ATE582T1 - N-benzoyl-retinylamine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische mittel und die verwendung dieser verbindungen bei der therapie und prophylaxe von praekanzerosen und karzinomen der haut. - Google Patents
N-benzoyl-retinylamine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische mittel und die verwendung dieser verbindungen bei der therapie und prophylaxe von praekanzerosen und karzinomen der haut.Info
- Publication number
- ATE582T1 ATE582T1 AT79103683T AT79103683T ATE582T1 AT E582 T1 ATE582 T1 AT E582T1 AT 79103683 T AT79103683 T AT 79103683T AT 79103683 T AT79103683 T AT 79103683T AT E582 T1 ATE582 T1 AT E582T1
- Authority
- AT
- Austria
- Prior art keywords
- retinylamine
- benzoyl
- preparation
- precancerose
- prophylaxis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- ZZJBFINBCCYNFG-XTDDRVAVSA-N n-[(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl]benzamide Chemical compound CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/CNC(=O)C1=CC=CC=C1 ZZJBFINBCCYNFG-XTDDRVAVSA-N 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 201000008261 skin carcinoma Diseases 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- LPNBBFKOUUSUDB-UHFFFAOYSA-N p-toluic acid Chemical compound CC1=CC=C(C(O)=O)C=C1 LPNBBFKOUUSUDB-UHFFFAOYSA-N 0.000 abstract 2
- ILYSIVSSNXQZQG-OVSJKPMPSA-N (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-amine Chemical compound NC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C ILYSIVSSNXQZQG-OVSJKPMPSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/18—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782843915 DE2843915A1 (de) | 1978-10-07 | 1978-10-07 | N-benzoyl-retinylamine |
| EP79103683A EP0010209B1 (de) | 1978-10-07 | 1979-09-28 | N-Benzoyl-retinylamine, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Mittel und die Verwendung dieser Verbindungen bei der Therapie und Prophylaxe von Praekanzerosen und Karzinomen der Haut |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE582T1 true ATE582T1 (de) | 1982-02-15 |
Family
ID=6051730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT79103683T ATE582T1 (de) | 1978-10-07 | 1979-09-28 | N-benzoyl-retinylamine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische mittel und die verwendung dieser verbindungen bei der therapie und prophylaxe von praekanzerosen und karzinomen der haut. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0010209B1 (de) |
| JP (1) | JPS5551060A (de) |
| AT (1) | ATE582T1 (de) |
| CA (1) | CA1127655A (de) |
| DE (2) | DE2843915A1 (de) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH529742A (de) * | 1970-02-02 | 1972-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Vitamin-A-Säureamiden |
| ES402985A1 (es) * | 1971-05-19 | 1975-04-16 | Rhone Poulenc Sa | Procedimiento para la obtencion de halogenuros de retinilo. |
| DE2300107C2 (de) * | 1973-01-03 | 1982-03-11 | Basf Ag, 6700 Ludwigshafen | Vitamin A-Säureanilid-4-carbonsäureäthylester, Verfahren zu seiner Herstellung und diesen enthaltende Zubereitungen |
-
1978
- 1978-10-07 DE DE19782843915 patent/DE2843915A1/de active Pending
-
1979
- 1979-09-28 AT AT79103683T patent/ATE582T1/de active
- 1979-09-28 CA CA336,669A patent/CA1127655A/en not_active Expired
- 1979-09-28 EP EP79103683A patent/EP0010209B1/de not_active Expired
- 1979-09-28 DE DE7979103683T patent/DE2961892D1/de not_active Expired
- 1979-10-05 JP JP12811479A patent/JPS5551060A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1127655A (en) | 1982-07-13 |
| DE2843915A1 (de) | 1980-04-24 |
| EP0010209B1 (de) | 1982-01-20 |
| DE2961892D1 (en) | 1982-03-04 |
| JPS5551060A (en) | 1980-04-14 |
| EP0010209A1 (de) | 1980-04-30 |
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