AU1889495A - Vector for liver-specific gene therapy - Google Patents

Vector for liver-specific gene therapy

Info

Publication number
AU1889495A
AU1889495A AU18894/95A AU1889495A AU1889495A AU 1889495 A AU1889495 A AU 1889495A AU 18894/95 A AU18894/95 A AU 18894/95A AU 1889495 A AU1889495 A AU 1889495A AU 1889495 A AU1889495 A AU 1889495A
Authority
AU
Australia
Prior art keywords
die
der
vektor
gentherapie
einem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU18894/95A
Inventor
Christian Hofmann
Volker Sandig
Michael Strauss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Publication of AU1889495A publication Critical patent/AU1889495A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Abstract

Die Erfindung betrifft einen Vektor für die leberspezifische Gentherapie; Anwendungsgebiete sind die Medizin und die Gentechnik. Ziel der Erfindung ist die Konstruktion eines Vektors, der Leberzellen hochspezifisch findet, von den Zellen effektiv aufgenommen wird und auch mehrere bzw. sehr grosse therapeutische Gene aufnehmen kann. Der Vektor soll für die Gentherapie beim Menschen einsetzbar sein. Der erfindungsgemässe Vektor besteht aus einem Insektenvirus, vorzugsweise einem Vertreter der Baculoviren oder einem nuklearen Polyhedrosis-Virus, welches die Komponenten eine therapeutische DNA-Sequenz, einen für die Genexpression in der Leber geeigneten Promoter und ggf. eine Etablierungssequenz enthält.
AU18894/95A 1994-03-04 1995-02-28 Vector for liver-specific gene therapy Abandoned AU1889495A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4407859A DE4407859C1 (en) 1994-03-04 1994-03-04 Vector for liver-specific gene therapy
DE4407859 1994-03-04
PCT/DE1995/000333 WO1995023866A1 (en) 1994-03-04 1995-02-28 Vector for liver-specific gene therapy

Publications (1)

Publication Number Publication Date
AU1889495A true AU1889495A (en) 1995-09-18

Family

ID=6512269

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18894/95A Abandoned AU1889495A (en) 1994-03-04 1995-02-28 Vector for liver-specific gene therapy

Country Status (6)

Country Link
EP (1) EP0746624B1 (en)
JP (1) JPH10501402A (en)
AT (1) ATE211178T1 (en)
AU (1) AU1889495A (en)
DE (1) DE4407859C1 (en)
WO (1) WO1995023866A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871986A (en) 1994-09-23 1999-02-16 The General Hospital Corporation Use of a baculovirus to express and exogenous gene in a mammalian cell
AU702830B2 (en) * 1994-09-23 1999-03-04 General Hospital Corporation, The Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell
WO1998012311A2 (en) 1996-09-11 1998-03-26 The General Hospital Corporation Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell
US6183993B1 (en) 1996-09-11 2001-02-06 The General Hospital Corporation Complement-resistant non-mammalian DNA viruses and uses thereof
JP2001508645A (en) 1996-09-11 2001-07-03 ザ ジェネラル ホスピタル コーポレーション Non-mammalian DNA virus with altered coat protein
ES2136583T1 (en) * 1996-10-18 1999-12-01 Canji Inc PROCEDURES AND COMPOSITIONS FOR THE SUPPLY AND EXPRESSION OF INTERFERON ALPHA NUCLEIC ACIDS.
DE19735593C2 (en) * 1997-08-15 1999-08-26 Hepavec Ag Fuer Gentherapie Coat protein-modified baculovirus vector for gene therapy
EP1232276B8 (en) * 1999-11-16 2007-06-27 Genzyme Corporation Vectors and transgenes with regulatory elements for gene delivery to the liver
GB0206357D0 (en) * 2002-03-18 2002-05-01 Univ Bath Cells
JP7244547B2 (en) 2018-02-19 2023-03-22 ホモロジー・メディシンズ・インコーポレイテッド Adeno-associated virus compositions and methods of use thereof for restoring F8 gene function
TW202140791A (en) 2020-01-13 2021-11-01 美商霍蒙拉奇醫藥公司 Methods of treating phenylketonuria

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004687A (en) * 1985-05-21 1991-04-02 University Of Georgia Research Foundation, Inc. Insect virus vector with broadened host range
JPH03500482A (en) * 1987-06-16 1991-02-07 オハイオ ユニバーシティ Regulation of foreign gene expression in transgenic animals by diet and hormones under the control of the promoter of the gene related to phosphoenolpyruvate carboxykinase
FR2650838A1 (en) * 1989-08-09 1991-02-15 Transgene Sa FACTOR IX EXPRESSION VECTORS IN A SUPERIOR EUKARYOTE CELL, PROCESS FOR THE PREPARATION OF FACTOR IX BY TRANSGENIC ANIMALS, AND FACTOR IX OBTAINED
DE4339922C1 (en) * 1993-09-03 1994-10-06 Max Planck Gesellschaft Vector for gene therapy of the liver

Also Published As

Publication number Publication date
DE4407859C1 (en) 1995-03-02
ATE211178T1 (en) 2002-01-15
EP0746624A1 (en) 1996-12-11
WO1995023866A1 (en) 1995-09-08
EP0746624B1 (en) 2001-12-19
JPH10501402A (en) 1998-02-10

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