ATE72992T1 - Antikoerper nuetzlich als fuehrungsagenzien und konjugate die sie enthalten. - Google Patents

Antikoerper nuetzlich als fuehrungsagenzien und konjugate die sie enthalten.

Info

Publication number
ATE72992T1
ATE72992T1 AT86401482T AT86401482T ATE72992T1 AT E72992 T1 ATE72992 T1 AT E72992T1 AT 86401482 T AT86401482 T AT 86401482T AT 86401482 T AT86401482 T AT 86401482T AT E72992 T1 ATE72992 T1 AT E72992T1
Authority
AT
Austria
Prior art keywords
target cells
fragment
conjugates
contain
antibodies useful
Prior art date
Application number
AT86401482T
Other languages
English (en)
Inventor
Yves-Jacques Emile Schneider
Esther Aboud-Pirak
Andre Benoit Leon Trouet
Original Assignee
Ire Celltarg Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ire Celltarg Sa filed Critical Ire Celltarg Sa
Application granted granted Critical
Publication of ATE72992T1 publication Critical patent/ATE72992T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT86401482T 1985-07-04 1986-07-03 Antikoerper nuetzlich als fuehrungsagenzien und konjugate die sie enthalten. ATE72992T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8510234A FR2584293B1 (fr) 1985-07-04 1985-07-04 Anticorps utiles comme agents de pilotage et conjugues les incorporant
EP86401482A EP0208615B1 (de) 1985-07-04 1986-07-03 Antikörper nützlich als Führungsagenzien und Konjugate die sie enthalten

Publications (1)

Publication Number Publication Date
ATE72992T1 true ATE72992T1 (de) 1992-03-15

Family

ID=9320971

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86401482T ATE72992T1 (de) 1985-07-04 1986-07-03 Antikoerper nuetzlich als fuehrungsagenzien und konjugate die sie enthalten.

Country Status (6)

Country Link
EP (1) EP0208615B1 (de)
JP (1) JP2608272B2 (de)
AT (1) ATE72992T1 (de)
CA (1) CA1289474C (de)
DE (1) DE3684050D1 (de)
FR (1) FR2584293B1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2610198B1 (fr) * 1987-02-03 1990-06-15 Ire Celltarg Sa Conjugues d'hydrazide d'alcaloide de vinca lie a une immunoglobuline, procede de preparation et compositions pharmaceutiques en comprenant
IE64781B1 (en) * 1987-03-11 1995-09-06 Erba Carlo Spa Immunoglobulin conjugates
EP0336383A3 (de) * 1988-04-07 1990-08-16 Takeda Chemical Industries, Ltd. Menschliches rekombinantes Lymphotoxin
GB9120467D0 (en) * 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
AU694546C (en) 1994-08-19 2001-09-06 La Region Wallonne Compounds, pharmaceutical composition and diagnostic device comprising same and their use
BE1008580A3 (fr) * 1994-08-19 1996-06-04 Univ Catholique Louvain Prodrogues, composition pharmaceutiques les comprenant et leur utilisation.
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
CA2413149A1 (en) 2000-06-14 2001-12-20 Medarex, Inc. Prodrug compounds with isoleucine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4315851A (en) * 1978-12-29 1982-02-16 Kureha Kagaku Kogyo Kabushiki Kaisha Pharmaceutical composition having antitumor activity
EP0037388B1 (de) * 1980-03-31 1984-12-12 Institut International De Pathologie Cellulaire Et Moleculaire Pharmazeutische Stoffe, deren Herstellung und Präparate in denen diese enthalten sind
US4376765A (en) * 1980-03-31 1983-03-15 Institut International De Pathologie Cellulaire Et Moleculaire Medicaments, their preparation and compositions containing same
EP0124502B1 (de) * 1983-04-29 1991-06-12 OMNICHEM Société anonyme Konjugierte Vinblastin-Verbindungen und ihre Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
JPS6072826A (ja) * 1983-09-26 1985-04-24 バイオ−レスポンス・インコ−ポレ−テツド 疾患細胞の生体内治療物質
JPS60172935A (ja) * 1984-02-16 1985-09-06 Green Cross Corp:The 制癌作用物質複合体の製造方法

Also Published As

Publication number Publication date
DE3684050D1 (de) 1992-04-09
JP2608272B2 (ja) 1997-05-07
EP0208615B1 (de) 1992-03-04
FR2584293A1 (fr) 1987-01-09
CA1289474C (fr) 1991-09-24
EP0208615A1 (de) 1987-01-14
JPS6270320A (ja) 1987-03-31
FR2584293B1 (fr) 1989-03-17

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ATE72992T1 (de) Antikoerper nuetzlich als fuehrungsagenzien und konjugate die sie enthalten.
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Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time