ATE61059T1 - Verfahren zur herstellung von vincristin. - Google Patents
Verfahren zur herstellung von vincristin.Info
- Publication number
- ATE61059T1 ATE61059T1 AT86401179T AT86401179T ATE61059T1 AT E61059 T1 ATE61059 T1 AT E61059T1 AT 86401179 T AT86401179 T AT 86401179T AT 86401179 T AT86401179 T AT 86401179T AT E61059 T1 ATE61059 T1 AT E61059T1
- Authority
- AT
- Austria
- Prior art keywords
- vincristin
- production
- salts
- present
- vincristine
- Prior art date
Links
- 229960004528 vincristine Drugs 0.000 title abstract 3
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title abstract 3
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 1
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 abstract 1
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 229960003048 vinblastine Drugs 0.000 abstract 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8508333A FR2582651B1 (fr) | 1985-06-03 | 1985-06-03 | Procede de preparation de vincristine |
| EP86401179A EP0207831B1 (de) | 1985-06-03 | 1986-06-03 | Verfahren zur Herstellung von Vincristin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE61059T1 true ATE61059T1 (de) | 1991-03-15 |
Family
ID=9319808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86401179T ATE61059T1 (de) | 1985-06-03 | 1986-06-03 | Verfahren zur herstellung von vincristin. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4767855A (de) |
| EP (1) | EP0207831B1 (de) |
| JP (1) | JPH07110866B2 (de) |
| AT (1) | ATE61059T1 (de) |
| CA (1) | CA1260932A (de) |
| DE (1) | DE3677646D1 (de) |
| ES (1) | ES8706703A1 (de) |
| FR (1) | FR2582651B1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001036007A2 (en) * | 1999-11-12 | 2001-05-25 | Angiotech Pharmaceuticals, Inc. | Compositions of a combination of radioactive therapy and cell-cycle inhibitors |
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899493A (en) * | 1972-12-29 | 1975-08-12 | Richter Gedeon Vegyeszet | Chromic acid oxidation of vinblastine sulfate to form vincristine |
| GB1551054A (en) * | 1976-03-04 | 1979-08-22 | Atta Ur Rahman | Syntheses of vinblastine vincristine and vinrosidine |
| US4375432A (en) * | 1981-05-12 | 1983-03-01 | Eli Lilly And Company | Method of preparing vincristine |
| LU84640A1 (fr) * | 1983-02-10 | 1984-11-08 | Onmichem S A | Nouveau procede d'obtention de la vincristine et du sulfate de vincristine |
| HU190219B (en) * | 1984-01-06 | 1986-08-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives |
-
1985
- 1985-06-03 FR FR8508333A patent/FR2582651B1/fr not_active Expired
-
1986
- 1986-05-30 ES ES555499A patent/ES8706703A1/es not_active Expired
- 1986-06-02 US US06/869,433 patent/US4767855A/en not_active Expired - Lifetime
- 1986-06-02 CA CA000510611A patent/CA1260932A/fr not_active Expired
- 1986-06-03 JP JP61129016A patent/JPH07110866B2/ja not_active Expired - Lifetime
- 1986-06-03 DE DE8686401179T patent/DE3677646D1/de not_active Expired - Lifetime
- 1986-06-03 EP EP86401179A patent/EP0207831B1/de not_active Expired - Lifetime
- 1986-06-03 AT AT86401179T patent/ATE61059T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3677646D1 (de) | 1991-04-04 |
| FR2582651A1 (fr) | 1986-12-05 |
| CA1260932A (fr) | 1989-09-26 |
| JPH07110866B2 (ja) | 1995-11-29 |
| EP0207831A1 (de) | 1987-01-07 |
| US4767855A (en) | 1988-08-30 |
| FR2582651B1 (fr) | 1987-08-28 |
| JPS61293989A (ja) | 1986-12-24 |
| ES8706703A1 (es) | 1987-07-01 |
| ES555499A0 (es) | 1987-07-01 |
| EP0207831B1 (de) | 1991-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |