ATE468343T1 - Verfahren zur reinigung von tacrolimus - Google Patents
Verfahren zur reinigung von tacrolimusInfo
- Publication number
- ATE468343T1 ATE468343T1 AT07753283T AT07753283T ATE468343T1 AT E468343 T1 ATE468343 T1 AT E468343T1 AT 07753283 T AT07753283 T AT 07753283T AT 07753283 T AT07753283 T AT 07753283T AT E468343 T1 ATE468343 T1 AT E468343T1
- Authority
- AT
- Austria
- Prior art keywords
- tacrolimus
- silver modified
- exchange resin
- gel
- sorbent
- Prior art date
Links
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 title abstract 3
- 229960001967 tacrolimus Drugs 0.000 title abstract 3
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229910052709 silver Inorganic materials 0.000 abstract 3
- 239000004332 silver Substances 0.000 abstract 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 2
- 239000000741 silica gel Substances 0.000 abstract 2
- 229910002027 silica gel Inorganic materials 0.000 abstract 2
- 229960001866 silicon dioxide Drugs 0.000 abstract 2
- -1 silver modified aluminum oxide Chemical class 0.000 abstract 2
- 239000002594 sorbent Substances 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000005526 G1 to G0 transition Effects 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 239000003729 cation exchange resin Substances 0.000 abstract 1
- 238000011097 chromatography purification Methods 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 229910001928 zirconium oxide Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78275306P | 2006-03-15 | 2006-03-15 | |
| US84732306P | 2006-09-25 | 2006-09-25 | |
| US86035906P | 2006-11-20 | 2006-11-20 | |
| US87482306P | 2006-12-13 | 2006-12-13 | |
| US87986907P | 2007-01-10 | 2007-01-10 | |
| PCT/US2007/006642 WO2007106587A2 (en) | 2006-03-15 | 2007-03-15 | Process for purifying tacrolimus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE468343T1 true ATE468343T1 (de) | 2010-06-15 |
Family
ID=42827361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07753283T ATE468343T1 (de) | 2006-03-15 | 2007-03-15 | Verfahren zur reinigung von tacrolimus |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1896488B1 (de) |
| AT (1) | ATE468343T1 (de) |
| CA (1) | CA2640161A1 (de) |
| WO (1) | WO2007106587A2 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102936253B (zh) * | 2012-11-12 | 2016-01-06 | 华北制药集团新药研究开发有限责任公司 | 一种高纯度他克莫司的制备方法 |
| CN106083892B (zh) * | 2016-06-13 | 2019-02-19 | 杭州中美华东制药有限公司 | 他克莫司化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01011566A (es) * | 1999-05-25 | 2002-06-04 | Fujisawa Pharmaceutical Co | Metodo para separar compuestos organicos analogos. |
| TW553946B (en) * | 1999-09-08 | 2003-09-21 | Fujisawa Pharmaceutical Co | Method for separating lactone-containing high-molecular weight compounds |
| US7704725B2 (en) * | 2004-04-12 | 2010-04-27 | Biocon Limited | Process for the production of macrolides using a novel strain, Streptomyces sp. BICC 7522 |
| WO2007013017A1 (en) * | 2005-07-29 | 2007-02-01 | Ranbaxy Laboratories Limited | A process for purification of macrolides |
-
2007
- 2007-03-15 WO PCT/US2007/006642 patent/WO2007106587A2/en not_active Ceased
- 2007-03-15 EP EP07753283A patent/EP1896488B1/de not_active Not-in-force
- 2007-03-15 CA CA002640161A patent/CA2640161A1/en not_active Abandoned
- 2007-03-15 AT AT07753283T patent/ATE468343T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007106587A2 (en) | 2007-09-20 |
| EP1896488A2 (de) | 2008-03-12 |
| EP1896488B1 (de) | 2010-05-19 |
| CA2640161A1 (en) | 2007-09-20 |
| WO2007106587A9 (en) | 2007-11-22 |
| WO2007106587A3 (en) | 2008-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |