ATE532791T1 - In der 8-stellung modifiziertes purin- nukleosidderivat und dessen medizinische verwendung - Google Patents
In der 8-stellung modifiziertes purin- nukleosidderivat und dessen medizinische verwendungInfo
- Publication number
- ATE532791T1 ATE532791T1 AT05783540T AT05783540T ATE532791T1 AT E532791 T1 ATE532791 T1 AT E532791T1 AT 05783540 T AT05783540 T AT 05783540T AT 05783540 T AT05783540 T AT 05783540T AT E532791 T1 ATE532791 T1 AT E532791T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- modified
- optionally substituted
- useful
- ring
- Prior art date
Links
- 150000003834 purine nucleoside derivatives Chemical class 0.000 title abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 201000005569 Gout Diseases 0.000 abstract 1
- 201000001431 Hyperuricemia Diseases 0.000 abstract 1
- 206010046337 Urate nephropathy Diseases 0.000 abstract 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 229940116269 uric acid Drugs 0.000 abstract 1
- 208000008281 urolithiasis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004270740 | 2004-09-17 | ||
| PCT/JP2005/016894 WO2006030803A1 (ja) | 2004-09-17 | 2005-09-14 | ８位修飾プリンヌクレオシド誘導体及びその医薬用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE532791T1 true ATE532791T1 (de) | 2011-11-15 |
Family
ID=36060055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05783540T ATE532791T1 (de) | 2004-09-17 | 2005-09-14 | In der 8-stellung modifiziertes purin- nukleosidderivat und dessen medizinische verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7795236B2 (de) |
| EP (1) | EP1813623B1 (de) |
| JP (1) | JP4932488B2 (de) |
| AT (1) | ATE532791T1 (de) |
| CA (1) | CA2580236A1 (de) |
| ES (1) | ES2373668T3 (de) |
| TW (1) | TW200626609A (de) |
| WO (1) | WO2006030803A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006115137A1 (ja) * | 2005-04-22 | 2008-12-18 | キッセイ薬品工業株式会社 | ２−アミノベンズイミダゾール誘導体及びその医薬用途 |
| MX2009004051A (es) * | 2006-10-20 | 2009-05-11 | Regeneron Pharma | Uso de antagonistas de il-1 para tratar gota y pseudo gota. |
| US20110171192A1 (en) | 2008-09-05 | 2011-07-14 | Hiroshi Tomiyama | Substituted amine derivative and medicinal composition comprising same as the active ingredient |
| US20130102652A1 (en) * | 2010-03-23 | 2013-04-25 | University Of Utah Research Foundation | Methods and compositions related to modified adenosines for controlling off-target effects in rna interference |
| EP3551611A1 (de) | 2016-12-09 | 2019-10-16 | Celtaxsys Inc. | Monamin- und monoaminderivate als inhibitoren der leukotrien a4-hydrolase |
| CN108329372B (zh) * | 2017-01-20 | 2022-07-26 | 浙江省亚热带作物研究所 | N6-(2-羟乙基)腺苷及其衍生物在制备治疗痛风药物中的应用 |
| US11986480B2 (en) | 2017-02-03 | 2024-05-21 | Tohoku University | Heterocyclic compound |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6294522B1 (en) * | 1999-12-03 | 2001-09-25 | Cv Therapeutics, Inc. | N6 heterocyclic 8-modified adenosine derivatives |
| US20030008841A1 (en) * | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| US6727231B1 (en) * | 2000-10-12 | 2004-04-27 | Repligen Corporation | Uridine therapy for patients with elevated purine levels |
| GB2372741A (en) * | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,8-Disubstituted adenosine derivatives and their different uses |
-
2005
- 2005-09-14 WO PCT/JP2005/016894 patent/WO2006030803A1/ja not_active Ceased
- 2005-09-14 JP JP2006535162A patent/JP4932488B2/ja not_active Expired - Fee Related
- 2005-09-14 ES ES05783540T patent/ES2373668T3/es not_active Expired - Lifetime
- 2005-09-14 CA CA002580236A patent/CA2580236A1/en not_active Abandoned
- 2005-09-14 EP EP05783540A patent/EP1813623B1/de not_active Expired - Lifetime
- 2005-09-14 AT AT05783540T patent/ATE532791T1/de active
- 2005-09-16 TW TW094132030A patent/TW200626609A/zh unknown
-
2007
- 2007-03-13 US US11/717,741 patent/US7795236B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006030803A1 (ja) | 2006-03-23 |
| EP1813623B1 (de) | 2011-11-09 |
| ES2373668T3 (es) | 2012-02-07 |
| US7795236B2 (en) | 2010-09-14 |
| EP1813623A1 (de) | 2007-08-01 |
| US20070179115A1 (en) | 2007-08-02 |
| CA2580236A1 (en) | 2006-03-23 |
| EP1813623A4 (de) | 2010-08-18 |
| JP4932488B2 (ja) | 2012-05-16 |
| US20100249054A9 (en) | 2010-09-30 |
| TW200626609A (en) | 2006-08-01 |
| JPWO2006030803A1 (ja) | 2008-05-15 |
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