ATE503182T1 - Klinisches verfahren zur genetischen abtastung von neugeborenen mithilfe der tandemmassenspektrometrie - Google Patents
Klinisches verfahren zur genetischen abtastung von neugeborenen mithilfe der tandemmassenspektrometrieInfo
- Publication number
- ATE503182T1 ATE503182T1 AT08161251T AT08161251T ATE503182T1 AT E503182 T1 ATE503182 T1 AT E503182T1 AT 08161251 T AT08161251 T AT 08161251T AT 08161251 T AT08161251 T AT 08161251T AT E503182 T1 ATE503182 T1 AT E503182T1
- Authority
- AT
- Austria
- Prior art keywords
- mass spectrometry
- tandem mass
- quality assurance
- results
- newborns
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004885 tandem mass spectrometry Methods 0.000 title abstract 3
- 230000002068 genetic effect Effects 0.000 title 1
- 238000005070 sampling Methods 0.000 title 1
- 238000000275 quality assurance Methods 0.000 abstract 3
- 239000002207 metabolite Substances 0.000 abstract 2
- 238000001228 spectrum Methods 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Physiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Sampling And Sample Adjustment (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00947150A EP1299720B1 (de) | 2000-07-07 | 2000-07-07 | Klinische verfahren zum genetischen screenen von neugeborenen unter verwendung der tandemmassenspektrometrie |
| PCT/US2000/018716 WO2002004945A1 (en) | 1999-03-26 | 2000-07-07 | Clinical method for the genetic screening of newborns using tandem mass spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE503182T1 true ATE503182T1 (de) | 2011-04-15 |
Family
ID=21741569
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00947150T ATE408826T1 (de) | 2000-07-07 | 2000-07-07 | Klinische verfahren zum genetischen screenen von neugeborenen unter verwendung der tandemmassenspektrometrie |
| AT08161251T ATE503182T1 (de) | 2000-07-07 | 2000-07-07 | Klinisches verfahren zur genetischen abtastung von neugeborenen mithilfe der tandemmassenspektrometrie |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00947150T ATE408826T1 (de) | 2000-07-07 | 2000-07-07 | Klinische verfahren zum genetischen screenen von neugeborenen unter verwendung der tandemmassenspektrometrie |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6258605B1 (de) |
| EP (2) | EP2000800B1 (de) |
| AT (2) | ATE408826T1 (de) |
| AU (1) | AU2000260808A1 (de) |
| DE (2) | DE60040303D1 (de) |
| DK (1) | DK1299720T3 (de) |
| ES (1) | ES2316373T3 (de) |
| WO (1) | WO2002004945A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7238531B2 (en) * | 1999-01-30 | 2007-07-03 | Pediatrix Screening, Inc. | Method for interpreting tandem mass spectrometry data for clinical diagnosis |
| US7011977B2 (en) * | 1999-01-30 | 2006-03-14 | Sigma-Tau Pharmaceuticals, Inc. | Quantification of carnitine levels in dialysis patients |
| US7297545B2 (en) | 1999-01-30 | 2007-11-20 | Pediatrix Screening, Inc. | Clinical method for the genetic screening of newborns using tandem mass spectrometry and internal standards therefor |
| JP2003524394A (ja) * | 1999-02-11 | 2003-08-19 | マキシジェン， インコーポレイテッド | ハイスループット質量分析法 |
| US7013707B2 (en) * | 1999-11-19 | 2006-03-21 | Perkinelmer Las, Inc | Method and apparatus for enhanced detection of a specie using a gas chromatograph |
| EP1113269B1 (de) * | 1999-12-29 | 2006-10-18 | PerkinElmer Life Sciences, Inc. | Testtablett, Kit und Verfahren zum Screening von Körperflüssigkeiten von Neugeborenen durch Tandem-Massenspektrometrie |
| US7329489B2 (en) * | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| JP2003530130A (ja) * | 2000-04-14 | 2003-10-14 | メタボロン インコーポレイテッド | メタボロミクスを使用した薬物発見、疾患の処置、及び診断のための方法 |
| EP1355728A4 (de) * | 2001-01-29 | 2005-01-12 | Metara Inc | Automatisierte prozessintegrierte isotopen- und massenspektrometrie |
| GB0128498D0 (en) * | 2001-11-28 | 2002-01-23 | Inst Of Child Health | International standards for sphingolipids |
| US6800489B2 (en) | 2002-06-05 | 2004-10-05 | Izaak Walton Killam Health Center | Electrospray tandem mass spectrometry of transition metal diimine complexes of amino acids, α-hydroxyketones and hexose phosphates for newborn screening |
| WO2004023097A2 (en) * | 2002-09-03 | 2004-03-18 | Anticancer, Inc. | Homocysteine assay adaptable to screening |
| US7298876B1 (en) * | 2002-11-04 | 2007-11-20 | R2 Technology, Inc. | Method and apparatus for quality assurance and quality control in radiological equipment using automatic analysis tools |
| WO2004076681A2 (en) * | 2003-02-24 | 2004-09-10 | Waters Investments Limited | System and method for processing identified metabolites |
| US20050014279A1 (en) * | 2003-07-14 | 2005-01-20 | Nguyen Hoa Duc | Method of analysis of amine by mass spectrometry |
| WO2006025863A2 (en) * | 2004-08-30 | 2006-03-09 | Perkinelmer Las, Inc. | Simultaneous detection of metabolic enzyme activity and metabolite levels |
| US20050048499A1 (en) * | 2003-08-29 | 2005-03-03 | Perkin Elmer Life Sciences, Inc. | Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns |
| US7485435B2 (en) * | 2004-08-30 | 2009-02-03 | Perkinelmer Las, Inc. | Simultaneous detection of metabolic enzyme activity and metabolite levels |
| GB0415046D0 (en) * | 2004-07-05 | 2004-08-04 | Micromass Ltd | Mass spectrometer |
| WO2006098192A1 (ja) * | 2005-03-16 | 2006-09-21 | Ajinomoto Co., Inc. | 生体状態評価装置、生体状態評価方法、生体状態評価システム、生体状態評価プログラム、評価関数作成装置、評価関数作成方法、評価関数作成プログラムおよび記録媒体 |
| CA2608965C (en) * | 2005-06-30 | 2014-08-19 | Biocrates Life Sciences Ag | Device for quantitative analysis of a metabolite profile |
| WO2008033575A2 (en) * | 2006-09-15 | 2008-03-20 | Metabolon, Inc. | Methods of identifying biochemical pathways |
| EP2330402B1 (de) | 2009-12-01 | 2017-02-15 | Spark Holland B.V. | Verfahren und Vorrichtung zur Desorption einer Blutprobe aus einem medizinischen Testblatt |
| CA2945165A1 (en) | 2014-04-08 | 2015-10-15 | Metabolon, Inc. | Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment |
| CN108645924B (zh) * | 2017-06-22 | 2021-07-20 | 南方医科大学 | 基于超高效液相色谱串联质谱技术的新生儿代谢物的检测方法 |
| AU2018371784B2 (en) | 2017-11-22 | 2024-10-17 | Sun Pharmaceutical Industries, Inc. | Deuterated analogs of D-serine and uses thereof |
| CN108982569A (zh) * | 2018-07-20 | 2018-12-11 | 中国科学院昆明植物研究所 | 一种同时定量血浆内、外源性葡萄糖的二维核磁共振方法 |
| CN116186557A (zh) * | 2023-01-17 | 2023-05-30 | 长城汽车股份有限公司 | 充电站数据准确性校验方法、装置及电子设备 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2250632B (en) | 1990-10-18 | 1994-11-23 | Unisearch Ltd | Tandem mass spectrometry systems based on time-of-flight analyser |
| US5352891A (en) | 1993-07-16 | 1994-10-04 | The Regents Of The University Of California | Method and apparatus for estimating molecular mass from electrospray spectra |
| US5538897A (en) | 1994-03-14 | 1996-07-23 | University Of Washington | Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases |
| US5629210A (en) * | 1995-06-02 | 1997-05-13 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Rapid screening test for smith-lemli-opitz syndrome |
-
1999
- 1999-03-26 US US09/277,119 patent/US6258605B1/en not_active Expired - Lifetime
-
2000
- 2000-07-07 WO PCT/US2000/018716 patent/WO2002004945A1/en not_active Ceased
- 2000-07-07 ES ES00947150T patent/ES2316373T3/es not_active Expired - Lifetime
- 2000-07-07 AU AU2000260808A patent/AU2000260808A1/en not_active Abandoned
- 2000-07-07 EP EP08161251A patent/EP2000800B1/de not_active Expired - Lifetime
- 2000-07-07 DK DK00947150T patent/DK1299720T3/da active
- 2000-07-07 EP EP00947150A patent/EP1299720B1/de not_active Expired - Lifetime
- 2000-07-07 DE DE60040303T patent/DE60040303D1/de not_active Expired - Lifetime
- 2000-07-07 AT AT00947150T patent/ATE408826T1/de active
- 2000-07-07 AT AT08161251T patent/ATE503182T1/de not_active IP Right Cessation
- 2000-07-07 DE DE60045783T patent/DE60045783D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2316373T3 (es) | 2009-04-16 |
| AU2000260808A1 (en) | 2002-01-21 |
| EP2000800A2 (de) | 2008-12-10 |
| EP1299720B1 (de) | 2008-09-17 |
| DK1299720T3 (da) | 2009-01-26 |
| EP2000800A3 (de) | 2008-12-17 |
| DE60040303D1 (de) | 2008-10-30 |
| EP1299720A1 (de) | 2003-04-09 |
| EP2000800B1 (de) | 2011-03-23 |
| ATE408826T1 (de) | 2008-10-15 |
| US6258605B1 (en) | 2001-07-10 |
| DE60045783D1 (de) | 2011-05-05 |
| EP1299720A4 (de) | 2006-07-26 |
| WO2002004945A1 (en) | 2002-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |