ATE57T1 - 4,5-METHANO-BUFADIENOLIDE RHAMMOSIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM. - Google Patents

4,5-METHANO-BUFADIENOLIDE RHAMMOSIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.

Info

Publication number
ATE57T1
ATE57T1 AT79103501T AT79103501T ATE57T1 AT E57 T1 ATE57 T1 AT E57T1 AT 79103501 T AT79103501 T AT 79103501T AT 79103501 T AT79103501 T AT 79103501T AT E57 T1 ATE57 T1 AT E57T1
Authority
AT
Austria
Prior art keywords
bufadienolide
methano
rhammosides
preparation
pharmaceuticals containing
Prior art date
Application number
AT79103501T
Other languages
German (de)
Inventor
Hans Peter Dr. Albrecht
Gerda Dr. Von Philipsborn
Hans Ulrich Dr. Siebeneick
Manfred Dr. Raschack
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of ATE57T1 publication Critical patent/ATE57T1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J53/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002Carbocyclic rings fused
    • C07J53/0043 membered carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

4,5-methano-bufadienolide-rhamnosides of the formula I <IMAGE> I where R1 is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, R2 and R3 are identical or different and each is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, or both together are <IMAGE> where R4 and R5 are identical or different and each is hydrogen or alkyl or alkoxy of 1 or 2 carbon atoms. The novel compounds may be used for counteracting cardiac insufficiency.
AT79103501T 1978-09-21 1979-09-18 4,5-METHANO-BUFADIENOLIDE RHAMMOSIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM. ATE57T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782841074 DE2841074A1 (en) 1978-09-21 1978-09-21 4,5-METHANO-BUFADIENOLIDE RHAMNOSIDE, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THE SAME
EP79103501A EP0009232B1 (en) 1978-09-21 1979-09-18 4,5-methano-bufadienolide-rhamnosides, process for their preparation and medicines containing them

Publications (1)

Publication Number Publication Date
ATE57T1 true ATE57T1 (en) 1981-05-15

Family

ID=6050038

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79103501T ATE57T1 (en) 1978-09-21 1979-09-18 4,5-METHANO-BUFADIENOLIDE RHAMMOSIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.

Country Status (7)

Country Link
US (1) US4242332A (en)
EP (1) EP0009232B1 (en)
JP (1) JPS5545677A (en)
AT (1) ATE57T1 (en)
DE (2) DE2841074A1 (en)
DK (1) DK392579A (en)
IE (1) IE48836B1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260736A (en) * 1978-08-14 1981-04-07 Kureha Kagaku Kogyo Kabushiki Kaisha Steroid hormone-antitumor derivatives
US4331802A (en) * 1980-10-01 1982-05-25 Advance Biofactures Corporation Organometallic reagents and their use in the synthesis of cardenolides and isocardenolides
US4380624A (en) * 1981-07-31 1983-04-19 Advance Biofactures Corp. Novel isomers of bufalin and resibufogenin and their preparation
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
US7361478B2 (en) * 2001-11-20 2008-04-22 Allergan, Inc. High-throughput screen for identifying selective persistent sodium channels channel blockers
GB0713463D0 (en) 2007-07-11 2007-08-22 Btg Int Ltd Modulators of hypoxia inducible factor-1 and related uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1910207C3 (en) * 1969-02-28 1978-04-13 Knoll Ag, 6700 Ludwigshafen Process for their manufacture
BE786645A (en) * 1971-07-22 1973-01-24 Hoechst Ag HETEROSIDES OF 14.15 BETA -EPOXY-CARDENOLIDES AND 14.15 BETA -EPOXY BUFADIENOLIDES AND MEDICINAL PRODUCTS THAT CONTAINER

Also Published As

Publication number Publication date
US4242332A (en) 1980-12-30
EP0009232B1 (en) 1981-05-06
DK392579A (en) 1980-03-22
DE2960324D1 (en) 1981-08-13
JPS5545677A (en) 1980-03-31
DE2841074A1 (en) 1980-04-03
IE48836B1 (en) 1985-05-29
EP0009232A1 (en) 1980-04-02
IE791781L (en) 1980-03-21

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee