ATE853T1 - NEW IMIDAZO(1,2-A)IMIDAZOLES, THEIR ACID ADDITION SALTS, MEDICINES CONTAINING THEM AND PROCESSES FOR THEIR MANUFACTURE. - Google Patents

NEW IMIDAZO(1,2-A)IMIDAZOLES, THEIR ACID ADDITION SALTS, MEDICINES CONTAINING THEM AND PROCESSES FOR THEIR MANUFACTURE.

Info

Publication number
ATE853T1
ATE853T1 AT79101590T AT79101590T ATE853T1 AT E853 T1 ATE853 T1 AT E853T1 AT 79101590 T AT79101590 T AT 79101590T AT 79101590 T AT79101590 T AT 79101590T AT E853 T1 ATE853 T1 AT E853T1
Authority
AT
Austria
Prior art keywords
acid addition
addition salts
imidazoles
manufacture
processes
Prior art date
Application number
AT79101590T
Other languages
German (de)
Inventor
Helmut Dr. Staehle
Herbert Dr. Koeppe
Werner Dr. Kummer
Walter Prof. Dr. Kobinger
Christian Dr. Mag. Lillie
Ludwig Dr. Pichler
Original Assignee
C.H. Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn filed Critical C.H. Boehringer Sohn
Application granted granted Critical
Publication of ATE853T1 publication Critical patent/ATE853T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

Compounds of the formula <IMAGE> wherein R1, R2 and R3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, methoxy or trifluoromethyl, provided that one of them is other than hydrogen; and R4 and R5, which may be identical to or different from each other, are each hydrogen or methyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
AT79101590T 1978-06-23 1979-05-23 NEW IMIDAZO(1,2-A)IMIDAZOLES, THEIR ACID ADDITION SALTS, MEDICINES CONTAINING THEM AND PROCESSES FOR THEIR MANUFACTURE. ATE853T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782827617 DE2827617A1 (en) 1978-06-23 1978-06-23 NEW IMIDAZO ANGLE CLAMP ON 1,2- ALPHA ANGLE CLAMP ON IMIDAZOLE, THEIR ACID ADDITIONAL SALTS, THE MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF
EP79101590A EP0006451B1 (en) 1978-06-23 1979-05-23 Imidazo (1,2-a) imidazoles, their acid addition salts, medicaments containing them and process for their preparation

Publications (1)

Publication Number Publication Date
ATE853T1 true ATE853T1 (en) 1982-04-15

Family

ID=6042588

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101590T ATE853T1 (en) 1978-06-23 1979-05-23 NEW IMIDAZO(1,2-A)IMIDAZOLES, THEIR ACID ADDITION SALTS, MEDICINES CONTAINING THEM AND PROCESSES FOR THEIR MANUFACTURE.

Country Status (18)

Country Link
US (1) US4210659A (en)
EP (1) EP0006451B1 (en)
JP (1) JPS554392A (en)
AT (1) ATE853T1 (en)
AU (1) AU519287B2 (en)
CA (1) CA1115280A (en)
DE (2) DE2827617A1 (en)
DK (1) DK146389C (en)
ES (4) ES481799A1 (en)
FI (1) FI65068C (en)
IE (1) IE48355B1 (en)
IL (1) IL57627A (en)
MX (1) MX5687E (en)
NO (1) NO151465C (en)
NZ (1) NZ190801A (en)
PT (1) PT69804A (en)
YU (1) YU42307B (en)
ZA (1) ZA793108B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042636A1 (en) * 1980-11-12 1982-06-16 C.H. Boehringer Sohn, 6507 Ingelheim NEW 7- (2,6-DIBROM-4-METHYLPHENYL) -2,3-DIHYDRO-IMIDAZO (1,2-A) IMIDAZOLES, THEIR ACID ADDITIONAL SALTS, THESE MEDICINAL PRODUCTS AND METHOD FOR THE PRODUCTION THEREOF
DE3124701A1 (en) * 1981-06-24 1983-01-13 Boehringer Ingelheim KG, 6507 Ingelheim NEW L-SUBSTITUTED IMIDAZO (1,2-A) IMIDAZOLES, THEIR ACID ADDITION SALTS, THE MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF
JP2004505978A (en) * 2000-08-09 2004-02-26 ベーリンガー　インゲルハイム　ファーマシューティカルズ　インコーポレイテッド Synthesis of (R) -3- (4-bromobenzyl) -1- (3,5-dichlorophenyl) -5-iodo-3-methyl-1-H-imidazo [1,2-a] imidazol-2-one
EP1359916A4 (en) * 2001-01-26 2004-04-07 Bristol Myers Squibb Co Imidazolyl derivatives as corticotropin releasing factor inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2393826A (en) * 1944-02-28 1946-01-29 Commercial Solvents Corp 1,3,7-triazabicyclo [3.3.0] octanes
DE2109524A1 (en) * 1971-03-01 1972-09-07 CH. Boehringer Sohn, 6507 Ingelheim 2,3-dihydr-dioxo-imidazo (1,2-a) imidazoles or pyrimidines - with hypotensive and neuroleptic activity
DE2118261A1 (en) * 1971-04-15 1972-11-02 C.H. Boehringer Sohn, 6507 Ingelheim New N-containing bicycles, their acid addition salts and processes for their production
US3865836A (en) * 1972-12-08 1975-02-11 Janssen Pharmaceutica Nv Bicyclic imidazoles

Also Published As

Publication number Publication date
AU4827579A (en) 1980-01-03
ES485180A1 (en) 1980-05-16
EP0006451A1 (en) 1980-01-09
IE48355B1 (en) 1984-12-26
CA1115280A (en) 1981-12-29
ES485181A1 (en) 1980-05-16
IE791184L (en) 1979-12-23
DK262879A (en) 1979-12-24
ES481799A1 (en) 1980-02-16
FI65068B (en) 1983-11-30
FI65068C (en) 1984-03-12
DK146389C (en) 1984-03-05
US4210659A (en) 1980-07-01
ZA793108B (en) 1981-02-25
YU147179A (en) 1983-06-30
NO151465B (en) 1985-01-02
NO792099L (en) 1979-12-28
EP0006451B1 (en) 1982-04-14
DE2827617A1 (en) 1980-01-10
NO151465C (en) 1985-04-17
PT69804A (en) 1979-07-01
JPS554392A (en) 1980-01-12
DE2962503D1 (en) 1982-05-27
DK146389B (en) 1983-09-26
IL57627A (en) 1982-02-28
MX5687E (en) 1983-12-09
ES485182A1 (en) 1980-05-16
YU42307B (en) 1988-08-31
AU519287B2 (en) 1981-11-19
NZ190801A (en) 1984-05-31
JPH0127073B2 (en) 1989-05-26
FI791996A (en) 1979-12-24
IL57627A0 (en) 1979-10-31

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