ATE485053T1 - MIMETIC PEPTIDES FOR EPITOPE OF APOLIPOPROTEIN B-100, CONCATEMER AND MODIFIED PEPTIDES THEREOF, AND THE VACCINE COMPOSITION CONTAINING SUCH PEPTIDES - Google Patents

MIMETIC PEPTIDES FOR EPITOPE OF APOLIPOPROTEIN B-100, CONCATEMER AND MODIFIED PEPTIDES THEREOF, AND THE VACCINE COMPOSITION CONTAINING SUCH PEPTIDES

Info

Publication number
ATE485053T1
ATE485053T1 AT01965715T AT01965715T ATE485053T1 AT E485053 T1 ATE485053 T1 AT E485053T1 AT 01965715 T AT01965715 T AT 01965715T AT 01965715 T AT01965715 T AT 01965715T AT E485053 T1 ATE485053 T1 AT E485053T1
Authority
AT
Austria
Prior art keywords
peptides
apolipoprotein
epitope
vaccine composition
mimetic
Prior art date
Application number
AT01965715T
Other languages
German (de)
Inventor
Hyo-Joon Kim
Hae-Jung Joung
Original Assignee
Hyo-Joon Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyo-Joon Kim filed Critical Hyo-Joon Kim
Priority claimed from PCT/KR2001/001492 external-priority patent/WO2002020040A1/en
Application granted granted Critical
Publication of ATE485053T1 publication Critical patent/ATE485053T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0012—Lipids; Lipoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PURPOSE: Provided are mimetic peptides for epitope of apolipoprotein b-100, their concatemers and modified peptides, and a vaccine composition comprising them. The vaccine composition is used for the treatment of obesity. CONSTITUTION: The mimetic peptides for epitope of apolipoprotein B-100 are represented by the SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3. Their concatemers consist of 1-15, preferably 4 mimetic peptides. The vaccine composition for the treatment of obesity contains them and is formulated into an intradermal injection. Their manufacturing method comprises the steps of: inserting DNA coding mimetic peptides for epitope of apolipoprotein b-100, their concatemers and modified peptides, into a vector; transforming a strain with the vector then culturing it; and separating mimetic peptides for epitope of apolipoprotein b-100, their concatemers and modified peptides from the culture.
AT01965715T 2000-09-04 2001-09-04 MIMETIC PEPTIDES FOR EPITOPE OF APOLIPOPROTEIN B-100, CONCATEMER AND MODIFIED PEPTIDES THEREOF, AND THE VACCINE COMPOSITION CONTAINING SUCH PEPTIDES ATE485053T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20000052055 2000-09-04
KR10-2001-0054005A KR100472841B1 (en) 2000-09-04 2001-09-04 Mimetic peptides for epitope of apolipoprotein B-100, concatemer and modified peptides thereof, and the vaccine composition comprising the same
PCT/KR2001/001492 WO2002020040A1 (en) 2000-09-04 2001-09-04 Mimetic peptides for epitope of apolipoprotein b-100, concatemer and modified peptides thereof, and the vaccine composition comprising the same

Publications (1)

Publication Number Publication Date
ATE485053T1 true ATE485053T1 (en) 2010-11-15

Family

ID=19687156

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01965715T ATE485053T1 (en) 2000-09-04 2001-09-04 MIMETIC PEPTIDES FOR EPITOPE OF APOLIPOPROTEIN B-100, CONCATEMER AND MODIFIED PEPTIDES THEREOF, AND THE VACCINE COMPOSITION CONTAINING SUCH PEPTIDES

Country Status (4)

Country Link
KR (1) KR100472841B1 (en)
AT (1) ATE485053T1 (en)
DE (1) DE60143300D1 (en)
ZA (1) ZA200203383B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100639397B1 (en) 2004-03-18 2006-10-26 (주)에스제이바이오메드 Anti-obese immuogenic hybrid polypeptides and anti-obese vaccine composition comprising the same
BRPI0717223A2 (en) 2006-09-25 2013-09-24 Sj Biomed Inc anti-obesity hybrid immunogenic polypeptides and anti-obesity vaccine composition comprising the same
KR20230042053A (en) * 2020-07-22 2023-03-27 (주)쓰리에이치바이오 Peptides for Immunotherapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5408038A (en) * 1991-10-09 1995-04-18 The Scripps Research Institute Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides
KR100330310B1 (en) * 1998-06-18 2002-08-08 한국과학기술연구원 New Monoclonal Antibodies to Human Plasma Apolipoprotein B-100 and Hybridoma Cell Lines Producing Them

Also Published As

Publication number Publication date
KR100472841B1 (en) 2005-03-07
ZA200203383B (en) 2002-12-10
DE60143300D1 (en) 2010-12-02
KR20020018971A (en) 2002-03-09

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