ATE63318T1 - Immunosuppressive verbindungen, deren mikrobiologische verfahren zur herstellung und deren verwendung als arzneimittel. - Google Patents
Immunosuppressive verbindungen, deren mikrobiologische verfahren zur herstellung und deren verwendung als arzneimittel.Info
- Publication number
- ATE63318T1 ATE63318T1 AT85114935T AT85114935T ATE63318T1 AT E63318 T1 ATE63318 T1 AT E63318T1 AT 85114935 T AT85114935 T AT 85114935T AT 85114935 T AT85114935 T AT 85114935T AT E63318 T1 ATE63318 T1 AT E63318T1
- Authority
- AT
- Austria
- Prior art keywords
- plipastatin
- production
- medicinal products
- ala
- microbiological methods
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000013048 microbiological method Methods 0.000 title 1
- CUOJDWBMJMRDHN-UHFFFAOYSA-N plipastatin Chemical compound N1C(=O)C(CCC(N)=O)NC(=O)C2CCCN2C(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)O)NC(=O)C(NC(=O)C(CCCN)NC(=O)C(CCC(O)=O)NC(=O)CC(O)CCCCCCCCCCCCC)CC(C=C2)=CC=C2OC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 CUOJDWBMJMRDHN-UHFFFAOYSA-N 0.000 abstract 4
- 108010069329 plipastatin Proteins 0.000 abstract 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical group CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 229960002989 glutamic acid Drugs 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
- C12R2001/085—Bacillus cereus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59256475A JPS61134398A (ja) | 1984-12-06 | 1984-12-06 | 新生理活性物質プリパスタチン及びその製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE63318T1 true ATE63318T1 (de) | 1991-05-15 |
Family
ID=17293148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85114935T ATE63318T1 (de) | 1984-12-06 | 1985-11-26 | Immunosuppressive verbindungen, deren mikrobiologische verfahren zur herstellung und deren verwendung als arzneimittel. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4742155A (esLanguage) |
| EP (1) | EP0192828B1 (esLanguage) |
| JP (1) | JPS61134398A (esLanguage) |
| KR (1) | KR920006881B1 (esLanguage) |
| AT (1) | ATE63318T1 (esLanguage) |
| AU (1) | AU583553B2 (esLanguage) |
| DE (1) | DE3582791D1 (esLanguage) |
| DK (1) | DK564785A (esLanguage) |
| ES (1) | ES8701197A1 (esLanguage) |
| GR (1) | GR852894B (esLanguage) |
| HU (1) | HU193838B (esLanguage) |
| PT (1) | PT81615B (esLanguage) |
| ZA (1) | ZA859315B (esLanguage) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5436140A (en) * | 1988-02-02 | 1995-07-25 | Fujisawa Pharmaceutical Co., Ltd. | Process for producing WS-9326A and WS-9326B |
| US5217952A (en) * | 1988-02-02 | 1993-06-08 | Fujisawa Pharmaceutical Co., Ltd. | Peptides WS-9326a and WS-9326b, derivatives thereof and uses thereof |
| IN167138B (esLanguage) * | 1988-08-17 | 1990-09-01 | Hoechst India | |
| US5619066A (en) | 1990-05-15 | 1997-04-08 | Dallas Semiconductor Corporation | Memory for an electronic token |
| US5656602A (en) * | 1991-07-04 | 1997-08-12 | Garvan Institute Of Medical Research | PLA2 inhibitory compounds |
| CA2289916C (en) * | 1997-05-09 | 2010-06-08 | Agraquest, Inc. | A novel strain of bacillus for controlling plant diseases and corn rootworm |
| CN117683074B (zh) * | 2023-12-13 | 2024-08-16 | 山东绿邦生物科技有限公司 | 蜡样芽孢杆菌、蛋白酶抑制剂以及提高蛋白渣产量的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4201771A (en) * | 1979-03-12 | 1980-05-06 | Merck & Co., Inc. | Antibiotic A43F |
-
1984
- 1984-12-06 JP JP59256475A patent/JPS61134398A/ja active Pending
-
1985
- 1985-11-25 AU AU50307/85A patent/AU583553B2/en not_active Ceased
- 1985-11-26 DE DE8585114935T patent/DE3582791D1/de not_active Expired - Lifetime
- 1985-11-26 EP EP85114935A patent/EP0192828B1/en not_active Expired - Lifetime
- 1985-11-26 AT AT85114935T patent/ATE63318T1/de not_active IP Right Cessation
- 1985-11-26 US US06/801,809 patent/US4742155A/en not_active Expired - Fee Related
- 1985-12-02 GR GR852894A patent/GR852894B/el unknown
- 1985-12-04 KR KR1019850009104A patent/KR920006881B1/ko not_active Expired
- 1985-12-04 HU HU854644A patent/HU193838B/hu unknown
- 1985-12-04 ES ES549565A patent/ES8701197A1/es not_active Expired
- 1985-12-05 DK DK564785A patent/DK564785A/da not_active Application Discontinuation
- 1985-12-05 PT PT81615A patent/PT81615B/pt not_active IP Right Cessation
- 1985-12-05 ZA ZA859315A patent/ZA859315B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0192828A2 (en) | 1986-09-03 |
| DK564785A (da) | 1986-06-07 |
| KR920006881B1 (ko) | 1992-08-21 |
| US4742155A (en) | 1988-05-03 |
| ES549565A0 (es) | 1986-11-16 |
| KR860005027A (ko) | 1986-07-16 |
| DK564785D0 (da) | 1985-12-05 |
| AU5030785A (en) | 1986-06-12 |
| AU583553B2 (en) | 1989-05-04 |
| DE3582791D1 (de) | 1991-06-13 |
| ZA859315B (en) | 1986-10-29 |
| PT81615B (pt) | 1988-02-17 |
| EP0192828A3 (en) | 1988-06-01 |
| HUT40707A (en) | 1987-01-28 |
| HU193838B (en) | 1987-12-28 |
| GR852894B (esLanguage) | 1986-04-01 |
| PT81615A (en) | 1986-01-01 |
| ES8701197A1 (es) | 1986-11-16 |
| EP0192828B1 (en) | 1991-05-08 |
| JPS61134398A (ja) | 1986-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |