ATE519857T1 - Lichtemittierende mikroorganismen und viren für die diagnose von erkrankungen die mit verletztem oder entzündetem gewebe zusammenhängen - Google Patents
Lichtemittierende mikroorganismen und viren für die diagnose von erkrankungen die mit verletztem oder entzündetem gewebe zusammenhängenInfo
- Publication number
- ATE519857T1 ATE519857T1 AT03735553T AT03735553T ATE519857T1 AT E519857 T1 ATE519857 T1 AT E519857T1 AT 03735553 T AT03735553 T AT 03735553T AT 03735553 T AT03735553 T AT 03735553T AT E519857 T1 ATE519857 T1 AT E519857T1
- Authority
- AT
- Austria
- Prior art keywords
- inflamed tissue
- injured
- viruses
- protein
- light
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000006830 Luminescent Proteins Human genes 0.000 abstract 1
- 108010047357 Luminescent Proteins Proteins 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 102000034287 fluorescent proteins Human genes 0.000 abstract 1
- 108091006047 fluorescent proteins Proteins 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000012800 visualization Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1896—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes not provided for elsewhere, e.g. cells, viruses, ghosts, red blood cells, virus capsides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Radiology & Medical Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02012552A EP1369491A1 (de) | 2002-06-05 | 2002-06-05 | Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe |
| PCT/EP2003/005907 WO2003104485A2 (en) | 2002-06-05 | 2003-06-05 | Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519857T1 true ATE519857T1 (de) | 2011-08-15 |
Family
ID=29433119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03735553T ATE519857T1 (de) | 2002-06-05 | 2003-06-05 | Lichtemittierende mikroorganismen und viren für die diagnose von erkrankungen die mit verletztem oder entzündetem gewebe zusammenhängen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8137904B2 (de) |
| EP (2) | EP1369491A1 (de) |
| JP (1) | JP4390699B2 (de) |
| CN (1) | CN1668758A (de) |
| AT (1) | ATE519857T1 (de) |
| AU (2) | AU2003236696A1 (de) |
| CA (1) | CA2488227A1 (de) |
| IL (2) | IL165350A0 (de) |
| RU (1) | RU2375456C2 (de) |
| SG (1) | SG165992A1 (de) |
| WO (1) | WO2003104485A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1281767A3 (de) | 2001-07-31 | 2003-05-28 | Aladar A. Szalay | Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren |
| EP1369491A1 (de) | 2002-06-05 | 2003-12-10 | Aladar A. Szalay | Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe |
| US20030228261A1 (en) * | 2002-06-05 | 2003-12-11 | Aladar Szalay | Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue |
| RU2376371C2 (ru) * | 2003-06-18 | 2009-12-20 | Дженелюкс Корпорейшн | Модифицированные рекомбинантные вакцинирующие вирусы и другие микроорганизмы и их применение |
| TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| WO2008100292A2 (en) | 2006-10-16 | 2008-08-21 | Genelux Corporation | Modified vaccinia virus strains for use in diagnostic and therapeutic methods |
| WO2008150496A2 (en) * | 2007-05-31 | 2008-12-11 | Genelux Corporation | Assay for sensitivity to chemotherapeutic agents |
| WO2008156655A2 (en) | 2007-06-15 | 2008-12-24 | Genelux Corporation | Vaccinia virus vectors encoding a sodium-dependent transporter protein for imaging and/or treatment of tumors |
| EP2173368A1 (de) * | 2007-07-18 | 2010-04-14 | Genelux Corporation | Verwendung eines chemotherapeutischen mittels zur herstellung eines medikaments zur behandlung oder linderung einer mit einer onkolytischen virentherapie verbundenen unerwünschten nebenwirkung |
| WO2009126189A1 (en) | 2008-01-11 | 2009-10-15 | Genelux Corporation | Methods and compositions for detection of bacteria and treatment of diseases and disorders |
| US20120052003A9 (en) * | 2008-05-16 | 2012-03-01 | Szalay Aladar A | Microorganisms for preventing and treating neoplasms accompanying cellular therapy |
| CA2836299A1 (en) | 2011-04-15 | 2012-10-18 | Genelux Corporation | Clonal strains of attenuated vaccinia viruses and methods of use thereof |
| JP6037259B2 (ja) * | 2011-04-28 | 2016-12-07 | 国立大学法人 千葉大学 | 一酸化窒素を探知するための形質転換用組換えベクター、およびこれを用いた一酸化窒素センサ細胞 |
| US8859256B2 (en) | 2011-10-05 | 2014-10-14 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
| RU2513686C2 (ru) * | 2012-08-24 | 2014-04-20 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pG1-Rm7, ОБЕСПЕЧИВАЮЩАЯ СИНТЕЗ ГИБРИДНОГО БЕЛКА G1-Rm7, И ГИБРИДНЫЙ БЕЛОК, СВЯЗЫВАЮЩИЙ ФАКТОР НЕКРОЗА ОПУХОЛЕЙ И ОБЛАДАЮЩИЙ БИОЛЮМИНЕСЦЕНТНОЙ АКТИВНОСТЬЮ |
| HK1220488A1 (zh) | 2013-03-15 | 2017-05-05 | The Children's Hospital Of Philadelphia | 含有填充者/填充物多核苷酸序列的载体及其使用方法 |
| CN116004721A (zh) | 2013-07-12 | 2023-04-25 | 费城儿童医院 | Aav载体和用于抗aav(腺相关病毒)中和抗体的检测 |
| US9642586B2 (en) * | 2014-08-18 | 2017-05-09 | Siemens Aktiengesellschaft | Computer-aided analysis of medical images |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2018049362A1 (en) * | 2016-09-12 | 2018-03-15 | Massachusetts Institute Of Technology | Transcriptional sensor for bile acids in bacteroides thetaiotaomicron |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| CN107418996A (zh) * | 2017-04-19 | 2017-12-01 | 中国食品药品检定研究院 | 一种检测血管支架材料体外内皮化的模型制备及应用 |
| CN109402127B (zh) * | 2018-09-29 | 2021-12-10 | 复旦大学附属眼耳鼻喉科医院 | 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用 |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US31643A (en) * | 1861-03-05 | Bons l | ||
| US213741A (en) * | 1879-04-01 | Improvement in portable platforms for fire and other ladders | ||
| US69491A (en) * | 1867-10-01 | Newark | ||
| EP0037441B1 (de) | 1980-03-10 | 1984-05-09 | Seiji Arakawa | Pharmazeutische Zusammensetzungen zur zellulären Immunopotentialisation und als Antitumor-Mittel, Verfahren zu ihrer Herstellung und der darin verwendete Mikroorganismus |
| US4442203A (en) | 1981-06-30 | 1984-04-10 | Massachusetts Institute Of Technology | Gene amplification assay for detecting tumor promoters |
| US5833975A (en) | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| US4722848A (en) * | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US4778759A (en) * | 1982-07-09 | 1988-10-18 | Boyce, Thompson Institute For Plant Research, Inc. | Genetic engineering in cyanobacteria |
| US5221623A (en) * | 1986-07-22 | 1993-06-22 | Boyce Thompson Institute For Plant Research, Inc. | Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms |
| US6007806A (en) | 1986-08-13 | 1999-12-28 | Transgene S.A. | Expression of a tumor-specific antigen by a recombinant vector virus and use thereof in preventive or curative treatment of the corresponding tumor |
| US5283187A (en) * | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5650148A (en) * | 1988-12-15 | 1997-07-22 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system |
| DE69032841T2 (de) * | 1989-01-23 | 1999-05-12 | Chiron Corp., Emeryville, Calif. | Rekombinante zellen für therapien von infektionen und hyperprolieferative störungen und deren herstellung |
| US5618531A (en) * | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| US5863542A (en) * | 1991-03-07 | 1999-01-26 | Virogenetics Corporation | Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts |
| US5212082A (en) * | 1991-03-13 | 1993-05-18 | New York University | Genetically modified tyrosine hydroxylase and uses thereof |
| HK1001832A1 (en) | 1991-04-25 | 1998-07-10 | Brown University Research Foundation | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
| US5800829A (en) * | 1991-04-25 | 1998-09-01 | Brown University Research Foundation | Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core |
| US5718902A (en) * | 1991-06-17 | 1998-02-17 | The Regents Of The University Of California | Double recombinant vaccinia virus vaccines |
| US5411860A (en) * | 1992-04-07 | 1995-05-02 | The Johns Hopkins University | Amplification of human MDM2 gene in human tumors |
| US5762959A (en) * | 1992-05-29 | 1998-06-09 | Vivorx, Inc. | Microencapsulation of cells |
| JP4098355B2 (ja) * | 1993-08-12 | 2008-06-11 | ニューロテック ユーエスエー, インコーポレイテッド | 遺伝的に改変された細胞を含む生体適合性免疫隔離カプセル |
| US6491905B1 (en) | 1993-09-14 | 2002-12-10 | The Uab Research Foundation | Recombinant bacterial cells for delivery of PNP to tumor cells |
| FR2710536B1 (fr) | 1993-09-29 | 1995-12-22 | Transgene Sa | Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire. |
| US6416754B1 (en) * | 1994-03-03 | 2002-07-09 | The Board Of Trustees Of The Leland Stanford Junior University | Anaerobe targeted enzyme-mediated prodrug therapy |
| US5550050A (en) * | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
| US6093700A (en) * | 1995-05-11 | 2000-07-25 | Thomas Jefferson University | Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF |
| US6455673B1 (en) * | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
| US6649143B1 (en) | 1994-07-01 | 2003-11-18 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
| US5650135A (en) | 1994-07-01 | 1997-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
| DE4425382C2 (de) | 1994-07-19 | 1997-08-14 | Univ Hohenheim | Salmonella-Lebendimpfstoff |
| US5853717A (en) * | 1994-07-20 | 1998-12-29 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
| US5853385A (en) | 1994-08-26 | 1998-12-29 | Cytotherapeutics, Inc. | Encapsulated PC12 cell transplants for treatment of Parkinson's disease |
| ES2154738T3 (es) * | 1994-10-03 | 2001-04-16 | Us Gov Health & Human Serv | Composicion que comprende un virus recombinante que expresa un antigeno y un virus recombinante que expresa una molecula inmunoestimuladora. |
| US6045802A (en) * | 1994-10-03 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule |
| US5693533A (en) | 1994-12-07 | 1997-12-02 | The Goodwin Institue For Cancer Research | Human breast carcinoma cell line capable of production of a spontaneously metastasizing tumor in animals for use in anticancer drug testing |
| US6150170A (en) | 1998-05-03 | 2000-11-21 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same |
| US6503703B1 (en) * | 1995-05-19 | 2003-01-07 | Mount Sinai School Of Medicine Of New York University | Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication |
| US5704910A (en) * | 1995-06-05 | 1998-01-06 | Nephros Therapeutics, Inc. | Implantable device and use therefor |
| US6190657B1 (en) * | 1995-06-07 | 2001-02-20 | Yale University | Vectors for the diagnosis and treatment of solid tumors including melanoma |
| US5646298A (en) * | 1995-06-07 | 1997-07-08 | Procoron, Inc. | Cyclopropylindole prodrugs |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| US6025155A (en) * | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US6077697A (en) * | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US20030033617A1 (en) * | 1996-04-10 | 2003-02-13 | Gyula Hadlaczky | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US20020160970A1 (en) | 1996-04-10 | 2002-10-31 | Gyula Hadlaczky | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US5976796A (en) | 1996-10-04 | 1999-11-02 | Loma Linda University | Construction and expression of renilla luciferase and green fluorescent protein fusion genes |
| US5842431A (en) | 1997-02-19 | 1998-12-01 | Wu; Chong-Ming | Rotating shuttle and presser plate arrangement |
| US6251384B1 (en) * | 1997-04-28 | 2001-06-26 | Anticancer, Inc. | Metastasis models using green fluorescent protein (GFP) as a marker |
| US6235968B1 (en) * | 1997-04-28 | 2001-05-22 | Anticancer, Inc. | Metastasis models using green fluorescent protein (GFP) as a marker |
| US6232523B1 (en) * | 1997-04-28 | 2001-05-15 | Anticancer, Inc. | Metastasis models using green fluorescent protein (GFP) as a marker |
| US6265557B1 (en) * | 1997-05-09 | 2001-07-24 | Loma Linda University Medical Center | ABO histo-blood group O alleles of the baboon |
| US6713284B2 (en) * | 1997-06-25 | 2004-03-30 | The United States Of America As Represented By The Secretary Of The Army | Bacterial superantigen vaccines |
| US6080849A (en) * | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| US6099848A (en) * | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US6106826A (en) * | 1997-12-17 | 2000-08-22 | Wisconsin Alumni Research Foundation | Replication competent, avirulent Herpes simplex virus as a vector for neural and ocular gene therapy |
| DE29924318U1 (de) * | 1999-01-14 | 2002-09-19 | Fleischmann, Wilhelm, Dr.med., 74321 Bietigheim-Bissingen | Verbandsmaterial |
| US6087168A (en) | 1999-01-20 | 2000-07-11 | Cedars Sinai Medical Center | Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells |
| US6713293B1 (en) * | 1999-02-08 | 2004-03-30 | Friedrich Grummt | Encapsulated cells containing an amplified expression vector as a drug delivery device |
| US6428968B1 (en) * | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| US6511967B1 (en) * | 1999-04-23 | 2003-01-28 | The General Hospital Corporation | Use of an internalizing transferrin receptor to image transgene expression |
| CA2375189C (en) * | 1999-05-28 | 2010-02-09 | The Government Of The United States Of America | A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector |
| US6627190B2 (en) * | 1999-07-12 | 2003-09-30 | Saint Louis University | Recombinant adenovirus vectors that are replication-competent in tert-expressing cells |
| WO2001025399A2 (en) * | 1999-10-04 | 2001-04-12 | Vion Pharmaceuticals, Inc. | Non-invasive tumor imaging by tumor-targeted bacteria |
| US6589531B1 (en) * | 2000-01-21 | 2003-07-08 | The Regents Of The University Of California | Recombinant yellow fever virus and method of use thereof |
| US20010029023A1 (en) * | 2000-01-26 | 2001-10-11 | Szalay Aladar A. | Method for the evaluation of implantable materials |
| EP1294906B1 (de) | 2000-03-17 | 2009-01-21 | Anticancer, Inc. | Optisches abbildungssystem zur darstellung der genexpression des gesamten körpers und anwendungen |
| DE10013511A1 (de) * | 2000-03-20 | 2001-10-11 | Brand Gmbh & Co Kg | Mehrkanal-Pipettiereinrichtung sowie Pipettenschaft dafür |
| JP4231226B2 (ja) | 2000-04-04 | 2009-02-25 | 新日本製鐵株式会社 | 圧延h形鋼の製造方法 |
| CA2341356C (en) * | 2000-04-14 | 2011-10-11 | Transgene S.A. | Poxvirus with targeted infection specificity |
| CA2342040C (en) * | 2000-09-21 | 2012-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Anaerobic bacterium as a drug for cancer gene therapy |
| JP3642755B2 (ja) | 2000-09-21 | 2005-04-27 | 純 天野 | 嫌気性菌を用いた遺伝子治療用医薬 |
| JP2005520781A (ja) * | 2001-07-09 | 2005-07-14 | アンチキャンサー インコーポレーテッド | 蛍光タンパク質をマーカーとして用いた感染の画像化 |
| EP1281767A3 (de) | 2001-07-31 | 2003-05-28 | Aladar A. Szalay | Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren |
| EP1281772A1 (de) * | 2001-07-31 | 2003-02-05 | Aladar A. Szalay | Lichtemittierende Mikroorganismen und Zellen zum Nachweis und zur Therapie von Krebs |
| US20030198627A1 (en) | 2001-09-01 | 2003-10-23 | Gert-Jan Arts | siRNA knockout assay method and constructs |
| WO2003030720A2 (en) * | 2001-10-09 | 2003-04-17 | The Children's Hospital Of Philadelphia | Materials and methods for preventing or reducing scar formation |
| AU2002350235A1 (en) | 2001-11-21 | 2003-06-10 | The Johns Hopkins University | Combination bacteriolytic therapy for the treatment of tumors |
| KR101142380B1 (ko) * | 2001-12-31 | 2012-05-18 | 안티캔서, 인코포레이티드 | 박테리아 종양 치료의 모니터링 시스템 |
| JP2005531507A (ja) * | 2002-03-02 | 2005-10-20 | ザ ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | ストローマ細胞前駆体による抗癌物質の局所的な産生および/または送達方法 |
| WO2003078640A2 (en) | 2002-03-15 | 2003-09-25 | Baxter International Inc. | Recombinant drug-sensitive vaccinia virus as smallpox vaccine |
| US20030213007A1 (en) | 2002-03-27 | 2003-11-13 | Slattery Charles Wilbur | Human milk produced by human mammary tissue implanted in non-human host animals and uses thereof |
| CA2486980A1 (en) | 2002-05-29 | 2003-12-11 | The Regents Of The University Of California | Attenuated listeria spp. and methods for using the same |
| US20030228261A1 (en) | 2002-06-05 | 2003-12-11 | Aladar Szalay | Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue |
| EP1369491A1 (de) | 2002-06-05 | 2003-12-10 | Aladar A. Szalay | Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe |
| WO2004044175A2 (en) | 2002-11-12 | 2004-05-27 | Anticancer, Inc. | Fluorescence guided cell capture |
| RU2376371C2 (ru) | 2003-06-18 | 2009-12-20 | Дженелюкс Корпорейшн | Модифицированные рекомбинантные вакцинирующие вирусы и другие микроорганизмы и их применение |
| EP1489164A1 (de) | 2003-06-18 | 2004-12-22 | Genelux GmbH | Rekombinante Vaccinia-Viren mit modifizierten F3-Genen, Verwendungen davon |
| EP1526185B1 (de) | 2003-10-22 | 2012-09-12 | Genelux Corporation | Verwendung von Mikroorganismen oder Zellen zur Autoimmunisierung gegen Tumoren |
| DE60329594D1 (de) | 2003-08-14 | 2009-11-19 | Genelux Corp | Methode zur Herstellung eines Polypeptides, einer RNA oder einer anderen Verbindung in Tumorgewebe |
| WO2005057488A2 (en) | 2003-12-03 | 2005-06-23 | Anticancer, Inc. | Modular system for multi-color, whole body fluorescence imaging |
| US20080038204A1 (en) | 2004-01-26 | 2008-02-14 | Meng Yang | Whole Body Imaging Using Portable Observation Systems |
| TW200819540A (en) * | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| WO2008100292A2 (en) * | 2006-10-16 | 2008-08-21 | Genelux Corporation | Modified vaccinia virus strains for use in diagnostic and therapeutic methods |
| WO2008150496A2 (en) * | 2007-05-31 | 2008-12-11 | Genelux Corporation | Assay for sensitivity to chemotherapeutic agents |
| EP2173368A1 (de) * | 2007-07-18 | 2010-04-14 | Genelux Corporation | Verwendung eines chemotherapeutischen mittels zur herstellung eines medikaments zur behandlung oder linderung einer mit einer onkolytischen virentherapie verbundenen unerwünschten nebenwirkung |
| WO2009054996A2 (en) * | 2007-10-25 | 2009-04-30 | Genelux Corporation | Systems and methods for viral therapy |
| WO2009126189A1 (en) * | 2008-01-11 | 2009-10-15 | Genelux Corporation | Methods and compositions for detection of bacteria and treatment of diseases and disorders |
| US20120052003A9 (en) | 2008-05-16 | 2012-03-01 | Szalay Aladar A | Microorganisms for preventing and treating neoplasms accompanying cellular therapy |
-
2002
- 2002-06-05 EP EP02012552A patent/EP1369491A1/de not_active Withdrawn
-
2003
- 2003-06-05 RU RU2004135547/13A patent/RU2375456C2/ru not_active IP Right Cessation
- 2003-06-05 JP JP2004511544A patent/JP4390699B2/ja not_active Expired - Fee Related
- 2003-06-05 US US10/516,785 patent/US8137904B2/en not_active Expired - Fee Related
- 2003-06-05 EP EP03735553A patent/EP1509617B1/de not_active Expired - Lifetime
- 2003-06-05 WO PCT/EP2003/005907 patent/WO2003104485A2/en not_active Ceased
- 2003-06-05 AT AT03735553T patent/ATE519857T1/de not_active IP Right Cessation
- 2003-06-05 IL IL16535003A patent/IL165350A0/xx unknown
- 2003-06-05 CA CA002488227A patent/CA2488227A1/en not_active Abandoned
- 2003-06-05 AU AU2003236696A patent/AU2003236696A1/en not_active Abandoned
- 2003-06-05 CN CNA038127873A patent/CN1668758A/zh active Pending
- 2003-06-05 SG SG200701613-2A patent/SG165992A1/en unknown
-
2004
- 2004-11-23 IL IL165350A patent/IL165350A/en not_active IP Right Cessation
-
2008
- 2008-07-03 AU AU2008202946A patent/AU2008202946B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US8137904B2 (en) | 2012-03-20 |
| IL165350A (en) | 2012-03-29 |
| AU2008202946B2 (en) | 2011-03-24 |
| EP1509617A2 (de) | 2005-03-02 |
| EP1509617B1 (de) | 2011-08-10 |
| CN1668758A (zh) | 2005-09-14 |
| RU2004135547A (ru) | 2006-11-20 |
| CA2488227A1 (en) | 2003-12-18 |
| WO2003104485A2 (en) | 2003-12-18 |
| US20050249670A1 (en) | 2005-11-10 |
| EP1369491A1 (de) | 2003-12-10 |
| IL165350A0 (en) | 2006-01-15 |
| JP4390699B2 (ja) | 2009-12-24 |
| SG165992A1 (en) | 2010-11-29 |
| AU2008202946A1 (en) | 2008-07-24 |
| WO2003104485A3 (en) | 2004-04-29 |
| JP2005528922A (ja) | 2005-09-29 |
| AU2003236696A1 (en) | 2003-12-22 |
| RU2375456C2 (ru) | 2009-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE519857T1 (de) | Lichtemittierende mikroorganismen und viren für die diagnose von erkrankungen die mit verletztem oder entzündetem gewebe zusammenhängen | |
| DE60234793D1 (de) | LIVP Stamm von Vaccinia-Virus zur Diagnose und Behandlung von Tumoren | |
| Golub et al. | Tetracyclines inhibit tissue collagenase activity: a new mechanism in the treatment of periodontal disease | |
| KAUFMAN et al. | Subdural empyema: analysis of 17 recent cases and review of the literature | |
| BR0207310A (pt) | Composição farmacêutica de interferon gama ou de pirfenidona com diagnósticos moleculares para o melhor tratamento de doenças pulmonares intersticiais | |
| ATE85080T1 (de) | Menschlicher transformationswachstumsfaktor und vorlaeufer oder fragment hiervon, zellen, dna, vektoren und verfahren zu ihrer herstellung, zusammensetzungen und produkte, die diese enthalten, sowie davon abgeleitete antikoerper und diagnostizierverfahren. | |
| Reed et al. | The first case of Ignatzschineria ureiclastica/larvae in the United States presenting as a myiatic wound infection | |
| ATE395602T1 (de) | Verwendung von hmgb-proteinen und dafür codierenden nukleinsäuren | |
| ATE328899T1 (de) | Zellkernlokalisierendes protein für beta-catenin | |
| BARTON et al. | Granuloma inguinale treated with streptomycin: Report of three cases | |
| Nagaratnam et al. | Anorexia nervosa in a 70 year old man | |
| Martínez‐Doménech et al. | Ultrasonography for early detection of non‐infectious necrotizing fasciitis secondary to cutaneous loxoscelism. | |
| ATE278011T1 (de) | Human dnase ii | |
| Valerón-Almazán et al. | Extensive, non-healing scalp ulcer associated with trauma-induced chronic osteomyelitis | |
| DE50214523D1 (de) | Nukleotidträger zur diagnose und therapie oraler erkrankungen | |
| RU94008771A (ru) | Способ прогнозирования продолжительности жизни онкологических больных 4-ой стадии заболевания после диагностических хирургических вмешательств | |
| Bellastella et al. | Comment on Mäkimattila et al. Every Fifth Individual With Type 1 Diabetes Suffers From an Additional Autoimmune Disease: A Finnish Nationwide Study. Diabetes Care 2020; 43: 1041–1047 | |
| Mamillapalli et al. | Diverse roles of salivary microbiota in the onset and severity of periodontal disease | |
| Harris | Medical genetics | |
| Tombleson et al. | Immediate Tellurite Test in Diphtheria | |
| ATE420210T1 (de) | Diagnose des brustkrebsrisikos | |
| Zambon et al. | Tetracyclines inhibit tissue coiiagenase activity | |
| Daly et al. | Unilocular hydatid cyst disease in the mid-South | |
| Singh et al. | Multiple Eschars in Scrub Typhus | |
| Chen et al. | Ludwig's angina caused by a migrating fish bone |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |