ATE582T1 - N-BENZOYL-RETINYLAMINE, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL AGENTS CONTAINING THEM AND THE USE OF THESE COMPOUNDS IN THE THERAPY AND PROPHYLAXIS OF PRECANCEROSE AND CARCINOMA OF THE SKIN. - Google Patents

N-BENZOYL-RETINYLAMINE, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL AGENTS CONTAINING THEM AND THE USE OF THESE COMPOUNDS IN THE THERAPY AND PROPHYLAXIS OF PRECANCEROSE AND CARCINOMA OF THE SKIN.

Info

Publication number
ATE582T1
ATE582T1 AT79103683T AT79103683T ATE582T1 AT E582 T1 ATE582 T1 AT E582T1 AT 79103683 T AT79103683 T AT 79103683T AT 79103683 T AT79103683 T AT 79103683T AT E582 T1 ATE582 T1 AT E582T1
Authority
AT
Austria
Prior art keywords
retinylamine
benzoyl
preparation
precancerose
prophylaxis
Prior art date
Application number
AT79103683T
Other languages
German (de)
Inventor
Joachim Dr. Paust
Axel Dr. Nuerrenbach
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Application granted granted Critical
Publication of ATE582T1 publication Critical patent/ATE582T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/18—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

1. Claim for the Contracting State : AT A process for the preparation of benzoyl-retinylamines of the formula I see diagramm : EP0010209,P6,F3 where R is hydrogen or methyl, characterized in that retinylamine is reacted in the conventional manner with a functional derivative of benzoic acid of p-toluic acid. 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LU, NL, SE A benzoyl-retinylamine of the formula I see diagramm : EP0010209,P6,F2 where R ist hydrogen or methyl.
AT79103683T 1978-10-07 1979-09-28 N-BENZOYL-RETINYLAMINE, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL AGENTS CONTAINING THEM AND THE USE OF THESE COMPOUNDS IN THE THERAPY AND PROPHYLAXIS OF PRECANCEROSE AND CARCINOMA OF THE SKIN. ATE582T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782843915 DE2843915A1 (en) 1978-10-07 1978-10-07 N-BENZOYL RETINYLAMINE
EP79103683A EP0010209B1 (en) 1978-10-07 1979-09-28 N-benzoyl-retinyl amines, process for their preparation, pharmaceutical compositions comprising them and the use of these compounds for the therapy and prophylaxis of precanceroses and carcinomas of the skin

Publications (1)

Publication Number Publication Date
ATE582T1 true ATE582T1 (en) 1982-02-15

Family

ID=6051730

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79103683T ATE582T1 (en) 1978-10-07 1979-09-28 N-BENZOYL-RETINYLAMINE, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL AGENTS CONTAINING THEM AND THE USE OF THESE COMPOUNDS IN THE THERAPY AND PROPHYLAXIS OF PRECANCEROSE AND CARCINOMA OF THE SKIN.

Country Status (5)

Country Link
EP (1) EP0010209B1 (en)
JP (1) JPS5551060A (en)
AT (1) ATE582T1 (en)
CA (1) CA1127655A (en)
DE (2) DE2843915A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH529742A (en) * 1970-02-02 1972-10-31 Hoffmann La Roche Process for the production of vitamin A acid amides
ES402985A1 (en) * 1971-05-19 1975-04-16 Rhone Poulenc Sa Preparation of retinyl halides
DE2300107C2 (en) * 1973-01-03 1982-03-11 Basf Ag, 6700 Ludwigshafen Vitamin A acid anilide-4-carboxylic acid ethyl ester, process for its production and preparations containing it

Also Published As

Publication number Publication date
EP0010209A1 (en) 1980-04-30
JPS5551060A (en) 1980-04-14
DE2843915A1 (en) 1980-04-24
DE2961892D1 (en) 1982-03-04
CA1127655A (en) 1982-07-13
EP0010209B1 (en) 1982-01-20

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