ATE530639T1 - Mikroorganismen und verfahren zur verbesserten produktion von panthothenat - Google Patents
Mikroorganismen und verfahren zur verbesserten produktion von panthothenatInfo
- Publication number
- ATE530639T1 ATE530639T1 AT02746888T AT02746888T ATE530639T1 AT E530639 T1 ATE530639 T1 AT E530639T1 AT 02746888 T AT02746888 T AT 02746888T AT 02746888 T AT02746888 T AT 02746888T AT E530639 T1 ATE530639 T1 AT E530639T1
- Authority
- AT
- Austria
- Prior art keywords
- microorganisms
- methods
- featured
- panthothenate
- invention features
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 abstract 2
- 230000001851 biosynthetic effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- OTOIIPJYVQJATP-BYPYZUCNSA-M (R)-pantoate Chemical compound OCC(C)(C)[C@@H](O)C([O-])=O OTOIIPJYVQJATP-BYPYZUCNSA-M 0.000 abstract 1
- PKVVTUWHANFMQC-UHFFFAOYSA-N 2-dehydropantoic acid Chemical compound OCC(C)(C)C(=O)C(O)=O PKVVTUWHANFMQC-UHFFFAOYSA-N 0.000 abstract 1
- QYNUQALWYRSVHF-ABLWVSNPSA-N 5,10-methylenetetrahydrofolic acid Chemical compound C1N2C=3C(=O)NC(N)=NC=3NCC2CN1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-ABLWVSNPSA-N 0.000 abstract 1
- GFKCZHFKMGKIAQ-ABLWVSNPSA-N N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 Chemical class N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 GFKCZHFKMGKIAQ-ABLWVSNPSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940014662 pantothenate Drugs 0.000 abstract 1
- 235000019161 pantothenic acid Nutrition 0.000 abstract 1
- 239000011713 pantothenic acid Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2002/021336 WO2004005527A1 (en) | 2002-07-03 | 2002-07-03 | Microorganisms and processes for enhanced production of pantothenate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE530639T1 true ATE530639T1 (de) | 2011-11-15 |
Family
ID=30113576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02746888T ATE530639T1 (de) | 2002-07-03 | 2002-07-03 | Mikroorganismen und verfahren zur verbesserten produktion von panthothenat |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060099692A1 (de) |
| EP (1) | EP1520030B1 (de) |
| JP (1) | JP2005531326A (de) |
| CN (1) | CN100455669C (de) |
| AT (1) | ATE530639T1 (de) |
| AU (1) | AU2002316575A1 (de) |
| CA (1) | CA2491137A1 (de) |
| DK (1) | DK1520030T3 (de) |
| HU (1) | HUP0500383A2 (de) |
| MX (1) | MXPA04012807A (de) |
| WO (1) | WO2004005527A1 (de) |
| ZA (1) | ZA200500949B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7989187B2 (en) | 2002-07-03 | 2011-08-02 | Basf Se | Microorganisms and processes for enhanced production of pantothenate |
| CN101448950B (zh) | 2006-05-16 | 2014-02-12 | 帝斯曼知识产权资产管理有限公司 | 用于生产泛醇的工艺 |
| EP4406615A3 (de) | 2009-10-26 | 2024-12-11 | F. Hoffmann-La Roche AG | Verfahren zur herstellung eines glykosylierten immunglobulins |
| WO2012175575A2 (en) | 2011-06-21 | 2012-12-27 | Dsm Ip Assets B.V. | Increased vitamin b5 production |
| WO2012175574A1 (en) | 2011-06-21 | 2012-12-27 | Dsm Ip Assets B.V. | Increased pantothenate (vitamin b5) production |
| WO2013163576A1 (en) * | 2012-04-27 | 2013-10-31 | Retrophin, Inc. | Pantothenate derivatives for the treatment of neurologic disorders |
| CN108456701B (zh) * | 2018-03-23 | 2020-10-16 | 精晶药业股份有限公司 | 一种d-泛解酸内酯的制备方法 |
| CN112458073B (zh) * | 2020-12-01 | 2021-12-10 | 北京化工大学 | 一种h-蛋白突变体及其应用 |
| CN113637618B (zh) * | 2021-06-04 | 2024-02-02 | 浙江工业大学 | 一种d-泛酸生产菌、构建方法及应用 |
| CN115595328B (zh) * | 2022-03-07 | 2026-02-13 | 中国科学院微生物研究所 | 天冬氨酸脱羧酶在发酵生产维生素b5中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19846499A1 (de) * | 1998-10-09 | 2000-04-20 | Degussa | Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierenden Nukleotidsequenzen |
| CZ20021013A3 (en) * | 1999-09-21 | 2002-12-11 | Omnigene Bioproducts | Methods and microorganisms for production of panto-compounds |
| ATE347589T1 (de) * | 2001-01-19 | 2006-12-15 | Basf Ag | Verfahren und mikroorganismus zur verbesserten produktion von pantothenat |
| WO2002057474A2 (en) * | 2001-01-19 | 2002-07-25 | Basf Aktiengesellschaft | Processes for enhanced production of pantothenate |
| EP1402046A1 (de) * | 2001-07-03 | 2004-03-31 | Degussa AG | Verfahren zur fermentativen herstellung von pantothensäure und/oder ihren salzen |
-
2002
- 2002-07-03 CN CNB028292669A patent/CN100455669C/zh not_active Expired - Fee Related
- 2002-07-03 EP EP02746888A patent/EP1520030B1/de not_active Expired - Lifetime
- 2002-07-03 CA CA002491137A patent/CA2491137A1/en not_active Abandoned
- 2002-07-03 US US10/520,210 patent/US20060099692A1/en not_active Abandoned
- 2002-07-03 MX MXPA04012807A patent/MXPA04012807A/es not_active Application Discontinuation
- 2002-07-03 DK DK02746888.3T patent/DK1520030T3/da active
- 2002-07-03 AU AU2002316575A patent/AU2002316575A1/en not_active Abandoned
- 2002-07-03 JP JP2004519495A patent/JP2005531326A/ja active Pending
- 2002-07-03 WO PCT/US2002/021336 patent/WO2004005527A1/en not_active Ceased
- 2002-07-03 AT AT02746888T patent/ATE530639T1/de not_active IP Right Cessation
- 2002-07-03 HU HU0500383A patent/HUP0500383A2/hu unknown
-
2005
- 2005-02-02 ZA ZA200500949A patent/ZA200500949B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0500383A2 (hu) | 2005-08-29 |
| CN100455669C (zh) | 2009-01-28 |
| DK1520030T3 (da) | 2012-02-27 |
| CN1639349A (zh) | 2005-07-13 |
| EP1520030A1 (de) | 2005-04-06 |
| EP1520030B1 (de) | 2011-10-26 |
| MXPA04012807A (es) | 2005-02-24 |
| AU2002316575A1 (en) | 2004-01-23 |
| JP2005531326A (ja) | 2005-10-20 |
| WO2004005527A1 (en) | 2004-01-15 |
| CA2491137A1 (en) | 2004-01-15 |
| US20060099692A1 (en) | 2006-05-11 |
| ZA200500949B (en) | 2006-12-27 |
| EP1520030A4 (de) | 2010-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |