ATE484576T1 - Chimäre bauchspeicheldrüse - Google Patents

Chimäre bauchspeicheldrüse

Info

Publication number
ATE484576T1
ATE484576T1 AT03745590T AT03745590T ATE484576T1 AT E484576 T1 ATE484576 T1 AT E484576T1 AT 03745590 T AT03745590 T AT 03745590T AT 03745590 T AT03745590 T AT 03745590T AT E484576 T1 ATE484576 T1 AT E484576T1
Authority
AT
Austria
Prior art keywords
recipient
mammalian
pancreatic
tissue
pancreatic tissue
Prior art date
Application number
AT03745590T
Other languages
English (en)
Inventor
Marc Hammerman
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of ATE484576T1 publication Critical patent/ATE484576T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03745590T 2002-03-25 2003-03-24 Chimäre bauchspeicheldrüse ATE484576T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36718102P 2002-03-25 2002-03-25
PCT/US2003/009091 WO2003083064A2 (en) 2002-03-25 2003-03-24 Chimeric pancreas

Publications (1)

Publication Number Publication Date
ATE484576T1 true ATE484576T1 (de) 2010-10-15

Family

ID=28675331

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03745590T ATE484576T1 (de) 2002-03-25 2003-03-24 Chimäre bauchspeicheldrüse

Country Status (16)

Country Link
US (2) US7384630B2 (de)
EP (1) EP1487967B1 (de)
JP (1) JP2005521497A (de)
KR (1) KR20040099350A (de)
CN (1) CN1643133A (de)
AT (1) ATE484576T1 (de)
AU (1) AU2003259298B2 (de)
BR (1) BR0308718A (de)
CA (1) CA2477538C (de)
DE (1) DE60334534D1 (de)
EA (1) EA200401244A1 (de)
IL (1) IL164250A0 (de)
MX (1) MXPA04009411A (de)
NO (1) NO20044540L (de)
WO (1) WO2003083064A2 (de)
ZA (1) ZA200406983B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL165425A0 (en) * 2004-11-28 2006-01-15 Yeda Res & Dev Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
US20090155229A1 (en) * 2004-12-06 2009-06-18 Avner Yayon Chondrocyte-based implant for the delivery of therapeutic agents
US8916147B2 (en) * 2005-08-24 2014-12-23 Yeda Research and Devolpment Co. Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US8709400B2 (en) 2009-07-27 2014-04-29 Washington University Inducement of organogenetic tolerance for pancreatic xenotransplant
EP2491957A4 (de) * 2009-08-02 2013-10-02 Univ Tokyo Womens Medical Inselzellenfolie, herstellungsverfahren dafür und verwendung davon
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804178A (en) * 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
JPH06503001A (ja) * 1991-08-02 1994-04-07 システミックス，インコーポレイティド 免疫不全宿主における原基移植物
ATE180164T1 (de) * 1993-09-07 1999-06-15 Gergely Gerhard Brausemischung mit alkalisalzen oder lysinaten saurer, unlöslicher oder schwer löslicher wirkstoffe
US5560911A (en) * 1993-10-12 1996-10-01 Oklahoma Medical Research Foundation Method of inhibiting acute complement mediated cytotoxicity with anti-idiotypic antibodies
US5629194A (en) * 1994-10-21 1997-05-13 Diacrin, Inc. Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity
US6866843B2 (en) 1999-12-06 2005-03-15 Viacell, Inc. Method of transplanting in a mammal and treating diabetes mellitus by administering a pseudo-islet like aggregate differentiated from a nestin-positive pancreatic stem cell
AU2001274860A1 (en) * 2000-05-18 2001-11-26 Biotransplant, Inc. Process for reducing antibody response against xenografts
US20030031652A1 (en) * 2001-04-16 2003-02-13 Bernhard Hering Systems and methods for inducing mixed chimerism

Also Published As

Publication number Publication date
EP1487967A4 (de) 2005-05-11
JP2005521497A (ja) 2005-07-21
US20080318202A1 (en) 2008-12-25
IL164250A0 (en) 2005-12-18
AU2003259298B2 (en) 2006-08-31
EP1487967B1 (de) 2010-10-13
NO20044540L (no) 2004-10-22
BR0308718A (pt) 2005-01-04
WO2003083064A2 (en) 2003-10-09
DE60334534D1 (de) 2010-11-25
WO2003083064A3 (en) 2004-03-25
AU2003259298A1 (en) 2003-10-13
EA200401244A1 (ru) 2005-02-24
EP1487967A2 (de) 2004-12-22
CA2477538C (en) 2008-01-29
CN1643133A (zh) 2005-07-20
US20030198628A1 (en) 2003-10-23
KR20040099350A (ko) 2004-11-26
MXPA04009411A (es) 2005-01-25
CA2477538A1 (en) 2003-10-09
ZA200406983B (en) 2005-09-22
US7384630B2 (en) 2008-06-10

Similar Documents

Publication Publication Date Title
MX2009014273A (es) Metodos y composiciones para expansion e implantacion optimizadas de celulas madre mesenquimales.
DE69937888D1 (de) Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
WO2008048663A3 (en) Novel process for devitalized/acellular tissue for transplantation
TW200726474A (en) The immunophenotype and immunogenicity of human adipose derived cells
WO2010022395A3 (en) Methods of reprogramming cells
WO2006107850A3 (en) Preventing rejection of transplanted tissue using regulatory t cells
DE60334534D1 (de) Chimäre bauchspeicheldrüse
WO2001023528A8 (en) Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
WO2009050742A8 (en) Use of microvesicles (mvs) for preparing a medicament having adjuvant activity on endothelial cell transplantation, particularly in the treatment of diabetes by pancreatic islet transplantation, and related method
WO2003059276A3 (en) Novel mammalian multipotent stem cells and compositions, methods of preparation and methods of administration thereof
WO2006113881A3 (en) Method of using stroma cells from cord blood to expand and engraft nucleated cells from cord blood
EA201071133A1 (ru) Композиция для укладки волос
MX2008000787A (es) Metodo facil para trasplantar condrocito inyectable para trasplante autologo de condrocitos.
GB0411052D0 (en) Method of producing human beta cell lines
WO2006017567A3 (en) Customizing stem cell-derived cardiomyocytes for transplantation
AU5380201A (en) Method for expansion of epithelial stem cells
ATE335475T1 (de) Verwendung von beschleunigten lymphozyten zielansteuernden wirkstoffen zur herstellung eines medikaments für die behandlung der verzögertern transplantat-funktion
EA200701598A1 (ru) Способ и композиция для восстановления эпителиальных и других клеток и тканей
JP2005521497A5 (de)
WO2011059733A3 (en) Use of lipoic acid in cell transplantation
TW200833836A (en) An improved method of cultivating the Cordyceps Militaris by adding sugar cane fiber
SE0401807L (sv) Förfaranden och kompositioner för nytillväxt av kryopreserverade tallembryon
Sackett et al. Human embryonic stem cells (hESC) as a source of insulin-producing cells
DK1664307T3 (da) Ny endospermspecifik plantepromotor til afgröder
WO2006079107A3 (en) Transplantation compositions and methods for treating diabetes

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties