ATE617T1 - STEROID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR APPLICATION IN RADIOIMMUNOASSAYS. - Google Patents
STEROID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR APPLICATION IN RADIOIMMUNOASSAYS.Info
- Publication number
- ATE617T1 ATE617T1 AT79101578T AT79101578T ATE617T1 AT E617 T1 ATE617 T1 AT E617T1 AT 79101578 T AT79101578 T AT 79101578T AT 79101578 T AT79101578 T AT 79101578T AT E617 T1 ATE617 T1 AT E617T1
- Authority
- AT
- Austria
- Prior art keywords
- radioimmunoassays
- steroid
- processes
- production
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
Abstract
Radiolabeled steroid derivatives having the formula <IMAGE> wherein St is a 6-dehydro derivative of a 3-oxo-4,5-dehydro steroid intended for radioimmunoassay, said steroid being saturated in the 1,2-position; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4; and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays. The unlabeled analogs can be coupled with an immunogenic carrier and used to induce antibody formation in animals.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/908,294 US4323511A (en) | 1978-05-22 | 1978-05-22 | Steroid derivatives and their use in radioimmunoassays |
EP79101578A EP0005558B1 (en) | 1978-05-22 | 1979-05-22 | Steroid derivatives, process for their preparation and their use in radioimmunoassays |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE617T1 true ATE617T1 (en) | 1982-02-15 |
Family
ID=25425538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT79101578T ATE617T1 (en) | 1978-05-22 | 1979-05-22 | STEROID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR APPLICATION IN RADIOIMMUNOASSAYS. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4323511A (en) |
EP (1) | EP0005558B1 (en) |
JP (1) | JPS54151959A (en) |
AT (1) | ATE617T1 (en) |
AU (1) | AU523079B2 (en) |
CA (1) | CA1142915A (en) |
DE (1) | DE2961949D1 (en) |
IL (1) | IL57303A0 (en) |
ZA (1) | ZA791923B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4243608A (en) * | 1979-05-14 | 1981-01-06 | E. R. Squibb & Sons, Inc. | 3-(4-Hydroxyphenyl)pentanedioic acid, monohydrazide, derivatives and analogs |
FR2537586A1 (en) * | 1982-12-13 | 1984-06-15 | Roussel Uclaf | IODE BRANCHED RADIOACTIVE ESTRATRIENE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR APPLICATION TO RADIOIMMUNOLOGICAL ASSAYS |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1118409A (en) * | 1977-08-12 | 1982-02-16 | Jack Bernstein | Steroid derivatives and their use in radioimmunoassays |
-
1978
- 1978-05-22 US US05/908,294 patent/US4323511A/en not_active Expired - Lifetime
-
1979
- 1979-04-23 ZA ZA791923A patent/ZA791923B/en unknown
- 1979-04-24 AU AU46414/79A patent/AU523079B2/en not_active Expired
- 1979-04-25 CA CA000326279A patent/CA1142915A/en not_active Expired
- 1979-05-16 IL IL57303A patent/IL57303A0/en not_active IP Right Cessation
- 1979-05-22 DE DE7979101578T patent/DE2961949D1/en not_active Expired
- 1979-05-22 JP JP6376879A patent/JPS54151959A/en active Pending
- 1979-05-22 EP EP79101578A patent/EP0005558B1/en not_active Expired
- 1979-05-22 AT AT79101578T patent/ATE617T1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US4323511A (en) | 1982-04-06 |
IL57303A0 (en) | 1979-09-30 |
AU4641479A (en) | 1979-11-29 |
EP0005558A1 (en) | 1979-11-28 |
AU523079B2 (en) | 1982-07-08 |
ZA791923B (en) | 1980-04-30 |
CA1142915A (en) | 1983-03-15 |
DE2961949D1 (en) | 1982-03-11 |
JPS54151959A (en) | 1979-11-29 |
EP0005558B1 (en) | 1982-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |