ATE483469T1 - Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren - Google Patents
Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptorenInfo
- Publication number
- ATE483469T1 ATE483469T1 AT03764547T AT03764547T ATE483469T1 AT E483469 T1 ATE483469 T1 AT E483469T1 AT 03764547 T AT03764547 T AT 03764547T AT 03764547 T AT03764547 T AT 03764547T AT E483469 T1 ATE483469 T1 AT E483469T1
- Authority
- AT
- Austria
- Prior art keywords
- antigen
- induce
- expand
- cells
- platforms
- Prior art date
Links
- 210000004698 lymphocyte Anatomy 0.000 title abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 230000002452 interceptive effect Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4612—B-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4614—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/464488—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
- A61K39/464491—Melan-A/MART
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/605—MHC molecules or ligands thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39578102P | 2002-07-12 | 2002-07-12 | |
PCT/US2003/021790 WO2004006951A1 (en) | 2002-07-12 | 2003-07-14 | Reagents and methods for engaging unique clonotypic lymphocyte receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE483469T1 true ATE483469T1 (de) | 2010-10-15 |
Family
ID=30115927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03764547T ATE483469T1 (de) | 2002-07-12 | 2003-07-14 | Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren |
Country Status (8)
Country | Link |
---|---|
US (3) | US20040115216A1 (de) |
EP (1) | EP1551449B1 (de) |
JP (2) | JP5068931B2 (de) |
AT (1) | ATE483469T1 (de) |
AU (1) | AU2003256506B2 (de) |
CA (2) | CA2493081C (de) |
DE (1) | DE60334474D1 (de) |
WO (1) | WO2004006951A1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7435596B2 (en) * | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
JP2007525225A (ja) | 2004-02-26 | 2007-09-06 | イミュノバティブ セラピーズ, リミテッド | 細胞治療のためのt細胞を調製するための方法 |
ATE449161T1 (de) * | 2004-03-04 | 2009-12-15 | Leukocare Ag | Leukozytenstimulations-matrix |
US20060068424A1 (en) * | 2004-08-13 | 2006-03-30 | Fuji Photo Film Co., Ltd. | Biosensor |
EP1957982A2 (de) * | 2005-12-05 | 2008-08-20 | Guava Technologies, Inc. | Charakterisierung von analyten auf teilchenbasis |
US20100028450A1 (en) * | 2006-01-25 | 2010-02-04 | The Board Of Trustees Of The University Of Illinoi S | Tolerogenic biodegradable artificial antigen presenting system |
US20070269457A1 (en) * | 2006-05-16 | 2007-11-22 | The Buck Institute For Age Research | Immunotherapeutic compositions and methods |
US9334522B2 (en) | 2006-09-13 | 2016-05-10 | The Trustees Of Columbia University In The City Of New York | Agents and methods to elicit anti-tumor immune response |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
EP2719774B8 (de) | 2008-11-07 | 2020-04-22 | Adaptive Biotechnologies Corporation | Verfahren zur Überwachung von Zuständen durch Sequenzanalyse |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
DK3059337T3 (da) | 2009-01-15 | 2019-07-22 | Adaptive Biotechnologies Corp | Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier |
SG10201403451QA (en) | 2009-06-25 | 2014-09-26 | Hutchinson Fred Cancer Res | Method of measuring adaptive immunity |
NZ597975A (en) * | 2009-07-09 | 2014-06-27 | Tigenix S A | Methods and compositions for use in cellular therapies |
US11090363B2 (en) | 2009-07-10 | 2021-08-17 | University of Pittsburgh—of the Commonwealth System of Higher Education | Vasoactive intestinal peptide release from microparticles |
WO2011006029A1 (en) | 2009-07-10 | 2011-01-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Artificial cell constructs for inducing immunological tolerance |
US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
BR112013011842A2 (pt) | 2010-11-12 | 2016-08-16 | Getts Consulting And Project Man | partículas de imunomoduladoras modificadas |
EP2663316A2 (de) * | 2011-01-12 | 2013-11-20 | TiGenix, S.A.U. | Aus fettgewebe stammende mesenchymale stammzellen für die intralymphatische verabreichung bei autoimmun- und entzündungserkrankungen |
US20150030619A1 (en) * | 2011-09-06 | 2015-01-29 | The Trustees Of Columbia University In The City Of New York | Activation and Expansion of T Cell Subsets Using Biocompatible Solid Substrates with Tunable Rigidity |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
EP2768982A4 (de) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | Quantifizierung von adaptiven immunzellgenomen in einer komplexen mischung von zellen |
CN104136603A (zh) * | 2011-12-09 | 2014-11-05 | 约翰霍普金斯大学 | 具有限定和动态形状的人工抗原递呈细胞 |
EP3904536A1 (de) | 2011-12-09 | 2021-11-03 | Adaptive Biotechnologies Corporation | Diagnose von lymphoid-malignität und nachweis minimaler resterkrankungen |
US9499865B2 (en) * | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
EP3372694A1 (de) | 2012-03-05 | 2018-09-12 | Adaptive Biotechnologies Corporation | Festlegung von gepaarten immunrezeptorketten aus frequenzabgestimmten untereinheiten |
CN109116033A (zh) * | 2012-03-06 | 2019-01-01 | 塞莱克特生物疗法有限公司 | 用于选择抗细胞凋亡信号传导细胞的装置和方法及其用途 |
US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
DK2831276T3 (da) | 2012-05-08 | 2016-08-01 | Adaptive Biotechnologies Corp | Sammensætninger og fremgangsmåde til at måle og kalibrere amplifikations-bias i multipleks-PCR-reaktioner |
US10201596B2 (en) | 2012-06-21 | 2019-02-12 | Northwestern University | Peptide conjugated particles for the treatment of allergy |
EP2904111B1 (de) | 2012-10-01 | 2017-12-06 | Adaptive Biotechnologies Corporation | Immunkompetenzbeurteilung durch adaptive immunrezeptordiversität und klonalitätscharakterisierung |
US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
EP2956481B1 (de) | 2013-02-15 | 2020-07-01 | The Johns Hopkins University | Antigenspezifische t-zell-umleiter |
BR112015022597A2 (pt) | 2013-03-13 | 2017-10-24 | Cour Pharmaceuticals Dev Company | partículas modificadoras da imunidade para o tratamento de inflamação |
MX2015012920A (es) | 2013-03-14 | 2016-06-02 | Univ Johns Hopkins | Celulas presentadoras de antígeno artificial de nanoescala. |
US20160058856A1 (en) * | 2013-04-05 | 2016-03-03 | Kyushu University, National University Corporation | Anti-tumor dna vaccine |
EP3995145A1 (de) | 2013-06-24 | 2022-05-11 | NexImmune, Inc. | Zusammensetzungen und verfahren für die immuntherapie |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
RS59801B2 (sr) | 2013-08-13 | 2024-03-29 | Univ Northwestern | Čestice konjugovane peptidom |
RU2696876C2 (ru) | 2013-11-04 | 2019-08-07 | Ютиай Лимитед Партнершип | Способы и композиции для устойчивой иммунотерапии |
ES2741740T3 (es) | 2014-03-05 | 2020-02-12 | Adaptive Biotechnologies Corp | Métodos que usan moléculas sintéticas que contienen segmentos de nucleótidos aleatorios |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
WO2015157664A2 (en) | 2014-04-10 | 2015-10-15 | The Trustees Of Columbia University In The City Of New York | Methods, compositions, and systems for activation and expansion of cells |
MX2017003625A (es) | 2014-09-17 | 2017-10-11 | Univ Johns Hopkins | Reactivos y metodos para identificar, enriquecer y/o expander celulas t especificas de antigeno. |
EP3212790B1 (de) | 2014-10-29 | 2020-03-25 | Adaptive Biotechnologies Corp. | Hochmultiplexierter gleichzeitiger nachweis von für adaptive gepaarte immunrezeptorheterodimere codierenden nukleinsäuren aus einer vielzahl von proben |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
US11066705B2 (en) | 2014-11-25 | 2021-07-20 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
CN116869964A (zh) | 2014-12-24 | 2023-10-13 | 耐克西缪恩有限公司 | 用于免疫疗法的纳米颗粒组合物和方法 |
EP3262196B1 (de) | 2015-02-24 | 2020-12-09 | Adaptive Biotechnologies Corp. | Verfahren zur bestimmung des hla-status mittels immunrepertoiresequenzierung |
AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
AU2016275312B2 (en) | 2015-05-06 | 2021-12-23 | Uti Limited Partnership | Nanoparticle compositions for sustained therapy |
CN115109158A (zh) | 2015-05-07 | 2022-09-27 | 阿吉纳斯公司 | 抗ox40抗体及其使用方法 |
CA3007233A1 (en) | 2015-12-02 | 2017-06-08 | Agenus Inc. | Antibodies and methods of use thereof |
US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
WO2018046468A1 (en) * | 2016-09-06 | 2018-03-15 | F. Hoffmann-La Roche Ag | Mhc-bound peptide arrays and methods of use thereof |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
US20230138095A1 (en) * | 2018-06-20 | 2023-05-04 | Danmarks Tekniske Universitet | Scaffolds with stabilized mhc molecules for immune-cell manipulation |
CA3112813A1 (en) * | 2018-09-21 | 2020-03-26 | Berkeley Lights, Inc. | Functionalized well plate, methods of preparation and use thereof |
MX2021005372A (es) | 2018-11-08 | 2021-09-14 | Neximmune Inc | Composiciones de linfocitos t con propiedades fenotípicas mejoradas. |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3140113A (en) * | 1962-02-08 | 1964-07-07 | Bethlehem Steel Corp | Transfer finger assembly |
JPH03504975A (ja) * | 1988-06-14 | 1991-10-31 | セル―エスシーアイ コーポレイション | 異種官能性細胞免疫剤、それを含有するワクチン及びその使用方法 |
US5194425A (en) * | 1988-06-23 | 1993-03-16 | Anergen, Inc. | Mhc-mediated toxic conjugates useful in ameliorating autoimmunity |
DE3825615A1 (de) * | 1988-07-28 | 1990-02-01 | Behringwerke Ag | Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung |
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5574205A (en) * | 1989-07-25 | 1996-11-12 | Cell Genesys | Homologous recombination for universal donor cells and chimeric mammalian hosts |
US6011146A (en) * | 1991-11-15 | 2000-01-04 | Institut Pasteur | Altered major histocompatibility complex (MHC) determinant and methods of using the determinant |
US5583031A (en) * | 1992-02-06 | 1996-12-10 | President And Fellows Of Harvard College | Empty major histocompatibility class II heterodimers |
AU681853B2 (en) * | 1992-05-26 | 1997-09-11 | Rijksuniversiteit Leiden | Peptides of human p53 protein for use in human T cell response inducing compositions, and human p53 protein-specific cytotoxic T-lymphocytes |
FR2698880B1 (fr) * | 1992-11-25 | 1995-02-24 | Inst Nat Sante Rech Med | Procédé de production de récepteurs T solubles, produits ainsi obtenus et leur utilisation dans des compositions diagnostiques ou thérapeutiques. |
US5420244A (en) * | 1993-08-06 | 1995-05-30 | The United States Of America As Represented By The Department Of Health And Human Services | Methods and compositions for diagnosing HTLV-I associated myelopathy and adult T-cell leukemia |
US5820866A (en) * | 1994-03-04 | 1998-10-13 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for T cell regulation |
DE69519101T3 (de) * | 1994-07-29 | 2010-08-05 | Sunol Molecular Corp., Miramar | Mhc-komplexe und ihre verwendung |
US5635363A (en) * | 1995-02-28 | 1997-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for the detection, quantitation and purification of antigen-specific T cells |
US5869270A (en) * | 1996-01-31 | 1999-02-09 | Sunol Molecular Corporation | Single chain MHC complexes and uses thereof |
US6140113A (en) * | 1996-03-28 | 2000-10-31 | The Johns Hopkins University | Polynucleotides encoding molecular complexes which modify immune responses |
US6458354B1 (en) * | 1996-03-28 | 2002-10-01 | The Johns Hopkins University | Molecular complexes which modify immune responses |
AU729406B2 (en) * | 1996-03-28 | 2001-02-01 | Johns Hopkins University, The | Soluble divalent and multivalent heterodimeric analogs of proteins |
PT937251E (pt) * | 1996-09-06 | 2007-01-31 | Ortho Mcneil Pharm Inc | Purificação de células específicas de antigénio |
US6268411B1 (en) * | 1997-09-11 | 2001-07-31 | The Johns Hopkins University | Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses |
US7655249B2 (en) * | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US6787154B2 (en) * | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
WO2000040968A1 (en) * | 1999-01-05 | 2000-07-13 | Unilever Plc | Binding of antibody fragments to solid supports |
US6269411B1 (en) * | 1999-08-12 | 2001-07-31 | Hewlett-Packard Company | System for enabling stacking of autochanger modules |
WO2001080833A1 (en) * | 2000-04-20 | 2001-11-01 | Salvatore Albani | Methods for isolation, quantification, characterization and modulation of antigen-specific t cells |
AU2001288863A1 (en) * | 2000-09-15 | 2002-03-26 | Ortho-Mcneil Pharmaceutical, Inc. | Compositions and methods for inducing specific cytolytic t cell responses |
ES2643582T3 (es) * | 2001-02-20 | 2017-11-23 | Janssen Pharmaceuticals, Inc. | Antígeno de Drosophila artificial que presenta célula para preparar suspensión de células CD8 para su uso en el tratamiento del cáncer |
US7638325B2 (en) * | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
WO2009135178A2 (en) * | 2008-05-02 | 2009-11-05 | Flower Robert W | Methods for production and use of substance-loaded erythrocytes (s-les) for observation and treatment of microvascular hemodynamics |
-
2003
- 2003-07-14 WO PCT/US2003/021790 patent/WO2004006951A1/en active Application Filing
- 2003-07-14 DE DE60334474T patent/DE60334474D1/de not_active Expired - Lifetime
- 2003-07-14 EP EP03764547A patent/EP1551449B1/de not_active Expired - Lifetime
- 2003-07-14 CA CA2493081A patent/CA2493081C/en not_active Expired - Fee Related
- 2003-07-14 JP JP2004521720A patent/JP5068931B2/ja not_active Expired - Fee Related
- 2003-07-14 US US10/618,267 patent/US20040115216A1/en not_active Abandoned
- 2003-07-14 CA CA2800113A patent/CA2800113C/en not_active Expired - Fee Related
- 2003-07-14 AU AU2003256506A patent/AU2003256506B2/en not_active Ceased
- 2003-07-14 AT AT03764547T patent/ATE483469T1/de not_active IP Right Cessation
-
2009
- 2009-07-21 US US12/506,289 patent/US20100008920A1/en not_active Abandoned
-
2012
- 2012-04-16 JP JP2012092552A patent/JP5921303B2/ja not_active Expired - Fee Related
-
2017
- 2017-02-14 US US15/432,393 patent/US20170261497A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1551449A4 (de) | 2006-01-04 |
CA2493081C (en) | 2013-04-23 |
US20100008920A1 (en) | 2010-01-14 |
CA2800113C (en) | 2015-02-03 |
CA2800113A1 (en) | 2004-01-22 |
CA2493081A1 (en) | 2004-01-22 |
JP2005538083A (ja) | 2005-12-15 |
JP5921303B2 (ja) | 2016-05-24 |
EP1551449B1 (de) | 2010-10-06 |
JP2012184233A (ja) | 2012-09-27 |
US20170261497A1 (en) | 2017-09-14 |
US20040115216A1 (en) | 2004-06-17 |
EP1551449A1 (de) | 2005-07-13 |
WO2004006951A1 (en) | 2004-01-22 |
AU2003256506B2 (en) | 2009-06-04 |
JP5068931B2 (ja) | 2012-11-07 |
DE60334474D1 (de) | 2010-11-18 |
AU2003256506A1 (en) | 2004-02-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE483469T1 (de) | Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren | |
ATE446745T1 (de) | Antikörper mit t-zell-rezeptor-artiger spezifität,aber höherer affinität und seine verwendung zum nachweis und zur behandlung von krebs, virusinfektionen und autoimmunkrankheiten | |
CY1118504T1 (el) | Τριμερης πρωτεϊνη συντηξης του συνδετη οχ40 στην περιοχη ανοσοσφαιρινης και τροποι χρησης | |
EP1566635A4 (de) | Mikrowell-array-chip zum nachweis eines antigenspezifischen lymphozyten, verfahren zum nachweis eines antigenspezifischen lymphozyten und verfahren zur klonierung eines antigenrezeptorgens eines antigenspezifischen lymphozyten | |
CY1119561T1 (el) | Μορια προσδεσης | |
TW200732350A (en) | Methods for generating monovalent IgG | |
CY1110689T1 (el) | Συνθεσεις οι οποιες περιλαμβανουν πολυπεπτιδια | |
DE69230146T2 (de) | Monoklonale antikörper gegen putative hcv-e2/ns1-proteine und verfahren zu ihrer verwendung | |
CY1112342T1 (el) | Χιμαιρικα, υβριδικα και διαδοχικα πολυπεπτιδια μηνιγγοκοκκικου νμβ1870 | |
CY1110557T1 (el) | Αντισωματα ιντερλευκινης-10 | |
ATE411522T1 (de) | Hochaffine t-zellrezeptorproteine und verfahren | |
PE20030065A1 (es) | Metodos para administrar anticuerpos anti-tnfalfa | |
ATE464374T1 (de) | Assay zum schnellen nachweis vom humanen aktivierten protein c und hochspezifischer monoklonaler antikörper dagegen | |
WO2004091543A3 (en) | Method of treating autoimmune disease by inducing antigen presentation by tolerance inducing antigen presenting cells | |
DK1194167T3 (da) | Immunoterapi af autoimmune sygdomme under anvendelse af B-cellespecifikke antistoffer | |
Yang et al. | Multiplex mapping of CD4 T cell epitopes using class II tetramers | |
ATE451618T1 (de) | Verfahren zur identifizierung von epitopen in zusammenhang mit immunogenität bei biopharmazeutika | |
RU2005106841A (ru) | Эпитопы т-клеток в эритропоэтине | |
ATE408832T1 (de) | Verfahren zum nachweis von blutzell-antigenen und gegen diese gerichtete antikörper | |
DE602004015611D1 (de) | Evaluierung adjuvanshaltiger impfstoffe | |
Ise et al. | Primary response of naive CD4+ T cells to amino acid-substituted analogs of an antigenic peptide can show distinct activation patterns: Th1-and Th2-type cytokine secretion, and helper activity for antibody production without apparent cytokine secretion | |
Staines et al. | Whither monoclonal antibodies? | |
WO2004087747A3 (en) | Citrullinated synthetic peptides and uses thereof | |
DE69020914D1 (de) | Monoklonale Antikörper von Ratten gegen menschliche Antigene und Verfahren zu deren Herstellung. | |
Bhanot | Results from modeling of B-Cell receptors binding to antigen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |