AU2001245358A1 - Production of antibodies in transgenic plastids - Google Patents

Production of antibodies in transgenic plastids

Info

Publication number
AU2001245358A1
AU2001245358A1 AU2001245358A AU4535801A AU2001245358A1 AU 2001245358 A1 AU2001245358 A1 AU 2001245358A1 AU 2001245358 A AU2001245358 A AU 2001245358A AU 4535801 A AU4535801 A AU 4535801A AU 2001245358 A1 AU2001245358 A1 AU 2001245358A1
Authority
AU
Australia
Prior art keywords
plastid
chain
plant
immunoglobulin
expression vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001245358A
Other languages
English (en)
Inventor
Henry Daniell
Keith Wycoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Auburn University
University of Central Florida
Original Assignee
Auburn University
University of Central Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auburn University, University of Central Florida filed Critical Auburn University
Publication of AU2001245358A1 publication Critical patent/AU2001245358A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214Plastid transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/13Immunoglobulins specific features characterized by their source of isolation or production isolated from plants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2001245358A 2000-02-29 2001-02-28 Production of antibodies in transgenic plastids Abandoned AU2001245358A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18566100P 2000-02-29 2000-02-29
US60185661 2000-02-29
PCT/US2001/006274 WO2001064929A1 (fr) 2000-02-29 2001-02-28 Production d'anticorps dans des plastes transgeniques

Publications (1)

Publication Number Publication Date
AU2001245358A1 true AU2001245358A1 (en) 2001-09-12

Family

ID=22681926

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001245358A Abandoned AU2001245358A1 (en) 2000-02-29 2001-02-28 Production of antibodies in transgenic plastids

Country Status (4)

Country Link
EP (1) EP1268832A4 (fr)
AU (1) AU2001245358A1 (fr)
CA (1) CA2401965A1 (fr)
WO (1) WO2001064929A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2278523C (fr) 1997-01-17 2013-06-18 The Scripps Research Institute Proteine de liaison a l'arn et site de liaison utile a l'expression de molecules de recombinaison
US20100251425A9 (en) 1998-05-15 2010-09-30 University Of Central Florida Expression of human interferon in transgenic chloroplasts
EP1274846A4 (fr) * 2000-03-01 2004-09-29 Univ Auburn VECTEUR DE TRANSFORMATION DE PLASTIDES POUR L'EXPRESSION DE PROTéINES HUMAINES DANS LES PLANTES
US7951378B2 (en) 2000-04-28 2011-05-31 Planet Biotechnology Inc. Immunoadhesin comprising a chimeric ICAM-1 molecule produced in a plant
US20020168367A1 (en) * 2000-04-28 2002-11-14 Planet Biotechnology Incorporated Novel immunoadhesins for treating and preventing viral and bacterial diseases
CA2483337C (fr) * 2002-04-23 2015-10-27 The Scripps Research Institute Expression de polypeptides dans des chloroplastes, et compositions et procedes permettant de les exprimer
AU2008202053B2 (en) * 2002-04-23 2012-11-01 The Scripps Research Institute Expression of polypeptides in chloroplasts, and compositions and methods for expressing same
CA2491639A1 (fr) 2002-07-03 2004-01-15 University Of Central Florida Expression de igf-1 humain dans des plastes transgeniques
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
PT2314629E (pt) 2002-07-18 2014-01-22 Merus B V Produção recombinante de misturas de anticorpos
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
ES2408582T3 (es) 2003-05-30 2013-06-21 Merus B.V. Biblioteca de Fab para la preparación de una mezcla de anticuerpos
JP5912211B2 (ja) 2004-01-20 2016-04-27 メルス ビー.ヴィー. 結合タンパク質の混合物
WO2006066340A1 (fr) * 2004-12-21 2006-06-29 Grain Biotech Australia Pty Ltd Procede permettant l'expression elevee d'immunoglobuline dans des vegetaux
WO2007053183A2 (fr) 2005-05-27 2007-05-10 University Of Central Florida Chloroplastes genetiquement modifies pour exprimer des proteines pharmaceutiques
US10752909B2 (en) 2007-03-30 2020-08-25 The Trustees Of The University Of Pennsylvania Chloroplasts engineered to express pharmaceutical proteins in edible plants
AU2008260555B2 (en) 2007-06-01 2012-07-26 Sapphire Energy, Inc. High throughput screening of genetically modified photosynthetic organisms
WO2009036087A1 (fr) 2007-09-11 2009-03-19 Sapphire Energy, Inc. Procédés de fabrication de produits organiques avec des organismes photosynthétiques, produits obtenus et compositions pour l'obtention de ceux-ci
US10689633B2 (en) 2008-02-29 2020-06-23 The Trustees Of The University Of Pennsylvania Expression of β-mannanase in chloroplasts and its utilization in lignocellulosic woody biomass hydrolysis
WO2011057243A2 (fr) 2009-11-09 2011-05-12 University Of Central Florida Research Foundation, Inc. Administration par voie orale d'agents de tolérance exprimés chez les plantes
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
PT2505654T (pt) 2010-02-08 2016-11-18 Regeneron Pharma Rato de cadeia leve comum
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
WO2012122512A1 (fr) 2011-03-10 2012-09-13 Hco Antibody, Inc. Production recombinante de mélanges d'anticorps monocaténaires
WO2012122528A1 (fr) 2011-03-10 2012-09-13 Hco Antibody, Inc. Molécules de type anticorps tricaténaires bispécifiques
EP3865581A1 (fr) 2011-08-05 2021-08-18 Regeneron Pharmaceuticals, Inc. Souris à chaîne légère universelle humanisée
WO2013063049A1 (fr) 2011-10-24 2013-05-02 University Of Central Florida Research Foundation, Inc. Sous-motif d'exendine 4 de la toxine cholérique b exprimé dans un plastide administré par voie orale pour le traitement du diabète de type 2
NZ772318A (en) 2012-04-20 2023-06-30 Merus Nv Methods and means for the production of ig-like molecules
EP3119194B1 (fr) 2014-03-21 2021-04-28 Regeneron Pharmaceuticals, Inc. Animaux non humains qui produisent des protéines de liaison monodomaine
US11111314B2 (en) 2015-03-19 2021-09-07 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
EP4114959A4 (fr) * 2020-03-02 2024-04-03 ExpressTec LLC Rendement d'expression d'immunoglobuline a amélioré dans des eucaryotes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451513A (en) * 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
US5877402A (en) * 1990-05-01 1999-03-02 Rutgers, The State University Of New Jersey DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein
US5576198A (en) * 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
US5925806A (en) * 1995-06-06 1999-07-20 Mcbride; Kevin E. Controlled expression of transgenic constructs in plant plastids
CA2278523C (fr) * 1997-01-17 2013-06-18 The Scripps Research Institute Proteine de liaison a l'arn et site de liaison utile a l'expression de molecules de recombinaison
CN1262661C (zh) * 1997-08-07 2006-07-05 奥本大学 通用的叶绿体整合和表达载体、其转化植物及产物
AR020090A1 (es) * 1998-06-15 2002-04-10 John Innes Ct Celula vegetal monocotiledonea o semilla de ella,planta o parte de una planta, metodo para hacer una celula vegetal monocotiledonea, metodo para hacer unaplanta, uso de una construccion de expresion para producir una celula de planta o semilla monocotiledonea, y uso de una construccion de expresion
ATE360072T1 (de) * 1998-07-10 2007-05-15 Calgene Llc Expression eukarotischer peptide in pflanzenplastiden
CN1330718A (zh) * 1998-10-07 2002-01-09 辛根塔参与股份公司 植物中的治疗活性蛋白质

Also Published As

Publication number Publication date
CA2401965A1 (fr) 2001-09-07
EP1268832A4 (fr) 2003-04-02
EP1268832A1 (fr) 2003-01-02
WO2001064929A1 (fr) 2001-09-07

Similar Documents

Publication Publication Date Title
US20060282920A1 (en) Production of antibodies in transgenic plastids
AU2001245358A1 (en) Production of antibodies in transgenic plastids
De Muynck et al. Production of antibodies in plants: status after twenty years
CA2208783C (fr) Procedes de production d'immunoglobulines contenant des proteines de protection dans les plantes et leur utilisation
Larrick et al. Production of secretory IgA antibodies in plants
AU731137B2 (en) Transgenic plants expressing assembled secretory antibodies
EP1799813B1 (fr) Systeme et procede de production d'anticorps dans la culture de cellules vegetales
Brar et al. Expression of a single-chain variable-fragment antibody against a Fusarium virguliforme toxin peptide enhances tolerance to sudden death syndrome in transgenic soybean plants
WO1996021012A9 (fr) Procedes de production d'immunoglobulines contenant des proteines de protection dans les plantes et leur utilisation
JP2008194054A (ja) 植物における防御タンパク質を含む免疫グロブリンの製造法およびその使用
US20080115244A1 (en) Method for producing immunoglobulins containing protection proteins and their use
US6852319B2 (en) Method of use of transgenic plant expressed antibodies
US20090041776A1 (en) Production of cancer-specific antibodies in plants
AU2008261532A1 (en) Protein production in plants
US20120034207A1 (en) Production of her receptor antibodies in plant
US20050241023A1 (en) Transgenic plants expressing assembled secretory antibodies
AU773602B2 (en) Methods for producing immunoglobulins containing protection proteins in plants and their use
Ma in Transgenic Plants
Larrick et al. Transgenic Plants for Production of Immunotherapeutic Agents
Larrick et al. I. PLANT BIOREACTORS FOR IMMUNOTHERAPEUTIC PROTEINS
Komarnytskyy Production of recombinant proteins in plant exudates
Devine Expression Of Heterologous Proteins In Transgenic Tobacco Chloroplasts To Produce A Biopharmaceutical And Biopolymer
AU2004201094A1 (en) Methods for Producing Immunoglobulins Containing Protection Proteins in Plants and Their Use
AU5400101A (en) Trangenic plants expressing assembled secretory antibodies