ATE470351T1 - Nichtmenschliches tiermodell, das nicht auf eine immunopotenzierende synthetische verbindung anspricht - Google Patents
Nichtmenschliches tiermodell, das nicht auf eine immunopotenzierende synthetische verbindung ansprichtInfo
- Publication number
- ATE470351T1 ATE470351T1 AT02803565T AT02803565T ATE470351T1 AT E470351 T1 ATE470351 T1 AT E470351T1 AT 02803565 T AT02803565 T AT 02803565T AT 02803565 T AT02803565 T AT 02803565T AT E470351 T1 ATE470351 T1 AT E470351T1
- Authority
- AT
- Austria
- Prior art keywords
- mouse
- gene
- tlr7
- synthetic compound
- animal model
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000010171 animal model Methods 0.000 title abstract 2
- 230000002434 immunopotentiative effect Effects 0.000 title abstract 2
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 101100153387 Homo sapiens TLR7 gene Proteins 0.000 abstract 2
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 abstract 2
- 101150033086 TLR7 gene Proteins 0.000 abstract 2
- 102100039390 Toll-like receptor 7 Human genes 0.000 abstract 2
- 210000001671 embryonic stem cell Anatomy 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 241000699670 Mus sp. Species 0.000 abstract 1
- 210000002459 blastocyst Anatomy 0.000 abstract 1
- SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical compound OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229940124669 imidazoquinoline Drugs 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 238000011813 knockout mouse model Methods 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knockout animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Animal Husbandry (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001358295 | 2001-11-22 | ||
PCT/JP2002/012234 WO2003043588A1 (fr) | 2001-11-22 | 2002-11-22 | Modele animal non humain ne reagissant pas a un compose synthetique d'immunopotentialisation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE470351T1 true ATE470351T1 (de) | 2010-06-15 |
Family
ID=19169496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02803565T ATE470351T1 (de) | 2001-11-22 | 2002-11-22 | Nichtmenschliches tiermodell, das nicht auf eine immunopotenzierende synthetische verbindung anspricht |
Country Status (6)
Country | Link |
---|---|
US (1) | US7608750B2 (de) |
EP (1) | EP1459727B1 (de) |
AT (1) | ATE470351T1 (de) |
CA (1) | CA2468011C (de) |
DE (1) | DE60236686D1 (de) |
WO (1) | WO2003043588A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8961477B2 (en) | 2003-08-25 | 2015-02-24 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
US10092524B2 (en) | 2008-06-11 | 2018-10-09 | Edge Therapeutics, Inc. | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
US20120122867A1 (en) * | 2009-05-21 | 2012-05-17 | Nicholas James Bennet | Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases |
WO2011068226A1 (ja) * | 2009-12-03 | 2011-06-09 | 株式会社アウレオ | マクロファージ貪食能活性化組成物および/またはマクロファージにおけるサイトカイン産生促進組成物 |
NZ602000A (en) * | 2010-02-22 | 2015-05-29 | Edge Therapeutics Inc | Methods and compositions to treat hemorrhagic conditions of the brain |
JP6336899B2 (ja) | 2011-04-05 | 2018-06-06 | エッジ セラピューティクス インコーポレイテッド | 脳血流に影響する脳損傷後の結果を改善するための脳室内ドラッグデリバリーシステム |
CN113373178A (zh) * | 2021-08-13 | 2021-09-10 | 上海南方模式生物科技股份有限公司 | 一种tlr8基因人源化动物模型的构建方法及应用 |
WO2024012578A1 (zh) * | 2022-07-15 | 2024-01-18 | 百奥赛图(北京)医药科技股份有限公司 | 一种tlr7和/或tlr8基因人源化修饰的非人动物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6943240B2 (en) * | 2000-09-15 | 2005-09-13 | Coley Pharmaceuticals Gmbh | Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist |
AU2002343728A1 (en) * | 2001-11-16 | 2003-06-10 | 3M Innovative Properties Company | Methods and compositions related to irm compounds and toll-like receptor pathways |
-
2002
- 2002-11-22 DE DE60236686T patent/DE60236686D1/de not_active Expired - Lifetime
- 2002-11-22 WO PCT/JP2002/012234 patent/WO2003043588A1/ja active Application Filing
- 2002-11-22 AT AT02803565T patent/ATE470351T1/de not_active IP Right Cessation
- 2002-11-22 US US10/496,501 patent/US7608750B2/en not_active Expired - Lifetime
- 2002-11-22 EP EP02803565A patent/EP1459727B1/de not_active Expired - Lifetime
- 2002-11-22 CA CA2468011A patent/CA2468011C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2468011A1 (en) | 2003-05-30 |
WO2003043588A1 (fr) | 2003-05-30 |
US7608750B2 (en) | 2009-10-27 |
EP1459727A4 (de) | 2006-09-06 |
CA2468011C (en) | 2012-04-10 |
EP1459727A1 (de) | 2004-09-22 |
JP4493336B2 (ja) | 2010-06-30 |
EP1459727B1 (de) | 2010-06-09 |
US20050235372A1 (en) | 2005-10-20 |
DE60236686D1 (de) | 2010-07-22 |
JPWO2003043588A1 (ja) | 2005-03-10 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |