ATE555126T1 - Relaxin-chimere polypeptide und deren herstellung und anwendung - Google Patents

Relaxin-chimere polypeptide und deren herstellung und anwendung

Info

Publication number
ATE555126T1
ATE555126T1 AT05791027T AT05791027T ATE555126T1 AT E555126 T1 ATE555126 T1 AT E555126T1 AT 05791027 T AT05791027 T AT 05791027T AT 05791027 T AT05791027 T AT 05791027T AT E555126 T1 ATE555126 T1 AT E555126T1
Authority
AT
Austria
Prior art keywords
polypeptides
relaxin
chimere
preparation
gpcr135
Prior art date
Application number
AT05791027T
Other languages
English (en)
Inventor
Pascal Bonaventure
Chester Kuei
Changlu Liu
Timothy Lovenberg
Steven Sutton
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE555126T1 publication Critical patent/ATE555126T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05791027T 2004-08-25 2005-08-25 Relaxin-chimere polypeptide und deren herstellung und anwendung ATE555126T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60434004P 2004-08-25 2004-08-25
PCT/US2005/030257 WO2006026355A2 (en) 2004-08-25 2005-08-25 Relaxin-chimeric polypeptides and their preparation and use

Publications (1)

Publication Number Publication Date
ATE555126T1 true ATE555126T1 (de) 2012-05-15

Family

ID=36000575

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05791027T ATE555126T1 (de) 2004-08-25 2005-08-25 Relaxin-chimere polypeptide und deren herstellung und anwendung

Country Status (4)

Country Link
EP (1) EP1789452B1 (de)
JP (1) JP2008512091A (de)
AT (1) ATE555126T1 (de)
WO (1) WO2006026355A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006112737A1 (en) * 2005-04-20 2006-10-26 Protemix Discovery Limited Vesiculins
ATE549351T1 (de) 2007-01-30 2012-03-15 Janssen Pharmaceutica Nv Chimärer peptidantagonist für gpcr135 oder gpcr142
AU2008318278B2 (en) * 2007-10-30 2014-05-29 Howard Florey Institute Chimeric relaxin polypeptides comprising an A and B chain derived from different relaxin family peptides
US8637452B2 (en) 2011-02-23 2014-01-28 Massachusetts Institute Of Technology Water soluble membrane proteins and methods for the preparation and use thereof
WO2015149085A2 (en) * 2014-03-27 2015-10-01 Massachusetts Institute Of Technology Warer-soluble trans-membrane proteins and methods for the preparation and use thereof
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001236817A1 (en) * 2000-03-10 2001-09-24 Zymogenetics Inc. Insulin homolog polypeptide zins4
WO2001081562A1 (fr) * 2000-04-21 2001-11-01 Takeda Chemical Industries, Ltd. Nouveaux polypeptides appartenant a la famille insuline/igf/relaxine et adn correspondants

Also Published As

Publication number Publication date
JP2008512091A (ja) 2008-04-24
EP1789452B1 (de) 2012-04-25
EP1789452A2 (de) 2007-05-30
WO2006026355A3 (en) 2006-12-21
WO2006026355A2 (en) 2006-03-09
EP1789452A4 (de) 2008-11-05

Similar Documents

Publication Publication Date Title
ATE286907T1 (de) Cytokinin-designiertes lerk-5
ATE529442T1 (de) Verbesserte humane interferon-moleküle und ihre verwendungen
ATE555126T1 (de) Relaxin-chimere polypeptide und deren herstellung und anwendung
ATE416190T1 (de) Polypeptide mit bindungsaffinität für her2
DE602006018969D1 (de) Herstellung und reinigung von il-29
DE602006019050D1 (de) Polypeptide mit cellobiohydrolaseaktivität und dafür kodierende polynukleotide
ATE512980T1 (de) Polypeptide mit beta-glucosidase-aktivität sowie diese codierende polynukleotide
CY1111486T1 (el) Μιμητικα αντισωματα (mimetibodies) δεσμευμενα με υποδοχεα μελανοκορτινης, συνθεσεις, μεθοδοι και χρησεις
TW200611910A (en) Interferon-alpha polypeptides and conjugates
EA201301072A1 (ru) Антитела против il-23p19 и их применение
BRPI0613770A2 (pt) anticorpos anti-cd26 e métodos de uso destes
AR036711A1 (es) Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico
WO2006083276A3 (en) Interferon-alpha polypeptides and conjugates
ATE353955T1 (de) Durch zelloberflächenmoleküle induzierte makrophagenaktivierung
DE60233176D1 (de) Aus chaperonin-polypeptiden gebildete geordnete biologische nanostrukturen
NO20073808L (no) BCMA polypeptider og anvendelser derav
DK1576967T3 (da) Rekombinant protein, der bærer epitoper fra det humane papillomvirus indsat i et adenylatcyclaseprotein eller et fragment deraf samt dets terapeutiske anvendelse
BRPI0512798A (pt) molécula de ácido nucleico recombinante, célula, método para produzir uma proteìna de interesse, uso de uma seqüência de ácido nucleico tendo atividade anti-repressora, métodos para gerar uma célula hospedeira expressando dois polipeptìdios de interesse, e para expressar dois polipeptìdios de interesse
ES2114548T3 (es) Procedimiento y composiciones para ensayos de complementacion de enzima utilizando la region omega de beta-galactosidasa.
WO2002036627A3 (en) Interferons, uses and compositions related thereto
PL372972A1 (en) Engineered baculoviruses and their use
WO2004081027A3 (en) Neoplasm specific antibodies and uses thereof
DE602005016417D1 (de) Neue polypeptide zur in-vintro-isolierung und vorbeugung von infektionen mit legionella pneumophila
WO2006069765A3 (en) Secreted polypeptide species involved in multiple sclerosis
WO2004005351A3 (en) Neoplasm specific antibodies and uses thereof