AU2000279849A2 - Medical dressings with multiple adhesives and methods of manufacturing - Google Patents
Medical dressings with multiple adhesives and methods of manufacturingInfo
- Publication number
- AU2000279849A2 AU2000279849A2 AU2000279849A AU2000279849A AU2000279849A2 AU 2000279849 A2 AU2000279849 A2 AU 2000279849A2 AU 2000279849 A AU2000279849 A AU 2000279849A AU 2000279849 A AU2000279849 A AU 2000279849A AU 2000279849 A2 AU2000279849 A2 AU 2000279849A2
- Authority
- AU
- Australia
- Prior art keywords
- pressure sensitive
- adhesive
- sensitive adhesive
- liner
- dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Description
MEDICAL DRESSINGS WITH MULTIPLE ADHESIVES AND METHODS OF MANUFACTURING
Field Of The Invention
The present invention generally relates to adhesive medical dressings. More particularly, the present invention provides a medical dressing with multiple exposed adhesives, one of which includes a bioactive agent. The present invention also provides a masked adhesive transfer process.
Background
The use of transparent film dressings continues to grow at an accelerated rate. In addition to their use as protective layers over wounds, where they facilitate healing in a moist environment while acting as a barrier to contaminating liquids and bacteria, the films are also used over catheters to prevent contamination of the catheter insertion site by contaminating liquids and bacteria. Dressings fitting the above description are available under a number of trade names such as TEGADERM™ (3M Company, St. Paul, Minnesota), BIOCLUSINE™ (Johnson & Johnson Company, New Brunswick, New Jersey), and OP-SITE™ (T.J. Smith & Nephew, Hull. England).
The adhesives used to secure the dressings in place on a patient are typically fairly aggressive, i.e., the adhesives have a high tack, to prevent unwanted release from a wound edge or catheter site. Many of the adhesives are also contact transparent to allow visual monitoring of wounds or catheter sites without removing the dressings. One of the purposes of the dressings is to reduce or prevent infection of wounds or catheter sites. Attempts have been made to include antimicrobial agents in dressings to further improve the ability of dressings to reduce or prevent infection by reducing migration of infectious agents across the dressing surfaces. These attempts typically have significant drawbacks. One approach to incorporating antimicrobial agents in medical dressings involves the inclusion of a pad that acts as a carrier for the antimicrobial agent. The pads, however, typically prevent visual monitoring of the wound or catheter site located directly beneath
the pad. The pads are also typically not adhesive, i.e.. they cannot adhere to the wound or catheter site. As a result, the dressing is not as firmly secured as a similar dressing that does not include a pad.
Other approaches have involved incorporating antimicrobial agents directly into the pressure sensitive adhesive used on a dressing, but this approach also suffers from drawbacks. For example, in those pressure sensitive adhesives that provide desired levels of tack to a patient's skin (to, e.g., prevent edge lift off of the dressing), the antimicrobial agents are also bound so well that they are not available in effective concentrations at the wound or catheter site. Pressure sensitive adhesive formulations incorporating antimicrobial agents that are available in effective concentrations at a wound or catheter site are known. See, e.g., U.S. Patent Nos. 5,614,310 and 5,908.693 (both to Delgado et al.). These pressure sensitive adhesives, however, exhibit tack to skin that is reduced upon exposure to moisture such as, e.g., sweat, when in place on a patient. As a result, these pressure sensitive adhesives do not present good candidates for use as the only adhesive exposed on, e.g., medical dressings that require relatively high tack to reduce the likelihood of unwanted removal.
Summary of the Invention The present invention provides medical dressings that include multiple exposed pressure sensitive adhesives. One of the pressure sensitive adhesives includes a bioactive agent and is substantially contact transparent. It may also be preferred that all of the adhesives are substantially contact transparent.
Also provided are methods of manufacturing the medical dressings. By providing multiple exposed pressure sensitive adhesives, the pressure sensitive adhesive formulations can be varied to provide desired properties in different areas of the dressing. For example, one of the exposed pressure sensitive adhesives may exhibit relatively high tack to skin while another exposed pressure sensitive adhesive may serve as a vehicle for a bioactive agent while still providing some adhesive properties. The term "substantially contact transparent," as used in connection with the present invention, means that, when adhered to a patient's skin, a wound or catheter site can be
visually monitored through those portions of the backing and pressure sensitive adhesive or adhesives in contact with the patient's skin without requiring removal of the dressing. The term "bioactive agent," as used in connection with the present invention, includes pharmacologically active ingredients, such as drugs, antibiotic agents, antimicrobial agents, etc.
In some embodiments, a pressure sensitive adhesive that exhibits relatively high tack to skin may be provided around the periphery of the dressing while a pressure sensitive adhesive incorporating a bioactive agent is provided in the center of the dressing. As a result, the edges of the dressing can be firmly secured to a patient, while the center of the dressing provides, e.g., a degree of infection control if the bioactive agent is antimicrobial. In other embodiments, a higher tack pressure sensitive adhesive may be provided at two opposing sides of the dressing with a bioactive adhesive located in between the opposing portions of higher tack adhesive.
The different adhesives may be applied directly to different areas of the dressing backing such that different areas of the backing include only one pressure sensitive adhesive. Alternatively, one or more of the pressure sensitive adhesives may be provided over one or more pre-applied areas of pressure sensitive adhesive such that the pressure sensitive adhesives are located in multiple layers over a portion of the dressing. In all cases, however, at least two different pressure sensitive adhesives are exposed on the bottom surface of the dressing. It is further preferred that all of the pressure sensitive adhesives are moisture vapor permeable and/or provided using techniques (e.g., pattern coating) that provide a desired level of moisture vapor permeability.
The present invention also provides methods of transferring adhesives using a mask such that the adhesive is transferred to selected areas of a receiving surface. The mask may be provided in the form of a liner including a plurality of voids formed therein.
This method can provide precise control over registration of the transferred adhesive on the receiving surface, e.g., a backing. Registration control may be particularly important if the adhesive is transferred to, e.g., a backing and carrier composite including windows to facilitate delivery of the backing. In such a situation, it may be desirable to accurately register the transferred adhesive with, e.g., the windows in the carrier. Examples of such dressings are found in, e.g., U.S. Patent No. 5,531,855 (Heinecke et al.).
In one aspect, the present invention provides a medical dressing having top and bottom surfaces, the medical dressing including a substantially contact transparent backing; a first pressure sensitive adhesive exposed on the bottom surface of the dressing; and a second pressure sensitive adhesive exposed on the bottom surface of the dressing, wherein the second pressure sensitive adhesive includes at least one bioactive agent and is substantially contact transparent.
In another aspect, the present invention provides a method of manufacturing a medical dressing having top and bottom surfaces by providing a substantially contact transparent backing; providing a first pressure sensitive adhesive that is exposed on the bottom surface of the dressing; and providing a second pressure sensitive adhesive that is exposed on the bottom surface of the dressing, wherein the second pressure sensitive adhesive includes at least one bioactive agent and is substantially contact transparent.
In another aspect, the present invention provides a method of transferring an adhesive to a substrate by providing a mask liner including a plurality of voids formed therein; locating a receiving surface proximate a first side of the mask liner, wherein at least a portion of the receiving surface is exposed through at least one of the plurality of voids in the mask liner; providing transfer adhesive on a transfer liner; and transferring at least a portion of the transfer adhesive to the portion of the receiving surface exposed through the void in the mask liner.
These and other features and advantages of the articles and methods of the present invention are discussed below.
Brief Description of the Drawings Figure 1 is a plan view of the adhesive surface of one medical dressing according to the present invention.
Figure 2 is a cross-sectional view of the dressing of Figure 1, taken along line 2-2 in Figure 1.
Figure 3 is a cross-sectional view an alternative dressing.
Figures 4A and 4B are plan views of the bottom surfaces of alternative medical dressings including multiple exposed pressure sensitive adhesives according to the present invention.
Figure 5 is an exploded view of one dressing according to the present invention including a carrier frame with a window formed therein.
Figure 6 is a schematic diagram of one process of providing multiple adhesives on a substrate.
Figure 7 is a schematic diagram of a process for laminating a liner and forming discrete products using the substrate and adhesives of Figure 6.
Detailed Description of Illustrative Embodiments of the Invention
The present invention is particularly useful in the field of pressure sensitive adhesive medical dressings having high moisture vapor permeable film backings. Issued U.S. Patent No. 3,645,835 and European Patent Application Publication No. 0 437 944 describe methods of making such films and methods for testing their permeability.
Preferably, the film/adhesive composite dressings should transmit moisture vapor at a rate equal to or greater than human skin. In one aspect, the adhesive coated film may advantageously transmit moisture vapor at a rate of at least 300 g/m2/24 hrs/37°C/100- 10% RH, more preferably at least 700 g/m2/24 hrs/37°C/ 100-10% RH. and most preferably at least 2000 g/m2/24 hrs/37°C/100-10% RH using the inverted cup method as described in
U.S. Patent Nos. 3,645,835 and 5.849,325.
The backing film is also preferably conformable to anatomical surfaces. As such, when the backing is applied to an anatomical surface, it conforms to the surface even when the surface is moved. The preferred backing is also conformable to anatomical joints. When the joint is flexed and then returned to its unflexed position, the backing stretches to accommodate the flexion of the joint, but is resilient enough to continue to conform to the joint when the joint is returned to its unflexed condition. A description of this characteristic of backings preferred for use with the present invention can be found in U.S. Patent Nos. 5,088,483 and 5,160.315.
A description of some backings that may be preferred for use in the medical dressings of the present invention can be found in issued U.S. Patent Nos. 5,088,483 and 5,160,315, as well as European Patent Application Publication No. 0 437 944.
Particularly preferred film backings may be selected from the group of elastomeric polyurethane, copolvester, or polyether block amide films, or combinations thereof. These films combine the desirable properties of resiliency, high moisture vapor permeability, and transparency that may be preferred in the backings. Also, although the backings are depicted below as monolayer articles, it will be understood that they could include multiple layers as described in, e.g., European Patent Application Publication No. 0 437 944.
Pressure sensitive adhesives that can be used in the medical dressings of the present invention include adhesives that are preferably compatible with human or animal skin, more preferably those that are of the class known as "hypoallergenic" adhesives. Examples of some adhesives useful in connection with the invention include, but are not limited to the acrylate copolymers described in U.S. Patent No. RE 24,906, particularly a
97:3 iso-octyl acrylate:acrylamide copolymer. Also useful is an 70:15:15 isooctyl acrylate: ethyleneoxide acrylate:acrylic acid terpolymer, as described in U.S. Patent No. 4,737,410 (see Example 31). Other useful adhesives are described in U.S. Patent Nos. 3,389,827; 4,112,213; 4,310,509; and 4,323,557; as well as UK Patent No. 1280631 (see, e.g., polyvinyl ether adhesives) and European Patent Nos. 35399 and 51935. Some useful pressure sensitive adhesives may include bioactive agents as described in, e.g., U.S. Patent Nos. 4,310,509; 4,323.557; 5,614.310; and 5,908,693. Some preferred bioactive agents may be antimicrobial agents to enhance wound or catheter site infection control.
The layer or layers of pressure sensitive adhesives located on the backings of the medical dressings of the invention preferably transmit moisture vapor at a rate greater than or equal to that of human skin. While such a characteristic can be achieved through the selection of an appropriate adhesive, it is also contemplated in the present invention that other methods of achieving a high relative rate of moisture vapor transmission may be used, such as, e.g., pattern coating the adhesive. In addition to moisture vapor permeability and hypoallergenicity, it may also be preferred that the adhesives exhibit high initial tack upon application to the skin or the
surface of a nail. One such pressure sensitive adhesive is described in U.S. Patent No. 5,849,325, and other useful adhesives may include polyvinyl ether adhesives as discussed in, e.g., UK Patent No. 1280631. One advantage of an adhesive exhibiting high initial tack is additional securing of, e.g., a catheter by the dressing may be more quickly enhanced as opposed to adhesives that have a lower initial tack.
The medical dressings of the present invention may also include a low adhesion coating on the backing, which may be preferably coated as a solution of polyvinyl N- octadecyl carbamate and a blend of silicone resins, as described in, e.g., U.S. Patent No. 5,531 ,855. While it may be preferred that the medical dressings of the present invention include a low adhesion coating, medical dressings without such a coating are also considered to be within the scope of the present invention.
When provided as a part of the medical dressing (before delivery), suitable liners are available from a variety of manufacturers in a wide variety of proprietary materials. Those skilled in the art will normally test those liners in simulated use conditions against an adhesive of choice to arrive at a product with the desired release characteristics. The materials used to supply the liners for the flexible film dressings manufactured according to the present invention are preferably substantially more rigid than the backing film.
Figures 1 and 2 depict an illustrative embodiment of one medical dressing according to the present invention. The dressing 10 has a backing 12, a bottom surface 14 and a top surface 16. The bottom surface 14 of the dressing is that surface that is designed to face the patient when the dressing 10 is applied and is typically the surface of the dressing on which any pressure sensitive adhesives used to secure the dressings 10 are exposed. The backing 12 is preferably a polymeric film that is substantially contact transparent. Two different pressure sensitive adhesives 20 and 30 are exposed on the bottom surface 14 of the dressing 10. In the illustrated embodiment, a first adhesive 20 is exposed over a portion of the bottom surface 14 of the dressing 10 while a second adhesive 30 is exposed over a second portion of the bottom surface 14. The second adhesive 30 may preferably include at least one bioactive agent. As shown in the dressing 10, it may be preferred that the second adhesive 30 be exposed within a distinct area on the bottom surface 14 of the dressing 10. It may also be
preferred that the first adhesive 20 be located about the perimeter of the bottom face 14, more preferably substantially the entire perimeter of the bottom face 14. In other words, it may be preferred that the first adhesive 20 form a border around the bottom face 14 of the backing 12. One potential and possibly preferred difference between the first adhesive 20 and the second adhesive 30 (which contains a bioactive agent) is that the tack of the first adhesive 20 on the skin or nail of a patient may be higher than the tack of the second adhesive 30. In other words, the adhesive bond formed between the first adhesive 20 and a patient is stronger than the bond formed between the second adhesive 30 and the patient. One potential advantage of using adhesives with different tack is that, where the first adhesive 20 located in a border around the second adhesive 30 or on opposing ends of the dressing (see. e.g., Figure 4A), the backing may be more firmly secured to the patient. That may prevent or reduce inadvertent lift-off of the edges of the dressings.
It may also be preferred that the second adhesive 30 form a desired shape. One example of a desired shape is illustrated in Figure 1, where the second adhesive 30 forms a cross pattern on the bottom face 14 of the backing 12. In instances where the different adhesives can be visually distinguished from each other, the pattern formed by the adhesives 20 and 30 may assist in accurate placement of the second adhesive 30 over a desired location on a patient. In some instances, it may be desirable to provide a colorant as a part of the adhesives or the backing (or otherwise) to further assist in placement of the dressing 10. In other instances, the constituents in the adhesive may exhibit a color without the addition of colorants.
The cross-sectional view of the dressing 10 also depicts that, in the illustrated embodiment, the first pressure sensitive adhesive 20 is located over substantially all of the bottom surface 14 of the dressing 10. Where the second pressure sensitive adhesive 30 is found, it is located over the first adhesive 20. As a result, the second pressure sensitive adhesive 30 may not have any direct contact with the backing 12. The first pressure sensitive adhesive 20 is exposed in those areas where the second pressure sensitive adhesive 30 is not found. An alternative dressing construction is depicted in cross-section in Figure 3. In that embodiment, the first pressure sensitive adhesive 120 is not located over all of the
bottom face 1 14 of the backing 1 12. Rather, the first pressure sensitive adhesive 120 is provided only on the edges of the backing 112. The second pressure sensitive adhesive 130 can then be located directly on the backing 112, rather than over the first adhesive 120 (as in dressing 10). The two adhesives 120 and 130 may preferably overlap along their edges 122 and 132 as shown to prevent adhesive voids that may negatively impact retention of the dressing 110 on the skin of a patient. Alternatively, the edges of the different adhesives may not overlap.
Figure 4A illustrates an alternative medical dressing 210 with a first pressure sensitive adhesive 220 exposed on opposing sides or edges of the bottom surface 214 of the dressing 210. A strip of a second pressure sensitive adhesive 230 is exposed on the bottom surface 214 of the dressing 210 between the opposing strips of the first pressure sensitive adhesive 220. The exposed strip of second adhesive 230 may preferably be located down the center of the bottom face 214.
Figure 4B illustrates another illustrative medical dressing 310 that includes a backing 312 on which a first pressure sensitive adhesive 320 is exposed in certain areas. A second pressure sensitive adhesive 330 is also exposed on the bottom surface of the dressing 310. In contrast to the various embodiments described above, the second pressure sensitive adhesive 330 on the dressing 310 is exposed in a plurality of distinct areas rather than a single distinct area. The size and/or shape of the distinct areas of exposed second pressure sensitive adhesive 330 may be uniform as illustrated in Figure 4B. Alternatively, the size and/or shape of the distinct areas may vary. Furthermore, the arrangement of the distinct areas may be ordered or random.
Figure 5 illustrates another medical dressing 410 that includes a carrier delivery system. The medical dressing 410 includes a backing 412 that is preferably conformable as described above; first and second pressure sensitive adhesives 420 and 430 that are exposed on the bottom surface of the dressing 410 (although they are depicted as attached to the liner 450 in Figure 5 for the purposes of illustration only); and a carrier 440 attached to the backing 412. Also depicted in Figure 5 is a liner 450 that bonds to the exposed portions of the first and second pressure sensitive adhesives 420 and 430 to protect them until the backing 412 is delivered. When the backing 412 used in the medical dressings of the present invention is one of the flexible polymeric films discussed above, it is often
desirable to supply a carrier or some other support that is substantially more rigid than the backing 412 to prevent the backing from wrinkling or folding onto itself in whole or in part during application of the dressing 410.
The top face 416 of the backing 412 may also include a low adhesion coating 413 such as that described in, e.g., U.S. Patent No. 5,531 ,855, to reduce surface friction between the backing and other objects or surfaces which also reduces unwanted removal of the backing 412 after application to a wearer. It will be understood that the low adhesion coating 413 is optional and that it may or may not be provided.
In Figure 5, a portion of the carrier 440 is preferably removed creating a window 442 exposing a portion of the top face 416 of the backing 412. It will be understood, however, that in some instances the carrier 440 may not include a window 442, i.e., the carrier 440 may be coextensive with the backing 412.
In those medical dressings 410 in which a window 442 is provided, removal, during manufacturing, of the window portion of the carrier 440 that would normally cover window 442 is optional. Removal does eliminate one step in the delivery process (i.e., the step of removing a portion of the carrier material from the window 442 prior to removing the backing 412 from the liner 450) and reduces the waste stream at the consumer level. However, some customers may prefer that the portion of the carrier 440 normally covering window 442 remain intact until the dressing 410 reaches the end user. The portion of the carrier 440 that remains after window removal preferably extends about at least a substantial portion of the periphery of the backing 412 to support it after removal from the liner 450.
Carrier 440 may also preferably include at least one tab 444 (two are illustrated in Figure 5) that extends beyond the perimeter of backing 412 to assist in removal of the backing 412 from the liner 450 without contacting the exposed adhesives 420 or 430. It is preferred that the tabs 444 be completely integral with the carrier 440 such that pulling the tab 444 and integral carrier 440 away from the liner 450 results in removal of the carrier 440, backing 412 and adhesives 420 and 430 from the liner 450.
The carrier 440 may preferably be attached to backing 412 (over any low adhesion coating, if provided) with a heat seal bond. Other bonding mechanisms, such as adhesives, mechanical bonds, wax coatings, surface energy attraction, etc. can be used in place of the
preferred heat seal bond. Regardless of the type of bonding used to attach the carrier 440 to the backing 412, the bond should be secure, yet releasable, i.e., the carrier 440 and backing 412 can be separated without destroying the integrity of the backing 412 or the bond between the exposed pressure sensitive adhesives 420 and 430 on the backing and the skin of a wearer after application of the backing 412.
If the carrier material 440 is heat-sealable to the backing 412 for the purpose of manufacturing the medical dressings, the carrier 440 may be, e.g., polyethylene/vinyl acetate copolymer-coated papers and polyester films. One example of a preferred heat- sealable carrier material is a polyethylene/vinyl acetate copolymer-coated super calendered Kraft paper (1-80BKG-157 PE; DCP-Lohja, Inc. Westchester, Illinois). Methods and materials conducive to heat sealing are described in U.S. Patent Nos. 5,531,855 (Heinecke et al.) and 5,738,642 (Heinecke et al).
The release liner 450 preferably includes a release surface that contacts the exposed pressure sensitive adhesives 420 and 430 when the medical dressing 410 is manufactured. The release surface on the liner 450 is preferably at least coextensive with the exposed pressure sensitive adhesives 420 and 430, but may in some instances be larger (including the entire surface of the liner 450) to simplify manufacturing of the dressings 410. Examples of suitable release materials for use on the release surface include silicones such as UV-9300 and UN-9315 available from GE Silicones, General Electric Company, Waterford, New York. The release material would preferably be coated on the release surface at weights sufficient to provide the desired release characteristics to allow removal of the backing 412 when desired.
The release liner 450 itself could be made of kraft papers, polyethylene, polypropylene, polyester or composites of any of these materials. As discussed above, the release surface preferably includes release materials such as fluorochemicals or silicones.
For example, U.S. Patent No. 4,472,480, describes low surface energy perfluorochemical liners. Some preferred liners are papers, polyolefin films, or polyester films coated with silicone release materials. Examples of commercially available silicone coated release papers are POLNSLIK™ silicone release papers available from Rexam Release (Oak Brook, Illinois) and silicone release papers supplied by DCP-Lohja, Inc. (Westchester,
Illinois).
Other combinations of adhesives and release materials are contemplated for use with embodiments according to the present invention. Those skilled in the art will be familiar with the processes of testing new combinations of adhesives and release surfaces to arrive at the combination of qualities desired in a final product. The considerations pertinent to the selection of silicone release surfaces can be found in Chapter 18 of the
Handbook of Pressure Sensitive Adhesive Technology, Nan Nostrand-Reinhold, 1982, pp. 384-403. U.S. Patent No. 4,472,480 also describes considerations pertinent to the selection of a perfluoropolyether release liner.
Medical dressings with multiple exposed pressure sensitive adhesives on their bottom surfaces can be manufactured by a variety of processes such as, e.g., screen or rotogravure printing, of one or more of the pressure sensitive adhesives.
Figure 6 is, however, a schematic diagram of one method of providing multiple exposed adhesives on a substrate, such as, e.g., a backing used in a medical dressing. The methods of providing multiple exposed pressure sensitive adhesives according to the present invention are not limited to the manufacture of adhesive medical dressings.
Rather, the methods could be used in any situation in which a pressure sensitive adhesive is desired to be transferred to a receiving surface through voids in a mask liner. The result is that the transferred adhesive can be accurately located and transferred as desired. The transfer method described below relates to medical dressings, although the pressure sensitive adhesive transfer method should not be so limited.
The method includes providing a mask liner 560 that moves through a station 570 in which a pattern of voids 562 are formed. In one method, the voids 562 are formed by die cutting with the removed portions 564 of the liner 560 are removed by, e.g., a vacuum system or any other suitable technique. The mask liner 560 including the voids 562 is then directed into a transfer station
572 along with a backing 512 that preferably includes a layer of backing adhesive 520 on its bottom surface. The backing 512 preferably also includes a carrier layer 540 attached to the top surface of the backing 512. As discussed above, a carrier 540 may be particularly useful if the backing 512 is a flexible film. Also, it will be understood that the carrier 540 may be laminated to the backing 512 after the transfer station 572. The
carrier 540 preferably includes a pattern of windows 542 that are preferably die-cut in the carrier layer 540.
Also directed into the transfer station 572 is a transfer liner 580 that includes a transfer adhesive 530 on the upper surface as shown in Figure 6. It may be preferred that substantially all of the upper surface of the transfer liner 580 be coated with the transfer adhesive 530. Alternatively, only a portion of the upper surface of the transfer liner 580 may be coated with the transfer adhesive 530 to reduce adhesive waste.
At the transfer station 572, the portion of the transfer adhesive 530 that contacts the backing 512 and backing adhesive 520 composite is transferred thereto. The remainder of the transfer adhesive 530 either remains attached to the transfer liner 580 as shown in
Figure 6 or is transferred to the bottom surface of the mask liner 560.
After removal of the mask liner 560 from contact with the backing adhesive 520 and backing 512, the transfer adhesive 530 remains on the backing adhesive 520 in a pattern that matches the pattern of voids in the mask liner 560. Figure 7 illustrates another process in which the product of the process depicted in
Figure 6, i.e., the backing 512, backing adhesive 520 and transfer adhesive 530, are mated to a product liner 550 at a liner station 574. Following lamination of the liner 550 to the backing 512 using adhesives 520 and 530, the web can be sheeted or otherwise separated at, e.g., a sheeting station 576 to form dressings 510. One advantage of using a die-cut mask liner 560 through which the transfer adhesive 530 is transferred is that registration can be maintained between the voids 562 in the mask liner 560 and any features provided in one or more of the backing 512, backing adhesive 520, and carrier 540. Registration control is provided because all of the features are formed in controllable die-cut operations. Another advantage is that if the transfer adhesive 530 is not amenable to other processes of providing discrete patterns of adhesive such as, e.g., printing or other processes, it may transfer cleanly in a process using a mask liner with voids.
Although various illustrative embodiments of dressings and methods of manufacturing the same have been described above, it should be understood that additional variations are possible. As one example, additional components may be added to the
medical dressings, such as the catheter support strips discussed in U.S. Patent No. 5,520,629.
EXAMPLES
The features and advantages of the present invention illustrated in the following examples, which incorporate particular materials and amounts, should not be construed to unduly limit this invention. All materials are commercially available unless otherwise stated or apparent. All parts, percentages, ratios, etc., in the examples are by weight unless otherwise indicated.
EXAMPLE 1: Medical Dressing Preparation Using Rotary Screen Printer
A medical dressing including a transparent film backing, a first pressure-sensitive adhesive, and a second pressure-sensitive adhesive containing an antimicrobial agent was constructed using a rotary screen printer according to the following procedure. An antimicrobial microsphere adhesive was prepared by mixing together the following ingredients:
1. adhesive microspheres (1217 g) prepared as described in U.S. Pat. No. 5,614,310 (Delgado, et al.) and including (prior to polymerization) isooctyl acrylate (90 parts), N-vinylpyrrolidone (5 parts), and poly(ethylene oxide) acrylate (5 parts);
2. poly(N-vinylpyrrolidone) (121.7 g, K90, ISP Technologies, Inc.. Wayne, NJ);
3. glycerol (334.8 g, Dow Chemical Co., Midland, MI); and
4. 20% aqueous chlorhexidine gluconate (CHG) solution (334.8 g, Xttrium Laboratories, Chicago, IL). The antimicrobial microsphere adhesive was coated using a rotary screen printer
(available from Stork, Charlotte, NC) through a 60-mesh screen as a 2.54-cm stripe on a silicone-coated release liner and dried at 82°C. The dried adhesive thickness was 0.1-0.4 mil (2.5-10 microns). Similarly, the adhesive was coated through a 40-mesh screen with patterns in the form of 5.1 -cm diameter circles and 2.54-cm squares. The adhesive thickness of the latter patterns was 1.7-2.0 mil (43-50 microns).
Individual adhesives were transferred by hand to TEGADERM™ transparent dressings (3M Company, St. Paul, MN) by cutting out a portion of the dressing liner slightly larger than the pattern and applying the adhesive pattern to the adhesive face of the dressing with light finger pressure.
EXAMPLE 2: Medical Dressing Preparation Using Mask Transfer Liner
A medical dressing including a transparent film backing, a first pressure-sensitive adhesive, and a second pressure-sensitive adhesive containing an antimicrobial agent was constructed using manufacturing equipment and a mask transfer liner according to the following procedure.
A primary adhesive web was prepared as described in Example 1 of U.S. Pat. No. 5,160,315 (Heinecke, et al.). The web included a 0.8-mil (20-micron) polyurethane film laminated to an adhesive [isooctyl acrylate/acrylamide (97/3 weight ratio) copolymer] coated differential release liner made of two-side silicone coated paper. An antimicrobial microsphere adhesive was prepared by mixing together the following ingredients:
1. adhesive microspheres (100 g) prepared as described in U.S. Pat. No. 5,614,310 (Delgado, et al.) and including (prior to polymerization) isooctyl acrylate (90 parts), N-vinylpyrrolidone (5 parts), and poly(ethylene oxide) acrylate (5 parts);
2. poly(N-vinylpyrrolidone) (4 g, K90, BASF);
3. glycerol (5.5 g, Aldrich, Milwaukee, WI);
4. 20% aqueous chlorhexidine gluconate (CHG) solution (9.6 g, Xttrium Laboratories, Chicago, IL); 5. sorbitol (5.5 g, Lonza Group, Fairlawn, NJ); and
6. SILWET L-77 (0.8722 g, OSI Specialties, Friendly, WV).
A transfer adhesive web was prepared by coating the antimicrobial adhesive described above at 25 g/m2 on the "tight side" of a differential release liner made of two- side silicone coated paper to form the transfer adhesive web.
A mask transfer liner manufactured of bleached Kraft paper (one side polyethylene coated followed by silicone coated and the other side untreated) was die cut to form a series of voids along the center of the liner.
A medical dressing was constructed by laminating the primary adhesive web, the transfer adhesive web, and the mask transfer liner together at a single nip roll. The mask transfer liner was sandwiched between the primary adhesive web and the transfer adhesive web so that the antimicrobial adhesive on the transfer adhesive web transferred through the voids in the mask transfer liner and adhered as adhesive islands along the center of the adhesive side of the primary adhesive web. The mask transfer liner was positioned so that the silicone-treated side faced the primary adhesive web and the untreated side faced the transfer adhesive web. The primary adhesive web (now having a series of antimicrobial adhesive islands) was then laminated on the adhesive side to a product release liner made of bleached, one-side polyethylene and then silicone coated, one-side untreated, Kraft paper to form a composite web. The composite web with both adhesives located thereon was then converted into final medical dressings as described in Example 1 of U.S. Pat. No. 5,531,855 (Heinecke, et al.). Briefly, carrier material was die cut to form windows that were then removed. The carrier material was heat laminated to the film side of the composite web and the resulting web was cut into the required dressing size using rotary equipment.
EXAMPLE 3: Medical Dressing Preparation Using Mask Transfer Liner
A medical dressing was prepared as described in Example 2, except that the mask transfer liner was bleached, two-side silicone coated, differential release Kraft paper. The liner was positioned so that the "tight side" of the differential release mask transfer liner faced the transfer adhesive web.
EXAMPLE 4: Medical Dressing Preparation Using Mask Transfer Liner
A medical dressing was prepared as described in Example 3, except that the antimicrobial adhesive was coated at 33 g/m2 on the transfer adhesive web.
EXAMPLES 5-7: Medical Dressing Preparation Using Mask Transfer Liner
Medical dressings were prepared as described in Example 3, except that the antimicrobial adhesive was coated at either 10 g/m2 (Example 5), 17 g/m2 (Example 6), or 33 g/m2 (Example 7) on the transfer adhesive web.
It is to be understood that the above description is intended to be illustrative, and not restrictive. Various modifications and alterations of this invention will become apparent to those skilled in the art from the foregoing description without departing from the scope of this invention, and it should be understood that this invention is not to be unduly limited to the illustrative embodiments set forth herein.
Claims (16)
1. A medical dressing having top and bottom surfaces comprising: a substantially contact transparent backing; a first pressure sensitive adhesive exposed on the bottom surface of the dressing; and a second pressure sensitive adhesive exposed on the bottom surface of the dressing, wherein the second pressure sensitive adhesive comprises at least one bioactive agent and is substantially contact transparent.
2. A medical dressing according to claim 1, wherein the second pressure sensitive adhesive is located on the first pressure sensitive adhesive.
3. A medical dressing according to claim 1, wherein the second pressure sensitive adhesive is in direct contact with the backing.
4. A medical dressing according to any one of claims 1-3, wherein the exposed second pressure sensitive adhesive is located in at least one distinct area on the bottom surface of the dressing, and further wherein the exposed first pressure sensitive adhesive forms a border around the distinct area of the exposed second pressure sensitive adhesive.
5. A medical dressing according to any one of claims 1-4, wherein the first pressure sensitive adhesive has a higher tack to skin than the second pressure sensitive adhesive, and wherein the at least one bioactive agent comprises an antimicrobial agent.
6. A method of manufacturing a medical dressing having top and bottom surfaces comprising: providing a substantially contact transparent backing; providing a first pressure sensitive adhesive that is exposed on the bottom surface of the dressing; and providing a second pressure sensitive adhesive that is exposed on the bottom surface of the dressing, wherein the second pressure sensitive adhesive comprises at least one bioactive agent and is substantially contact transparent.
7. A method according to claim 6, wherein providing the second pressure sensitive adhesive comprises locating the second pressure sensitive adhesive on the first pressure sensitive adhesive.
8. A method according to claim 6, wherein providing the second pressure sensitive adhesive comprises locating the second pressure sensitive adhesive in direct contact with the backing.
9. A method according to any one of claims 6-8, wherein the exposed second pressure sensitive adhesive is located in at least one distinct area on the bottom surface of the dressing, and further wherein the exposed first pressure sensitive adhesive forms a border around the distinct area of the exposed second pressure sensitive adhesive.
10. A method according to any one of claims 6-9, wherein the first pressure sensitive adhesive has a higher tack to skin than the second pressure sensitive adhesive, and wherein the at least one bioactive agent comprises an antimicrobial agent.
11. A method of transferring an adhesive to a substrate comprising: providing a mask liner comprising a plurality of voids formed therein; locating a receiving surface proximate a first side of the mask liner, wherein at least a portion of the receiving surface is exposed through at least one of the plurality of voids in the mask liner; providing transfer adhesive on a transfer liner; and transferring at least a portion of the transfer adhesive to the portion of the receiving surface exposed through the void in the mask liner.
12. A method according to claim 11 , wherein the transferring comprises laminating the receiving surface, mask liner, transfer adhesive, and transfer liner together, and wherein the receiving surface contacts the transfer adhesive through the voids in the mask liner.
13. A method according to claim 12, wherein the transfer liner, mask liner and receiving surface each comprise a substantially continuous web, and further wherein the laminating comprises laminating the receiving surface, mask liner, transfer adhesive, and transfer liner together in a nip, whereby the receiving surface contacts the transfer adhesive through the voids in the mask liner.
14. A method according to any one of claims 11-13, wherein the transfer adhesive is substantially continuous over a release surface of the transfer liner.
15. A method according to any one of claims 11-14, wherein the receiving surface comprises a first adhesive, and further wherein a major surface of the mask liner facing the first adhesive comprises a release coating.
16. A method according to any one of claims 11-15, wherein a maj or surface of the mask liner facing the transfer adhesive is substantially free of a release coating.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52413900A | 2000-03-10 | 2000-03-10 | |
| US09/524,139 | 2000-03-10 | ||
| PCT/US2000/026090 WO2001068021A1 (en) | 2000-03-10 | 2000-09-25 | Medical dressings with multiple adhesives and methods of manufacturing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2000279849A1 AU2000279849A1 (en) | 2001-12-06 |
| AU2000279849A2 true AU2000279849A2 (en) | 2003-05-08 |
| AU2000279849B2 AU2000279849B2 (en) | 2005-05-19 |
Family
ID=24087929
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2000279849A Ceased AU2000279849B2 (en) | 2000-03-10 | 2000-09-25 | Medical dressings with multiple adhesives and methods of manufacturing |
| AU7984900A Pending AU7984900A (en) | 2000-03-10 | 2000-09-25 | Medical dressings with multiple adhesives and methods of manufacturing |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU7984900A Pending AU7984900A (en) | 2000-03-10 | 2000-09-25 | Medical dressings with multiple adhesives and methods of manufacturing |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6461467B2 (en) |
| EP (2) | EP1267767B1 (en) |
| JP (1) | JP4773026B2 (en) |
| AT (2) | ATE318566T1 (en) |
| AU (2) | AU2000279849B2 (en) |
| BR (1) | BR0017149B1 (en) |
| CA (2) | CA2626268A1 (en) |
| DE (1) | DE60026343T2 (en) |
| ES (1) | ES2257330T3 (en) |
| MX (1) | MXPA02008606A (en) |
| TW (1) | TW562669B (en) |
| WO (1) | WO2001068021A1 (en) |
Families Citing this family (154)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6831205B2 (en) * | 1999-11-29 | 2004-12-14 | Clozex Medical, Llc | Bandage for wound or incision closure |
| CA2626268A1 (en) * | 2000-03-10 | 2001-09-20 | 3M Innovative Properties Company | Medical dressings with multiple adhesives and methods of manufacturing |
| SE0200885L (en) * | 2002-03-22 | 2003-09-23 | Moelnlycke Health Care Ab | Wrap-up product with adhesive edge |
| US7005143B2 (en) * | 2002-04-12 | 2006-02-28 | 3M Innovative Properties Company | Gel materials, medical articles, and methods |
| US7846141B2 (en) | 2002-09-03 | 2010-12-07 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
| CA2405368C (en) * | 2002-09-26 | 2011-06-21 | Crosslink Technology Inc. | Method of adhering a material to another material and product produced by the method |
| GB0224986D0 (en) | 2002-10-28 | 2002-12-04 | Smith & Nephew | Apparatus |
| US7612248B2 (en) * | 2002-12-19 | 2009-11-03 | 3M Innovative Properties Company | Absorbent medical articles |
| US7154017B2 (en) * | 2002-12-31 | 2006-12-26 | Ossur Hf | Method for producing a wound dressing |
| US20040143220A1 (en) * | 2003-01-17 | 2004-07-22 | George Worthley | Wound and catheter dressing and a method for making and applying a dressing |
| US8920590B1 (en) * | 2003-04-14 | 2014-12-30 | Winfield Laboratories, Inc. | Tamper evident seal for a medical container |
| US6998511B2 (en) * | 2003-05-03 | 2006-02-14 | George Medical | Dressing and a method for applying the same |
| US9278155B2 (en) | 2003-06-05 | 2016-03-08 | 3M Innovative Properties Company | Adhesive compositions, articles incorporating same and methods of manufacture |
| US20050013957A1 (en) * | 2003-07-15 | 2005-01-20 | Boris Leschinsky | Disposable medical article with multiple adhesives for skin attachment |
| US8636763B2 (en) * | 2003-07-24 | 2014-01-28 | Clozex Medical, Llc | Device for laceration or incision closure |
| US7838718B2 (en) * | 2003-07-24 | 2010-11-23 | Clozex Medical, Llc | Device for laceration or incision closure |
| US7414168B2 (en) * | 2003-07-24 | 2008-08-19 | Clozex Medical Llc | Device for laceration or incision closure |
| US20050021081A1 (en) * | 2003-07-24 | 2005-01-27 | Clozex Medical, Llc | Device for laceration or incision closure |
| US7354446B2 (en) * | 2003-07-24 | 2008-04-08 | Clozex Medical, Llc | Device for laceration or incision closure |
| DK1675536T3 (en) | 2003-09-17 | 2016-04-18 | Bsn Medical Gmbh | WOUND COMPOUND AND PROCEDURE FOR PREPARING IT |
| US7531711B2 (en) | 2003-09-17 | 2009-05-12 | Ossur Hf | Wound dressing and method for manufacturing the same |
| US20050070688A1 (en) * | 2003-09-26 | 2005-03-31 | 3M Innovative Properties Company | Reactive hydrophilic oligomers |
| US7332641B2 (en) * | 2003-10-10 | 2008-02-19 | Clozex Medical Llc | Interlaced compositions and methods of production |
| GB0325129D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus in situ |
| US7384984B2 (en) * | 2003-12-10 | 2008-06-10 | 3M Innovative Properties Company | Reactive hydrophilic oligomers |
| EP1711147B1 (en) * | 2004-01-27 | 2011-01-19 | Coloplast A/S | An absorbing article with zones of different surface properties |
| US20050163978A1 (en) * | 2004-01-27 | 2005-07-28 | Esben Strobech | Article having a surface showing adhesive properties |
| US7074839B2 (en) * | 2004-03-01 | 2006-07-11 | 3M Innovative Properties Company | Crosslinkable hydrophilic materials from reactive oligomers having pendent photoinitiator groups |
| US7342047B2 (en) * | 2004-03-02 | 2008-03-11 | 3M Innovative Properties Company | Crosslinkable hydrophilic materials from reactive oligomers having pendent unsaturated groups |
| US20050249791A1 (en) * | 2004-05-07 | 2005-11-10 | 3M Innovative Properties Company | Antimicrobial articles |
| US7563941B2 (en) | 2004-09-10 | 2009-07-21 | Clozex Medical, Llc | Modular wound dressing system |
| US7576256B2 (en) * | 2004-12-10 | 2009-08-18 | Abigo Medical Ab | Wound dressing with a bacterial adsorbing composition |
| US7335690B2 (en) * | 2005-01-25 | 2008-02-26 | 3M Innovative Properties Company | Crosslinkable hydrophilic materials from polymers having pendent Michael donor groups |
| US8609131B2 (en) * | 2005-01-25 | 2013-12-17 | 3M Innovative Properties Company | Absorbent dressing comprising hydrophilic polymer prepared via Michael reaction |
| CA2611224C (en) * | 2005-06-10 | 2014-01-21 | 3M Innovative Properties Company | Method for handling adhesive laminate sections |
| US20070038246A1 (en) * | 2005-08-09 | 2007-02-15 | Clozex Medical, Llc | Four component wound closure device with locking strip |
| US8105353B2 (en) | 2005-08-09 | 2012-01-31 | Clozex Medical, Llc | Wound closure kit and method of using the same |
| CN101257875A (en) | 2005-09-06 | 2008-09-03 | 泰科保健集团有限合伙公司 | Self contained wound dressing with micropump |
| BRPI0601479A (en) * | 2006-05-03 | 2007-12-18 | Johnson & Johnson Ind Ltda | adhesive bandage |
| US7779625B2 (en) | 2006-05-11 | 2010-08-24 | Kalypto Medical, Inc. | Device and method for wound therapy |
| US7981949B2 (en) * | 2006-05-23 | 2011-07-19 | 3M Innovative Properties Company | Curable hydrophilic compositions |
| CA2600249C (en) * | 2006-09-12 | 2014-05-20 | Tyco Healthcare Group Lp | Thin film dressing |
| ES2340085T5 (en) | 2006-09-28 | 2014-04-16 | Smith & Nephew, Inc. | Portable wound therapy system |
| EP3513820A1 (en) | 2007-03-14 | 2019-07-24 | The Board of Trustees of the Leland Stanford University | Devices for application of reduced pressure therapy |
| EP2027838A1 (en) * | 2007-08-20 | 2009-02-25 | Bio-Racer | Breathing sheet material having an adhesive coating layer and manufacturing method there for |
| ATE485797T1 (en) * | 2007-08-21 | 2010-11-15 | Lohmann Therapie Syst Lts | METHOD FOR MULTI-LINE ASSEMBLING TRANSDERMAL THERAPEUTIC PLASTERS |
| CA2702338C (en) | 2007-10-11 | 2016-11-08 | Spiracur, Inc. | Closed incision negative pressure wound therapy device and methods of use |
| GB2455962A (en) | 2007-12-24 | 2009-07-01 | Ethicon Inc | Reinforced adhesive backing sheet, for plaster |
| DK2252342T3 (en) * | 2008-02-14 | 2014-11-03 | Spiracur Inc | Devices and methods for treating damaged tissue |
| KR101608548B1 (en) | 2008-03-05 | 2016-04-01 | 케이씨아이 라이센싱 인코포레이티드 | Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site |
| US9033942B2 (en) | 2008-03-07 | 2015-05-19 | Smith & Nephew, Inc. | Wound dressing port and associated wound dressing |
| US8298200B2 (en) | 2009-06-01 | 2012-10-30 | Tyco Healthcare Group Lp | System for providing continual drainage in negative pressure wound therapy |
| JP5289862B2 (en) | 2008-08-28 | 2013-09-11 | 日東電工株式会社 | Patch |
| US20100055158A1 (en) * | 2008-08-28 | 2010-03-04 | Tyco Healthcare Group Lp | Environmentally Activated Compositions, Articles and Methods |
| US8617199B2 (en) * | 2008-09-30 | 2013-12-31 | 3M Innovative Properties Company | Thin film nasal dilator with delivery system |
| WO2010068502A1 (en) | 2008-11-25 | 2010-06-17 | Spiracur Inc. | Device for delivery of reduced pressure to body surfaces |
| US20100224205A1 (en) * | 2008-12-09 | 2010-09-09 | Shekhar Mitra | Device and methods for modifying keratinous surfaces |
| WO2010080907A1 (en) | 2009-01-07 | 2010-07-15 | Spiracur Inc. | Reduced pressure therapy of the sacral region |
| EP2373270B8 (en) | 2009-01-07 | 2023-04-12 | entrotech life sciences, inc. | Chlorhexidine-containing antimicrobial laminates |
| CA2749085A1 (en) * | 2009-01-16 | 2010-07-22 | The Procter & Gamble Company | Apparatus and methods for modifying keratinous surfaces |
| WO2010102146A1 (en) | 2009-03-04 | 2010-09-10 | Spiracur Inc. | Devices and methods to apply alternating level of reduced pressure to tissue |
| DK2416816T3 (en) | 2009-04-10 | 2014-12-01 | Spiracur Inc | Methods and devices for use of a treatment with negative pressure in a closed incision |
| US8444614B2 (en) | 2009-04-10 | 2013-05-21 | Spiracur, Inc. | Methods and devices for applying closed incision negative pressure wound therapy |
| JP6001449B2 (en) | 2009-06-16 | 2016-10-05 | スリーエム イノベイティブ プロパティズ カンパニー | Flexible adhesive medical article comprising a self-supporting substrate |
| US20100324516A1 (en) | 2009-06-18 | 2010-12-23 | Tyco Healthcare Group Lp | Apparatus for Vacuum Bridging and/or Exudate Collection |
| EP3520830B1 (en) | 2009-12-22 | 2023-10-18 | Smith & Nephew, Inc. | Apparatuses for negative pressure wound therapy |
| US8814842B2 (en) | 2010-03-16 | 2014-08-26 | Kci Licensing, Inc. | Delivery-and-fluid-storage bridges for use with reduced-pressure systems |
| US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
| USRE48117E1 (en) | 2010-05-07 | 2020-07-28 | Smith & Nephew, Inc. | Apparatuses and methods for negative pressure wound therapy |
| US8753322B2 (en) | 2010-08-10 | 2014-06-17 | Spiracur Inc. | Controlled negative pressure apparatus and alarm mechanism |
| US8795246B2 (en) | 2010-08-10 | 2014-08-05 | Spiracur Inc. | Alarm system |
| RU2582866C2 (en) | 2010-12-22 | 2016-04-27 | Смит Энд Нефью, Инк. | Device and method of wound healing with negative pressure |
| USD714433S1 (en) | 2010-12-22 | 2014-09-30 | Smith & Nephew, Inc. | Suction adapter |
| GB2488749A (en) | 2011-01-31 | 2012-09-12 | Systagenix Wound Man Ip Co Bv | Laminated silicone coated wound dressing |
| GB201106491D0 (en) | 2011-04-15 | 2011-06-01 | Systagenix Wound Man Ip Co Bv | Patterened silicone coating |
| CN107252383A (en) | 2011-07-14 | 2017-10-17 | 史密夫及内修公开有限公司 | Wound dressing and treatment method |
| EP2802304B1 (en) | 2011-12-16 | 2015-12-09 | KCI Licensing, Inc. | Releasable medical drapes |
| US10940047B2 (en) | 2011-12-16 | 2021-03-09 | Kci Licensing, Inc. | Sealing systems and methods employing a hybrid switchable drape |
| CA3122007A1 (en) | 2012-03-12 | 2013-09-19 | Smith & Nephew Plc | Reduced pressure apparatus and methods |
| US9987465B2 (en) | 2012-05-18 | 2018-06-05 | Medline Industries, Inc. | Window dressing having force concentrating adhesion elements |
| JP6400570B2 (en) | 2012-05-23 | 2018-10-10 | スミス アンド ネフュー ピーエルシーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ | Apparatus and method for local negative pressure closure therapy |
| JP6307504B2 (en) | 2012-08-01 | 2018-04-04 | スミス アンド ネフュー ピーエルシーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ | Wound dressing |
| BR112015002116A2 (en) | 2012-08-01 | 2017-08-22 | Smith & Nephew | WOUND DRESSING AND TREATMENT METHOD |
| WO2014035981A1 (en) | 2012-08-28 | 2014-03-06 | 3M Innovative Properties Company | Chlorhexidine gluconate compositions, resin systems and articles |
| SG11201503860RA (en) * | 2012-11-16 | 2015-06-29 | Kci Licensing Inc | Medical drape with pattern adhesive layers and method of manufacturing same |
| GB201222770D0 (en) | 2012-12-18 | 2013-01-30 | Systagenix Wound Man Ip Co Bv | Wound dressing with adhesive margin |
| JP5688121B2 (en) * | 2013-06-05 | 2015-03-25 | 日東電工株式会社 | Patch |
| EP3578209B1 (en) | 2013-08-26 | 2023-12-20 | 3M Innovative Properties Company | Dressing interface with moisture controlling feature and sealing function |
| US10946124B2 (en) | 2013-10-28 | 2021-03-16 | Kci Licensing, Inc. | Hybrid sealing tape |
| US9956120B2 (en) | 2013-10-30 | 2018-05-01 | Kci Licensing, Inc. | Dressing with sealing and retention interface |
| CN110652396B (en) | 2013-10-30 | 2021-11-23 | 3M创新知识产权公司 | Dressing with perforations of different sizes |
| WO2015065615A1 (en) | 2013-10-30 | 2015-05-07 | Kci Licensing, Inc. | Absorbent conduit and system |
| US10398814B2 (en) | 2013-10-30 | 2019-09-03 | Kci Licensing, Inc. | Condensate absorbing and dissipating system |
| US10561536B2 (en) | 2013-12-31 | 2020-02-18 | 3M Innovative Properties Company | Conformable drape cover dressing |
| WO2015130471A1 (en) | 2014-02-28 | 2015-09-03 | Kci Licensing, Inc. | Hybrid drape having a gel-coated perforated mesh |
| US11026844B2 (en) | 2014-03-03 | 2021-06-08 | Kci Licensing, Inc. | Low profile flexible pressure transmission conduit |
| WO2015161302A1 (en) | 2014-04-18 | 2015-10-22 | Entrotech Life Sciences, Inc. | Methods of processing chlorhexidine-containing polymerizable compositions and antimicrobial articles formed thereby |
| EP3137029B1 (en) | 2014-05-02 | 2020-09-09 | KCI Licensing, Inc. | Fluid storage devices, systems, and methods |
| EP2944565B1 (en) | 2014-05-13 | 2017-09-27 | Entrotech, Inc. | Erosion protective sleeve |
| US10561534B2 (en) | 2014-06-05 | 2020-02-18 | Kci Licensing, Inc. | Dressing with fluid acquisition and distribution characteristics |
| WO2015191821A2 (en) | 2014-06-13 | 2015-12-17 | The Procter & Gamble Company | Apparatus and methods for modifying keratinous surfaces |
| CA2949116C (en) | 2014-06-13 | 2018-11-06 | The Procter & Gamble Company | Apparatus and methods for modifying keratinous surfaces |
| US20160114349A1 (en) | 2014-06-13 | 2016-04-28 | The Procter & Gamble Company | Device and methods for depositing materials on hard surfaces |
| US10156036B2 (en) | 2014-06-13 | 2018-12-18 | The Procter & Gamble Company | Device and methods for applying compositions to fabric surfaces |
| US20150359714A1 (en) | 2014-06-13 | 2015-12-17 | The Procter & Gamble Company | Treatment compositions, apparatus and methods for modifying keratinous surfaces |
| JP6633001B2 (en) | 2014-06-13 | 2020-01-22 | ザ プロクター アンド ギャンブル カンパニーＴｈｅ Ｐｒｏｃｔｅｒ ＆ Ｇａｍｂｌｅ Ｃｏｍｐａｎｙ | Apparatus and method for modifying a keratinous surface |
| US10518291B2 (en) | 2014-06-13 | 2019-12-31 | The Procter & Gamble Company | Device and methods for modifying surfaces |
| US10188192B2 (en) | 2014-06-13 | 2019-01-29 | The Procter & Gamble Company | Apparatus and methods for modifying keratinous surfaces |
| US9522101B2 (en) | 2014-06-13 | 2016-12-20 | The Procter & Gamble Company | Cartridges for the deposition of treatment compositions on keratinous surfaces |
| US9949552B2 (en) | 2014-07-25 | 2018-04-24 | The Procter & Gamble Company | Handheld treatment apparatus for modifying keratinous surfaces |
| US10188193B2 (en) | 2014-07-25 | 2019-01-29 | The Procter & Gamble Company | Applicator heads for handheld treatment apparatus for modifying keratinous surfaces |
| US10314378B2 (en) | 2014-07-25 | 2019-06-11 | The Procter & Gamble Company | Cartridge assembly for a dispensing device |
| US11083880B2 (en) | 2014-07-25 | 2021-08-10 | The Procter & Gamble Company | Angled cartridge assembly for a dispensing device |
| US9955769B2 (en) | 2014-07-25 | 2018-05-01 | The Procter & Gamble Company | Applicator heads for handheld treatment apparatus for modifying keratinous surfaces |
| ES2921990T3 (en) | 2014-09-10 | 2022-09-05 | Bard Inc C R | Protective dressing for a medical device placed on the skin |
| US10398604B2 (en) | 2014-12-17 | 2019-09-03 | Kci Licensing, Inc. | Dressing with offloading capability |
| WO2016109418A1 (en) | 2014-12-30 | 2016-07-07 | 3M Innovative Properties Company | Wound dressing with multiple adhesive layers |
| EP3294245B1 (en) | 2015-05-08 | 2019-09-04 | KCI Licensing, Inc. | Low acuity dressing with integral pump |
| US11116302B2 (en) | 2015-06-11 | 2021-09-14 | The Procter & Gamble Company | Apparatus and methods for modifying keratinous surfaces |
| US9949547B2 (en) | 2015-06-11 | 2018-04-24 | The Procter & Gamble Company | Cartridges for use in an apparatus for modifying keratinous surfaces |
| JP6878314B2 (en) | 2015-06-11 | 2021-05-26 | ザ プロクター アンド ギャンブル カンパニーＴｈｅ Ｐｒｏｃｔｅｒ ＆ Ｇａｍｂｌｅ Ｃｏｍｐａｎｙ | Equipment and methods for applying the composition to the surface |
| US9962532B2 (en) | 2015-06-11 | 2018-05-08 | The Procter & Gamble Company | Cartridges for use in an apparatus for modifying keratinous surfaces |
| US10435590B2 (en) | 2015-06-19 | 2019-10-08 | 3M Innovative Properties Company | Segmented transfer tape and method of making and use thereof |
| WO2016205189A1 (en) | 2015-06-19 | 2016-12-22 | 3M Innovative Properties Company | Micro-optical assemblies including transparent substrates having graphic layer and method of making thereof |
| KR20180020221A (en) | 2015-06-19 | 2018-02-27 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Segmented and non-segmented transfer tape, articles therefrom, and methods of making and using the same |
| EP3741335B1 (en) | 2015-09-01 | 2023-05-24 | KCI Licensing, Inc. | Dressing with increased apposition force |
| EP3892310A1 (en) | 2015-09-17 | 2021-10-13 | 3M Innovative Properties Co. | Hybrid silicone and acrylic adhesive cover for use with wound treatment |
| USD804678S1 (en) | 2015-09-30 | 2017-12-05 | 3M Innovative Properties Company | Oval surgical drape with a retraction member |
| USD804677S1 (en) | 2015-09-30 | 2017-12-05 | 3M Innovative Properties Company | Surgical drape with a retraction member |
| US10391042B2 (en) | 2015-12-07 | 2019-08-27 | The Procter & Gamble Company | Treatment compositions, apparatus and methods for modifying keratinous surfaces |
| US9616668B1 (en) | 2015-12-07 | 2017-04-11 | The Procter & Gamble Company | Servicing cassettes for handheld fluid jet apparatuses for use in modifying surfaces |
| US10166799B2 (en) | 2015-12-07 | 2019-01-01 | The Procter & Gamble Company | Service stations for handheld fluid jet apparatuses |
| EP3281617B1 (en) * | 2016-08-10 | 2020-09-23 | Advanced Medical Solutions Limited | Wound dressing |
| GB2555584B (en) | 2016-10-28 | 2020-05-27 | Smith & Nephew | Multi-layered wound dressing and method of manufacture |
| KR102507247B1 (en) * | 2016-12-26 | 2023-03-06 | 메트로놈 헬스, 인크. | Adhesive system with strong adhesive outer ring and low effective modulus of elasticity |
| US10470935B2 (en) * | 2017-03-23 | 2019-11-12 | Ethicon, Inc. | Skin closure systems and devices of improved flexibility and stretchability for bendable joints |
| USD852368S1 (en) | 2017-03-27 | 2019-06-25 | Avery Dennison Corporation | Catheter dressing |
| US10945515B2 (en) | 2017-06-16 | 2021-03-16 | The Procter & Gamble Company | Personal care device with audible feedback |
| US11090238B2 (en) | 2017-06-16 | 2021-08-17 | The Procter & Gamble Company | Array of cosmetic compositions for camouflaging tonal imperfections |
| CA3064495C (en) | 2017-06-16 | 2022-08-30 | The Procter & Gamble Company | Computer asissted colorimetric make up method for camouflaging skin color deviations |
| DE102017131014A1 (en) * | 2017-12-21 | 2019-06-27 | Paul Hartmann Ag | Method for processing a substrate |
| GB201811449D0 (en) | 2018-07-12 | 2018-08-29 | Smith & Nephew | Apparatuses and methods for negative pressure wound therapy |
| USD921206S1 (en) | 2019-09-10 | 2021-06-01 | Medline Industries, Inc. | Window dressing |
| USD923182S1 (en) | 2019-09-10 | 2021-06-22 | Medline Industries, Inc. | Window dressing |
| USD921205S1 (en) | 2019-09-10 | 2021-06-01 | Medline Industries, Inc. | Window dressing |
| WO2021090136A1 (en) | 2019-11-04 | 2021-05-14 | 3M Innovative Properties Company | A reinforced adhesive substrate |
| EP3818968B1 (en) | 2019-11-05 | 2024-01-17 | 3M Innovative Properties Company | Adhesive medical article having fluid management properties |
| US20220387226A1 (en) * | 2019-11-20 | 2022-12-08 | 3M Innovative Properties Company | Medical tapes with high optical clarity when over-taped |
| GB202000574D0 (en) | 2020-01-15 | 2020-02-26 | Smith & Nephew | Fluidic connectors for negative pressure wound therapy |
| EP3939555A1 (en) | 2020-07-14 | 2022-01-19 | 3M Innovative Properties Company | Adhesive eyelid closure article |
| JP2023552590A (en) | 2020-12-11 | 2023-12-18 | スリーエム イノベイティブ プロパティズ カンパニー | Perforated tape for medical applications |
| EP4440378A1 (en) | 2021-12-03 | 2024-10-09 | The Procter & Gamble Company | Personal care device with audible feedback |
| US20230255279A1 (en) * | 2022-02-11 | 2023-08-17 | Abdallah ALASRAJ | Thighs protector |
| US20240238128A1 (en) * | 2023-01-13 | 2024-07-18 | Deroyal Industries, Inc. | Incision dressing |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1280631A (en) | 1917-10-03 | 1918-10-08 | Alfred Charles Atkinson | Device for heating metal-casting molds. |
| USRE24906E (en) | 1955-11-18 | 1960-12-13 | Pressure-sensitive adhesive sheet material | |
| US4112213A (en) | 1964-09-28 | 1978-09-05 | Johnson & Johnson | Pressure sensitive adhesive tapes and method of making same |
| US3389827A (en) | 1967-04-10 | 1968-06-25 | Minnesota Mining & Mfg | Easy-open container and sealing tape |
| GB1280631A (en) | 1968-07-09 | 1972-07-05 | Smith & Nephew | Adhesive materials |
| NO134790C (en) | 1968-07-09 | 1984-03-22 | Smith & Nephew | Kleber ,; PRESSURE SENSITIVE, WATERPUME-PERMEABLE PRODUCT FOR SKIN USE BY HUMANS. |
| US3811438A (en) * | 1972-03-30 | 1974-05-21 | G Economou | Adhesive tapes and bandages |
| US4263085A (en) | 1978-06-26 | 1981-04-21 | Ellis Jon P | Tape product for forming indicia, and process and apparatus for producing same, and products produced using such tape product |
| US4310509A (en) | 1979-07-31 | 1982-01-12 | Minnesota Mining And Manufacturing Company | Pressure-sensitive adhesive having a broad spectrum antimicrobial therein |
| US4323557A (en) | 1979-07-31 | 1982-04-06 | Minnesota Mining & Manufacturing Company | Pressure-sensitive adhesive containing iodine |
| DE3069183D1 (en) | 1979-11-28 | 1984-10-18 | Sida Soc Decoration Applic | Device for the localized distribution of electrifiable material and printing apparatus equipped with this device |
| ATE11870T1 (en) | 1980-03-05 | 1985-03-15 | Smith & Nephew Ass | ADHESIVES SUITABLE FOR USE ON THE SKIN. |
| CA1192825A (en) | 1980-11-10 | 1985-09-03 | Minnesota Mining And Manufacturing Company | Device and method for applying conformable, thin adhesive-coated films |
| US4472780A (en) | 1981-09-28 | 1984-09-18 | The Boeing Company | Fly-by-wire lateral control system |
| AU560088B2 (en) | 1982-04-08 | 1987-03-26 | Smith & Nephew Associated Companies Plc | Surgical adhesive dressing |
| US4537647A (en) * | 1982-10-06 | 1985-08-27 | The Boeing Company | Method for applying turbulators to wind tunnel models |
| DE3330866A1 (en) | 1983-08-26 | 1985-03-14 | Kufner Textilwerke GmbH, 8000 München | UPPER FABRIC FOR CLOTHING AND PRODUCTION PROCESS AND TRANSFER UNIT THEREFOR |
| US4579616A (en) | 1983-11-14 | 1986-04-01 | The Perkin-Elmer Corporation | Method of fabrication of an optically flat membrane |
| US4668602A (en) | 1984-08-17 | 1987-05-26 | Fuji Photo Film Co., Ltd. | Instant film unit |
| US4762766A (en) | 1986-01-14 | 1988-08-09 | Kroy Inc. | Dry transfer film with photosensitized color carrying layer and photosensitized pressure sensitive adhesive layer wherein photosensitizer is o-quinone diazide |
| US4759968A (en) | 1986-04-01 | 1988-07-26 | Minnesota Mining And Manufacturing Company | Transfer graphic article |
| US4919994A (en) | 1986-04-01 | 1990-04-24 | Minnesota Mining And Manufacturing Company | Dry transfer graphics article and methods of preparation and use thereof |
| US4795516A (en) | 1986-05-21 | 1989-01-03 | Minnesota Mining And Manufacturing Company | Method of continuous production of a biomedical electrode |
| US4824702A (en) | 1986-06-11 | 1989-04-25 | Straub Dale K | Transfer adhesive sheet material |
| US4737410A (en) | 1986-11-28 | 1988-04-12 | Minnesota Mining And Manufacturing Company | Polyalkyloxazoline-reinforced acrylic pressure-sensitive adhesive composition |
| JPH0816053B2 (en) * | 1986-12-04 | 1996-02-21 | 大正製薬株式会社 | Method of manufacturing patch |
| US4791284A (en) | 1987-10-29 | 1988-12-13 | Richard Ludden | Method for etching a bar code on metal |
| US4931282A (en) | 1987-11-25 | 1990-06-05 | Minnesota Mining And Manufacturing Company | Pressure-sensitive medical sealant |
| US4950699A (en) * | 1988-01-11 | 1990-08-21 | Genetic Laboratories, Inc. | Wound dressing incorporating collagen in adhesive layer |
| US4952618A (en) | 1988-05-03 | 1990-08-28 | Minnesota Mining And Manufacturing Company | Hydrocolloid/adhesive composition |
| CA1340190C (en) * | 1988-08-01 | 1998-12-15 | The Kendall Company | Discontinuous adhesive surface |
| US5088483A (en) | 1988-11-04 | 1992-02-18 | Minnesota Mining And Manufacturing Co. | Adhesive frame bandage |
| CA1320409C (en) * | 1988-11-04 | 1993-07-20 | Steven B. Heinecke | Adhesive frame bandage |
| CA2030593C (en) * | 1989-12-29 | 2002-03-26 | Donald H. Lucast | Multi-layered dressing |
| AU635414B2 (en) | 1990-04-18 | 1993-03-18 | Terumo Kabushiki Kaisha | Hollow fiber type liquid processing apparatus |
| US5092323A (en) | 1990-06-29 | 1992-03-03 | Hollister Incorporated | Moisture-absorbing, site-revealing adhesive dressing |
| US5160315A (en) | 1991-04-05 | 1992-11-03 | Minnesota Mining And Manufacturing Company | Combined adhesive strip and transparent dressing delivery system |
| EP0603208B1 (en) | 1991-09-12 | 1998-09-23 | Minnesota Mining And Manufacturing Company | Patterned pressure sensitive adhesive transfer tape |
| DK0612232T3 (en) * | 1991-11-06 | 1999-11-08 | Bioderm Inc | Closing wound dressing and applicator |
| US5276079A (en) | 1991-11-15 | 1994-01-04 | Minnesota Mining And Manufacturing Company | Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same |
| JPH068698A (en) * | 1992-06-26 | 1994-01-18 | Nitto Denko Corp | Transcription sheet for sticky body |
| JP3164654B2 (en) * | 1992-07-27 | 2001-05-08 | 日東電工株式会社 | Adhesive transfer device |
| JP3164655B2 (en) * | 1992-07-27 | 2001-05-08 | 日東電工株式会社 | Adhesive transfer method |
| DE4232279C1 (en) | 1992-09-25 | 1993-10-21 | Lohmann Therapie Syst Lts | Transfer process for the production of transdermal therapeutic systems |
| CA2104046C (en) | 1992-10-05 | 1998-09-15 | Yen-Lane Chen | Adhesive compositions, wound dressings and methods |
| DE4307889C2 (en) | 1993-03-12 | 1997-04-10 | Axel Donat | Process for the automatic weeding and transfer of computer-cut self-adhesive films and foils for carrying out the process |
| BR9405902A (en) | 1993-03-22 | 1995-12-26 | Minnesota Mining & Mfg | Composite adhesive bandage and manufacturing process |
| US5391249A (en) | 1993-11-01 | 1995-02-21 | Uarco Incorporated | Method and apparatus for producing internally apertured pressure-sensitive labels |
| FR2716534B1 (en) | 1994-02-22 | 1996-05-24 | Univ Nantes | Method and device for transient measurement of surface temperatures and fluxes. |
| JP2807729B2 (en) | 1994-10-14 | 1998-10-08 | 株式会社カトー精工 | Method and apparatus for manufacturing switch sheet |
| US5614310A (en) | 1994-11-04 | 1997-03-25 | Minnesota Mining And Manufacturing Company | Low trauma wound dressing with improved moisture vapor permeability |
| US5702753A (en) | 1994-11-22 | 1997-12-30 | Minnesota Mining And Manufacturing Company | Method of manufacturing a diagnostic electrode |
| US5741387A (en) * | 1995-08-15 | 1998-04-21 | Riverside Industries, Inc. | Lithographic printing process and transfer sheet |
| US5849325A (en) | 1996-10-07 | 1998-12-15 | Minnesota Mining And Manufacturing Company | Moisture-regulating adhesive dressing |
| DE19727032A1 (en) * | 1997-06-25 | 1999-01-07 | Hartmann Paul Ag | band Aid |
| US6136128A (en) * | 1998-06-23 | 2000-10-24 | Amerasia International Technology, Inc. | Method of making an adhesive preform lid for electronic devices |
| JP3557356B2 (en) * | 1998-11-04 | 2004-08-25 | 株式会社大塚製薬工場 | Patch for sanitary management of vascular catheter insertion site |
| CA2626268A1 (en) * | 2000-03-10 | 2001-09-20 | 3M Innovative Properties Company | Medical dressings with multiple adhesives and methods of manufacturing |
-
2000
- 2000-09-25 CA CA002626268A patent/CA2626268A1/en not_active Abandoned
- 2000-09-25 CA CA002400228A patent/CA2400228C/en not_active Expired - Fee Related
- 2000-09-25 DE DE60026343T patent/DE60026343T2/en not_active Expired - Lifetime
- 2000-09-25 EP EP00970475A patent/EP1267767B1/en not_active Expired - Lifetime
- 2000-09-25 BR BRPI0017149-2A patent/BR0017149B1/en not_active IP Right Cessation
- 2000-09-25 AU AU2000279849A patent/AU2000279849B2/en not_active Ceased
- 2000-09-25 JP JP2001566488A patent/JP4773026B2/en not_active Expired - Fee Related
- 2000-09-25 AT AT00970475T patent/ATE318566T1/en not_active IP Right Cessation
- 2000-09-25 AT AT05112185T patent/ATE556683T1/en active
- 2000-09-25 WO PCT/US2000/026090 patent/WO2001068021A1/en active IP Right Grant
- 2000-09-25 EP EP05112185A patent/EP1658833B1/en not_active Expired - Lifetime
- 2000-09-25 ES ES00970475T patent/ES2257330T3/en not_active Expired - Lifetime
- 2000-09-25 AU AU7984900A patent/AU7984900A/en active Pending
- 2000-09-25 MX MXPA02008606A patent/MXPA02008606A/en active IP Right Grant
-
2001
- 2001-03-06 TW TW090105134A patent/TW562669B/en not_active IP Right Cessation
- 2001-04-23 US US09/840,405 patent/US6461467B2/en not_active Expired - Lifetime
-
2002
- 2002-09-03 US US10/233,698 patent/US20030007999A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1658833B1 (en) | Method of manufacturing medical dressings with multiple adhesives | |
| AU2000279849A2 (en) | Medical dressings with multiple adhesives and methods of manufacturing | |
| AU2000279849A1 (en) | Medical dressings with multiple adhesives and methods of manufacturing | |
| US6436432B2 (en) | Absorbent pad dressing frame delivery system | |
| AU640116B2 (en) | One piece adhesive bandage and package unit | |
| US4753232A (en) | Adhesive wound dressings | |
| JP5080384B2 (en) | Packaged medical adhesive composite | |
| CA2635677C (en) | Thin film delivery system and method of manufacture | |
| CA1323269C (en) | Thin film surgical dressing with delivery system | |
| US5840052A (en) | Adhesive dressing applicator | |
| AU2010201213B2 (en) | Conformable wound dressing | |
| US20110208103A1 (en) | Disposable medical article with multiple adhesives for skin attachment | |
| JPS6187549A (en) | Adhesive dressing and it production and use | |
| GB2157955A (en) | Adhesive wound dressing | |
| WO2011081810A2 (en) | Packaged medical adhesive composite and method of delivering the composite | |
| EP0566816A1 (en) | Two-hand pouch patch application | |
| EP0675702B1 (en) | Adhesive dressing |