ATE90T1 - DIAGNOSTIC AGENT FOR THE DETECTION OF LEUKOCYTES IN BODY FLUID AND AS CHROMOGENIC SULPHONE PHTHALEIN ESTERS SUITABLE FOR THEREFORE, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE FOR THE MANUFACTURE OF DIAGNOSTIC AGENT FOR DETECTING LEUKOCYTES IN BODY FLUID. - Google Patents

DIAGNOSTIC AGENT FOR THE DETECTION OF LEUKOCYTES IN BODY FLUID AND AS CHROMOGENIC SULPHONE PHTHALEIN ESTERS SUITABLE FOR THEREFORE, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE FOR THE MANUFACTURE OF DIAGNOSTIC AGENT FOR DETECTING LEUKOCYTES IN BODY FLUID.

Info

Publication number
ATE90T1
ATE90T1 AT79101828T AT79101828T ATE90T1 AT E90 T1 ATE90 T1 AT E90T1 AT 79101828 T AT79101828 T AT 79101828T AT 79101828 T AT79101828 T AT 79101828T AT E90 T1 ATE90 T1 AT E90T1
Authority
AT
Austria
Prior art keywords
leukocytes
diagnostic agent
body fluid
detection
sulphone
Prior art date
Application number
AT79101828T
Other languages
German (de)
Inventor
Dieter Dr. Berger
Franz Dr. Braun
Guenter Frey
Werner Dr. Guethlein
Wolfgang Dr. Werner
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Application granted granted Critical
Publication of ATE90T1 publication Critical patent/ATE90T1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Diagnostic agent for the detection of leukocytes in body fluids, comprising an absorbent carrier which is impregnated with a chromogen and a buffer substance, wherein the chromogen is a sulfonphthalein ester of the formula <IMAGE> wherein R1 is a carboxylic acid residue optionally substituted by halogen or lower alkoxy; or is an amino acid or peptide residue having a nitrogen protective group; R2 is a halogen atom or a lower alkyl radical; and R3 and R4 are individually selected from hydrogen and halogen. Certain of the chromogen are provided as novel compounds.
AT79101828T 1978-06-20 1979-06-08 DIAGNOSTIC AGENT FOR THE DETECTION OF LEUKOCYTES IN BODY FLUID AND AS CHROMOGENIC SULPHONE PHTHALEIN ESTERS SUITABLE FOR THEREFORE, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE FOR THE MANUFACTURE OF DIAGNOSTIC AGENT FOR DETECTING LEUKOCYTES IN BODY FLUID. ATE90T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782826965 DE2826965A1 (en) 1978-06-20 1978-06-20 DIAGNOSTIC AGENT FOR DETECTING LEUCOCYTES IN BODY LIQUIDS AND CHROMOGENES SUITABLE FOR THIS
EP79101828A EP0007407B1 (en) 1978-06-20 1979-06-08 Diagnostic composition for the detection of leukocytes in body fluids, sulfophthalein esters as chromogens used for this composition, method of their preparation and their use for preparing diagnostic compositions

Publications (1)

Publication Number Publication Date
ATE90T1 true ATE90T1 (en) 1981-07-15

Family

ID=6042236

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101828T ATE90T1 (en) 1978-06-20 1979-06-08 DIAGNOSTIC AGENT FOR THE DETECTION OF LEUKOCYTES IN BODY FLUID AND AS CHROMOGENIC SULPHONE PHTHALEIN ESTERS SUITABLE FOR THEREFORE, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE FOR THE MANUFACTURE OF DIAGNOSTIC AGENT FOR DETECTING LEUKOCYTES IN BODY FLUID.

Country Status (10)

Country Link
US (1) US4331760A (en)
EP (1) EP0007407B1 (en)
JP (1) JPS552992A (en)
AT (1) ATE90T1 (en)
CA (1) CA1129848A (en)
CS (1) CS220789B2 (en)
DE (2) DE2826965A1 (en)
HU (1) HU179435B (en)
YU (1) YU142679A (en)
ZA (1) ZA793037B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2905531A1 (en) * 1979-02-14 1981-01-08 Boehringer Mannheim Gmbh DIAGNOSTIC AGENT FOR DETECTING LEUCOCYTES IN BODY LIQUIDS
US4537718A (en) * 1982-10-26 1985-08-27 Columbia University In The City Of New York Impermeant spectroscopic probes
US4610961A (en) * 1982-12-27 1986-09-09 Eastman Kodak Company Inhibition of reduction activities of leukocytes
DE3413120A1 (en) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. ANALYSIS METHOD AND MEANS FOR DETECTING ESTEROLYTIC AND / OR PROTEOLYTIC ENZYMS
DE3413118A1 (en) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. ANALYSIS METHOD AND MEANS FOR DETECTING ESTEROLYTIC AND / OR PROTEOLYTIC ENZYMS
DE3412939A1 (en) * 1984-04-06 1985-10-17 Behringwerke Ag, 3550 Marburg SUBSTRATES FOR HYDROLASES, METHOD FOR THEIR PRODUCTION AND THEIR USE
US5384411A (en) * 1991-06-20 1995-01-24 Hewlett-Packard Company Immobilization of PH-sensitive dyes to solid supports
EP0618980A1 (en) * 1991-12-09 1994-10-12 Abbott Laboratories Colorimetric determination of peroxidase and peroxide
AU6352296A (en) * 1995-07-20 1997-02-18 Advanced Bioconcept, Inc. Cell sorting with fluorescent peptides
US6815423B1 (en) 1995-07-20 2004-11-09 Perkinelmer Las, Inc. Fluorescent substance P
WO2000063423A2 (en) * 1999-04-16 2000-10-26 Zymetx, Inc. Viral detection method using viral encoded enzymes and chemiluminescent substrates
US20030147777A1 (en) * 2002-01-23 2003-08-07 Ghanekar Vinay D. Test composition and device for the determination of cyanuric acid in water
US7727206B2 (en) * 2005-12-27 2010-06-01 Gorres Geoffrey H Device for monitoring a patient for a urinary tract infection
FR2949113B1 (en) * 2009-08-11 2012-04-13 Advanced Accelerator Applic SULTON-BASED COMPOUNDS, DERIVATIVES THEREOF SUITED BY NUCLEOPHILES, IN PARTICULAR RADIONUCLEIDS, METHODS AND APPLICATIONS
CN112964704B (en) * 2021-02-04 2024-03-22 甘肃润达药业有限公司 Ledebouriella lactone detection test paper, color chart and rapid detection method

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA722579A (en) * 1965-11-30 L. Babson Arthur Diagnostic preparation for the determination of serum alkaline phosphatase
US1786611A (en) * 1928-04-04 1930-12-30 Hynson Westcott & Dunning Inc Halogenated sulphone phthaleins
CH409198A (en) * 1957-08-17 1966-03-15 Svoboda Vlastimil Process for the preparation of substituted sulfonphthalein dyes
US3087794A (en) * 1960-05-23 1963-04-30 Miles Lab Chemical test for differentiating leucocytes from erythrocytes
CH397921A (en) * 1960-11-21 1965-08-31 Ciba Geigy Process for the production of sulfur dyes
GB1128371A (en) * 1965-10-04 1968-09-25 Miles Lab Diagnostic composition
CH506792A (en) * 1968-09-20 1971-04-30 Merck Ag E New means and method for lipase determination
US3741875A (en) * 1970-10-30 1973-06-26 Mount Sinai Res Foundation Inc Process and apparatus for obtaining a differential white blood cell count
JPS5338621B1 (en) * 1971-03-08 1978-10-17
JPS5342438B2 (en) * 1974-05-20 1978-11-11
US4045290A (en) * 1975-02-28 1977-08-30 Princeton Biomedix Incorporated Diagnostic method and compounds for use therewith
US4022667A (en) * 1975-09-22 1977-05-10 The University Of Alabama Substrate solution for carboxylic ester hydrolase determination
US4046514A (en) * 1976-11-24 1977-09-06 Miles Laboratories, Inc. Test device and method for determining a component in a sample

Also Published As

Publication number Publication date
CA1129848A (en) 1982-08-17
JPS631347B2 (en) 1988-01-12
DE2960421D1 (en) 1981-09-24
YU142679A (en) 1983-04-30
US4331760A (en) 1982-05-25
JPS552992A (en) 1980-01-10
EP0007407A1 (en) 1980-02-06
ZA793037B (en) 1980-07-30
EP0007407B1 (en) 1981-06-17
CS220789B2 (en) 1983-04-29
HU179435B (en) 1982-10-28
DE2826965A1 (en) 1980-01-17

Similar Documents

Publication Publication Date Title
ATE90T1 (en) DIAGNOSTIC AGENT FOR THE DETECTION OF LEUKOCYTES IN BODY FLUID AND AS CHROMOGENIC SULPHONE PHTHALEIN ESTERS SUITABLE FOR THEREFORE, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE FOR THE MANUFACTURE OF DIAGNOSTIC AGENT FOR DETECTING LEUKOCYTES IN BODY FLUID.
SE8702158L (en) IMIDAZOKINOLINYLETER DERIVATIVES
ATE43640T1 (en) COMPOSITION AND TEST DEVICE FOR DETECTING LEUKOCYTES, ESTERASE AND PROTEASE IN A TEST SAMPLE.
ATE66676T1 (en) PROCESS FOR THE MANUFACTURE OF 1TRIAZOLYLETHYLETHER DERIVATIVES, AS WELL AS MICROBICIDES CONTAINING NEW 1-TRIAZOLYL-PHENOXYPHENYLETHYLETHER DERIVATIVES AS ACTIVE SUBSTANCES AND THEIR USE.
DE69013882D1 (en) Composition, device and method for examining a peroxidatively active substance.
ATE48157T1 (en) A COMPOSITION AND TEST DEVICE CONTAINING A ZWITTERION AS A BINDING AGENT FOR THE DETECTION OF LEUKOCYTES.
ATE22115T1 (en) MEANS AND METHODS FOR DETECTING HYDROGEN PEROXIDE OR PEROXIDASES.
ATE69239T1 (en) OLIGOPEPTIDYLNITRILE DERIVATIVES, AGENTS CONTAINING THEM, PROCESSES FOR THEIR PREPARATION AND THEIR USE.
DE3650518D1 (en) Beta-lactam antibiotics, process for their preparation and their use as and in medicinal products
ATE10139T1 (en) DIAGNOSTIC AGENT FOR THE DETECTION OF LEUKOCYTES IN BODY FLUID AND AS CHROMOGENIC AZO DYE ESTERS SUITABLE FOR THEREFORE, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE FOR THE MANUFACTURE OF DIAGNOSTIC AGENT FOR DETECTING LEUKOCYTES IN BODY FLUID.
IL66353A0 (en) Imidazoline derivatives,processes for their preparation and pharmaceutical preparations containing the same
NO831566L (en) ESTERASE ACTIVITY TEST IN A LIQUID TEST.
IT1132593B (en) WINDING BODY OF YARNS (FOCACCIA) AS WELL AS PROCEDURE AND DEVICE FOR ITS SETTING UP
ATE40823T1 (en) USE OF SOLVENTS IN THE PREPARATION OF S-TRIAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION OF S-TRIAZINE DERIVATIVES.
ATE73782T1 (en) METHOD AND REAGENT FOR THE DETERMINATION OF SUBSTRATES OR ENZYME ACTIVITIES.
ES525256A0 (en) PROCEDURE FOR OBTAINING 2-NITRO-1,1-ETENDIAMINES
ATE55132T1 (en) SUBSTITUTED 6-HYDROXYMETHYLCARBAPENEMANTIBIOTICS, PROCESSES FOR THEIR PREPARATION AND THEIR USE.
DE69331377D1 (en) METHOD AND COMPOSITIONS FOR DIAGNOSIS OF CAT SCRATCH DISEASE AND BACTERIAL ANGIOMATOSIS
ATE28636T1 (en) PYRIDAZINONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS FUNGICIDES.
ATE3992T1 (en) MEANS FOR DETECTING PEROXIDICALLY ACTIVE SUBSTANCES AND USE OF POLYVINYLMETHYLACYLAMIDE IN SUCH.
DE69105661D1 (en) (Meth) acrylic acid esters containing thiocyanate group, process for their preparation and their use in the production of new polymers.
ATE4536T1 (en) INDAN-4-YL-N-ALKYL-CARBAMINE, PROCESS FOR THEIR PREPARATION AND USE AS FUNGICIDES.
DK149450C (en) PROCEDURE FOR THE PREPARATION OF 4-HYDROXYQUINOLINES
ATE554T1 (en) PROCESS FOR THE PREPARATION OF 4-AMINO-DIPHENYLAMINES.
SE8402305D0 (en) SETTLE TO DETERMINE KATEPSIN B IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES, AND SUITABLE COMPOUNDS