AU2001257464A1 - Reductive alkylation process on glycopeptides - Google Patents

Reductive alkylation process on glycopeptides

Info

Publication number
AU2001257464A1
AU2001257464A1 AU2001257464A AU5746401A AU2001257464A1 AU 2001257464 A1 AU2001257464 A1 AU 2001257464A1 AU 2001257464 A AU2001257464 A AU 2001257464A AU 5746401 A AU5746401 A AU 5746401A AU 2001257464 A1 AU2001257464 A1 AU 2001257464A1
Authority
AU
Australia
Prior art keywords
reductive alkylation
glycopeptides
alkylation process
saccharide
amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001257464A
Inventor
Martin S. Linsell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innoviva Inc
Original Assignee
Advanced Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc filed Critical Advanced Medicine Inc
Publication of AU2001257464A1 publication Critical patent/AU2001257464A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention provides a novel reductive alkylation method useful for selectively alkylating saccharide-amines of glycopeptide antibiotics.
AU2001257464A 2000-05-02 2001-05-01 Reductive alkylation process on glycopeptides Abandoned AU2001257464A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20117800P 2000-05-02 2000-05-02
US60/201,178 2000-05-02
US21314800P 2000-06-22 2000-06-22
US60/213,148 2000-06-22
PCT/US2001/014017 WO2001083521A2 (en) 2000-05-02 2001-05-01 Reductive alkylation process on glycopeptides

Publications (1)

Publication Number Publication Date
AU2001257464A1 true AU2001257464A1 (en) 2001-11-12

Family

ID=26896472

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001257464A Abandoned AU2001257464A1 (en) 2000-05-02 2001-05-01 Reductive alkylation process on glycopeptides

Country Status (13)

Country Link
US (1) US6831150B2 (en)
EP (1) EP1276759B1 (en)
JP (2) JP4713810B2 (en)
KR (1) KR100856479B1 (en)
CN (1) CN100532392C (en)
AT (1) ATE402951T1 (en)
AU (1) AU2001257464A1 (en)
CA (1) CA2407994C (en)
DE (1) DE60135102D1 (en)
ES (1) ES2311014T3 (en)
NO (1) NO330134B1 (en)
SI (1) SI1276759T1 (en)
WO (1) WO2001083521A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
EP2753638A1 (en) 2011-09-09 2014-07-16 Sandoz AG Process for the synthesis of telavancin and its pharmaceutically acceptable salts as well as n-protected derivatives thereof
EP2753637A1 (en) 2011-09-09 2014-07-16 Sandoz AG Process for the synthesis of telavancin, its pharmaceutically acceptable salts as well as an n-protected imine-derivative of telavancin
CN103897040B (en) * 2012-12-27 2018-05-22 浙江医药股份有限公司新昌制药厂 Novel glycopeptide class compound or pharmaceutically acceptable salt thereof and preparation method thereof and pharmaceutical composition and purposes
CN106188243B (en) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 Preparation method of oritavancin
WO2017194385A1 (en) * 2016-05-09 2017-11-16 Xellia Pharmaceuticals Aps Stabilized glycopeptide antibiotic formulations
CN108409837B (en) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 Glycopeptide compound with anti-drug resistance bacterial activity, preparation method and application thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78597A0 (en) 1985-04-25 1986-08-31 Lilly Co Eli Novel glycopeptide derivatives
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4644533A (en) * 1985-05-06 1987-02-17 American Telephone & Telegraph Company Packet switch trunk circuit queueing arrangement
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
IL96603A (en) * 1989-12-13 1998-02-08 Lilly Co Eli Antibacterial glycopeptide derivatives, process for their preparation and pharmaceutical compositions containing them
US5750509A (en) * 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
PE40996A1 (en) * 1994-01-28 1996-10-14 Lilly Co Eli ANTIBIOTIC DERIVATIVE OF GLUCOPEPTIDE
US5919756A (en) 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
ID18900A (en) * 1996-11-21 1998-05-20 Lilly Co Eli ALLOCATION DOWN FROM ANTI-BIOTIC PEPTIDES
US5939382A (en) 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5916873A (en) 1997-04-17 1999-06-29 Eli Lilly And Company Teicoplanin derivatives
EP1060189A1 (en) 1998-02-20 2000-12-20 Advanced Medicine, Inc. Derivatives of glycopeptide antibacterial agents
HU230190B1 (en) 1998-12-23 2015-09-28 Theravance, Inc Glycopeptide derivatives and pharmaceutical compositions containing the same
WO2000059528A1 (en) 1999-04-02 2000-10-12 The Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same
AU2001259303A1 (en) * 2000-06-22 2002-01-02 Advanced Medicine, Inc. Glycopeptide carboxy-saccharide derivatives

Also Published As

Publication number Publication date
US20020010131A1 (en) 2002-01-24
CA2407994C (en) 2010-02-02
WO2001083521A2 (en) 2001-11-08
NO330134B1 (en) 2011-02-21
NO20025264D0 (en) 2002-11-01
KR100856479B1 (en) 2008-09-04
CN100532392C (en) 2009-08-26
JP2003531917A (en) 2003-10-28
EP1276759B1 (en) 2008-07-30
KR20020093110A (en) 2002-12-12
NO20025264L (en) 2002-12-18
CN1432023A (en) 2003-07-23
WO2001083521A3 (en) 2002-09-19
SI1276759T1 (en) 2008-12-31
JP4713810B2 (en) 2011-06-29
ATE402951T1 (en) 2008-08-15
ES2311014T3 (en) 2009-02-01
US6831150B2 (en) 2004-12-14
CA2407994A1 (en) 2001-11-08
JP2008222718A (en) 2008-09-25
EP1276759A2 (en) 2003-01-22
DE60135102D1 (en) 2008-09-11

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