ATE86104T1 - Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen. - Google Patents

Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen.

Info

Publication number
ATE86104T1
ATE86104T1 AT89900483T AT89900483T ATE86104T1 AT E86104 T1 ATE86104 T1 AT E86104T1 AT 89900483 T AT89900483 T AT 89900483T AT 89900483 T AT89900483 T AT 89900483T AT E86104 T1 ATE86104 T1 AT E86104T1
Authority
AT
Austria
Prior art keywords
acid
drug
lipophilic drug
cationic
aqueous phase
Prior art date
Application number
AT89900483T
Other languages
English (en)
Inventor
Eric Anton Forssen
Original Assignee
Vestar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22402210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE86104(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vestar Inc filed Critical Vestar Inc
Application granted granted Critical
Publication of ATE86104T1 publication Critical patent/ATE86104T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT89900483T 1987-11-18 1988-11-18 Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen. ATE86104T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12235487A 1987-11-18 1987-11-18
PCT/US1988/003995 WO1989004656A1 (en) 1987-11-18 1988-11-18 Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
EP89900483A EP0394314B2 (de) 1987-11-18 1988-11-18 Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen

Publications (1)

Publication Number Publication Date
ATE86104T1 true ATE86104T1 (de) 1993-03-15

Family

ID=22402210

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89900483T ATE86104T1 (de) 1987-11-18 1988-11-18 Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen.

Country Status (12)

Country Link
EP (1) EP0394314B2 (de)
JP (1) JP2870657B2 (de)
KR (1) KR960013282B1 (de)
AT (1) ATE86104T1 (de)
AU (1) AU609926B2 (de)
CA (1) CA1331860C (de)
DE (1) DE3878922T2 (de)
DK (1) DK175736B1 (de)
HK (1) HK120093A (de)
IE (1) IE63518B1 (de)
NO (1) NO300954B1 (de)
WO (1) WO1989004656A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227170A (en) * 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
AU652247B2 (en) * 1992-02-11 1994-08-18 Nexstar Pharmaceuticals, Inc. Inhibition of aggregation of drug containing particles
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
JP4467789B2 (ja) 1997-09-18 2010-05-26 パシラ ファーマシューティカルズ インコーポレーテッド 持続放出性リポソーム麻酔組成物
IL135989A0 (en) 1997-11-14 2001-05-20 Skyepharma Inc Processes for the production of multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4505830A (en) * 1981-09-21 1985-03-19 The Lubrizol Corporation Metal working using lubricants containing basic alkali metal salts
CA1270198A (en) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation of antineoplastic agents in liposomes
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents

Also Published As

Publication number Publication date
DK122190D0 (da) 1990-05-17
CA1331860C (en) 1994-09-06
JPH03501019A (ja) 1991-03-07
NO902184D0 (no) 1990-05-16
AU609926B2 (en) 1991-05-09
WO1989004656A1 (en) 1989-06-01
DK175736B1 (da) 2005-02-07
AU2816289A (en) 1989-06-14
KR960013282B1 (ko) 1996-10-02
EP0394314A1 (de) 1990-10-31
DE3878922D1 (de) 1993-04-08
EP0394314B2 (de) 1995-12-06
DE3878922T2 (de) 1996-04-11
NO902184L (no) 1990-07-13
JP2870657B2 (ja) 1999-03-17
EP0394314A4 (en) 1991-01-09
IE883441L (en) 1989-05-18
DK122190A (da) 1990-07-17
IE63518B1 (en) 1995-05-03
KR890701092A (ko) 1989-12-19
HK120093A (en) 1993-11-12
EP0394314B1 (de) 1993-03-03
NO300954B1 (no) 1997-08-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time