ATE77552T1 - Doxazosin als antiatherosklerotikum. - Google Patents
Doxazosin als antiatherosklerotikum.Info
- Publication number
- ATE77552T1 ATE77552T1 AT88305069T AT88305069T ATE77552T1 AT E77552 T1 ATE77552 T1 AT E77552T1 AT 88305069 T AT88305069 T AT 88305069T AT 88305069 T AT88305069 T AT 88305069T AT E77552 T1 ATE77552 T1 AT E77552T1
- Authority
- AT
- Austria
- Prior art keywords
- retarding
- atherosclerosis
- reducing
- doxazosine
- antiatherosclerotic
- Prior art date
Links
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001389 doxazosin Drugs 0.000 title abstract 2
- 230000000879 anti-atherosclerotic effect Effects 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 2
- 230000000979 retarding effect Effects 0.000 abstract 2
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/089,716 US4758569A (en) | 1987-08-26 | 1987-08-26 | Doxazosin as an anti-atherosclerosis agent |
| EP88305069A EP0305028B1 (en) | 1987-08-26 | 1988-06-03 | Doxazosin as an anti-atherosclerosis agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE77552T1 true ATE77552T1 (de) | 1992-07-15 |
Family
ID=22219243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88305069T ATE77552T1 (de) | 1987-08-26 | 1988-06-03 | Doxazosin als antiatherosklerotikum. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4758569A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0305028B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS6471817A (cg-RX-API-DMAC7.html) |
| KR (1) | KR910002145B1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE77552T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU594880B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1323572C (cg-RX-API-DMAC7.html) |
| DE (1) | DE3872333T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK170499B1 (cg-RX-API-DMAC7.html) |
| HU (1) | HU204196B (cg-RX-API-DMAC7.html) |
| IE (1) | IE60005B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL86735A (cg-RX-API-DMAC7.html) |
| MY (1) | MY103102A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ225053A (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA884237B (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4837111A (en) * | 1988-03-21 | 1989-06-06 | Alza Corporation | Dosage form for dispensing drug for human therapy |
| US5270323A (en) * | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
| US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
| DE69327128T2 (de) * | 1992-04-01 | 2000-04-20 | Pfizer, Inc. | Hydroxylierte Metaboliten und Derivate von Doxazosin gegen Atherosklerose |
| US5449679A (en) * | 1994-07-29 | 1995-09-12 | Leonard; Robert J. | Process and products for reducing biological fluid levels of a lipid soluble waste |
| US6177430B1 (en) | 1997-03-27 | 2001-01-23 | Pfizer Inc | Use of α1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
| IL120303A0 (en) * | 1996-03-27 | 1997-06-10 | Pfizer | Use of alpha1-adrenoreceptor antagonists in the prevention and treatment of cancer |
| JP2002536325A (ja) * | 1999-02-05 | 2002-10-29 | ナイトロシステムズ アイエヌシー | 疾患を治療するためのｌ−アルギニン基盤の処方およびその使用方法 |
| AU6951601A (en) | 2000-07-13 | 2002-01-30 | Takeda Chemical Industries Ltd | Lipid-rich plaque inhibitors |
| US20040019096A1 (en) * | 2001-10-23 | 2004-01-29 | Vlassios Andronis | Novel formulations of carvedilol |
| KR100496436B1 (ko) * | 2002-07-30 | 2005-06-20 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100538641B1 (ko) * | 2002-07-30 | 2005-12-22 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100462304B1 (ko) * | 2002-07-30 | 2004-12-17 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100467669B1 (ko) | 2002-08-21 | 2005-01-24 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| JP2006515765A (ja) | 2002-11-15 | 2006-06-08 | エスディージーアイ・ホールディングス・インコーポレーテッド | 滑膜性関節を治療するためのコラーゲンベース材料および方法 |
| US8118779B2 (en) | 2006-06-30 | 2012-02-21 | Warsaw Orthopedic, Inc. | Collagen delivery device |
| US8399619B2 (en) | 2006-06-30 | 2013-03-19 | Warsaw Orthopedic, Inc. | Injectable collagen material |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4130647A (en) * | 1977-07-08 | 1978-12-19 | Pfizer Inc. | Methods for treating congestive heart failure and ischemic heart disease |
| US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
| US4361564A (en) * | 1978-11-30 | 1982-11-30 | Edwards K David G | Renoprotective treatments employing vasodilator compounds |
| US4532135A (en) * | 1981-02-09 | 1985-07-30 | Edwards K David G | Renoprotective treatments employing vasodilator compounds |
| US4582832A (en) * | 1984-10-09 | 1986-04-15 | Pfizer Inc. | Trimazosin as an anti-atherosclerosis agent |
-
1987
- 1987-08-26 US US07/089,716 patent/US4758569A/en not_active Expired - Lifetime
-
1988
- 1988-06-03 EP EP88305069A patent/EP0305028B1/en not_active Expired - Lifetime
- 1988-06-03 DE DE8888305069T patent/DE3872333T2/de not_active Expired - Lifetime
- 1988-06-03 AT AT88305069T patent/ATE77552T1/de not_active IP Right Cessation
- 1988-06-07 IE IE169588A patent/IE60005B1/en not_active IP Right Cessation
- 1988-06-09 AU AU17529/88A patent/AU594880B2/en not_active Expired
- 1988-06-09 DK DK313688A patent/DK170499B1/da not_active IP Right Cessation
- 1988-06-14 IL IL8673588A patent/IL86735A/en not_active IP Right Cessation
- 1988-06-14 ZA ZA884237A patent/ZA884237B/xx unknown
- 1988-06-15 MY MYPI88000660A patent/MY103102A/en unknown
- 1988-06-16 NZ NZ225053A patent/NZ225053A/en unknown
- 1988-06-20 HU HU883139A patent/HU204196B/hu unknown
- 1988-07-30 KR KR1019880009761A patent/KR910002145B1/ko not_active Expired
- 1988-08-23 JP JP63209329A patent/JPS6471817A/ja active Granted
- 1988-08-23 CA CA000575443A patent/CA1323572C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL86735A0 (en) | 1988-11-30 |
| NZ225053A (en) | 1997-02-24 |
| KR890003379A (ko) | 1989-04-14 |
| DE3872333T2 (de) | 1992-12-03 |
| MY103102A (en) | 1993-04-30 |
| DK170499B1 (da) | 1995-10-02 |
| EP0305028A2 (en) | 1989-03-01 |
| AU594880B2 (en) | 1990-03-15 |
| AU1752988A (en) | 1989-03-02 |
| US4758569A (en) | 1988-07-19 |
| CA1323572C (en) | 1993-10-26 |
| IE60005B1 (en) | 1994-05-18 |
| DK313688A (da) | 1989-02-27 |
| JPS6471817A (en) | 1989-03-16 |
| EP0305028A3 (en) | 1990-03-14 |
| IE881695L (en) | 1989-02-26 |
| KR910002145B1 (ko) | 1991-04-06 |
| DE3872333D1 (de) | 1992-07-30 |
| DK313688D0 (da) | 1988-06-09 |
| ZA884237B (en) | 1990-02-28 |
| JPH0575729B2 (cg-RX-API-DMAC7.html) | 1993-10-21 |
| HUT51141A (en) | 1990-04-28 |
| HU204196B (en) | 1991-12-30 |
| IL86735A (en) | 1994-05-30 |
| EP0305028B1 (en) | 1992-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |