ATE797T1 - SUBSTITUTED AMINOALKANIC ACIDS, THEIR USE AND PRODUCTION AND PHARMACEUTICALS CONTAINING THEM. - Google Patents
SUBSTITUTED AMINOALKANIC ACIDS, THEIR USE AND PRODUCTION AND PHARMACEUTICALS CONTAINING THEM.Info
- Publication number
- ATE797T1 ATE797T1 AT79101911T AT79101911T ATE797T1 AT E797 T1 ATE797 T1 AT E797T1 AT 79101911 T AT79101911 T AT 79101911T AT 79101911 T AT79101911 T AT 79101911T AT E797 T1 ATE797 T1 AT E797T1
- Authority
- AT
- Austria
- Prior art keywords
- signifies
- liver
- production
- bile
- stomach
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 210000004185 liver Anatomy 0.000 abstract 3
- -1 alicyclic hydrocarbon radical Chemical class 0.000 abstract 2
- 210000000941 bile Anatomy 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000002784 stomach Anatomy 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Biophysics (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Acyl (bicyclic aryl) - aminoalkanoic acids of the general formula I <IMAGE> in which R<1> signifies an aliphatic or alicyclic hydrocarbon radical or an optionally substituted phenyl group, A signifies an optionally substituted and/or hydrogenated bicyclic aryl radical and n signifies 3, 4 or 5, as well as their salts of inorganic or organic bases exert in warm-blooded animals a protective action on the stomach and an increase in the pancreatic secretion, and in addition they exert an action on the liver and bile. Furthermore, they bring about an inhibition of the formation of glucose from lactate and pyruvate in the liver. They are suitable for the treatment and prophylaxis of diseases which a@ attributed to disorders of the stomach or intestine or to reduced performances of the pancreas, bile and/or liver, or the treatment of diabetes. Processes for the production of the compounds and suitable pharmaceutical products are given.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH650578 | 1978-06-14 | ||
| EP79101911A EP0006217B1 (en) | 1978-06-14 | 1979-06-12 | Substituted amino acids, their use and preparation, and compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE797T1 true ATE797T1 (en) | 1982-04-15 |
Family
ID=4310667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT79101911T ATE797T1 (en) | 1978-06-14 | 1979-06-12 | SUBSTITUTED AMINOALKANIC ACIDS, THEIR USE AND PRODUCTION AND PHARMACEUTICALS CONTAINING THEM. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0006217B1 (en) |
| JP (1) | JPS554375A (en) |
| AT (1) | ATE797T1 (en) |
| AU (1) | AU525311B2 (en) |
| BE (1) | BE876934A (en) |
| DE (2) | DE2962385D1 (en) |
| DK (1) | DK245079A (en) |
| ES (1) | ES481493A1 (en) |
| FR (1) | FR2432502A1 (en) |
| GB (1) | GB2024814A (en) |
| GR (1) | GR65664B (en) |
| HU (1) | HU180209B (en) |
| IL (1) | IL57553A0 (en) |
| NZ (1) | NZ190723A (en) |
| PL (1) | PL216291A1 (en) |
| PT (1) | PT69763A (en) |
| ZA (1) | ZA792944B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440941A (en) * | 1980-12-22 | 1984-04-03 | Usv Pharmaceutical Corporation | Aroyl-aminoacids, amides and esters thereof |
| US4521607A (en) * | 1981-02-27 | 1985-06-04 | Takeda Chemical Industries, Ltd. | Chromanyl glycines |
| US4686232A (en) * | 1983-02-28 | 1987-08-11 | Sumitomo Chemical Company, Limited | Fungicidal aniline derivatives |
| JPS61185140A (en) * | 1985-02-08 | 1986-08-18 | ゼニヤ海洋サ−ビス株式会社 | Apparatus for preventing generation of red tide |
| EP0221019B1 (en) * | 1985-10-14 | 1994-01-05 | Nippon Zoki Pharmaceutical Co. Ltd. | Peptides |
| JPS62205095A (en) * | 1986-03-04 | 1987-09-09 | Toyo Jozo Co Ltd | Novel physiologically active substance aldostatin and production thereof |
| JPH0226466U (en) * | 1988-08-03 | 1990-02-21 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3697563A (en) * | 1970-06-29 | 1972-10-10 | Inst Chemioterapico Italiano S | (3,4,5-trimethoxy-benzamido)-alkanoic acids for prophylaxis and treatment of cardiac disorders |
-
1979
- 1979-06-12 FR FR7914947A patent/FR2432502A1/en not_active Withdrawn
- 1979-06-12 AU AU47977/79A patent/AU525311B2/en not_active Expired - Fee Related
- 1979-06-12 PL PL21629179A patent/PL216291A1/xx unknown
- 1979-06-12 GB GB7920410A patent/GB2024814A/en not_active Withdrawn
- 1979-06-12 DE DE7979101911T patent/DE2962385D1/en not_active Expired
- 1979-06-12 DE DE19792923698 patent/DE2923698A1/en not_active Withdrawn
- 1979-06-12 EP EP79101911A patent/EP0006217B1/en not_active Expired
- 1979-06-12 JP JP7315179A patent/JPS554375A/en active Pending
- 1979-06-12 BE BE6/46862A patent/BE876934A/en unknown
- 1979-06-12 ES ES481493A patent/ES481493A1/en not_active Expired
- 1979-06-12 GR GR59322A patent/GR65664B/en unknown
- 1979-06-12 HU HU79BI588A patent/HU180209B/en unknown
- 1979-06-12 DK DK245079A patent/DK245079A/en not_active Application Discontinuation
- 1979-06-12 PT PT69763A patent/PT69763A/en unknown
- 1979-06-12 AT AT79101911T patent/ATE797T1/en not_active IP Right Cessation
- 1979-06-13 IL IL57553A patent/IL57553A0/en unknown
- 1979-06-13 ZA ZA792944A patent/ZA792944B/en unknown
- 1979-06-14 NZ NZ190723A patent/NZ190723A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2923698A1 (en) | 1980-01-03 |
| FR2432502A1 (en) | 1980-02-29 |
| DK245079A (en) | 1979-12-15 |
| NZ190723A (en) | 1981-12-15 |
| GR65664B (en) | 1980-10-16 |
| DE2962385D1 (en) | 1982-05-06 |
| AU525311B2 (en) | 1982-10-28 |
| AU4797779A (en) | 1979-12-20 |
| EP0006217A1 (en) | 1980-01-09 |
| JPS554375A (en) | 1980-01-12 |
| ZA792944B (en) | 1980-06-25 |
| EP0006217B1 (en) | 1982-03-31 |
| HU180209B (en) | 1983-02-28 |
| PL216291A1 (en) | 1980-03-24 |
| IL57553A0 (en) | 1979-10-31 |
| BE876934A (en) | 1979-12-12 |
| ES481493A1 (en) | 1980-03-01 |
| GB2024814A (en) | 1980-01-16 |
| PT69763A (en) | 1979-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE71080T1 (en) | BICYCLIC NAPHTHALINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS. | |
| ATE13422T1 (en) | DERIVATIVES OF 1-ARYL-2-AMINOMETHYL-CYCLOPROPANCARBOXAMIDES (Z), THEIR PRODUCTION AND USE FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS. | |
| SE8102193L (en) | THERAPEUTIC ACTIVE ORGANIC ASSOCIATION AND ITS USE | |
| NO179671C (en) | Substituted cyclohexane derivatives, their use in the manufacture of drugs and drugs for the treatment of type II diabetes and other diseases | |
| ATE797T1 (en) | SUBSTITUTED AMINOALKANIC ACIDS, THEIR USE AND PRODUCTION AND PHARMACEUTICALS CONTAINING THEM. | |
| DE3873870D1 (en) | ANDROSTAN-17-CARBONIC ACID ESTER, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT. | |
| ATE1093T1 (en) | SUBSTITUTED AMINO ACIDS, THEIR USE AND MANUFACTURE AND PHARMACEUTICALS CONTAINING THEM. | |
| ATE48276T1 (en) | 1,6-NAPHTHYRIDINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND MEDICATIONS CONTAINING THEM. | |
| DE3772301D1 (en) | 2-GUANIDINO-4-ARYL-THIAZOLE FOR THE TREATMENT OF PEPTIC Ulcers. | |
| DE3881484D1 (en) | OPTICALLY ACTIVE PRODUCTS OF 20,21-DINOREBURNAMENIN DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| FR2369288A1 (en) | PROCESS FOR THE PREPARATION OF ORGANIC TIN COMPOUNDS | |
| DK0551844T3 (en) | Sulfur-containing bile acid derivatives | |
| IE43501L (en) | Hydroxyacids. | |
| JPS57197258A (en) | Sulfonic ester derivative and its preparation | |
| SE8005309L (en) | NEW 5ALFA-PREGNAN-20-OL DERIVATIVES AND SALTS THEREOF WITH ACIDS, SET FOR PREPARATION AND USE OF IT, AS MEDICINAL PRODUCTS AND COMPOSITIONS CONTAINING THESE ASSOCIATIONS | |
| JPS54103879A (en) | Novel penicillamine | |
| ES8200361A1 (en) | Procedure for the preparation of derivatives of 4-aminomethyl-9,10-dihydro-benzo 4,5 ciclohepta 1,2b tiofeno n, N-di- substitute (Machine-translation by Google Translate, not legally binding) | |
| ES408236A1 (en) | Method for producing pure 3,6-dioxo-4-hydroxy-tetrahydropyridazines | |
| MD72C2 (en) | The method of obtaining chinolyncar borxylic acids or its salts which can be used in pharmaceutics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |