AU1906301A - Use of a buffer to prevent candida albicans infections on the skin - Google Patents
Use of a buffer to prevent candida albicans infections on the skin Download PDFInfo
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- AU1906301A AU1906301A AU19063/01A AU1906301A AU1906301A AU 1906301 A AU1906301 A AU 1906301A AU 19063/01 A AU19063/01 A AU 19063/01A AU 1906301 A AU1906301 A AU 1906301A AU 1906301 A AU1906301 A AU 1906301A
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- skin
- occlusive
- article
- buffering
- mucous membrane
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- 206010007134 Candida infections Diseases 0.000 title description 5
- 239000000872 buffer Substances 0.000 title description 2
- 241000222122 Candida albicans Species 0.000 claims description 17
- 239000002250 absorbent Substances 0.000 claims description 15
- 230000002745 absorbent Effects 0.000 claims description 15
- 230000003139 buffering effect Effects 0.000 claims description 15
- 229940095731 candida albicans Drugs 0.000 claims description 10
- 206010040880 Skin irritation Diseases 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 7
- 230000003902 lesion Effects 0.000 claims description 7
- 231100000344 non-irritating Toxicity 0.000 claims description 7
- 231100000252 nontoxic Toxicity 0.000 claims description 7
- 230000003000 nontoxic effect Effects 0.000 claims description 7
- 230000036556 skin irritation Effects 0.000 claims description 7
- 231100000475 skin irritation Toxicity 0.000 claims description 7
- 206010040882 skin lesion Diseases 0.000 claims description 7
- 231100000444 skin lesion Toxicity 0.000 claims description 7
- 230000003405 preventing effect Effects 0.000 claims description 5
- 230000007935 neutral effect Effects 0.000 claims description 3
- 239000011505 plaster Substances 0.000 claims description 3
- MBRHNTMUYWQHMR-UHFFFAOYSA-N 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one Chemical compound NCCO.ON1C(=O)C=C(C)C=C1C1CCCCC1 MBRHNTMUYWQHMR-UHFFFAOYSA-N 0.000 claims description 2
- 229940121375 antifungal agent Drugs 0.000 claims description 2
- 239000003429 antifungal agent Substances 0.000 claims description 2
- 229960004375 ciclopirox olamine Drugs 0.000 claims description 2
- 229960000988 nystatin Drugs 0.000 claims description 2
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 150000002460 imidazoles Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
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- 241000222120 Candida <Saccharomycetales> Species 0.000 description 9
- 238000009826 distribution Methods 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- 239000006172 buffering agent Substances 0.000 description 7
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- 229920001131 Pulp (paper) Polymers 0.000 description 2
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- 238000001727 in vivo Methods 0.000 description 2
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- 239000002985 plastic film Substances 0.000 description 2
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- 238000005070 sampling Methods 0.000 description 2
- 238000001629 sign test Methods 0.000 description 2
- 244000005714 skin microbiome Species 0.000 description 2
- 229920000247 superabsorbent polymer Polymers 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
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- 229920001817 Agar Polymers 0.000 description 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000031880 Intertrigo candida Diseases 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
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- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 206010053648 Vascular occlusion Diseases 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
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- 229910021641 deionized water Inorganic materials 0.000 description 1
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- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
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- 230000005808 skin problem Effects 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
WO 01/39582 PCT/SEOO/02165 Use of a buffer to prevent Candida albicans infections on the skin. The present application relates to using a substance capable of buffering within the pH range 2.0 - 5.5, for preparing a skin-occlusive or mucous membrane-occlusive 5 article for preventing skin irritations and lesions caused by Candida albicans. Ex amples of such articles are absorbent articles, such as diapers and sanitary napkins, wound dressings, such as bandages surgical tapes and plasters, gloves, prostheses and indwelling catheters. 10 Introduction Infections caused by Candida albicans may constitute a major problem in connec tion with using skin-occlusive, mucous membrane-occlusive and absorbent articles such as diapers, pantyliners, sanitary napkins and wound dressings. Candida albi 15 cans has been found to correlate with severity of diaper dermatitis (Benjamin L, Pe diatrician 1987, suppl. 1, p. 21 - 26). There are investigators that give C. Albicans a primary causative role in some expressions of diaper dermatitis (Leyden J and Klignan AM, Arch. Dermatol. 1978, vol 114, p. 56 - 59). 20 pH appears to be a major source of confusion and contradiction in the context of Candida ecology. Candid! carriage in vivo can occur readily over a broad range of pH. pH may be a factor of significance in the pathological status of C. albicans in vivo, but it does not exert its influence by affecting growth of the fungus, i.e. the rate of increase of its biomass (Odds FC, Candida and Candidosis. A review and ,25 bibliography. 2 "d ed. 1988, Bailliere Tindall). Dimorphism, the ability of C. albi cans to exist in a blastospore and a filamentous form, is reported to be influenced by pH (Buffo et al., Mycopathologia, vol. 85 (1984), p. 21-30; Odds (1988), supra). The blastospore form is favoured by slightly acidic pH and the filamentous form at neutral pH or above. Furthermore, it has been shown that microfilaments play an 30 important role during pH-regulated morphological transition (Yokoyama et al., Mi crobiology, vol. 140 (1994), p. 281-287). Clinical observations of diabetic patients, WO 01/39582 PCT/SEOO/02165 where a higher skin surface pH is possibly correlated to candidal intertrigo, have been reported (Yosipovitch et al., Diabetes Care, vol. 16 (1993), p. 560-563). As already mentioned, there is often a risk for infections, skin irritations and lesions when covering the skin or mucous membranes with absorbent articles, wound 5 dressings, plasters, gloves, prostheses and like articles. WO 98/57677 and EP 0 202 126 both disclose that a neutral or a slightly alkaline pH in connection with using absorbent articles may lead to skin irritation and problems with odorous substances. According to the documents these problems are caused by lipases and proteinases present on the skin and the problems can be overcome by decreasing the pH of the 10 absorbent article. The documents do not give any particular information about problems caused by Candida or how to reduce the virulence of Candida albicans. Summary of the invention 15 Now it has turned out that the virulence capability of Candida albicans can be sub stantially impaired by decreasing pH of a skin-occlusive or mucous membrane occlusive article to a value within the range from 2.0 to 5.5. Thus a skin-occlusive or mucous membrane-occlusive article such as an absorbent article (a diaper, a sanitary napkin, a pantyliner or a wound dressing, such as a bandage), a plaster, a 20 surgical tape, said article containing a pharmaceutically acceptable non-toxic and non-irritating substance capable of buffering within the pH range 2.0 - 5.5, is used to for preventing skin irritations and lesions caused by Candida albicans. Detailed description of the invention 25 Accordingly, the present invention relates to using an ingredient capable of buffer ing within the pH range 2.0 - 5.5, for preparing a skin-occlusive article for prevent ing skin irritations and lesions caused by Candida albicans. Any pharmaceutically acceptable, non-toxic and non-irritating ingredient capable of buffering within the 30 specified range can be used. Examples of suitable buffering ingredients are superab sorbent particles showing a level of neutralisation within the range of 20 - 50 %, 2 WO 01/39582 PCT/SEOO/02165 and pharmaceutically acceptable, non-toxic and non-irritating buffering solutions, such as organic salt buffering solutions, for example an acetate buffer or a citrate buffer. The buffering solution can be directly added to the skin-occlusive or mucous membrane-occlusive article. Alternatively, a pharmaceutically acceptable gel con 5 taining the buffering solution can be added. Examples of suitable gels include gels normally used for pharmaceutical purposes, such as agarose. An acid buffering substance according to the present invention is added to a skin occlusive article. As disclosed herein, the terms "skin-occlusive article" or "mucous 10 membrane-occlusive article" relates to an article, which is intended to cover the skin or mucous membranes of a person. A skin-occlusive article or mucous membrane occlusive article according to the present invention can be an absorbent article, such as a diaper, a sanitary napkin, a pantyliner or a wound dressing, a surgical tape, a plaster. gloves, prostheses or indwelling catheters. It is not critical for the invention 15 how the acid buffering substance is added, and accordingly it can be added to the skin-occlusive article in many different ways. Examples of suitable methods for adding the acid buffering substance to the skin occlusive article are administration of a solution containing the acid buffering substance, or administration of said sub stance as a powder or gel. The administration can be carried out in connection with 20 manufacturing said article or after said article has been manufactured. As disclosed herein, the term "pharmaceutically acceptable antifungal agent" relates to compounds normally used to treat Candida infections, such as imidazole deriva tives, nystatin and ciclopirox olamine. These compounds are added to the skin 25 occlusive or mucous membrane-occlusive article in amounts corresponding to com mon therapeutical doses. The present invention will now be described with reference to the enclosed figures and tables, in which: 30 3 WO 01/39582 PCT/SEOO/02165 Figure 1 shows an example of a diaper to which an acid buffering substance can be added in accordance with the invention; Figure 2 discloses the natural distribution of skin surface pH on volar forearms in 15 5 females. The observations are mean values of left and right arm; Figure 3 presents a diagram showing pH development of patch sites before, during and after wearing a patch buffered with an acid buffering substance and a regular reference patch; 10 Table I presents results from visual assessment of skin reaction to Candida albicans infection; and Table II shows growth of Candida albicans 24 hours after inoculation. 15 The diaper 100 disclosed in figure 1 comprises a liquid-permeable outer layer 1, for example made of a fibre fabric or a perforated plastic film, a liquid-impermeable outer layer 2, for example made of a plastic film or a hydrophobic fibre fabric, and finally an absorbent body 3 enclosed between the outer layers 1, 2. 20 The diaper is intended to surr6und the lower part of the trunk of the wearer like a pair of absorbing pants. It is therefore designed with two end parts 4, 5 as well as a narrower crutch part 6 between the end parts, which when the diaper is used is in tended to be arranged in the crutch of the wearer between the legs. In order to obtain 25 the desired pant design, adhesive flaps 7 are arranged close to the rear waist edge 8. Upon use, the adhesive flaps are fastened to the front part 5 of the diaper, close to the front waist edge 9, in order to hold the diaper together around the waist of the wearer. 30 Moreover, the diaper according to figure 1 comprises pretightened elastic means 10, which may consist of elastic strings, elastic threads, elastic foam or another suitable 4 WO 01/39582 PCT/SEOO/02165 material. The elastic means 10 are, for the sake simplicity, shown in outstreched condition. However, as soon as the stretching ceases they contract and form elastic bands in the diaper. 5 The absorbent body 3 in the example shown in figure 1 is formed by two layers 11,12, an upper liquid-receiving layer 11 and a lower layer 12 which spreads and distributes the liquid. The upper liquid-receiving layer must quickly be able to re ceive a large amount of liquid within a short amount of time, i.e. have a higher in stantaneous liquid absorption capability, but the lower storage and distribution layer 10 12 must have a high liquid distribution capability and be able to drain liquid out from the receiving layer 11 and distribute this liquid in the storage and distribution layer 12. The differences between the layers 11, 12 can be accomplished by density differences. A more compressed fibre structure distributes the liquid better than a corresponding fibre structure having a lower density. Such a low-density structure 15 has a higher instantaneous liquid absorption capability and a lower distribution ca pability due to its larger pore size. Different absorption capabilities can also be achieved by using different fibre structures having different characteristics. Thus chemically produced cellulose fluff pulp shows better distribution characteristics compared to, for instance, mechanically or chemi-thermomechanically produced 20 pulp, such as chemi-thermomechanical pulp (CTMP). A fibre structure containing chemically stiffened cellufose-fibres shows a higher instantaneous liquid absorption ability but a lower distribution ability compared to conventional chemical pulp. Other materials suitable as receiving layers 11 can be a wadding of natural fibres or a fluffy nonwoven material. 25 A partially neutralised superabsorbent is admixed in the upper liquid-receiving layer 11 of the absorbent body 3. This superabsorbent act as a acid buffering substance in accordance with the present invention. 30 A conventional superabsorbent is admixed in the lower liquid storage and distribu tion layer 12 of the absorbent body. It is advantageous to put a conventional super 5 WO 01/39582 PCT/SEOO/02165 absorbent in the lower liquid storage layer 12, because a conventional superabsorb ent has a higher total absorption capacity compared to a partially neutralised and pH-regulating superabsorbent. 5 Naturally, the invention also comprises other embodiments of the absorption body. The absorbent body may contain both partially neutralised superabsorbents and conventional superabsorbents, and both the superabsorbents can be equally distrib uted in both the upper and lower absorbent layers. Moreover, except for cellulose fluff pulp it is possible to only include one kind of superabsorbent material. In that 10 case, the superabsorbent material also acts as a pH-regulating substance in accor dance with the present invention. Experimental work 15 A study was carried out in order to determine whether different environmental pH affects Candida infections on skin. Fifteen female, healthy volunteers between 30 and 63 years of age (average 44.5 years) participated. The following routine proce dures and materials were used: 20 The experimental patches were made of common diaper materials and punched out as circular disks with a diameter of 70 mm. The outer side of polyethylene and the inner side (that will be placed towards the skin) of nonwoven polypropylene were glued together with a 10 mm edge around the inner circular core of 50 mm diameter. The inner core consisted of approximately 0.85 g cellulose pulp and approximately 25 0.15 g of superabsorbent polymer (IM 7100 and E127/97, Clairant GmbH, DE). The superabsorbent polymer was a polyacrylic acid, which was adjusted to either pH 4.5 or 6.0. It acts as a strong buffering system. 104 cells per ml C. albicans were sus pended in a physiological saline solution. 7 ml of this solution was added to each patch, 15 minutes before they were attached to the forearms. 30 6 WO 01/39582 PCT/SEOO/02165 Skin surface pH was measured with a Courage+Khazaka PH900, Mettler-Toledo flat electrode 304. Every morning and afternoon the instrument was calibrated at pH 4.0 and 7.0. The instrument accuracy is 0.1 units. A few drops of deionized water was added to the electrode before measurement and the average of three values was 5 recorded. The C. albicans strain used was type H29, kindly provided by Professor Lars Edebo, Department of Microbiology, Sahlgrenska University Hospital, GOteborg, SE. Cells were grown on Sabouraud's glucose agar at 37*C for 24 hours before use. 10 A modification of the Williamson-Kligman scrub technique was used for assess ment of the resident skin microflora and the added C. albicans. A stainless steel ring with an internal diameter of 2.6 cm and covering a skin area of 5.5 cm2 was used. One millimetre of sterile 0.075 M phosphate buffer (pH 7.9) containing 0.1% Triton 15 X-100 was poured into the ring, and the skin was gently rubbed with a blunt sterile glass rod for one minute and the fluid was removed with a Pasteur pipette (Faerge mann J. Mapping the Fungi of the Skin. Handbook of Non-invasive Methods and the Skin, chapter 10.2, CRC Press, 1995). Serial dilutions were performed in PBS and samples from the dilutions were plated out. Plates were incubated at 37*C and 20 read after 48h. The paired t test was used to test for statistical significance between pH differences, differences in number of Candida organisms. The differences in observed skin le 25 sions were tested by a sign test. At the start of the trial, skin microflora was determined with the scrub test. All sub jects had coagulase-negative Staphylococci (range 170-25000 colony-forming units (cfu)). Two of the subjects had Diphteroid sp (range 50 -2400 cfu). Four subjects had Bacillus sp (range 10-1200 cfu). One subject had S. aureus on one arm (10 cfu). 7 WO 01/39582 PCT/SEOO/02165 The amounts are given in colony-forming units per 5.5 cm 2 skin. No growth of C. albicans was found in any subject before the trial. The skin surface pH of the 15 volunteers was measured at the start and varied be 5 tween 4.5 and 6.0. The mean value was 5.2. The results are shown in figure 2. Patches preloaded with a Candida suspension (104 cells/ml) were taped to the fore arms of the volunteers. The patches had two different pH-values and were randomly placed on either left or right arm. The patches were worn under strict occlusion for 10 24 hours. The patches were removed, and after approximately 2 minutes pH values of the skin was measured. When the patches were removed after 24 hours of occlu sion the pH was 5.1 +/- 0.18 and 5.7 +/-0.29 (mean +/- SD) at the two respective sites. The difference is statistically significant at p<0.0001. The skin was visually examined and was sampled to determine the number of cfu of Candida in an area of 15 5.5 cm 2 . The summarised results are shown in table II. No statistically significant difference (P=0.64) was found between the "acidic" site and the reference site. Growth was found on both arms in 13 subjects. In one subject growth was found only on the "acidic" site, and in one subject only on the reference site. 20 After 48 hours, the pH measurements as well as the Candida sampling were re peated. The results of the pHineasurements are disclosed in figure 3. The results of the Candida samplings after 48 hours, i.e. 24 hours after the patches had been re moved and the lesions had become visually evident, show that 9 subjects had no growth at all of C. albicans. Three subjects showed low numbers (10-130 cfu) and 25 one subject had an increased growth since the day before (1400 and 4300 cfu on re spective arms). Two subjects were missing on this occasion, and accordingly no mi crobial data could be obtained. The skin lesions were visually assessed. No reaction = 0; faint reaction = 1; evident 30 reaction = 2; strong reaction = 3. The reading was blinded and the patch type un known to the assessor. The skin reactions were also recorded on photographs. This 8 WO 01/39582 PCT/SEOO/02165 visual assessment of skin reactions gave a very clear result. The acidic site had less severe reactions than the reference site in all 14 subjects that reacted. The sign test shows a statistically significant difference at p<O.001 for difference in reaction at the two sites. The detailed result is presented in table I. 5 Consequently, the pH-induced differences turned out not to be due to inhibited growth of Candida albicans. They are probably due to a pH influence of the viru lence capacity of the fungus and/or an improvement of the host's defence ability. 9
Claims (7)
1. Use of a pharmaceutically acceptable, non-toxic and non-irritating ingredient ca pable of buffering within the pH range 2.0 - 5.5, for preparing a skin-occlusive 5 article or a mucous membrane-occlusive article for preventing skin irritations and lesions caused by Candida albicans.
2. Use of a pharmaceutically acceptable, non-toxic and non-irritating ingredient ca pable of buffering within the pH range 2.0 - 5.5, together with a pharmaceutically 10 acceptable antifungal agent such as an imidazole derivative, nystatin and ciclopirox olamine, for preparing a skin-occlusive article or a mucous membrane-occlusive ar ticle for preventing skin irritations and lesions caused by Candida albicans.
3. Use according to claim 1 or claim 2, characterised in that the pharmaceutically 15 acceptable, non-toxic and non-irritating buffering ingredient is a partially neutral ised superabsorbent.
4. Use according to claim 1 or claim 2, characterised in that the pharmaceutically acceptable non-toxic and non-irritating buffering ingredient is an organic acid 20 salt buffering solution.
5. Use according to anyone of claims 1 - 4 for preparing a skin-occlusive or mucous membrane-occlusive article, which is an absorbent article such as a diaper, a sani tary napkin, or a pantyliner. 25
6. Use according to anyone of claims 1 - 4 for preparing a skin-occlusive or mucous membrane-occlusive article which is a wound dressing, a plaster, a surgical tape, or a like article. 10 WO 01/39582 PCT/SEOO/02165
7. Use according to anyone of claims 1 - 4 for preparing a skin-occlusive article or a mucous membrane-occlusive article, which is a glove, a prosthesis, or an in dwelling catheter. 11
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9904387A SE521431C2 (en) | 1999-12-02 | 1999-12-02 | Use of a pH buffering substance to prevent skin infections caused by Candida Albicans |
SE9904387 | 1999-12-02 | ||
PCT/SE2000/002165 WO2001039582A1 (en) | 1999-12-02 | 2000-11-06 | Use of a buffer to prevent candida albicans infections on the skin |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1906301A true AU1906301A (en) | 2001-06-12 |
AU778633B2 AU778633B2 (en) | 2004-12-16 |
Family
ID=20417954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU19063/01A Ceased AU778633B2 (en) | 1999-12-02 | 2000-11-06 | Use of a buffer to prevent candida albicans infections on the skin |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1233746A1 (en) |
JP (1) | JP2003515544A (en) |
KR (1) | KR20020060249A (en) |
AU (1) | AU778633B2 (en) |
BR (1) | BR0016005A (en) |
CA (1) | CA2392102A1 (en) |
CO (1) | CO5251413A1 (en) |
MX (1) | MXPA02005211A (en) |
PL (1) | PL355410A1 (en) |
RU (1) | RU2002117294A (en) |
SE (1) | SE521431C2 (en) |
SK (1) | SK7882002A3 (en) |
WO (1) | WO2001039582A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274154B1 (en) | 1999-04-07 | 2001-08-14 | Belle L Chou | Aloe Vera glove and manufacturing method |
US6630152B2 (en) | 1999-04-07 | 2003-10-07 | Shen Wei (Usa), Inc. | Aloe vera glove and manufacturing method |
EP1354586A1 (en) * | 2002-04-20 | 2003-10-22 | Aventis Pharma Deutschland GmbH | The use of hydroxpyridone-derivatives in wound healing |
US20030204893A1 (en) * | 2002-05-02 | 2003-11-06 | Chou Belle L. | Elastomeric flexible article and manufacturing method |
US9757285B2 (en) | 2011-03-07 | 2017-09-12 | Edgewell Personal Care Brands, Llc | Absorbent article including a buffer composition |
DE102011106046A1 (en) | 2011-06-30 | 2013-01-03 | Paul Hartmann Ag | Wound Care Product |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3794034A (en) * | 1973-02-27 | 1974-02-26 | J Jones | Odor reductant body waste pad |
PH23760A (en) * | 1985-05-15 | 1989-11-03 | Procter & Gamble | Disposable absorbent articles |
US4842593A (en) * | 1987-10-09 | 1989-06-27 | The Procter & Gamble Company | Disposable absorbent articles for incontinent individuals |
AU6044094A (en) * | 1994-01-17 | 1995-08-01 | Carlo Alfredo Graziani | Napkin with buffer substance |
SE511838C2 (en) * | 1997-06-17 | 1999-12-06 | Sca Hygiene Prod Ab | Reduction of undesirable side effects when using absorbent articles by means of pH control |
PL340606A1 (en) * | 1997-10-22 | 2001-02-12 | Jens Ponikau | Methods of and materials for treating and preventing mucositis |
AU3082099A (en) * | 1998-03-12 | 1999-09-27 | Procter & Gamble Company, The | Proton donating actives in absorbent articles |
-
1999
- 1999-12-02 SE SE9904387A patent/SE521431C2/en not_active IP Right Cessation
-
2000
- 2000-11-06 EP EP00981984A patent/EP1233746A1/en not_active Withdrawn
- 2000-11-06 CA CA002392102A patent/CA2392102A1/en not_active Abandoned
- 2000-11-06 WO PCT/SE2000/002165 patent/WO2001039582A1/en active IP Right Grant
- 2000-11-06 AU AU19063/01A patent/AU778633B2/en not_active Ceased
- 2000-11-06 JP JP2001541326A patent/JP2003515544A/en active Pending
- 2000-11-06 SK SK788-2002A patent/SK7882002A3/en unknown
- 2000-11-06 BR BR0016005-9A patent/BR0016005A/en not_active Application Discontinuation
- 2000-11-06 RU RU2002117294/15A patent/RU2002117294A/en unknown
- 2000-11-06 MX MXPA02005211A patent/MXPA02005211A/en active IP Right Grant
- 2000-11-06 KR KR1020027007092A patent/KR20020060249A/en not_active Application Discontinuation
- 2000-11-06 PL PL00355410A patent/PL355410A1/en not_active Application Discontinuation
- 2000-12-01 CO CO00092011A patent/CO5251413A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2003515544A (en) | 2003-05-07 |
SK7882002A3 (en) | 2002-12-03 |
CA2392102A1 (en) | 2001-06-07 |
KR20020060249A (en) | 2002-07-16 |
MXPA02005211A (en) | 2002-12-09 |
PL355410A1 (en) | 2004-04-19 |
AU778633B2 (en) | 2004-12-16 |
SE9904387D0 (en) | 1999-12-02 |
BR0016005A (en) | 2002-07-30 |
CO5251413A1 (en) | 2003-02-28 |
EP1233746A1 (en) | 2002-08-28 |
SE521431C2 (en) | 2003-11-04 |
WO2001039582A1 (en) | 2001-06-07 |
SE9904387L (en) | 2001-06-03 |
RU2002117294A (en) | 2004-01-27 |
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