ATE64733T1 - ((2,3,9,9a-tetrahydro-3-oxo-9a-substituierte-1h fluoren-7-yl)-oxy>ethanimidamide und ((2,3,9,9atetrahydro-3-oxo-9a-substituierte-1h-fluoren-7- yl)-oxy>ethanimidsaure hydrazide, ihre derivate und salze. - Google Patents

((2,3,9,9a-tetrahydro-3-oxo-9a-substituierte-1h fluoren-7-yl)-oxy>ethanimidamide und ((2,3,9,9atetrahydro-3-oxo-9a-substituierte-1h-fluoren-7- yl)-oxy>ethanimidsaure hydrazide, ihre derivate und salze.

Info

Publication number
ATE64733T1
ATE64733T1 AT86113183T AT86113183T ATE64733T1 AT E64733 T1 ATE64733 T1 AT E64733T1 AT 86113183 T AT86113183 T AT 86113183T AT 86113183 T AT86113183 T AT 86113183T AT E64733 T1 ATE64733 T1 AT E64733T1
Authority
AT
Austria
Prior art keywords
sup
fluoren
oxy
oxo
substituted
Prior art date
Application number
AT86113183T
Other languages
English (en)
Inventor
Edward J Cragoe
Otto W Woltersdorf
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE64733T1 publication Critical patent/ATE64733T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT86113183T 1985-09-26 1986-09-25 ((2,3,9,9a-tetrahydro-3-oxo-9a-substituierte-1h fluoren-7-yl)-oxy>ethanimidamide und ((2,3,9,9atetrahydro-3-oxo-9a-substituierte-1h-fluoren-7- yl)-oxy>ethanimidsaure hydrazide, ihre derivate und salze. ATE64733T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/780,145 US4604396A (en) 1985-09-26 1985-09-26 [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts
EP86113183A EP0217287B1 (de) 1985-09-26 1986-09-25 [(2,3,9,9a-Tetrahydro-3-oxo-9a-substituierte-1H-fluoren-7-yl)-oxy]ethanimidamide und [(2,3,9,9a-Tetrahydro-3-oxo-9a-substituierte-1H-fluoren-7-yl)-oxy]ethanimidsaure Hydrazide, ihre Derivate und Salze

Publications (1)

Publication Number Publication Date
ATE64733T1 true ATE64733T1 (de) 1991-07-15

Family

ID=25118757

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86113183T ATE64733T1 (de) 1985-09-26 1986-09-25 ((2,3,9,9a-tetrahydro-3-oxo-9a-substituierte-1h fluoren-7-yl)-oxy>ethanimidamide und ((2,3,9,9atetrahydro-3-oxo-9a-substituierte-1h-fluoren-7- yl)-oxy>ethanimidsaure hydrazide, ihre derivate und salze.

Country Status (8)

Country Link
US (1) US4604396A (de)
EP (1) EP0217287B1 (de)
JP (1) JPS6284052A (de)
AT (1) ATE64733T1 (de)
CA (1) CA1284329C (de)
DE (1) DE3679955D1 (de)
DK (1) DK457286A (de)
ES (1) ES2001801A6 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769370A (en) * 1986-09-24 1988-09-06 Merck & Co., Inc. (1,2-dichloro-8-oxo-5a-substituted-5a,6,7,8-tetrahydrodibenzofuran-3-yl)alkanoic acids and alkanimidamides
US4797391A (en) * 1986-09-24 1989-01-10 Merck & Co., Inc. ((5,6-dichloro-3-oxo-9,9a-disubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides
US4731471A (en) * 1986-11-03 1988-03-15 Merck & Co., Inc. (5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)-alkanoic acids and alkanimidamides bearing novel functional 9a-substituents
US4782073A (en) * 1986-12-24 1988-11-01 Merck & Co., Inc. Amides of [(5,6-dichloro-3-oxo-9-alpha-substituted-2,3,9,9-alpha-tetrahydrofluoren-7-yl-oxyl]acetic acids, and pharmaceutical compositions thereof
US4775695A (en) * 1987-06-01 1988-10-04 Merck & Co., Inc. Substituted amidinoalkoxy and amidinoalkylamino indanones and salts thereof
US4771076A (en) * 1987-06-01 1988-09-13 Merck & Co., Inc. [(2-substituted 1,2-dihydro-1-oxo-1H-inden-5-yl)oxy]alkanesulfonic acids and salts thereof
JP4674339B2 (ja) * 1998-08-07 2011-04-20 三菱化学株式会社 脳損傷の予防・治療剤
US6251898B1 (en) * 1999-08-24 2001-06-26 Questcor Pharmaceuticals, Inc. Medical use of fluorenone derivatives for treating and preventing brain and spinal injury
EP1257264B1 (de) * 2000-02-14 2011-09-14 Merck Sharp & Dohme Corp. Östrogenrezeptor modulatoren
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR051597A1 (es) * 2004-11-01 2007-01-24 Merck & Co Inc Moduladores de los receptores de estrogeno
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
EP3428153A1 (de) 2012-12-17 2019-01-16 Parion Sciences, Inc. 3,5-diamino-6-chlor-n-(n-(4-phenylbutyl) carbamimidoyl)-pyrazin-2-carboxamid-verbindungen
WO2014099676A1 (en) 2012-12-17 2014-06-26 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
CN110054580A (zh) * 2019-05-22 2019-07-26 苏州百灵威超精细材料有限公司 4-(4-n-马来酰亚胺苯基)丁酸酰肼盐酸盐的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4317922A (en) * 1979-10-19 1982-03-02 Merck & Co., Inc. [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives
US4337354A (en) * 1979-10-19 1982-06-29 Merck & Co., Inc. [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives
GR70295B (de) * 1979-10-19 1982-09-06 Merck & Co Inc
US4356313A (en) * 1979-10-19 1982-10-26 Merck & Co., Inc. [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts
US4356314A (en) * 1980-06-30 1982-10-26 Merck & Co., Inc. [5,6,9A-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives
US4316043A (en) * 1980-12-19 1982-02-16 Merck & Co., Inc. [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives

Also Published As

Publication number Publication date
EP0217287A2 (de) 1987-04-08
DK457286A (da) 1987-03-27
DK457286D0 (da) 1986-09-25
CA1284329C (en) 1991-05-21
DE3679955D1 (de) 1991-08-01
US4604396A (en) 1986-08-05
EP0217287A3 (en) 1988-07-20
JPS6284052A (ja) 1987-04-17
ES2001801A6 (es) 1988-06-16
EP0217287B1 (de) 1991-06-26

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee