ATE478149T1 - Verfahren zur gewinnung von indolocarbazolen mit hilfe von rebeccamycin-biosynthesegenen - Google Patents

Verfahren zur gewinnung von indolocarbazolen mit hilfe von rebeccamycin-biosynthesegenen

Info

Publication number
ATE478149T1
ATE478149T1 AT02801342T AT02801342T ATE478149T1 AT E478149 T1 ATE478149 T1 AT E478149T1 AT 02801342 T AT02801342 T AT 02801342T AT 02801342 T AT02801342 T AT 02801342T AT E478149 T1 ATE478149 T1 AT E478149T1
Authority
AT
Austria
Prior art keywords
rebeccamycin
indolocarbazoles
obtaining
production
biosynthesis genes
Prior art date
Application number
AT02801342T
Other languages
English (en)
Inventor
Reillo Cesar Sanchez
Brana Alfredo Fernandez
Fernandez Departam Salas
Fernandez Carmen Mendez
Original Assignee
Univ Oviedo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oviedo filed Critical Univ Oviedo
Application granted granted Critical
Publication of ATE478149T1 publication Critical patent/ATE478149T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT02801342T 2001-10-19 2002-10-17 Verfahren zur gewinnung von indolocarbazolen mit hilfe von rebeccamycin-biosynthesegenen ATE478149T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200102312A ES2255331B1 (es) 2001-10-19 2001-10-19 Procedimiento de obtencion de indolocarbazoles mediante la utilizacion de genes biosinteticos de rebecamicina.
PCT/ES2002/000492 WO2003033706A1 (es) 2001-10-19 2002-10-17 Procedimiento de obtencion de indolocarbazoles mediante la utilizacion de genes biosinteticos de rebecamicina

Publications (1)

Publication Number Publication Date
ATE478149T1 true ATE478149T1 (de) 2010-09-15

Family

ID=8499217

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02801342T ATE478149T1 (de) 2001-10-19 2002-10-17 Verfahren zur gewinnung von indolocarbazolen mit hilfe von rebeccamycin-biosynthesegenen

Country Status (7)

Country Link
US (1) US8207321B2 (de)
EP (1) EP1443113B1 (de)
AT (1) ATE478149T1 (de)
DE (1) DE60237382D1 (de)
ES (2) ES2255331B1 (de)
MX (1) MXPA04003701A (de)
WO (1) WO2003033706A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE553190T1 (de) * 2006-02-22 2012-04-15 Brain Biotechnology Res & Information Network Ag Neue halogenase
ES2326459B1 (es) * 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
US10344267B2 (en) 2013-11-27 2019-07-09 The University Of Chicago Directed evolution of a regioselective halogenase for increased thermostability
CN107674105B (zh) * 2017-09-27 2020-05-22 杭州科兴生物化工有限公司 吲哚咔唑类化合物及其制备方法和应用
EP4031671A1 (de) * 2019-09-16 2022-07-27 Danmarks Tekniske Universitet Hefezellen und verfahren zur herstellung von tryptophanderivaten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0769555B1 (de) * 1994-06-13 2003-09-03 Banyu Pharmaceutical Co., Ltd. Glycosyltransferase kodierendes gen und seine verwendung
WO1997008323A1 (en) * 1995-08-30 1997-03-06 Novartis Ag Staurosporin biosynthesis gene clusters

Also Published As

Publication number Publication date
US8207321B2 (en) 2012-06-26
US20080004326A1 (en) 2008-01-03
ES2255331A1 (es) 2006-06-16
ES2255331B1 (es) 2007-08-16
MXPA04003701A (es) 2005-04-08
EP1443113B1 (de) 2010-08-18
EP1443113A1 (de) 2004-08-04
ES2350685T3 (es) 2011-01-26
DE60237382D1 (de) 2010-09-30
WO2003033706A1 (es) 2003-04-24

Similar Documents

Publication Publication Date Title
WO2004013280A3 (en) ALLELE-SPECIFIC siRNA-MEDIATED GENE SILENCING
WO2004092331A3 (en) Composition and method for nucleic acid sequencing
AU2003295600A1 (en) Functional and hyperfunctional sirna
GB0127704D0 (en) Nucleic acid enrichment
ATE346938T1 (de) Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen
AU2001244677A1 (en) Method of amplifying nucleic acid by using double-stranded nucleic acid as template
MX2007006610A (es) Metodo para simplificar acidos nucleicos microbianos por modificacion quimica de citosinas.
ATE551352T1 (de) Peptidakzeptorbindungsverfahren
AU4969996A (en) Methods for the isothermal amplification of nucleic acid molecules
MX2009003795A (es) Preparacion de pirimidinas ribofuranosil nucleosidos.
WO2003102214A3 (en) Method for efficient rna interference in mammalian cells
WO2006083800A3 (en) Nucleic acid silencing of huntington's disease gene
FR2804971B1 (fr) Adn codant une acetohydroxyacide synthase, bacterie le contenant et procede de production de l-valine par culture de cette bacterie
DE60213803D1 (en) Happier mapping
EP1576160B8 (de) Borrelidin-derivate und ihre medizinische anwendung
WO2007032794A3 (en) Inhibition of viral gene expression using small interfering rna
AU2002314997A1 (en) Methods for low background cloning of dna using long oligonucleotides
AU2002314227A1 (en) Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules
WO2003100072A3 (de) Verfahren zur fermentativen herstellung schwefelhaltiger feinchemikalien
ATE478149T1 (de) Verfahren zur gewinnung von indolocarbazolen mit hilfe von rebeccamycin-biosynthesegenen
WO2005042705A3 (en) Short interfering rna and micro-rna compounds and methods of designing, making and using the same
ATE394501T1 (de) Verfahren zur herstellung zyklischer moleküle
AU2003213005A1 (en) RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN KINASE C ALPHA (PKC-ALPHA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
DE50210818D1 (de) Verfahren zur genexpression
AU2002326845A1 (en) Concentration and cleanup of nucleic acid samples

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties