ATE78698T1 - Reinigung von monomerem interferon. - Google Patents
Reinigung von monomerem interferon.Info
- Publication number
- ATE78698T1 ATE78698T1 AT88909257T AT88909257T ATE78698T1 AT E78698 T1 ATE78698 T1 AT E78698T1 AT 88909257 T AT88909257 T AT 88909257T AT 88909257 T AT88909257 T AT 88909257T AT E78698 T1 ATE78698 T1 AT E78698T1
- Authority
- AT
- Austria
- Prior art keywords
- interferon
- fmm2
- hydrophobicity
- alpha
- charge
- Prior art date
Links
- 108010050904 Interferons Proteins 0.000 title abstract 3
- 102000014150 Interferons Human genes 0.000 title abstract 3
- 229940079322 interferon Drugs 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title 1
- 239000000178 monomer Substances 0.000 abstract 3
- 102100040018 Interferon alpha-2 Human genes 0.000 abstract 1
- 108010078049 Interferon alpha-2 Proteins 0.000 abstract 1
- 238000005277 cation exchange chromatography Methods 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000004007 reversed phase HPLC Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/105,629 US4765903A (en) | 1987-10-06 | 1987-10-06 | Purification of monomeric interferon |
| US16707588A | 1988-03-11 | 1988-03-11 | |
| EP88909257A EP0396555B1 (de) | 1987-10-06 | 1988-10-03 | Reinigung von monomerem interferon |
| PCT/US1988/003409 WO1989003225A1 (en) | 1987-10-06 | 1988-10-03 | Purification of monomeric interferon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE78698T1 true ATE78698T1 (de) | 1992-08-15 |
Family
ID=26802768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88909257T ATE78698T1 (de) | 1987-10-06 | 1988-10-03 | Reinigung von monomerem interferon. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0396555B1 (de) |
| JP (1) | JPH03500410A (de) |
| AT (1) | ATE78698T1 (de) |
| CA (1) | CA1329307C (de) |
| DE (1) | DE3873353T2 (de) |
| WO (1) | WO1989003225A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2612115B2 (ja) * | 1991-08-08 | 1997-05-21 | 富士通株式会社 | Faxメール装置 |
| EP0626448A3 (de) * | 1993-05-26 | 1998-01-14 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
| EP2382237A1 (de) * | 2008-12-23 | 2011-11-02 | Schering Corporation | Aufreinigung von rekombinant hergestelltem interferon |
| CN111175404B (zh) * | 2020-01-19 | 2022-08-12 | 东莞市东阳光生物药研发有限公司 | 一种重组蛋白药物电荷异质性杂质的高效液相色谱检测方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4534906A (en) * | 1982-11-01 | 1985-08-13 | Genentech, Inc. | Removal of impurities from human leukocyte interferon preparations |
-
1988
- 1988-10-03 AT AT88909257T patent/ATE78698T1/de active
- 1988-10-03 DE DE8888909257T patent/DE3873353T2/de not_active Expired - Fee Related
- 1988-10-03 EP EP88909257A patent/EP0396555B1/de not_active Expired
- 1988-10-03 JP JP63508519A patent/JPH03500410A/ja active Pending
- 1988-10-03 WO PCT/US1988/003409 patent/WO1989003225A1/en not_active Ceased
- 1988-10-05 CA CA000579397A patent/CA1329307C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA1329307C (en) | 1994-05-03 |
| DE3873353T2 (de) | 1993-03-18 |
| EP0396555A4 (en) | 1990-12-27 |
| DE3873353D1 (de) | 1992-09-03 |
| JPH03500410A (ja) | 1991-01-31 |
| WO1989003225A1 (en) | 1989-04-20 |
| EP0396555B1 (de) | 1992-07-29 |
| EP0396555A1 (de) | 1990-11-14 |
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