AU2001258341A1 - 8beta-hydrocarbyl-substituted estratrienes for use as selective estrogens - Google Patents
8beta-hydrocarbyl-substituted estratrienes for use as selective estrogensInfo
- Publication number
- AU2001258341A1 AU2001258341A1 AU2001258341A AU2001258341A AU2001258341A1 AU 2001258341 A1 AU2001258341 A1 AU 2001258341A1 AU 2001258341 A AU2001258341 A AU 2001258341A AU 2001258341 A AU2001258341 A AU 2001258341A AU 2001258341 A1 AU2001258341 A1 AU 2001258341A1
- Authority
- AU
- Australia
- Prior art keywords
- 8beta
- hydrocarbyl
- selective estrogens
- substituted estratrienes
- estratrienes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940011871 Estrogens Drugs 0.000 title 1
- 229940030484 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM ESTROGENS Drugs 0.000 title 1
- 229940046080 endocrine therapy drugs Estrogens Drugs 0.000 title 1
- 150000002164 estratrienes Chemical class 0.000 title 1
- 239000000262 estrogen Substances 0.000 title 1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10019167A DE10019167A1 (en) | 2000-04-12 | 2000-04-12 | New 8 beta-substituted 11 beta-(pentyl or hexyl)-estra-1,3,5(10)-triene derivatives, are ovary-selective estrogen receptor ligands useful e.g. as female or male contraceptives or for treating ovarian carcinoma |
DE10019167.3 | 2000-04-12 | ||
US20737000P | 2000-05-26 | 2000-05-26 | |
US60/207,370 | 2000-05-26 | ||
PCT/EP2001/004290 WO2001077139A1 (en) | 2000-04-12 | 2001-04-12 | 8ss-HYDROCARBYL-SUBSTITUTED ESTRATRIENES FOR USE AS SELECTIVE ESTROGENS |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2001258341A1 true AU2001258341A1 (en) | 2002-01-10 |
AU2001258341B2 AU2001258341B2 (en) | 2007-03-15 |
Family
ID=26005365
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU5834101A Pending AU5834101A (en) | 2000-04-12 | 2001-04-12 | 8ss-hydrocarbyl-substituted estratrienes for use as selective estrogens |
AU2001273945A Abandoned AU2001273945A1 (en) | 2000-04-12 | 2001-04-12 | 8beta-substituted-11beta-pentyl- and 11beta-hexyl-estra-1,3,5(10)-triene derivatives |
AU2001258341A Ceased AU2001258341B2 (en) | 2000-04-12 | 2001-04-12 | 8beta-hydrocarbyl-substituted estratrienes for use as selective estrogens |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU5834101A Pending AU5834101A (en) | 2000-04-12 | 2001-04-12 | 8ss-hydrocarbyl-substituted estratrienes for use as selective estrogens |
AU2001273945A Abandoned AU2001273945A1 (en) | 2000-04-12 | 2001-04-12 | 8beta-substituted-11beta-pentyl- and 11beta-hexyl-estra-1,3,5(10)-triene derivatives |
Country Status (26)
Country | Link |
---|---|
US (3) | US20040029847A1 (en) |
EP (2) | EP1272504B1 (en) |
JP (2) | JP3828423B2 (en) |
CN (1) | CN100453549C (en) |
AT (2) | ATE302790T1 (en) |
AU (3) | AU5834101A (en) |
BG (1) | BG107173A (en) |
BR (1) | BR0109983A (en) |
CA (1) | CA2406177C (en) |
CZ (1) | CZ20023382A3 (en) |
DE (1) | DE50112561D1 (en) |
DK (2) | DK1272504T3 (en) |
EA (1) | EA006299B1 (en) |
EE (1) | EE200200589A (en) |
ES (2) | ES2287127T3 (en) |
HK (1) | HK1057219A1 (en) |
HR (1) | HRP20020892B1 (en) |
HU (1) | HUP0300335A2 (en) |
IL (2) | IL152248A0 (en) |
MX (1) | MXPA02010066A (en) |
NO (2) | NO325337B1 (en) |
NZ (1) | NZ543724A (en) |
PL (1) | PL207488B1 (en) |
PT (1) | PT1272504E (en) |
SK (1) | SK14632002A3 (en) |
WO (2) | WO2001077138A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1272504T3 (en) * | 2000-04-12 | 2007-10-01 | Bayer Schering Pharma Ag | 8. Beta-hydrocarbyl-substituted estradiol for use as selective estrogens |
DE10027887A1 (en) | 2000-05-31 | 2001-12-13 | Jenapharm Gmbh | Compounds with a sulfonamide group and pharmaceutical compositions containing these compounds |
DE10039199A1 (en) * | 2000-08-10 | 2002-02-21 | Schering Ag | Combination preparations from an ERß selective estrogen and a SERM or antiestrogen |
GB0020498D0 (en) * | 2000-08-18 | 2000-10-11 | Sterix Ltd | Compound |
DE10151363A1 (en) * | 2001-10-17 | 2003-05-08 | Schering Ag | Use of estrogen receptor beta agonists to prepare medicaments for producing somatotropic and organotropic effects on the CNS, circulatory, skeletal and immune system in aging men and women |
DE10226326A1 (en) * | 2002-06-11 | 2004-01-15 | Schering Ag | 9-alpha-substituted estratrienes as selective estrogens |
ATE410170T1 (en) * | 2003-03-27 | 2008-10-15 | Pantarhei Bioscience Bv | USE OF ESTROGENS TO TREAT MALE INFERTILITY |
DE10318896A1 (en) * | 2003-04-22 | 2004-11-25 | Schering Ag | 8beta-vinyl-11beta- (omega-substituted) alkyl-estra-1,3,5 (10) -trienes |
JP2007512279A (en) * | 2003-11-26 | 2007-05-17 | シエーリング アクチエンゲゼルシャフト | Selective estrogens 8β-vinyl-estradi-1,3,5 (10) -triene-3,17β-diol, and 17β-fluor-9α-vinyl-estradi-1,3,5 (10) -triene-3, Prevention and treatment of hypertensive heart disease with 16α-diol |
US7534780B2 (en) | 2004-05-21 | 2009-05-19 | Bayer Schering Pharma Aktiengesellschaft | Estradiol prodrugs |
DE102005057224A1 (en) * | 2005-11-29 | 2007-05-31 | Bayer Schering Pharma Ag | New 9-alpha substituted estratriene derivatives esterified with a sulfamoylphenyl-substituted acid residue, are prodrugs useful as carboanhydrase inhibitors for treating estrogen deficiency disorders |
DE102005057225A1 (en) * | 2005-11-29 | 2007-05-31 | Bayer Schering Pharma Ag | New 8-beta-substituted estratriene derivatives esterified with a sulfamoylphenyl-substituted acid residue, are prodrugs useful as carboanhydrase inhibitors for treating estrogen deficiency disorders |
EP2014672A1 (en) * | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma Aktiengesellschaft | 8-beta-substituted estratrienes as selectively active estrogens |
CN102006857B (en) * | 2008-02-13 | 2013-06-26 | 拜耳先灵医药股份有限公司 | Drug delivery system with stabilising effect |
BRPI0908477A2 (en) * | 2008-02-13 | 2018-03-27 | Bayer Schering Pharma Ag | estradiol-containing drug delivery system |
EP2143432A1 (en) * | 2008-07-11 | 2010-01-13 | Bayer Schering Pharma AG | 9-alpha estratriene derivatives as ER-beta selective ligands for the prevention and treatment of intestinal cancer |
JP2012509286A (en) * | 2008-11-21 | 2012-04-19 | バイエル ファーマ アクチエンゲゼルシャフト | Drug delivery system |
PT2782584T (en) | 2011-11-23 | 2021-09-02 | Therapeuticsmd Inc | Natural combination hormone replacement formulations and therapies |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
KR20180126582A (en) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | Steroid hormone pharmaceutical composition |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2743E (en) * | 1902-01-11 | 1904-12-15 | Adolphe Ernest Pointe | Bread making increasing yield and digestibility |
JPS454059Y1 (en) * | 1967-11-04 | 1970-02-25 | ||
JPS454060Y1 (en) * | 1967-12-11 | 1970-02-25 | ||
US3501530A (en) * | 1968-02-27 | 1970-03-17 | American Cyanamid Co | Substituted naphthalenones,naphthalenediones and d-homo - beta - nor estra-1,3,5(10),9(11)-tetraenes |
US3806546A (en) * | 1969-06-18 | 1974-04-23 | American Cyanamid Co | Steroid-like compounds and method of synthesis |
US3681407A (en) * | 1969-06-18 | 1972-08-01 | American Cyanamid Co | 3-methoxy 8{62 -methylestra 1,3,5(10),9(11)-tetraene-17{62 -carboxylic acid lower alkyl ester and intermediates in the preparation thereof |
US3709878A (en) * | 1970-07-20 | 1973-01-09 | Sandoz Ag | 8 alpha-methyl-substituted-steroids |
US3736345A (en) * | 1971-05-18 | 1973-05-29 | American Cyanamid Co | Steroid-like compounds and method of synthesis |
US4961931A (en) * | 1982-07-29 | 1990-10-09 | Alza Corporation | Method for the management of hyperplasia |
DE4018828C2 (en) * | 1989-06-08 | 1999-05-12 | Schering Ag | Process for the preparation of C7-alpha-substituted 8alpha- and 8ß-Estra-1,3,5 (10) -trienes and C8-alpha-substituted Estra-1,3,5 (10) -trienes as well as new intermediates for this process |
HU230492B1 (en) * | 1996-05-01 | 2016-08-29 | The Government Of The United States Of America | Novel 21-substituted progesterone derivatives as antiprogestational agents medicoments containing the same, use thereof |
DE69902684T2 (en) * | 1998-11-20 | 2003-04-24 | Akzo Nobel N.V., Arnheim/Arnhem | ESTROGENIC ESTRA-1,3,5 (10) -TRIEN COMPOUNDS WITH VARIOUS EFFECTS ON ESTROGEN RECEPTOR ALPHA AND BETA WITH AN UNLINED HYDROCARBON CHAIN OF 5-9 CARBON ATOMS IN POSITION 11 |
DK1272504T3 (en) * | 2000-04-12 | 2007-10-01 | Bayer Schering Pharma Ag | 8. Beta-hydrocarbyl-substituted estradiol for use as selective estrogens |
DE10019167A1 (en) * | 2000-04-12 | 2001-10-18 | Schering Ag | New 8 beta-substituted 11 beta-(pentyl or hexyl)-estra-1,3,5(10)-triene derivatives, are ovary-selective estrogen receptor ligands useful e.g. as female or male contraceptives or for treating ovarian carcinoma |
DE10318896A1 (en) * | 2003-04-22 | 2004-11-25 | Schering Ag | 8beta-vinyl-11beta- (omega-substituted) alkyl-estra-1,3,5 (10) -trienes |
-
2001
- 2001-04-12 DK DK01931609T patent/DK1272504T3/en active
- 2001-04-12 EP EP01931609A patent/EP1272504B1/en not_active Expired - Lifetime
- 2001-04-12 BR BR0109983-3A patent/BR0109983A/en not_active IP Right Cessation
- 2001-04-12 US US10/257,287 patent/US20040029847A1/en not_active Abandoned
- 2001-04-12 AU AU5834101A patent/AU5834101A/en active Pending
- 2001-04-12 AT AT01940331T patent/ATE302790T1/en not_active IP Right Cessation
- 2001-04-12 PL PL358667A patent/PL207488B1/en not_active IP Right Cessation
- 2001-04-12 AT AT01931609T patent/ATE363487T1/en active
- 2001-04-12 HU HU0300335A patent/HUP0300335A2/en unknown
- 2001-04-12 NZ NZ543724A patent/NZ543724A/en unknown
- 2001-04-12 CN CNB018107745A patent/CN100453549C/en not_active Expired - Fee Related
- 2001-04-12 MX MXPA02010066A patent/MXPA02010066A/en active IP Right Grant
- 2001-04-12 JP JP2001575608A patent/JP3828423B2/en not_active Expired - Lifetime
- 2001-04-12 WO PCT/EP2001/004289 patent/WO2001077138A1/en active IP Right Grant
- 2001-04-12 EA EA200201052A patent/EA006299B1/en not_active IP Right Cessation
- 2001-04-12 ES ES01931609T patent/ES2287127T3/en not_active Expired - Lifetime
- 2001-04-12 AU AU2001273945A patent/AU2001273945A1/en not_active Abandoned
- 2001-04-12 WO PCT/EP2001/004290 patent/WO2001077139A1/en active IP Right Grant
- 2001-04-12 ES ES01940331T patent/ES2245694T3/en not_active Expired - Lifetime
- 2001-04-12 IL IL15224801A patent/IL152248A0/en active IP Right Grant
- 2001-04-12 DE DE50112561T patent/DE50112561D1/en not_active Expired - Lifetime
- 2001-04-12 US US10/257,288 patent/US7378404B2/en not_active Expired - Fee Related
- 2001-04-12 SK SK1463-2002A patent/SK14632002A3/en unknown
- 2001-04-12 CZ CZ20023382A patent/CZ20023382A3/en unknown
- 2001-04-12 EE EEP200200589A patent/EE200200589A/en unknown
- 2001-04-12 EP EP01940331A patent/EP1272505B1/en not_active Expired - Lifetime
- 2001-04-12 PT PT01931609T patent/PT1272504E/en unknown
- 2001-04-12 AU AU2001258341A patent/AU2001258341B2/en not_active Ceased
- 2001-04-12 DK DK01940331T patent/DK1272505T3/en active
- 2001-04-12 CA CA2406177A patent/CA2406177C/en not_active Expired - Fee Related
-
2002
- 2002-10-08 BG BG107173A patent/BG107173A/en unknown
- 2002-10-10 IL IL152248A patent/IL152248A/en not_active IP Right Cessation
- 2002-10-11 NO NO20024908A patent/NO325337B1/en unknown
- 2002-10-11 NO NO20024907A patent/NO20024907L/en not_active Application Discontinuation
- 2002-11-11 HR HR20020892A patent/HRP20020892B1/en not_active IP Right Cessation
-
2004
- 2004-01-09 HK HK04100140.5A patent/HK1057219A1/en not_active IP Right Cessation
-
2008
- 2008-03-11 US US12/045,979 patent/US20080182829A1/en not_active Abandoned
- 2008-06-25 JP JP2008166585A patent/JP2008280355A/en active Pending
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