ATE497389T1 - Aus stammzellen erhaltener parakriner faktor h12 zur verwendung für die verringerung zelltodes oder für die reparatur von gewebe - Google Patents

Aus stammzellen erhaltener parakriner faktor h12 zur verwendung für die verringerung zelltodes oder für die reparatur von gewebe

Info

Publication number
ATE497389T1
ATE497389T1 AT06802032T AT06802032T ATE497389T1 AT E497389 T1 ATE497389 T1 AT E497389T1 AT 06802032 T AT06802032 T AT 06802032T AT 06802032 T AT06802032 T AT 06802032T AT E497389 T1 ATE497389 T1 AT E497389T1
Authority
AT
Austria
Prior art keywords
cell death
factor
tissue
paraccrine
repair
Prior art date
Application number
AT06802032T
Other languages
English (en)
Inventor
Victor Dzau
Mirotsou Maria
Jian Guo
Arjun Deb
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Application granted granted Critical
Publication of ATE497389T1 publication Critical patent/ATE497389T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
AT06802032T 2005-08-19 2006-08-21 Aus stammzellen erhaltener parakriner faktor h12 zur verwendung für die verringerung zelltodes oder für die reparatur von gewebe ATE497389T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71002805P 2005-08-19 2005-08-19
US71128705P 2005-08-25 2005-08-25
PCT/US2006/032656 WO2007022515A2 (en) 2005-08-19 2006-08-21 Stem cell derived factors for treating pathologic conditions

Publications (1)

Publication Number Publication Date
ATE497389T1 true ATE497389T1 (de) 2011-02-15

Family

ID=37758496

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06802032T ATE497389T1 (de) 2005-08-19 2006-08-21 Aus stammzellen erhaltener parakriner faktor h12 zur verwendung für die verringerung zelltodes oder für die reparatur von gewebe
AT08005943T ATE499110T1 (de) 2005-08-19 2006-08-21 Aus stammzellen erhaltener parakriner faktor sfrp1 zur verwendung für die verringerung zelltodes im herzgewebe

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT08005943T ATE499110T1 (de) 2005-08-19 2006-08-21 Aus stammzellen erhaltener parakriner faktor sfrp1 zur verwendung für die verringerung zelltodes im herzgewebe

Country Status (6)

Country Link
US (6) US7638128B2 (de)
EP (4) EP1977758B1 (de)
AT (2) ATE497389T1 (de)
CA (2) CA2619593C (de)
DE (2) DE602006019974D1 (de)
WO (1) WO2007022515A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893018B2 (en) * 2005-11-08 2011-02-22 Foundation For Biomedical Research And Innovation Method of treatment for ischemic heart disease
GB0707348D0 (en) * 2007-04-17 2007-05-23 Renovo Ltd Medicaments and methods for inhibition of scarring
US20110071086A1 (en) * 2007-11-04 2011-03-24 Dzau Victor J Compositions for tissue repair/regeneration
US20120156134A1 (en) 2007-12-20 2012-06-21 Shayne Squires Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease
CN102027374A (zh) 2008-04-30 2011-04-20 霍夫曼-拉罗奇有限公司 Sfrp-3在评价心力衰竭中的用途
GB0818725D0 (en) 2008-10-13 2008-11-19 Habib Nagy A Pharmaceutical composition
CA2755396A1 (en) * 2009-03-13 2010-09-16 Duke University Use of hasf as a protective agent against ischemic tissue damage
US20120107413A1 (en) * 2009-07-23 2012-05-03 Singapore Health Services Pte Ltd Pre-natal mesenchymal stem cells
JP5409222B2 (ja) * 2009-09-10 2014-02-05 学校法人慶應義塾 造血幹細胞の培養方法
WO2012175745A1 (en) * 2011-06-24 2012-12-27 National University Of Ireland, Galway Cell secreted proteins for the treatment of myocardial infarction
US9950032B2 (en) * 2011-10-27 2018-04-24 Agency For Science, Technology And Research (A*Star) Compositions and methods for lung regeneration
ES2869701T3 (es) 2012-08-01 2021-10-25 United Therapeutics Corp Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
EP2879682B1 (de) 2012-08-01 2018-03-21 United Therapeutics Corporation Behandlung von pulmonal-arteriellem hochdruck mit mesenchymalen stammzellen
US10080730B2 (en) * 2013-01-09 2018-09-25 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
CN105561338A (zh) * 2015-05-14 2016-05-11 首都医科大学附属北京口腔医院 Sfrp2在促进牙源性间充质干细胞成骨/成牙分化中的应用
WO2018064315A1 (en) * 2016-09-29 2018-04-05 North Carolina State University Stem cell biomimetic microparticles
AU2017350732B2 (en) 2016-10-24 2023-07-27 United Therapeutics Corporation Enhancement of MSC immunomodulatory properties by treprostinil
WO2022066714A2 (en) * 2020-09-22 2022-03-31 Children's Medical Center Corporation Delivery of sfrp-3 or foxm1 inhibitor to protect from and treat mitral regurgitation and heart failure

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE318915T1 (de) * 1996-09-24 2006-03-15 Tanox Inc Genfamilie von apoptose-verwandten peptiden, dadurch kodierte peptide und verfahren zu deren herstellung
CA2331386A1 (en) * 1998-06-26 2000-01-06 Incyte Pharmaceuticals, Inc. Human signal peptide-containing proteins
US20030027751A1 (en) * 2001-04-10 2003-02-06 Genvec, Inc. VEGF fusion proteins
WO2003080795A2 (en) * 2001-08-09 2003-10-02 Nuvelo Inc. Novel nucleic acids and secreted polypeptides
WO2003062376A2 (en) * 2002-01-16 2003-07-31 Incyte Genomics, Inc. Molecules for diagnostics and therapeutics
US20040258669A1 (en) * 2002-11-05 2004-12-23 Dzau Victor J. Mesenchymal stem cells and methods of use thereof
JP2006508682A (ja) * 2002-12-06 2006-03-16 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ β−カテニンシグナル伝達経路の調節による細胞傷害剤からの幹細胞の保護
WO2004087874A2 (en) * 2003-03-28 2004-10-14 Nuvelo, Inc. Novel nucleic acids and polypeptides

Also Published As

Publication number Publication date
EP1940445B1 (de) 2011-02-02
EP1940445A4 (de) 2008-10-15
US20140357703A1 (en) 2014-12-04
CA2619593A1 (en) 2007-02-22
US20140296152A1 (en) 2014-10-02
CA2619593C (en) 2018-12-11
CA3022238A1 (en) 2007-02-22
US20070259425A1 (en) 2007-11-08
US7638128B2 (en) 2009-12-29
EP1977758A3 (de) 2009-01-07
EP1977758A2 (de) 2008-10-08
EP2226079A3 (de) 2010-12-08
WO2007022515A9 (en) 2007-05-10
WO2007022515A3 (en) 2008-02-28
US8129344B2 (en) 2012-03-06
US9279012B2 (en) 2016-03-08
US20170128526A1 (en) 2017-05-11
US20120283183A9 (en) 2012-11-08
US20110003743A1 (en) 2011-01-06
EP1977758B1 (de) 2011-02-23
WO2007022515A2 (en) 2007-02-22
EP2226079B1 (de) 2012-07-11
EP1940445A2 (de) 2008-07-09
EP2548569B1 (de) 2014-01-29
EP2226079A2 (de) 2010-09-08
DE602006019974D1 (de) 2011-03-17
US8703710B2 (en) 2014-04-22
ATE499110T1 (de) 2011-03-15
US9353168B2 (en) 2016-05-31
US20080176207A1 (en) 2008-07-24
EP2548569A1 (de) 2013-01-23
DE602006020349D1 (de) 2011-04-07

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