ATE508630T1 - Verfahren und gerät für das einfrieren und auftauen von biologischen proben - Google Patents

Verfahren und gerät für das einfrieren und auftauen von biologischen proben

Info

Publication number
ATE508630T1
ATE508630T1 AT03704956T AT03704956T ATE508630T1 AT E508630 T1 ATE508630 T1 AT E508630T1 AT 03704956 T AT03704956 T AT 03704956T AT 03704956 T AT03704956 T AT 03704956T AT E508630 T1 ATE508630 T1 AT E508630T1
Authority
AT
Austria
Prior art keywords
temperature
freezing
biological samples
sample
thawing biological
Prior art date
Application number
AT03704956T
Other languages
English (en)
Inventor
Meir Uri
Original Assignee
Core Dynamics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Core Dynamics Ltd filed Critical Core Dynamics Ltd
Application granted granted Critical
Publication of ATE508630T1 publication Critical patent/ATE508630T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A01N1/0268—Carriers for immersion in cryogenic fluid, both for slow-freezing and vitrification, e.g. open or closed "straws" for embryos, oocytes or semen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
    • A01N1/0257—Stationary or portable vessels generating cryogenic temperatures
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/20—Heating; Cooling
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/22—Means for packing or storing viable microorganisms
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D13/00—Stationary devices, e.g. cold-rooms
    • F25D13/06—Stationary devices, e.g. cold-rooms with conveyors carrying articles to be cooled through the cooling space
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/02—Devices using other cold materials; Devices using cold-storage bodies using ice, e.g. ice-boxes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25C—PRODUCING, WORKING OR HANDLING ICE
    • F25C1/00—Producing ice
    • F25C1/18—Producing ice of a particular transparency or translucency, e.g. by injecting air
    • F25C1/20—Producing ice of a particular transparency or translucency, e.g. by injecting air by agitation
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
    • F25D3/11—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air with conveyors carrying articles to be cooled through the cooling space
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Combustion & Propulsion (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
AT03704956T 2002-01-08 2003-01-08 Verfahren und gerät für das einfrieren und auftauen von biologischen proben ATE508630T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34564302P 2002-01-08 2002-01-08
US39157502P 2002-06-27 2002-06-27
PCT/IL2003/000026 WO2003056919A2 (en) 2002-01-08 2003-01-08 Methods and device for freezing and thawing biological samples

Publications (1)

Publication Number Publication Date
ATE508630T1 true ATE508630T1 (de) 2011-05-15

Family

ID=26994492

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03704956T ATE508630T1 (de) 2002-01-08 2003-01-08 Verfahren und gerät für das einfrieren und auftauen von biologischen proben

Country Status (5)

Country Link
US (1) US20040265831A1 (de)
EP (1) EP1476013B1 (de)
AT (1) ATE508630T1 (de)
AU (1) AU2003207952A1 (de)
WO (1) WO2003056919A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7331186B2 (en) 2002-06-27 2008-02-19 I.M.T. Interface Multigrad Technology Ltd Changing the temperature of a liquid sample and a receptacle useful therefor
ATE494777T1 (de) * 2003-10-09 2011-01-15 Core Dynamics Ltd Verfahren zum tiefgefrieren, auftauen und transplantieren von lebensfähigem knorpel
WO2005072790A1 (en) 2004-02-02 2005-08-11 I.M.T. Interface Multigrad Technology Ltd. Device for directional cooling of biological matter
EP1711053A2 (de) 2004-02-02 2006-10-18 I.M.T. Interface Multigrad Technology Ltd. Biologisches material sowie verfahren und lösungen für seine konservierung
JP5096148B2 (ja) 2004-06-07 2012-12-12 コア・ダイナミクス・リミテッド 生物学的試料の殺菌方法
FI116946B (fi) * 2004-07-09 2006-04-13 Chip Man Technologies Oy Laitteisto solujen kuvaamiseksi
US8037696B2 (en) 2004-08-12 2011-10-18 Core Dynamics Limited Method and apparatus for freezing or thawing of a biological material
EP1909565A2 (de) 2005-08-03 2008-04-16 Interface Multigrad Technology (IMT) Ltd. Somatische zellen für die zelltherapie
GB0525115D0 (en) * 2005-12-09 2006-01-18 Oxford Biosensors Ltd Freeze drying of target substances
EP1986493A1 (de) * 2006-02-13 2008-11-05 I.M.T. Interface Multigrad Technology Ltd. Tiefgefrorene lebensfähige feste organe und tiefgefrierverfahren hierfür
US10674570B2 (en) 2006-02-21 2020-06-02 Goji Limited System and method for applying electromagnetic energy
US8839527B2 (en) 2006-02-21 2014-09-23 Goji Limited Drying apparatus and methods and accessories for use therewith
US8653482B2 (en) 2006-02-21 2014-02-18 Goji Limited RF controlled freezing
EP3585135A1 (de) 2006-02-21 2019-12-25 Goji Limited Elektromagnetische erwärmung
CN105472805B (zh) 2006-07-10 2018-07-06 高知有限公司 食物制备
US9131543B2 (en) 2007-08-30 2015-09-08 Goji Limited Dynamic impedance matching in RF resonator cavity
US20120122072A1 (en) 2008-11-10 2012-05-17 Rf Dynamics Ltd. Method and system for heating and/or thawing blood products
KR101457143B1 (ko) * 2009-06-17 2014-11-03 고쿠리츠다이가쿠호진 히로시마다이가쿠 정자용 희석액 및 이것을 이용한 인공수정 방법
KR101584397B1 (ko) 2009-11-10 2016-01-11 고지 엘티디. Ｒｆ 에너지를 사용하여 가열하기 위한 장치 및 방법
WO2011098996A2 (en) 2010-02-09 2011-08-18 Core Dynamics Ltd. Improved method for changing the temperature of a biological specimen
CN103004288B (zh) 2010-05-03 2015-12-16 高知有限公司 模态分析
US10576190B2 (en) 2014-08-08 2020-03-03 Fremon Scientific, Inc. Smart bag used in sensing physiological and/or physical parameters of bags containing biological substance
US10732083B2 (en) 2018-05-07 2020-08-04 Fremon Scientific, Inc. Thawing biological substances
US11287185B1 (en) 2020-09-09 2022-03-29 Stay Fresh Technology, LLC Freeze drying with constant-pressure and constant-temperature phases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4131200A (en) * 1976-07-06 1978-12-26 Union Carbide Corporation Thermoplastic blood bag
CA2146098A1 (en) * 1995-01-12 1996-07-13 Ray V. Rajotte Bulk cryopreservation of biological materials and uses for cryopreserved and encapsulated biological materials
US5873254A (en) * 1996-09-06 1999-02-23 Interface Multigrad Technology Device and methods for multigradient directional cooling and warming of biological samples
AU2001255432A1 (en) * 2000-04-17 2001-10-30 Organ Recovery Systems, Inc. Novel warming method of cryopreserved specimens
US20100143877A1 (en) * 2006-09-05 2010-06-10 Reproquest, Llc Composition for preserving reproductive cells and method of using

Also Published As

Publication number Publication date
WO2003056919A2 (en) 2003-07-17
EP1476013B1 (de) 2011-05-11
US20040265831A1 (en) 2004-12-30
AU2003207952A1 (en) 2003-07-24
AU2003207952A8 (en) 2003-07-24
EP1476013A2 (de) 2004-11-17
WO2003056919A3 (en) 2003-11-27

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