AU2001252378A1 - Medical implant materials - Google Patents

Medical implant materials

Info

Publication number
AU2001252378A1
AU2001252378A1 AU2001252378A AU5237801A AU2001252378A1 AU 2001252378 A1 AU2001252378 A1 AU 2001252378A1 AU 2001252378 A AU2001252378 A AU 2001252378A AU 5237801 A AU5237801 A AU 5237801A AU 2001252378 A1 AU2001252378 A1 AU 2001252378A1
Authority
AU
Australia
Prior art keywords
transglutaminase
medical implant
polymer
implant material
mammalian
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001252378A
Inventor
Paul Christian
Martin Griffin
Deborah Heath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nottingham Trent University
Original Assignee
Nottingham Trent University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nottingham Trent University filed Critical Nottingham Trent University
Publication of AU2001252378A1 publication Critical patent/AU2001252378A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)

Abstract

The present invention provides a medical implant material comprising mammalian transglutaminase and a polymer, wherein the transglutaminase is provided in the absence of free divalent metal ions and wherein the polymer is associated with the transglutaminase binding protein. Preferably, the transglutaminase is a tissue transglutaminase, which is coated on, impregnated into or covalently linked to the polymer. The polymer may be naturally occuring or synthetic, and may be biodegradable or non-biodegradable. The medical implant material may further comprise a reinforcing agent and/or one or more additional polymers. The invention further provides the use of a mammalian transglutaminase in a method for improving the biocompatibility of a medical implant material, the method comprising the steps of (i) providing a medical implant material comprising a polymer associated with a binding protein for binding the transglutaminase, and (ii) treating said material with a mammalian transglutaminase.
AU2001252378A 2000-05-12 2001-05-02 Medical implant materials Abandoned AU2001252378A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0011356.3A GB0011356D0 (en) 2000-05-12 2000-05-12 Medical implant materials
GB0011356 2000-05-12
PCT/GB2001/001910 WO2001085224A1 (en) 2000-05-12 2001-05-02 Medical implant materials

Publications (1)

Publication Number Publication Date
AU2001252378A1 true AU2001252378A1 (en) 2001-11-20

Family

ID=9891382

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001252378A Abandoned AU2001252378A1 (en) 2000-05-12 2001-05-02 Medical implant materials

Country Status (7)

Country Link
US (1) US7718168B2 (en)
EP (1) EP1280563B1 (en)
AT (1) ATE347914T1 (en)
AU (1) AU2001252378A1 (en)
DE (1) DE60125164T2 (en)
GB (1) GB0011356D0 (en)
WO (1) WO2001085224A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060024346A1 (en) * 2004-07-29 2006-02-02 Brody Richard S Stabilization of biologically active proteins with mixtures of polysaccharides and amino acid based compounds
EP1551978A4 (en) * 2002-09-13 2006-02-01 Univ California Nell-1 enhanced bone mineralization
GB0304993D0 (en) * 2003-03-05 2003-04-09 Univ Nottingham Trent Novel screening method
DE102004016065B3 (en) * 2004-03-30 2005-06-09 Zlb Behring Gmbh Bone substitute material comprises a porous material impregnated with a solution containing factor XIII
CA2566897A1 (en) * 2004-05-21 2005-12-01 Mds Inc. Doing Business Through Its Mds Pharma Services Division Method of quantifying the cell-binding properties of a medical device
GB0420091D0 (en) * 2004-09-10 2004-10-13 Univ Nottingham Trent Medical implant materials
ITPD20040312A1 (en) * 2004-12-15 2005-03-15 Fidia Advanced Biopolymers Srl PROSTHESIS AND SUPPORT FOR REPLACEMENT, REPAIR, REGENERATION OF THE MENISCUS
EP1887967A2 (en) * 2005-04-25 2008-02-20 Eric F. Bernstein Dermal fillers for biomedical applications in mammals and methods of using the same
US10300167B2 (en) * 2006-03-24 2019-05-28 Cabertech, Inc. Functionalized calcium phosphate artificial bone and joint compositions and methods of use and manufacture
EP3009477B1 (en) 2006-07-20 2024-01-24 Orbusneich Medical Pte. Ltd Bioabsorbable polymeric composition for a medical device
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
CN101631513B (en) 2006-10-20 2013-06-05 奥巴斯尼茨医学公司 Bioabsorbable polymeric composition and medical device
WO2008089257A2 (en) * 2007-01-16 2008-07-24 Cappella, Inc. Drug eluting medical device using polymeric therapeutics with transglutaminase substrates
GB2490655A (en) 2011-04-28 2012-11-14 Univ Aston Modulators of tissue transglutaminase
GB2513599A (en) * 2013-04-30 2014-11-05 King S College London Bone Growth Scaffold
WO2017223462A1 (en) * 2016-06-24 2017-12-28 President And Fellows Of Harvard College Composition and method for adhering biomaterials to a target surface
EP3573674A1 (en) * 2017-01-30 2019-12-04 LifeCell Corporation Transglutaminase treated products
CN109847098B (en) * 2019-01-22 2020-10-09 江南大学 Composite biological scaffold material for repairing bone defect

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2619933B2 (en) 1988-09-21 1997-06-11 ニッピゼラチン工業株式会社 Method for producing high polymerization degree gelatin
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5549904A (en) 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
US5939385A (en) * 1993-08-13 1999-08-17 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
US5834232A (en) 1996-05-01 1998-11-10 Zymogenetics, Inc. Cross-linked gelatin gels and methods of making them
US6039901A (en) 1997-01-31 2000-03-21 Givaudan Roure Flavors Corporation Enzymatically protein encapsulating oil particles by complex coacervation
CA2307954C (en) 1997-04-03 2010-07-13 California Institute Of Technology Enzyme-medicated modification of fibrin for tissue engineering
US6190896B1 (en) * 1997-11-14 2001-02-20 Bassam M. Fraij Active human cellular transglutaminase
US6919076B1 (en) * 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules

Also Published As

Publication number Publication date
DE60125164D1 (en) 2007-01-25
EP1280563A1 (en) 2003-02-05
DE60125164T2 (en) 2007-09-27
EP1280563B1 (en) 2006-12-13
WO2001085224A1 (en) 2001-11-15
ATE347914T1 (en) 2007-01-15
US20040030408A1 (en) 2004-02-12
US7718168B2 (en) 2010-05-18
GB0011356D0 (en) 2000-06-28

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