ATE74158T1 - Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes. - Google Patents

Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes.

Info

Publication number
ATE74158T1
ATE74158T1 AT86115226T AT86115226T ATE74158T1 AT E74158 T1 ATE74158 T1 AT E74158T1 AT 86115226 T AT86115226 T AT 86115226T AT 86115226 T AT86115226 T AT 86115226T AT E74158 T1 ATE74158 T1 AT E74158T1
Authority
AT
Austria
Prior art keywords
medium
reservoir
waste
cells
membrane
Prior art date
Application number
AT86115226T
Other languages
German (de)
English (en)
Inventor
William H Harm
Mark D Hirschel
Michael L Gruenberg
Original Assignee
Endotronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endotronics Inc filed Critical Endotronics Inc
Application granted granted Critical
Publication of ATE74158T1 publication Critical patent/ATE74158T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT86115226T 1985-11-04 1986-11-03 Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes. ATE74158T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/794,627 US4722902A (en) 1985-11-04 1985-11-04 Apparatus and method for culturing cells, removing waste and concentrating product
EP86115226A EP0224734B1 (en) 1985-11-04 1986-11-03 Apparatus and method for culturing cells, removing waste and concentrating product

Publications (1)

Publication Number Publication Date
ATE74158T1 true ATE74158T1 (de) 1992-04-15

Family

ID=25163183

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86115226T ATE74158T1 (de) 1985-11-04 1986-11-03 Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes.

Country Status (7)

Country Link
US (1) US4722902A (enExample)
EP (1) EP0224734B1 (enExample)
JP (1) JPS62171669A (enExample)
AT (1) ATE74158T1 (enExample)
AU (1) AU6463286A (enExample)
CA (1) CA1270455A (enExample)
DE (1) DE3684561D1 (enExample)

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US4921792A (en) * 1987-11-27 1990-05-01 Miles Inc. Continuous cell dispersion, cultivation and substance recovery process
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JP2777385B2 (ja) * 1988-11-30 1998-07-16 株式会社日立製作所 生物細胞の培養方法，培養システム及び培養装置
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FR2640638B1 (fr) * 1988-12-20 1991-02-15 Commissariat Energie Atomique Bioreacteur et dispositif pour la culture de cellules animales
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US5346826A (en) * 1989-10-18 1994-09-13 Andrews Franklin T Process for conducting biochemical reactions
JPH03175949A (ja) * 1989-12-05 1991-07-31 Hokkaido Prefecture 膜法によるスティックウォーターからの天然調味料の製造方法
US5268298A (en) * 1991-04-26 1993-12-07 Life Technologies, Inc. System for delivering oxygen to a cell culture medium
DE4116727C2 (de) 1991-05-17 1995-09-07 Uwe Dr Marx Verfahren und Vorrichtung zur gleichzeitigen Kultivierung unterschiedlicher Säugerzellen
US5330915A (en) * 1991-10-18 1994-07-19 Endotronics, Inc. Pressure control system for a bioreactor
US5353745A (en) * 1992-09-29 1994-10-11 Fahs Ii Richard W Aquaculture system and methods for using the same
US5424209A (en) * 1993-03-19 1995-06-13 Kearney; George P. Automated cell culture and testing system
US20050266548A1 (en) * 1995-03-28 2005-12-01 Kbi Biopharma, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation with improved rotor
US6660509B1 (en) 1995-03-28 2003-12-09 Kinetic Biosystems, Inc. Methods and devices for remediation and fermentation
US6214617B1 (en) 1995-03-28 2001-04-10 Kinetic Biosystems, Inc. Centrifugal fermentation process
US6916652B2 (en) * 1995-03-28 2005-07-12 Kinetic Biosystems, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation
US6133019A (en) * 1995-03-28 2000-10-17 Kinetic Biosystems, Inc. Centrifugal fermentation process
US5622819A (en) * 1995-03-28 1997-04-22 Kinetic Biosystems, Inc. Centrifugal fermentation process
US5728581A (en) * 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
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US20020182730A1 (en) * 1995-07-26 2002-12-05 Micheal L. Gruenberg Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
DE19727731A1 (de) * 1997-06-30 1999-01-07 Forschungszentrum Juelich Gmbh Verfahren und Vorrichtung zum Eintrag von Reagenzien in Reaktoren
US6703217B2 (en) 2000-01-31 2004-03-09 Kinetic Biosystems, Inc. Methods and devices for remediation and fermentation
WO2002028996A1 (en) * 2000-10-02 2002-04-11 Cannon Thomas F Automated bioculture and bioculture experiments system
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
FR2821947B1 (fr) * 2001-03-12 2003-05-16 Canon Kk Procede et dispositif de validation de parametres definissant une image
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20030134341A1 (en) * 2001-09-19 2003-07-17 Medcell Biologics, Llc. Th1 cell adoptive immunotherapy
US20030175272A1 (en) * 2002-03-07 2003-09-18 Medcell Biologics, Inc. Re-activated T-cells for adoptive immunotherapy
EP1517740B1 (en) * 2002-06-19 2016-10-19 NorthWest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
WO2006026835A1 (en) * 2004-09-10 2006-03-16 Unisearch Limited Device and method to prevent culture media degradation
JP2010519937A (ja) * 2007-03-05 2010-06-10 カリディアンビーシーティー、インコーポレーテッド 細胞増殖システムおよび使用方法
US20080220522A1 (en) * 2007-03-05 2008-09-11 Gambro Bct, Inc. Methods to Control Cell Movement in Hollow Fiber Bioreactors
US8906688B2 (en) * 2007-04-13 2014-12-09 Terumo Bct, Inc. Cell expansion system and methods of use
WO2010003759A2 (en) * 2008-06-17 2010-01-14 Dsm Ip Assets B.V. Cell culturing method
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
JP6039547B2 (ja) 2010-05-05 2016-12-07 テルモ ビーシーティー、インコーポレーテッド 中空糸型バイオリアクターシステムにおいて成長させた接着細胞を再播種する方法
EP2625264B1 (en) 2010-10-08 2022-12-07 Terumo BCT, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
EP3578522A1 (en) * 2010-12-06 2019-12-11 Pall Corporation Continuous processing methods for biological products
CN104540933A (zh) 2012-08-20 2015-04-22 泰尔茂比司特公司 在细胞扩增系统的生物反应器中加载和分配细胞的方法
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
US10633625B2 (en) 2013-11-16 2020-04-28 Terumo Bct, Inc. Expanding cells in a bioreactor
JP6783143B2 (ja) 2014-03-25 2020-11-11 テルモ ビーシーティー、インコーポレーテッド 培地の受動的補充
WO2015164808A1 (en) 2014-04-24 2015-10-29 Terumo Bct, Inc. Measuring flow rate
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
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KR20180074775A (ko) * 2015-10-26 2018-07-03 론자 리미티드 생물약제의 생산을 위한 제조 설비
EP3452575A4 (en) * 2016-05-05 2020-03-11 Terumo BCT, Inc. AUTOMATED PRODUCTION AND COLLECTION
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
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US3969190A (en) * 1971-05-17 1976-07-13 Martin Marietta Corporation Apparatus and method for microbial fermentation in a zero gravity environment
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US3992301A (en) * 1973-11-19 1976-11-16 Raypak, Inc. Automatic flushing system for membrane separation machines such as reverse osmosis machines
DE2726313C3 (de) * 1977-06-10 1980-02-07 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur in-vitro-Biosynthese von Hormonen, insbesondere von Insulin
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
GB2168617B (en) * 1984-12-12 1988-08-10 Bo Gustav Mattiasson A procedure and an apparatus for continuous separation and purification of reaction products

Also Published As

Publication number Publication date
AU6463286A (en) 1987-05-07
JPS62171669A (ja) 1987-07-28
DE3684561D1 (de) 1992-04-30
EP0224734B1 (en) 1992-03-25
EP0224734A1 (en) 1987-06-10
US4722902A (en) 1988-02-02
JPH0120866B2 (enExample) 1989-04-18
CA1270455A (en) 1990-06-19

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