ATE465242T1 - Exogene angiogene wachstumsfaktoren exprimierende keratinozyten - Google Patents

Exogene angiogene wachstumsfaktoren exprimierende keratinozyten

Info

Publication number
ATE465242T1
ATE465242T1 AT03726524T AT03726524T ATE465242T1 AT E465242 T1 ATE465242 T1 AT E465242T1 AT 03726524 T AT03726524 T AT 03726524T AT 03726524 T AT03726524 T AT 03726524T AT E465242 T1 ATE465242 T1 AT E465242T1
Authority
AT
Austria
Prior art keywords
growth factors
angiogenic growth
keratinocytes
skin tissue
cultured skin
Prior art date
Application number
AT03726524T
Other languages
English (en)
Inventor
Allen Comer
Michael Hoffmann
Lynn-Allen Hoffmann
Original Assignee
Stratatech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stratatech Corp filed Critical Stratatech Corp
Application granted granted Critical
Publication of ATE465242T1 publication Critical patent/ATE465242T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/17—Angiopoietin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Cosmetics (AREA)
AT03726524T 2002-04-30 2003-04-29 Exogene angiogene wachstumsfaktoren exprimierende keratinozyten ATE465242T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37648802P 2002-04-30 2002-04-30
US10/425,784 US7498167B2 (en) 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors
PCT/US2003/013327 WO2003093418A2 (en) 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors

Publications (1)

Publication Number Publication Date
ATE465242T1 true ATE465242T1 (de) 2010-05-15

Family

ID=29406758

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03726524T ATE465242T1 (de) 2002-04-30 2003-04-29 Exogene angiogene wachstumsfaktoren exprimierende keratinozyten

Country Status (9)

Country Link
US (5) US7498167B2 (de)
EP (1) EP1549738B1 (de)
JP (1) JP4753577B2 (de)
AT (1) ATE465242T1 (de)
CA (1) CA2483547C (de)
DE (1) DE60332256D1 (de)
IL (3) IL164817A0 (de)
NZ (1) NZ536205A (de)
WO (1) WO2003093418A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1549738B1 (de) 2002-04-30 2010-04-21 Stratatech Corporation Exogene angiogene wachstumsfaktoren exprimierende keratinozyten
CA2600177C (en) * 2005-03-01 2011-06-14 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
NO2215212T3 (de) 2007-11-14 2018-01-27
DK2352472T3 (en) 2008-11-04 2017-04-10 Stratatech Corp Dried and irradiated skin equivalents ready to use
US20100330046A1 (en) * 2009-05-21 2010-12-30 Stratatech Corporation Human skin substitutes expressing il-12
TWI488966B (zh) * 2010-07-09 2015-06-21 優普生物科技股份有限公司 Ｄｎａ疫苗
US8978234B2 (en) 2011-12-07 2015-03-17 MoMelan Technologies, Inc. Methods of manufacturing devices for generating skin grafts
US9597111B2 (en) 2010-08-06 2017-03-21 Kci Licensing, Inc. Methods for applying a skin graft
JP2012205516A (ja) * 2011-03-29 2012-10-25 Osaka Univ 人工皮膚モデルの製造方法、及び人工皮膚モデル
US9663564B2 (en) 2013-03-15 2017-05-30 The Regents Of The University Of California Vectors and methods to treat ischemia
US20140065110A1 (en) 2012-08-31 2014-03-06 The Regents Of The University Of California Genetically modified msc and therapeutic methods
WO2014072941A1 (en) 2012-11-09 2014-05-15 Marco Archetti Diffusible factors and cancer cells
PT3470018T (pt) 2013-03-13 2021-10-04 Stratatech Corp Criopreservação de substitutos de pele humana viáveis
CN105636532B (zh) 2013-03-14 2019-06-21 凯希特许有限公司 用于采集皮肤移植片的吸收性基底
US9993261B2 (en) 2013-12-31 2018-06-12 Kci Licensing, Inc. Sensor systems for skin graft harvesting
CN106028982B (zh) 2013-12-31 2020-06-12 凯希特许有限公司 流体辅助的皮肤移植物采集
EP3804774A1 (de) 2015-04-09 2021-04-14 3M Innovative Properties Co. System zur entnahme von hauttransplantaten
US11006974B2 (en) 2015-11-03 2021-05-18 Kci Licensing, Inc. Devices for creating an epidermal graft sheet
WO2017143229A1 (en) * 2016-02-19 2017-08-24 Kci Licensing, Inc. Transfected epidermal grafts and methods of making the same
EP4074818A3 (de) * 2016-12-09 2023-01-18 The University of Chicago Gewebeorganoide
AU2020353695A1 (en) * 2019-09-27 2022-03-31 Stratatech Corporation Methods for treating acute wounds and improving outcomes
WO2021231775A1 (en) * 2020-05-13 2021-11-18 Stratatech Copporation Viable bioengineered skin constructs
IL308553A (en) * 2021-06-08 2024-01-01 Stratatech Corp Cellularized bioengineered viable allogeneic skin constructs that secrete soluble factors associated with regenerative wound healing
EP4340855A1 (de) * 2021-08-13 2024-03-27 Triovance Holding LLC Hautersatzzusammensetzung und verfahren zur herstellung und verwendung davon

Family Cites Families (23)

* Cited by examiner, † Cited by third party
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US448096A (en) * 1891-03-10 Hydrant
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5292655A (en) * 1990-01-29 1994-03-08 Wille Jr John J Method for the formation of a histologically-complete skin substitute
CA2080693C (en) * 1990-04-24 2001-11-27 Mark Eisenberg Composite living skin equivalents
US5292566A (en) * 1990-05-22 1994-03-08 National Label Company Battery label with non-shrinkable top layer
IT1248934B (it) * 1990-06-01 1995-02-11 Fidia Spa Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle
US5693332C1 (en) * 1995-08-11 2001-01-09 Univ California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure
US5968546A (en) * 1997-05-16 1999-10-19 Baur; Marcus Keratinocyte culture from precursor cells
US20010048917A1 (en) * 1998-03-09 2001-12-06 Warren Hoeffler Skin equivalent and methods of forming and using same
US5989837A (en) * 1998-07-13 1999-11-23 Wisconsin Alumni Research Foundation Immortalized human keratinocyte cell line
US20030152562A1 (en) * 2001-10-23 2003-08-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Vitro micro-organs, and uses related thereto
US6458382B1 (en) * 1999-11-12 2002-10-01 Mirus Corporation Nucleic acid transfer complexes
WO2002036131A1 (en) * 2000-11-01 2002-05-10 Ludwig Institute For Cancer Research In vivo stimulation of angiogenic activity
US6846675B2 (en) * 2001-03-02 2005-01-25 Stratech Corporation Skin substitutes and uses thereof
US6849718B2 (en) * 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
WO2003018621A2 (en) * 2001-08-23 2003-03-06 Oxford Biomedica (Uk) Limited Genes
US6838430B2 (en) * 2001-09-28 2005-01-04 The Regents Of The University Of California Use of HIF-1a variants to accelerate wound healing
US20040190793A1 (en) * 2002-03-01 2004-09-30 Rorvig Mark E. Method for retrieving images by content measure metadata encoding
EP1549738B1 (de) * 2002-04-30 2010-04-21 Stratatech Corporation Exogene angiogene wachstumsfaktoren exprimierende keratinozyten
EP1546392A4 (de) * 2002-08-02 2006-05-24 Stratatech Corp Spezies-spezifischer dna-nachweis
AU2004247072B2 (en) * 2003-05-30 2007-09-13 Stratatech Corporation Room temperature storage of organs
AU2004262002B2 (en) * 2003-08-01 2010-03-25 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides

Also Published As

Publication number Publication date
US20040009591A1 (en) 2004-01-15
IL164817A (en) 2010-12-30
IL195518A (en) 2012-08-30
IL164817A0 (en) 2005-12-18
US7988959B2 (en) 2011-08-02
CA2483547A1 (en) 2003-11-13
US8808685B2 (en) 2014-08-19
US7915042B2 (en) 2011-03-29
WO2003093418A2 (en) 2003-11-13
JP4753577B2 (ja) 2011-08-24
US20110059057A1 (en) 2011-03-10
EP1549738A2 (de) 2005-07-06
EP1549738B1 (de) 2010-04-21
US20090169528A1 (en) 2009-07-02
WO2003093418A3 (en) 2005-04-21
CA2483547C (en) 2012-03-20
EP1549738A4 (de) 2006-11-02
AU2003228755A1 (en) 2003-11-17
US7807148B2 (en) 2010-10-05
NZ536205A (en) 2008-04-30
DE60332256D1 (de) 2010-06-02
JP2006509529A (ja) 2006-03-23
US7498167B2 (en) 2009-03-03
US20110286985A1 (en) 2011-11-24
US20050013807A1 (en) 2005-01-20

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