ATE74788T1 - Stroemungskammer mit flussablenkung fuer die abtrennung von partikeln aus einem fluessigen medium durch hochgradienten-magnettrenntechnik. - Google Patents

Stroemungskammer mit flussablenkung fuer die abtrennung von partikeln aus einem fluessigen medium durch hochgradienten-magnettrenntechnik.

Info

Publication number
ATE74788T1
ATE74788T1 AT86905637T AT86905637T ATE74788T1 AT E74788 T1 ATE74788 T1 AT E74788T1 AT 86905637 T AT86905637 T AT 86905637T AT 86905637 T AT86905637 T AT 86905637T AT E74788 T1 ATE74788 T1 AT E74788T1
Authority
AT
Austria
Prior art keywords
matrix
magnetic
flux
phase
particles
Prior art date
Application number
AT86905637T
Other languages
English (en)
Inventor
Marshall Donnie Graham
William Gerry Graham
Original Assignee
Coulter Electronics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Electronics filed Critical Coulter Electronics
Application granted granted Critical
Publication of ATE74788T1 publication Critical patent/ATE74788T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/033Component parts; Auxiliary operations characterised by the magnetic circuit
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/032Matrix cleaning systems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/033Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/033Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/034Component parts; Auxiliary operations characterised by the magnetic circuit characterised by the matrix elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/28Magnetic plugs and dipsticks
    • B03C1/288Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/18Magnetic separation whereby the particles are suspended in a liquid

Landscapes

  • Physical Or Chemical Processes And Apparatus (AREA)
  • External Artificial Organs (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
AT86905637T 1985-09-16 1986-09-09 Stroemungskammer mit flussablenkung fuer die abtrennung von partikeln aus einem fluessigen medium durch hochgradienten-magnettrenntechnik. ATE74788T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/776,567 US4664796A (en) 1985-09-16 1985-09-16 Flux diverting flow chamber for high gradient magnetic separation of particles from a liquid medium
EP86905637A EP0237549B1 (de) 1985-09-16 1986-09-09 Strömungskammer mit flussablenkung für die abtrennung von partikeln aus einem flüssigen medium durch hochgradienten-magnettrenntechnik
PCT/US1986/001853 WO1987001608A1 (en) 1985-09-16 1986-09-09 Flux diverting flow chamber for high gradient magnetic separation of particles from a liquid medium

Publications (1)

Publication Number Publication Date
ATE74788T1 true ATE74788T1 (de) 1992-05-15

Family

ID=25107762

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86905637T ATE74788T1 (de) 1985-09-16 1986-09-09 Stroemungskammer mit flussablenkung fuer die abtrennung von partikeln aus einem fluessigen medium durch hochgradienten-magnettrenntechnik.

Country Status (6)

Country Link
US (1) US4664796A (de)
EP (1) EP0237549B1 (de)
JP (1) JPS63501139A (de)
AT (1) ATE74788T1 (de)
DE (1) DE3684910D1 (de)
WO (1) WO1987001608A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5123901A (en) * 1988-02-25 1992-06-23 Carew E Bayne Method for separating pathogenic or toxic agents from a body fluid and return to body
US5536475A (en) * 1988-10-11 1996-07-16 Baxter International Inc. Apparatus for magnetic cell separation
US6020210A (en) * 1988-12-28 2000-02-01 Miltenvi Biotech Gmbh Methods and materials for high gradient magnetic separation of biological materials
WO1990007380A2 (en) * 1988-12-28 1990-07-12 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
US5622831A (en) * 1990-09-26 1997-04-22 Immunivest Corporation Methods and devices for manipulation of magnetically collected material
AU6357394A (en) * 1993-03-04 1994-09-26 Sapidyne, Inc. Assay flow apparatus and method
US5705059A (en) * 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
US5779892A (en) * 1996-11-15 1998-07-14 Miltenyi Biotec Gmbh Magnetic separator with magnetic compensated release mechanism for separating biological material
EP0941766B1 (de) 1998-03-12 2006-12-20 Miltenyi Biotec GmbH Mikrokolonnen-System für Magnettrennung
US7220596B2 (en) 1998-04-15 2007-05-22 Utah State University Real time detection of antigens
AU732426B2 (en) * 1998-12-29 2001-04-26 Ian Basil Shine A method of analysing a sample of free cells
US6159378A (en) * 1999-02-23 2000-12-12 Battelle Memorial Institute Apparatus and method for handling magnetic particles in a fluid
CN1136923C (zh) * 2001-03-13 2004-02-04 张兴东 血磁机动磁场的充磁装置
US20030095897A1 (en) * 2001-08-31 2003-05-22 Grate Jay W. Flow-controlled magnetic particle manipulation
US20030099954A1 (en) * 2001-11-26 2003-05-29 Stefan Miltenyi Apparatus and method for modification of magnetically immobilized biomolecules
WO2003049530A2 (en) * 2001-12-07 2003-06-19 Dyax Corporation Method and apparatus for washing magnetically responsive particles
US20030119057A1 (en) * 2001-12-20 2003-06-26 Board Of Regents Forming and modifying dielectrically-engineered microparticles
EP2359689B1 (de) 2002-09-27 2015-08-26 The General Hospital Corporation Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben
US20040157219A1 (en) * 2003-02-06 2004-08-12 Jianrong Lou Chemical treatment of biological samples for nucleic acid extraction and kits therefor
DE10354351B3 (de) * 2003-11-20 2005-06-16 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Verfahren und Vorrichtung zur verbesserten Reinigung einer an paramagnetische Mikropartikel gebundenen Substanz
US20050266433A1 (en) * 2004-03-03 2005-12-01 Ravi Kapur Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US20050239091A1 (en) * 2004-04-23 2005-10-27 Collis Matthew P Extraction of nucleic acids using small diameter magnetically-responsive particles
US20060024776A1 (en) * 2004-08-02 2006-02-02 Mcmillian Ray Magnetic particle capture of whole intact organisms from clinical samples
JP5053089B2 (ja) * 2004-08-03 2012-10-17 ベクトン・ディキンソン・アンド・カンパニー 化合物の直接単離および多成分サンプルの分別のための磁性材料の使用
EP1773865A1 (de) * 2004-08-03 2007-04-18 Becton, Dickinson and Company Verwendung von magnetischem material zum fraktionieren von proben
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
DK1996931T3 (en) * 2005-12-28 2014-02-17 Gen Hospital Corp Methods and systems for sorting of blood cells
CA2692186C (en) * 2007-06-29 2019-03-12 Becton, Dickinson And Company Methods for extraction and purification of components of biological samples
DE102007043281A1 (de) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
US20110177592A1 (en) * 2008-07-11 2011-07-21 Faustman Denise L Magnetic apparatus for blood separation
JP2012176382A (ja) * 2011-02-28 2012-09-13 Nippon Steel Engineering Co Ltd 磁気分離フィルター装置
DE102011015321A1 (de) 2011-03-28 2012-10-04 Ralph Heindrichs Verfahren zur kontinuierlichen selektiven Separation von Partikeln mittels Magnetismus
EP2694965B1 (de) 2011-04-05 2017-01-18 Purdue Research Foundation Mikrofluidisches system mit mikroöffnungen zur erkennung von einheiten mit hohem durchsatz
CN103501912B (zh) 2011-04-27 2017-10-24 贝克顿·迪金森公司 用于分离样品中磁性标记部分的设备和方法
SG11201807053TA (en) 2016-03-07 2018-09-27 X Zell Inc Compositions and methods for identifying rare cells
CN108580030B (zh) * 2018-03-29 2020-12-08 西北工业大学 一种以非接触方式约束非抗磁性物质的系统及约束方法
EP3693739A1 (de) 2019-02-06 2020-08-12 Stefan Schreier Verfahren und vorrichtung zur isolierung von gewünschten zellen aus einer probe nicht-magnetischer biologischer materialien
US11791590B2 (en) * 2020-04-22 2023-10-17 Keysight Technologies, Inc. Magnetic cable connection device and adapator
EP4115981A1 (de) * 2021-07-09 2023-01-11 Miltenyi Biotec B.V. & Co. KG Magnetische trennung mit rotierendem magnetfeld/rotierender säule
DE202021105458U1 (de) 2021-10-08 2023-01-24 Sanolibio Co., Ltd. Vorrichtung zur magnetischen Aufreinigung biologischer Proben

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE624224C (de) * 1933-01-31 1936-01-16 Ernst Moyat Magnetscheider
US2430157A (en) * 1939-07-29 1947-11-04 Jr William Byrd Magnetic separator for removing finely divided magnetic material from liquids
US2329893A (en) * 1940-09-10 1943-09-21 Magnetos Lucifer S A Magnetic device for the purification of fluids
US2823803A (en) * 1955-09-12 1958-02-18 Sinclair Machine Products Inc Magnetic filter
US3142787A (en) * 1962-04-27 1964-07-28 Brown & Sharpe Mfg Permanent magnetic block
US3164756A (en) * 1962-05-16 1965-01-05 Nix Steingroeve Elektro Physik Adjustable permanent magnet
US3367612A (en) * 1966-01-11 1968-02-06 Enco Mfg Company Adjustable indicator holder
US3489280A (en) * 1966-02-03 1970-01-13 Eriez Mfg Co Magnetic separator having field shaping poles
US3375925A (en) * 1966-10-18 1968-04-02 Carpco Res & Engineering Inc Magnetic separator
US3567026A (en) * 1968-09-20 1971-03-02 Massachusetts Inst Technology Magnetic device
US3616925A (en) * 1969-03-19 1971-11-02 United Conveyor Corp Apparatus for dewatering granular material
US3700555A (en) * 1970-10-12 1972-10-24 Technicon Instr Method and apparatus for lymphocyte separation from blood
US3709791A (en) * 1971-04-13 1973-01-09 Technicon Instr Method and apparatus for lymphocyte separation from blood
CA981010A (en) * 1971-04-20 1976-01-06 Matsushita Electric Industrial Co., Ltd. Piezoelectric ceramic compositions
BE792843A (fr) * 1971-12-22 1973-03-30 Kraftwerk Union Ag Filtre electromagnetique pour oxydes de fer
US3812629A (en) * 1972-08-15 1974-05-28 P Campbell Workholder
US4054513A (en) * 1973-07-10 1977-10-18 English Clays Lovering Pochin & Company Limited Magnetic separation, method and apparatus
US4116829A (en) * 1974-01-18 1978-09-26 English Clays Lovering Pochin & Company Limited Magnetic separation, method and apparatus
GB1501396A (en) * 1974-07-19 1978-02-15 English Clays Lovering Pochin Magnetic separators
US4051023A (en) * 1975-04-11 1977-09-27 Eriez Magnetics Combination electromagnet and permanent magnet separator
DE2517364A1 (de) * 1975-04-19 1976-10-28 Max Baermann Schaltbare, dauermagnetische haltevorrichtung
DE2628095C3 (de) * 1976-06-23 1981-08-06 Siemens AG, 1000 Berlin und 8000 München Magnetische Abscheidevorrichtung
JPS5387033A (en) * 1977-01-10 1978-08-01 Etsurou Fujita Method and apparatus for preventing environmental pollution by processing combustible fuel flow in magnetic field
JPS53130572A (en) * 1977-04-05 1978-11-14 Tdk Electronics Co Ltd Highhgradient magnetic separator using amorphous magnetic alloy
GB1599824A (en) * 1978-02-27 1981-10-07 Stekly Z J J Magnetic separator
IT7823323V0 (it) * 1978-11-17 1978-11-17 Cardone Tecnomagnetica Sollevatore magnetico a comando manuale.
JPS5578505A (en) * 1978-12-08 1980-06-13 Kanetsuu Kogyo Kk Attraction type magnetic device
US4314219A (en) * 1979-04-17 1982-02-02 Hitachi Metals, Ltd. Permanent magnet type lifting device
US4244822A (en) * 1979-08-09 1981-01-13 The Babcock & Wilcox Company Industrial technique magnetic apparatus
US4261815A (en) * 1979-12-31 1981-04-14 Massachusetts Institute Of Technology Magnetic separator and method
DE3123731A1 (de) * 1981-06-15 1982-12-30 Basf Ag, 6700 Ludwigshafen Chloressigsaeurecyclohexylamide, ihre herstellung, ihre verwendung zur herbizidbekaempfung und mittel dafuer
CA1184532A (en) * 1981-06-19 1985-03-26 Severin F. Sverre Magnetic water conditioning device
DE3247522A1 (de) * 1982-12-22 1984-06-28 Siemens AG, 1000 Berlin und 8000 München Vorrichtung der hochgradienten-magnettrenntechnik zum abscheiden magnetisierbarer teilchen
DE3312207A1 (de) * 1983-04-05 1984-10-11 Ukrainskij institut inženerov vodnogo chozjajstva, Rovno Einrichtung zur absonderung ferromagnetischer werkstoffe aus fluessigen medien
DE3314923C2 (de) * 1983-04-25 1986-10-02 Ukrainskij institut inženerov vodnogo chozjajstva, Rovno Magnetischer Abscheider
JPH119475A (ja) * 1997-06-25 1999-01-19 Zojirushi Corp 液体容器の流量調整装置

Also Published As

Publication number Publication date
DE3684910D1 (de) 1992-05-21
EP0237549A1 (de) 1987-09-23
US4664796A (en) 1987-05-12
EP0237549B1 (de) 1992-04-15
WO1987001608A1 (en) 1987-03-26
EP0237549A4 (de) 1988-09-28
JPS63501139A (ja) 1988-04-28

Similar Documents

Publication Publication Date Title
ATE74788T1 (de) Stroemungskammer mit flussablenkung fuer die abtrennung von partikeln aus einem fluessigen medium durch hochgradienten-magnettrenntechnik.
ATE20704T1 (de) Hochgradient-magnetabscheider.
Inglis et al. Microfluidic high gradient magnetic cell separation
US6120735A (en) Fractional cell sorter
DE69902458D1 (de) Magnetisches trennungssystem
Han et al. Diamagnetic capture mode magnetophoretic microseparator for blood cells
ES8406891A1 (es) Un procedimiento para filtrar un fluido contaminado que contiene materia en particulas de tamano inferior a la micra.
CA2285085A1 (en) Fractional cell sorter
AU1226999A (en) High gradient magnetic device and method for cell separation or purification
SE8201554L (sv) Sett att framstella substanser som alstrats av celler
WO2000062034A9 (en) Multistage electromagnetic separator for purifying cells, chemicals and protein structures
ES8700069A1 (es) Un metodo para recoger y atrapar particulas magneticas y no magneticas suspendidas en una corriente liquida que fluye en una tuberia
US4049398A (en) Separating oxygen from the air by means of dissolving air in a nonmagnetic, inert liquid and then paramagnetically collecting the oxygen from the liquid
CN114100704A (zh) 一种磁分选微流控芯片及其制作方法
CN114262665A (zh) 一种基于磁调控的全自动细胞分离装置
EA199800169A1 (ru) Устройство для фильтрации магнитного материала
ATE364448T1 (de) Hochgradienten-magnetfilter und verfahren zum abtrennen von schwach magnetisierbaren partikeln aus flüssigen medien
WO2022061528A1 (zh) 一种磁分选微流控芯片及其制作方法
ES8103990A1 (es) Perfeccionamientos en dispositivos para la separacion magne-tica de alto gradiente de particulas magnetizables de un me-dio fluyente
GB1192870A (en) Magnetic Filter
ES433925A1 (es) Metodo y su correspondiente aparato para separar particulas magnetizables de un fluido en el cual estan en suspension.
BR7606754A (pt) Processo e dispositivo para separacao de particulas magnetizaveis de um material solido de granulacao fina em suspensao em um meio portador,por meio de separacao magnetica de campo forte
Malville et al. Trajectories of chromospheric disk surges
Friedlaender et al. Status of magnetic separation
Han et al. A cascade mode magnetophoretic microseparator for high efficiency blood cell separations