmbh Compounds with a sulfonamide group and pharmaceutical compositions containing these compounds
DE10039199A1 (en) * 2000-08-10 2002-02-21 Schering Ag Combination preparations from an ERß selective estrogen and a SERM or antiestrogen
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DE10151363A1 (en) * 2001-10-17 2003-05-08 Schering Ag Use of estrogen receptor beta agonists to prepare medicaments for producing somatotropic and organotropic effects on the CNS, circulatory, skeletal and immune system in aging men and women
DE10226326A1 (en) * 2002-06-11 2004-01-15 Schering Ag 9-alpha-substituted estratrienes as selective estrogens
ATE410170T1 (en) * 2003-03-27 2008-10-15 Pantarhei Bioscience Bv USE OF ESTROGENS TO TREAT MALE INFERTILITY
DE10318896A1 (en) * 2003-04-22 2004-11-25 Schering Ag 8beta-vinyl-11beta- (omega-substituted) alkyl-estra-1,3,5 (10) -trienes
JP2007512279A (en) * 2003-11-26 2007-05-17 シエーリング アクチエンゲゼルシャフト Selective estrogens 8β-vinyl-estradi-1,3,5 (10) -triene-3,17β-diol, and 17β-fluor-9α-vinyl-estradi-1,3,5 (10) -triene-3, Prevention and treatment of hypertensive heart disease with 16α-diol
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
DE102005057224A1 (en) * 2005-11-29 2007-05-31 Bayer Schering Pharma Ag New 9-alpha substituted estratriene derivatives esterified with a sulfamoylphenyl-substituted acid residue, are prodrugs useful as carboanhydrase inhibitors for treating estrogen deficiency disorders
DE102005057225A1 (en) * 2005-11-29 2007-05-31 Bayer Schering Pharma Ag New 8-beta-substituted estratriene derivatives esterified with a sulfamoylphenyl-substituted acid residue, are prodrugs useful as carboanhydrase inhibitors for treating estrogen deficiency disorders
EP2014672A1 (en) * 2007-07-12 2009-01-14 Bayer Schering Pharma Aktiengesellschaft 8-beta-substituted estratrienes as selectively active estrogens
CN102006857B (en) * 2008-02-13 2013-06-26 拜耳先灵医药股份有限公司 Drug delivery system with stabilising effect
BRPI0908477A2 (en) * 2008-02-13 2018-03-27 Bayer Schering Pharma Ag estradiol-containing drug delivery system
EP2143432A1 (en) * 2008-07-11 2010-01-13 Bayer Schering Pharma AG 9-alpha estratriene derivatives as ER-beta selective ligands for the prevention and treatment of intestinal cancer
JP2012509286A (en) * 2008-11-21 2012-04-19 バイエル ファーマ アクチエンゲゼルシャフト Drug delivery system
PT2782584T (en) 2011-11-23 2021-09-02 Therapeuticsmd Inc Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR20180126582A (en) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

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JPS454059Y1 (en) * 1967-11-04 1970-02-25
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US3501530A (en) * 1968-02-27 1970-03-17 American Cyanamid Co Substituted naphthalenones,naphthalenediones and d-homo - beta - nor estra-1,3,5(10),9(11)-tetraenes
US3806546A (en) * 1969-06-18 1974-04-23 American Cyanamid Co Steroid-like compounds and method of synthesis
US3681407A (en) * 1969-06-18 1972-08-01 American Cyanamid Co 3-methoxy 8{62 -methylestra 1,3,5(10),9(11)-tetraene-17{62 -carboxylic acid lower alkyl ester and intermediates in the preparation thereof
US3709878A (en) * 1970-07-20 1973-01-09 Sandoz Ag 8 alpha-methyl-substituted-steroids
US3736345A (en) * 1971-05-18 1973-05-29 American Cyanamid Co Steroid-like compounds and method of synthesis
US4961931A (en) * 1982-07-29 1990-10-09 Alza Corporation Method for the management of hyperplasia
DE4018828C2 (en) * 1989-06-08 1999-05-12 Schering Ag Process for the preparation of C7-alpha-substituted 8alpha- and 8ß-Estra-1,3,5 (10) -trienes and C8-alpha-substituted Estra-1,3,5 (10) -trienes as well as new intermediates for this process
HU230492B1 (en) * 1996-05-01 2016-08-29 The Government Of The United States Of America Novel 21-substituted progesterone derivatives as antiprogestational agents medicoments containing the same, use thereof
DE69902684T2 (en) * 1998-11-20 2003-04-24 Akzo Nobel N.V., Arnheim/Arnhem ESTROGENIC ESTRA-1,3,5 (10) -TRIEN COMPOUNDS WITH VARIOUS EFFECTS ON ESTROGEN RECEPTOR ALPHA AND BETA WITH AN UNLINED HYDROCARBON CHAIN OF 5-9 CARBON ATOMS IN POSITION 11
DK1272504T3 (en) * 2000-04-12 2007-10-01 Bayer Schering Pharma Ag 8. Beta-hydrocarbyl-substituted estradiol for use as selective estrogens
DE10019167A1 (en) * 2000-04-12 2001-10-18 Schering Ag New 8 beta-substituted 11 beta-(pentyl or hexyl)-estra-1,3,5(10)-triene derivatives, are ovary-selective estrogen receptor ligands useful e.g. as female or male contraceptives or for treating ovarian carcinoma
DE10318896A1 (en) * 2003-04-22 2004-11-25 Schering Ag 8beta-vinyl-11beta- (omega-substituted) alkyl-estra-1,3,5 (10) -trienes

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