WO1998025653A3 - Improved hydrogel for tissue engineering - Google Patents

Improved hydrogel for tissue engineering Download PDF

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Publication number
WO1998025653A3
WO1998025653A3 PCT/US1997/022859 US9722859W WO9825653A3 WO 1998025653 A3 WO1998025653 A3 WO 1998025653A3 US 9722859 W US9722859 W US 9722859W WO 9825653 A3 WO9825653 A3 WO 9825653A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogel
mixture
multivalent
implanting
animal
Prior art date
Application number
PCT/US1997/022859
Other languages
French (fr)
Other versions
WO1998025653A2 (en
Inventor
Kermit M Borland
Tao Zhou
Gordon P Nelson
Anthony Atala
Original Assignee
Reprogenesis Inc
Kermit M Borland
Tao Zhou
Gordon P Nelson
Anthony Atala
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reprogenesis Inc, Kermit M Borland, Tao Zhou, Gordon P Nelson, Anthony Atala filed Critical Reprogenesis Inc
Priority to AU56986/98A priority Critical patent/AU742316B2/en
Priority to CA002274661A priority patent/CA2274661A1/en
Priority to EP97953182A priority patent/EP0944403A2/en
Priority to JP52699898A priority patent/JP4002299B2/en
Publication of WO1998025653A2 publication Critical patent/WO1998025653A2/en
Priority to JP2000512578A priority patent/JP2001517494A/en
Priority to AU94908/98A priority patent/AU743690B2/en
Priority to CA002304093A priority patent/CA2304093A1/en
Priority to EP98948313A priority patent/EP1015042A1/en
Priority to PCT/US1998/019417 priority patent/WO1999015211A1/en
Publication of WO1998025653A3 publication Critical patent/WO1998025653A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids

Abstract

This invention provides compositions for use in implanting into an animal comprising a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking. In a preferred mode, the polymer is cross-linked by multivalent ions; more preferably, a soluble salt of a multivalent ion and a sparingly soluble salt of a multivalent ion, these components being combined into a mixture which forms a partially hardened, injectable hydrogel, the consistency of the mixture being suitable for implanting the partially hardened hydrogel mixture into the animal, where the implanted, partially hardened hydrogel forms in situ a fully hardened hydrogel. Preferably, the mixture also contains a biocompatible sequestrant which competes with the biocompatible polymer for binding of the multivalent cross-linking ion. The composition may or may not contain living cells. The invention also provides methods for implanting the composition in an animal, optionally as an implant containing living cells.
PCT/US1997/022859 1996-12-10 1997-12-10 Improved hydrogel for tissue engineering WO1998025653A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU56986/98A AU742316B2 (en) 1996-12-10 1997-12-10 Improved hydrogel for tissue engineering
CA002274661A CA2274661A1 (en) 1996-12-10 1997-12-10 Improved hydrogel for tissue engineering
EP97953182A EP0944403A2 (en) 1996-12-10 1997-12-10 Improved hydrogel for tissue engineering
JP52699898A JP4002299B2 (en) 1996-12-10 1997-12-10 Improved hydrogel for tissue treatment
JP2000512578A JP2001517494A (en) 1997-09-19 1998-09-18 Improved hydrogels for tissue engineering
AU94908/98A AU743690B2 (en) 1997-09-19 1998-09-18 Improved hydrogel for tissue engineering
CA002304093A CA2304093A1 (en) 1997-09-19 1998-09-18 Improved hydrogel for tissue engineering
EP98948313A EP1015042A1 (en) 1997-09-19 1998-09-18 Improved hydrogel for tissue engineering
PCT/US1998/019417 WO1999015211A1 (en) 1997-09-19 1998-09-18 Improved hydrogel for tissue engineering

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US76273396A 1996-12-10 1996-12-10
US08/762,733 1996-12-10
US5108497P 1997-06-27 1997-06-27
US60/051,084 1997-06-27
US5955897P 1997-09-19 1997-09-19
US60/059,558 1997-09-19

Publications (2)

Publication Number Publication Date
WO1998025653A2 WO1998025653A2 (en) 1998-06-18
WO1998025653A3 true WO1998025653A3 (en) 1998-10-15

Family

ID=27367902

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/022859 WO1998025653A2 (en) 1996-12-10 1997-12-10 Improved hydrogel for tissue engineering

Country Status (5)

Country Link
EP (1) EP0944403A2 (en)
JP (1) JP4002299B2 (en)
AU (1) AU742316B2 (en)
CA (1) CA2274661A1 (en)
WO (1) WO1998025653A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3118499A (en) 1998-04-03 1999-10-25 Beth Israel Deaconess Medical Center Soft tissue reconstructor and method of use
AU1626500A (en) * 1998-11-16 2000-06-05 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stemcells
US6761887B1 (en) * 1998-11-16 2004-07-13 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
IT1311576B1 (en) * 1999-10-25 2002-03-13 Ghimas Spa INVASIVE MEDICAL DEVICE, IN PARTICULAR FOR GUIDED TISSUE REGENERATION.
US20040106896A1 (en) * 2002-11-29 2004-06-03 The Regents Of The University Of California System and method for forming a non-ablative cardiac conduction block
JP2009513182A (en) * 2005-07-21 2009-04-02 エフエムシー バイオポリマー エイエス Medical parts coated with a biocompatible coating that dissolves rapidly
KR101440170B1 (en) 2007-02-21 2014-09-12 모찌다 세이야쿠 가부시끼가이샤 Composition for treatment of cartilage disease
JP5161482B2 (en) * 2007-05-09 2013-03-13 オリンパス株式会社 Manufacturing method of biological tissue filling material
IL187707A0 (en) * 2007-11-27 2008-11-03 Univ Ben Gurion Alginate scaffold in hepatectomy
US8367637B2 (en) 2008-08-19 2013-02-05 Mochida Pharmaceutical Co., Ltd. Composition for treating arthritic disorder
US9308070B2 (en) 2008-12-15 2016-04-12 Allergan, Inc. Pliable silk medical device
US20110008437A1 (en) * 2009-04-20 2011-01-13 Altman Gregory H Silk Fibroin Hydrogels and Uses Thereof
WO2017044896A1 (en) * 2015-09-09 2017-03-16 Dsm Ip Assets B.V. Biomedical adhesive and sealant compositions and methods of use
CN113662909A (en) * 2016-04-01 2021-11-19 波士顿科学国际有限公司 Injectable compositions and methods of making and using the same
CN112969479A (en) * 2018-11-06 2021-06-15 国立癌症中心 Alginic acid based injectable gel system
CN114269396A (en) * 2019-08-27 2022-04-01 克朗医疗有限公司 Alginate-based particles as temporary embolization agents

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4103876A1 (en) * 1990-02-09 1991-08-14 Asahi Optical Co Ltd Fixing granular bone prosthesis material - with aq. soln. of gelation agent gelling in presence of calcium ions and aq. soln. of calcium cpd.
EP0459733A2 (en) * 1990-05-29 1991-12-04 Pronova Biopolymer As Alginate gels
WO1994025080A1 (en) * 1993-04-30 1994-11-10 Massachusetts Institute Of Technology Injectable polysaccharide-cell compositions
EP0727232A2 (en) * 1995-02-14 1996-08-21 Mentor Corporation Filling material for soft tissue implant prostheses and implants made therewith
WO1996040304A1 (en) * 1995-06-07 1996-12-19 Reprogenesis, Inc. Injectable hydrogel compositions
WO1997017038A1 (en) * 1995-11-09 1997-05-15 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
JPS63177791A (en) 1987-01-16 1988-07-21 Kibun Kk Production of immobilized enzyme or immobilized microorganism

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4103876A1 (en) * 1990-02-09 1991-08-14 Asahi Optical Co Ltd Fixing granular bone prosthesis material - with aq. soln. of gelation agent gelling in presence of calcium ions and aq. soln. of calcium cpd.
EP0459733A2 (en) * 1990-05-29 1991-12-04 Pronova Biopolymer As Alginate gels
WO1994025080A1 (en) * 1993-04-30 1994-11-10 Massachusetts Institute Of Technology Injectable polysaccharide-cell compositions
EP0727232A2 (en) * 1995-02-14 1996-08-21 Mentor Corporation Filling material for soft tissue implant prostheses and implants made therewith
WO1996040304A1 (en) * 1995-06-07 1996-12-19 Reprogenesis, Inc. Injectable hydrogel compositions
WO1997017038A1 (en) * 1995-11-09 1997-05-15 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions

Also Published As

Publication number Publication date
JP2001505809A (en) 2001-05-08
AU5698698A (en) 1998-07-03
CA2274661A1 (en) 1998-06-18
WO1998025653A2 (en) 1998-06-18
JP4002299B2 (en) 2007-10-31
AU742316B2 (en) 2001-12-20
EP0944403A2 (en) 1999-09-29

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