AU2001245358A1 - Production of antibodies in transgenic plastids - Google Patents
Production of antibodies in transgenic plastidsInfo
- Publication number
- AU2001245358A1 AU2001245358A1 AU2001245358A AU4535801A AU2001245358A1 AU 2001245358 A1 AU2001245358 A1 AU 2001245358A1 AU 2001245358 A AU2001245358 A AU 2001245358A AU 4535801 A AU4535801 A AU 4535801A AU 2001245358 A1 AU2001245358 A1 AU 2001245358A1
- Authority
- AU
- Australia
- Prior art keywords
- plastid
- chain
- plant
- immunoglobulin
- expression vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8214—Plastid transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/13—Immunoglobulins specific features characterized by their source of isolation or production isolated from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18566100P | 2000-02-29 | 2000-02-29 | |
US60185661 | 2000-02-29 | ||
PCT/US2001/006274 WO2001064929A1 (fr) | 2000-02-29 | 2001-02-28 | Production d'anticorps dans des plastes transgeniques |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001245358A1 true AU2001245358A1 (en) | 2001-09-12 |
Family
ID=22681926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001245358A Abandoned AU2001245358A1 (en) | 2000-02-29 | 2001-02-28 | Production of antibodies in transgenic plastids |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1268832A4 (fr) |
AU (1) | AU2001245358A1 (fr) |
CA (1) | CA2401965A1 (fr) |
WO (1) | WO2001064929A1 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2278523C (fr) | 1997-01-17 | 2013-06-18 | The Scripps Research Institute | Proteine de liaison a l'arn et site de liaison utile a l'expression de molecules de recombinaison |
US20100251425A9 (en) | 1998-05-15 | 2010-09-30 | University Of Central Florida | Expression of human interferon in transgenic chloroplasts |
EP1274846A4 (fr) * | 2000-03-01 | 2004-09-29 | Univ Auburn | VECTEUR DE TRANSFORMATION DE PLASTIDES POUR L'EXPRESSION DE PROTéINES HUMAINES DANS LES PLANTES |
US7951378B2 (en) | 2000-04-28 | 2011-05-31 | Planet Biotechnology Inc. | Immunoadhesin comprising a chimeric ICAM-1 molecule produced in a plant |
US20020168367A1 (en) * | 2000-04-28 | 2002-11-14 | Planet Biotechnology Incorporated | Novel immunoadhesins for treating and preventing viral and bacterial diseases |
CA2483337C (fr) * | 2002-04-23 | 2015-10-27 | The Scripps Research Institute | Expression de polypeptides dans des chloroplastes, et compositions et procedes permettant de les exprimer |
AU2008202053B2 (en) * | 2002-04-23 | 2012-11-01 | The Scripps Research Institute | Expression of polypeptides in chloroplasts, and compositions and methods for expressing same |
CA2491639A1 (fr) | 2002-07-03 | 2004-01-15 | University Of Central Florida | Expression de igf-1 humain dans des plastes transgeniques |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
PT2314629E (pt) | 2002-07-18 | 2014-01-22 | Merus B V | Produção recombinante de misturas de anticorpos |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
ES2408582T3 (es) | 2003-05-30 | 2013-06-21 | Merus B.V. | Biblioteca de Fab para la preparación de una mezcla de anticuerpos |
JP5912211B2 (ja) | 2004-01-20 | 2016-04-27 | メルス ビー.ヴィー. | 結合タンパク質の混合物 |
WO2006066340A1 (fr) * | 2004-12-21 | 2006-06-29 | Grain Biotech Australia Pty Ltd | Procede permettant l'expression elevee d'immunoglobuline dans des vegetaux |
WO2007053183A2 (fr) | 2005-05-27 | 2007-05-10 | University Of Central Florida | Chloroplastes genetiquement modifies pour exprimer des proteines pharmaceutiques |
US10752909B2 (en) | 2007-03-30 | 2020-08-25 | The Trustees Of The University Of Pennsylvania | Chloroplasts engineered to express pharmaceutical proteins in edible plants |
AU2008260555B2 (en) | 2007-06-01 | 2012-07-26 | Sapphire Energy, Inc. | High throughput screening of genetically modified photosynthetic organisms |
WO2009036087A1 (fr) | 2007-09-11 | 2009-03-19 | Sapphire Energy, Inc. | Procédés de fabrication de produits organiques avec des organismes photosynthétiques, produits obtenus et compositions pour l'obtention de ceux-ci |
US10689633B2 (en) | 2008-02-29 | 2020-06-23 | The Trustees Of The University Of Pennsylvania | Expression of β-mannanase in chloroplasts and its utilization in lignocellulosic woody biomass hydrolysis |
WO2011057243A2 (fr) | 2009-11-09 | 2011-05-12 | University Of Central Florida Research Foundation, Inc. | Administration par voie orale d'agents de tolérance exprimés chez les plantes |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
PT2505654T (pt) | 2010-02-08 | 2016-11-18 | Regeneron Pharma | Rato de cadeia leve comum |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
WO2012122512A1 (fr) | 2011-03-10 | 2012-09-13 | Hco Antibody, Inc. | Production recombinante de mélanges d'anticorps monocaténaires |
WO2012122528A1 (fr) | 2011-03-10 | 2012-09-13 | Hco Antibody, Inc. | Molécules de type anticorps tricaténaires bispécifiques |
EP3865581A1 (fr) | 2011-08-05 | 2021-08-18 | Regeneron Pharmaceuticals, Inc. | Souris à chaîne légère universelle humanisée |
WO2013063049A1 (fr) | 2011-10-24 | 2013-05-02 | University Of Central Florida Research Foundation, Inc. | Sous-motif d'exendine 4 de la toxine cholérique b exprimé dans un plastide administré par voie orale pour le traitement du diabète de type 2 |
NZ772318A (en) | 2012-04-20 | 2023-06-30 | Merus Nv | Methods and means for the production of ig-like molecules |
EP3119194B1 (fr) | 2014-03-21 | 2021-04-28 | Regeneron Pharmaceuticals, Inc. | Animaux non humains qui produisent des protéines de liaison monodomaine |
US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
EP4114959A4 (fr) * | 2020-03-02 | 2024-04-03 | ExpressTec LLC | Rendement d'expression d'immunoglobuline a amélioré dans des eucaryotes |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451513A (en) * | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
US5877402A (en) * | 1990-05-01 | 1999-03-02 | Rutgers, The State University Of New Jersey | DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein |
US5576198A (en) * | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
US5925806A (en) * | 1995-06-06 | 1999-07-20 | Mcbride; Kevin E. | Controlled expression of transgenic constructs in plant plastids |
CA2278523C (fr) * | 1997-01-17 | 2013-06-18 | The Scripps Research Institute | Proteine de liaison a l'arn et site de liaison utile a l'expression de molecules de recombinaison |
CN1262661C (zh) * | 1997-08-07 | 2006-07-05 | 奥本大学 | 通用的叶绿体整合和表达载体、其转化植物及产物 |
AR020090A1 (es) * | 1998-06-15 | 2002-04-10 | John Innes Ct | Celula vegetal monocotiledonea o semilla de ella,planta o parte de una planta, metodo para hacer una celula vegetal monocotiledonea, metodo para hacer unaplanta, uso de una construccion de expresion para producir una celula de planta o semilla monocotiledonea, y uso de una construccion de expresion |
ATE360072T1 (de) * | 1998-07-10 | 2007-05-15 | Calgene Llc | Expression eukarotischer peptide in pflanzenplastiden |
CN1330718A (zh) * | 1998-10-07 | 2002-01-09 | 辛根塔参与股份公司 | 植物中的治疗活性蛋白质 |
-
2001
- 2001-02-28 WO PCT/US2001/006274 patent/WO2001064929A1/fr not_active Application Discontinuation
- 2001-02-28 EP EP01918262A patent/EP1268832A4/fr not_active Withdrawn
- 2001-02-28 AU AU2001245358A patent/AU2001245358A1/en not_active Abandoned
- 2001-02-28 CA CA002401965A patent/CA2401965A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2401965A1 (fr) | 2001-09-07 |
EP1268832A4 (fr) | 2003-04-02 |
EP1268832A1 (fr) | 2003-01-02 |
WO2001064929A1 (fr) | 2001-09-07 |
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